Cloned (Comment) | Organism |
---|---|
expression in baculovirus system with Sf9 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
3alpha-tetrahydroprogesterone | - |
Homo sapiens | |
0.012 | - |
5alpha-dihydrotestosterone | - |
Homo sapiens | |
0.024 | - |
androsterone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
1-4 different enzyme isoforms | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | variations in different tissues concerning number of enzyme isoforms | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0135 | - |
- |
Homo sapiens |
0.031 | - |
substrate dihydrotestosterone | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-hydroxy-dihydrotestosterone + NAD+ | - |
Homo sapiens | 5alpha-androstan-3,17-dione + NADH | - |
r | |
3alpha-tetrahydroprogesterone + NADH | - |
Homo sapiens | 5alpha-dihydroprogesterone + NAD+ | - |
r | |
5alpha-androstan-3alpha,17beta-diol + NAD(P)+ | - |
Homo sapiens | 17beta-hydroxy-5alpha-androstan-3-one + NADPH | - |
r | |
5alpha-androstan-3alpha,17beta-diol + NAD(P)H | - |
Homo sapiens | 5alpha-dihydrotestosterone + NAD(P)+ | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | - |
Homo sapiens | 5alpha-androstan-3alpha,17beta-diol + NAD(P)+ | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | - |
Homo sapiens | (3beta,5alpha,17beta)-androstane-3,17-diol + NAD(P)+ | - |
r | |
androsterone + NAD(P)+ | - |
Homo sapiens | 5alpha-androstan-3,17-dione + NAD(P)H | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | cytosolic and microsomal enzymes have different cofactor preferences: cytosolic enzymes prefer NADP+/NADPH, microsomal prefer NAD+/NADH | Homo sapiens | |
NAD+ | preference for | Homo sapiens | |
NADH | preference for | Homo sapiens |