Cloned (Comment) | Organism |
---|---|
gene HSD11B1, variation exists in placental DNA methylation of HSD11B1, the variation is associated with mRNA expression of the gene, real-time PCR expression analysis. No correlation between HSD11B1 CpG1 and expression, and a strong positive correlation between CpG2 and expression. HSD11B1 gene expression is positively correlated with a single CpG site | Homo sapiens |
gene HSD11B2, variation exists in placental DNA methylation of HSD11B2, the variation is associated with mRNA expression of the gene, real-time PCR expression analysis. Sex-specific correlation between HSD11B2 methylation levels and expression, with females displaying a much stronger correlation between the two factors with no correlation for males, there is no sex-specific role of methylation in infant birth weight in either time points in pregnancy. HSD11B2 expression is negatively correlated with the mean methylation of four CpG sites within its promoter | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Homo sapiens | P80365 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
11-beta hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
11-beta hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
HSD11B type 1 | - |
Homo sapiens |
HSD11B type 2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the placenta acts as a master regulator for the fetal environment, mediating intrauterine exposures to stress through the activity of genes regulating glucocorticoids, including the 11beta-hydroxysteroid dehydrogenase (HSD11B) type 1 and 2 genes, variation in the genes are associated with infant birth weight. A significant association between methylation at a single CpG site within HSD11B1 and being born large for gestational age is detected. Correlations between methylation and gene expression. Methylation at a single CpG site within HSD11B1 is associated with infant birth weight, and that methylation at several different sites is correlated with gene expression. There is no sex-specific role of methylation in infant birth weight in either time points in pregnancy | Homo sapiens |
physiological function | the placenta acts as a master regulator for the fetal environment, mediating intrauterine exposures to stress through the activity of genes regulating glucocorticoids, including the 11beta-hydroxysteroid dehydrogenase (HSD11B) type 1 and 2 genes, variation in the genes are associated with infant birth weight. Correlations between methylation and gene expression, including sex-specific transcriptional regulation of HSD11B2 | Homo sapiens |