Literature summary for 1.1.5.13 extracted from

Shelar, S.; Shim, E.H.; Brinkley, G.J.; Kundu, A.; Carobbio, F.; Poston, T.; Tan, J.; Parekh, V.; Benson, D.; Crossman, D.K.; Buckhaults, P.J.; Rakheja, D.; Kirkman, R.; Sato, Y.; Ogawa, S.; Dutta, S.; Velu, S.E.; Emberley, E.; Pan, A.; Chen, J.; Huang, T.; Absher, D.; Becker, A.; Kunick, C.; Sudarshan, S.
Biochemical and epigenetic insights into L-2-hydroxyglutarate, a potential therapeutic target in renal cancer (2018), Clin. Cancer Res., 24, 6433-6446.

Application

Application	Comment	Organism
medicine	lower enzyme expression is associated with tumor progression and/or worsened prognosis in patients with renal cell carcinoma	Homo sapiens

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-2-hydroxyglutarate + a quinone	Homo sapiens	-	2-oxoglutarate + a quinol	-	?

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue	Comment	Organism	Textmining
769-P cell	-	Homo sapiens	-
A-498 cell	-	Homo sapiens	-
A-498 cell	mutation A241G in A498 cells	Homo sapiens	-
Caki-1 cell	-	Homo sapiens	-
OS-RC-2 cell	-	Homo sapiens	-
renal cell carcinoma cell	-	Homo sapiens	-
RXF-393 cell	-	Homo sapiens	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-2-hydroxyglutarate + a quinone	-	Homo sapiens	2-oxoglutarate + a quinol	-	?

Synonyms	Comment	Organism
L-2-HG dehydrogenase	-	Homo sapiens
L-2-hydroxyglutarate dehydrogenase	-	Homo sapiens
L2HGDH	-	Homo sapiens

General Information	Comment	Organism
physiological function	the enzyme suppresses both in vitro cell migration and in vivo tumor growth in renal cell carcinoma	Homo sapiens

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Release 2026.1 (March 2026)