Inhibitors | Comment | Organism | Structure |
---|---|---|---|
C-4 epimer galacturonate | displays marked substrate inhibition | Penicillium camemberti | |
glucuronate | weak substrate inhibition | Penicillium camemberti | |
L-gulonate | competitive inhibitor, Ki in the low mM range | Penicillium camemberti | |
L-gulono-1,4-lactone | competitive inhibitor, Ki in the low mM range | Penicillium camemberti | |
additional information | substrate inhibition by aldonic acids. The products L-galactonate and L-galactono-1,4-lactone are observed to mitigate substrate inhibition by galacturonate, with the lactone having a greater effect than the acid | Penicillium camemberti |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penicillium camemberti | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucurono-3,6-lactone + NADPH + H+ | - |
Penicillium camemberti | L-gulono-1,4-lactone | - |
r | |
L-galactonate + NADP+ | - |
Penicillium camemberti | D-galacturonate + NADPH + H+ | - |
r | |
L-gluconate + NADP+ | - |
Penicillium camemberti | D-glucuronate + NADPH + H+ | - |
r | |
additional information | the enzyme catalyzes the reduction of the C-1 carbon of D-glucuronate and C-4 epimer D-galacturonate to their corresponding aldonic acids. It is active on both glucuronic acid and galacturonic acid, with similar substrate specificities using the preferred cosubstrate NADPH. Substrate acceptance extends to lactone congeners, and D-glucurono-3,6-lactone is converted to L-gulono-1,4-lactone | Penicillium camemberti | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
galacturonate reductase | - |
Penicillium camemberti |
PcGOR | - |
Penicillium camemberti |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Penicillium camemberti | |
NADPH | - |
Penicillium camemberti |
General Information | Comment | Organism |
---|---|---|
physiological function | Penicillium camemberti reduces the C-1 carbon of D-glucuronate and C-4 epimer D-galacturonate to their corresponding aldonic acids, important reactions in both pectin catabolism and ascorbate biosynthesis. Enzyme PcGOR is active on both glucuronic acid and galacturonic acid, with similar substrate specificities (kcat/Km) using the preferred cosubstrate NADPH. Substrate acceptance extends to lactone congeners, and D-glucurono-3,6-lactone is converted to L-gulono-1,4-lactone, an immediate precursor of ascorbate | Penicillium camemberti |