Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasmic membrane | NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus | - |
- |
cytosol | NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-pregnan-3,20-dione + NAD(P)H + H+ | Rattus norvegicus | 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin | 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+ | - |
r | |
5alpha-pregnan-3,20-dione + NAD(P)H + H+ | Rattus norvegicus | activity higher during lactation in female rats | 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+ | - |
r | |
5alpha-pregnan-3,20-dione + NADPH | Rattus norvegicus | - |
3alpha-hydroxy-5alpha-pregnan-20-one + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
NADPH- and NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | distribution in brain regions of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus | - |
brain | NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity is decreased by 40-50% in lactating rats | Rattus norvegicus | - |
hypophysis | anterior | Rattus norvegicus | - |
hypophysis | cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, increase of both enzymes during lactation | Rattus norvegicus | - |
hypothalamus | cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-pregnan-3,20-dione + NAD(P)H | - |
Rattus norvegicus | 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
? | |
5alpha-pregnan-3,20-dione + NAD(P)H + H+ | 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin | Rattus norvegicus | 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+ | - |
r | |
5alpha-pregnan-3,20-dione + NAD(P)H + H+ | activity higher during lactation in female rats | Rattus norvegicus | 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+ | - |
r | |
5alpha-pregnan-3,20-dione + NADPH | - |
Rattus norvegicus | 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+ | - |
? | |
5alpha-pregnan-3,20-dione + NADPH | - |
Rattus norvegicus | 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase | NADH- and NADPH-linked | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | plasma membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus | |
NADPH | cytosolic NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus |