Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
photoreceptor inner segment | - |
Mus musculus | 1917 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinol + NADP+ | Mus musculus | - |
all-trans-retinal + NADPH + H+ | - |
? | |
all-trans-retinol + NADP+ | Mus musculus C57BL/6 x 129/Sv | - |
all-trans-retinal + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57BL/6 x 129/Sv | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | RDH12 localizes to photoreceptor inner segments | Mus musculus | - |
retina | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinol + NADP+ | - |
Mus musculus | all-trans-retinal + NADPH + H+ | - |
? | |
all-trans-retinol + NADP+ | - |
Mus musculus C57BL/6 x 129/Sv | all-trans-retinal + NADPH + H+ | - |
? | |
additional information | no activity with decanal | Mus musculus | ? | - |
? | |
additional information | no activity with decanal | Mus musculus C57BL/6 x 129/Sv | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RDH12 | - |
Mus musculus |
retinoid dehydrogenase/reductase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
evolution | RDHs that catalyze the interconversion of retinal and retinol involved in rhodopsin turnover are members of the family of short chain dehydrogenase/reductases | Mus musculus |
malfunction | loss-of-function mutations of RDH12 cause retinal degeneration in some forms of Leber congenital amaurosis. Outer segments of rods deficient in Rdh12 show no altered phenotype. Following exposure to light, a leak of retinoids from outer to inner segments is detected in rods from both wild-type and knock-out mice. In cells lacking Rdh8, EC 1.1.1.105, or Rdh12, this leak is mainly all-trans-retinal, overview. Retinal reductase activity is lost in RDH8-deficient mutants | Mus musculus |
physiological function | RDH12 activity in the photoreceptor inner segments is also key enzyme function. RDH12 in inner segments can protect vital cell organelles against aldehyde toxicity caused by an intracellular leak of all-trans-retinal, as well as other aldehydes originating both inside and outside the cell | Mus musculus |