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Literature summary for 1.1.1.27 extracted from

  • Young, A.; Oldford, C.; Mailloux, R.J.
    Lactate dehydrogenase supports lactate oxidation in mitochondria isolated from different mouse tissues (2020), Redox Biol., 28, 101339 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.27

Inhibitors

Inhibitors Comment Organism Structure
GSK 2837808A
-
 Mus musculus
Sodium oxamate
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-
liver
-
 Mus musculus
-
muscle
-
 Mus musculus
-

General Information

General Information Comment Organism
physiological function lactate can fuel the bioenergetics of heart, muscle, and liver mitochondria. Lactate is just as effective as pyruvate at stimulating mitochondrial coupling efficiency. Inclusion of LDH and pyruvate dehydrogenase inhibitors abolishes respiration in mitochondria energized with lactate. Lactate also fueled mitochondrial ROS generation and is just as effective as pyruvate at stimulating H2O2 production. Lactate-induced ROS production is inhibited by both LDH and PDH inhibitors Mus musculus