Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-aminonicotinamide | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | Mus musculus | the enzyme is involved in the oxidative pentose phosphate pathway | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9DCD0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphocyte | from spleen, lymph node or thymus | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | - |
Mus musculus | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | the enzyme is involved in the oxidative pentose phosphate pathway | Mus musculus | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphogluconate dehydrogenase | - |
Mus musculus |
6PGD | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
drug target | blockade of 6-phosphogluconate dehydrogenase reprograms CD8+ T cell metabolism to support superior effector function with higher tumoricidal activity. This metabolic checkpoint represents a key therapeutic target for cancer immunotherapies | Mus musculus |
malfunction | blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function | Mus musculus |
metabolism | the enzyme is involved in the oxidative pentose phosphate pathway | Mus musculus |
physiological function | the enzyme is a modulator of CD8+ T cell activation and differentiation | Mus musculus |