Literature summary for 1.1.1.27 extracted from

Tian, L.; Zhou, J.; Lv, Q.; Liu, F.; Yang, T.; Zhang, X.; Xu, M.; Rao, Z.
Rational engineering of the Plasmodium falciparum L-lactate dehydrogenase loop involved in catalytic proton transfer to improve chiral 2-hydroxybutyric acid production (2021), Int. J. Biol. Macromol., 179, 71-79 .

Search for more literature for 1.1.1.27

Protein Variants

Protein Variants	Comment	Organism
N197D	1.15fold increase in activity, 2.7fold increase in kcat/Km ratio, 2fold increase in production titer for asymmetric synthesis of (S)-2-hydroxybutanoic acid	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
40	-	half-life of wild-type is 50.4 h, of mutant N197D is 77.9 h	Plasmodium falciparum

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)