Literature summary for 1.1.1.21 extracted from

Yang, Y.; Yang, Q.; Yu, J.; Wan, W.; Wei, X.
Characterization of structural requirement for binding of gigantol and aldose reductase (2019), Front. Biosci. (Landmark Ed.), 24, 1024-1036 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking predicts the binding sites between aldose reductase and gigantol to be residues Trp111, His110, Tyr48 and Trp20	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	mutation of residues Trp111, His110, Tyr48 or Trp20 leads to a significant reduction in aldose reductase activity	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
gigantol	the binding of gigantol to aldose reductase is concentration-dependent and the maximum stoichiometric ratio of non-covalent bonding is 1:24.4. pH and temperature do not influence the interaction. Gigantol is protective against diabetic cataracts in rats induced by streptozotocin	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

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Release 2023.1 (January 2023)