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Literature summary for 1.1.3.13 extracted from
- Production of hydroxy acids selective double oxidation of diols by flavoprotein alcohol oxidase (2020), Angew. Chem. Int. Ed. Engl., 59, 4869-4872 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3 | - |
hexan-1-ol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium |  |
| 12.3 | - |
diethylene glycol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 12.9 | - |
hexane-1,6-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 52.6 | - |
pentane-1,4-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 69.6 | - |
pentane-1,5-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 119 | - |
2,2'-sulfanediyldi(ethan-1-ol) | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 198 | - |
Butane-1,4-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Phanerodontia chrysosporium | T2M2J4 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 5-aminopentan-1-ol + O2 | - |
Phanerodontia chrysosporium | 5-(piperidin-2-yl)-2,3,4,5-tetrahydropyridine + H2O2 | - |
? | |
| 2,2'-sulfanediyldi(ethan-1-ol) + O2 | - |
Phanerodontia chrysosporium | [(2-hydroxyethyl)sulfanyl]acetic acid + H2O2 | - |
? | |
| 2,2'-[ethane-1,2-diylbis(oxy)]di(ethan-1-ol) + O2 | - |
Phanerodontia chrysosporium | [2-(2-oxoethoxy)ethoxy]acetic acid + H2O2 | - |
? | |
| butane-1,4-diol + O2 | - |
Phanerodontia chrysosporium | oxolan-2-one + H2O2 | - |
? | |
| diethylene glycol + 2 O2 | - |
Phanerodontia chrysosporium | 2-(2-hydroxyethoxy)acetic acid + H2O2 | - |
? | |
| hexan-1-ol + O2 | - |
Phanerodontia chrysosporium | hexanoic acid + H2O2 | - |
? | |
| hexane-1,6-diol + O2 | - |
Phanerodontia chrysosporium | 6-oxohexanoic acid + cyclopent-1-ene-1-carbaldehyde + H2O2 | - |
? | |
| additional information | alcohol oxidase facilitates double and triple oxidations for a range of aliphatic diols. Depending on the diol substrate, the reaction results in formation of either lactones or hydroxy acids | Phanerodontia chrysosporium | ? | - |
- |
|
| octane-1,8-diol + O2 | - |
Phanerodontia chrysosporium | 6-oxooctanoic acid + H2O2 | - |
? | |
| pentane-1,4-diol + O2 | - |
Phanerodontia chrysosporium | 5-methyloxolan-2-one + H2O2 | - |
? | |
| pentane-1,5-diol + O2 | - |
Phanerodontia chrysosporium | 5-hydroxypentanoic acid + H2O2 | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.56 | - |
hexan-1-ol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 0.73 | - |
diethylene glycol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 1.28 | - |
pentane-1,4-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 3.48 | - |
pentane-1,5-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 3.56 | - |
2,2'-sulfanediyldi(ethan-1-ol) | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 4.07 | - |
hexane-1,6-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 6.74 | - |
Butane-1,4-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.024 | - |
pentane-1,4-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 0.03 | - |
2,2'-sulfanediyldi(ethan-1-ol) | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 0.034 | - |
Butane-1,4-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 0.05 | - |
pentane-1,5-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
| 0.316 | - |
hexane-1,6-diol | pH 7.5, temperature not specified in the publication | Phanerodontia chrysosporium | |
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