Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Mus musculus | - |
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? | |
arachidonate + O2 | Mus musculus C57BL/6J | - |
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P39654 | - |
- |
Mus musculus C57BL/6J | P39654 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Mueller cell | - |
Mus musculus | - |
retina | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Mus musculus | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? | |
arachidonate + O2 | - |
Mus musculus C57BL/6J | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12/15-lipoxygenase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | 12/15-lipoxygenase derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy via NADPH oxidase (NOX) and disruption of the balance in retinal levels of the vascular endothelial growth factor and pigment epithelium-derived factor. Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids, i.e. (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate, mechanism, overview. 12-HETE stimulates inflammatory cytokine production such as interleukin IL-6 and TNF-alpha from retinal Müller cells (rMCs) | Mus musculus |