Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(10-benzyl-3,4-dioxo-3,4-dihydro[1,2,4]triazino[4,3-a]benzimidazol-2(10H)-yl)acetic acid | - |
Bos taurus | |
(2R)-2,3-dihydroxypropanamide | - |
Bos taurus | |
(2R)-2-hydroxypropanamide | - |
Bos taurus | |
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide | - |
Bos taurus | |
(2R,3S,4S)-2,3,4,5-tetrahydroxypentanamide | - |
Bos taurus | |
(2S)-2,3-dihydroxypropanamide | - |
Bos taurus | |
(2S,3R,4R)-2,3,4,5-tetrahydroxypentanamide | - |
Bos taurus | |
(2S,3S)-2,3,4-trihydroxybutanamide | - |
Bos taurus | |
(4-benzyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetic acid | - |
Bos taurus | |
(4S)-6-fluoro-2,3-dihydro-2'H,5'H-spiro[1-benzopyran-4,4'-imidazolidine]-2',5'-dione | - |
Bos taurus | |
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one | - |
Bos taurus | |
2-(3,4-dihydroxyphenyl)-4H-pyrido[1,2-a]pyrimidin-4-one | - |
Bos taurus | |
2-(3,4-dihydroxyphenyl)-6-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one | - |
Bos taurus | |
2-(3,4-dihydroxyphenyl)-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one | - |
Bos taurus | |
2-(3,4-dimethoxyphenyl)-6-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one | - |
Bos taurus | |
2-(4-hydroxy-3-methoxyphenyl)-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one | - |
Bos taurus | |
2-(6-nitro-1,1,3-trioxo-1,3-dihydro-2H-1lambda~6~,2-benzothiazol-2-yl)propanoic acid | - |
Bos taurus | |
2-benzyl-1,3,3-trioxo-2,3-dihydro-1H-3lambda~6~-naphtho[1,2-d][1,2]thiazole-4-carboxylic acid | - |
Bos taurus | |
2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one | - |
Bos taurus | |
2-[(3,4-dihydroxyphenyl)methyl]-6-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one | - |
Bos taurus | |
3-(4-nitro-1,1,3-trioxo-1,3-dihydro-2H-1lambda~6~,2-benzothiazol-2-yl)propanoic acid | - |
Bos taurus | |
3-(6-acetamido-1,1,3-trioxo-1,3-dihydro-2H-1lambda~6~,2-benzothiazol-2-yl)propanoic acid | - |
Bos taurus | |
3-[6-(3-methylbutanamido)-1,1,3-trioxo-1,3-dihydro-2H-1lambda~6~,2-benzothiazol-2-yl]propanoic acid | - |
Bos taurus | |
4-[(3-nitrophenyl)methyl]-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylic acid | - |
Bos taurus | |
6-hydroxy-2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one | - |
Bos taurus | |
[(2E)-2-[2-(carboxymethyl)hydrazinylidene]-3-[[4-(trifluoromethyl)phenyl]methyl]-2,3-dihydro-1H-benzimidazol-1-yl](oxo)acetic acid | - |
Bos taurus | |
[(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid | - |
Bos taurus | |
[3,4-dioxo-10-[[4-(trifluoromethyl)phenyl]methyl]-3,4-dihydro[1,2,4]triazino[4,3-a]benzimidazol-2(10H)-yl]acetic acid | - |
Bos taurus | |
[3-[(4-chlorophenyl)methyl]-1,2,4-oxadiazol-5-yl]acetic acid | - |
Bos taurus | |
[5-methyl-7-oxo-4-(2-phenylethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]acetic acid | - |
Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | - |
x * 34000 | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NADPH + H+ | Bos taurus | - |
sorbitol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | P16116 | - |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from lens | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lens | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.2 | - |
purified native enzyme, substrate L-glyceraldehyde, pH 6.8, 37°C | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-glutathionyl-4-hydroxynonanal + NADPH + H+ | - |
Bos taurus | ? + NADP+ | - |
? | |
4-hydroxynonenal + NADPH + H+ | - |
Bos taurus | 4-hydroxynonanol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | - |
Bos taurus | sorbitol + NADP+ | - |
? | |
L-glyceraldehyde + NADPH + H+ | - |
Bos taurus | ? + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 34000 | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
AKR1B1 | - |
Bos taurus |
aldose reductase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Bos taurus |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the aldo-keto reductase superfamily | Bos taurus |
metabolism | the enzyme is the first rate-determining enzyme in the polyol pathway and catalyzes the reduction of glucose to sorbitol in the presence of NADPH as a cofactor. Sorbitol is in turn converted into fructose with accompanied reduction of NAD+ by sorbitol dehydrogenase | Bos taurus |