Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2-oxo-3-((3,4,5-trifluorophenyl)amino)quinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-((2,4-difluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)-acetic acid | - |
Rattus norvegicus | |
2-(3-((4-bromophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-((4-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-bromo-2-fluorophenoxy)-6-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-bromo-2-fluorophenoxy)-7-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-bromo-2-fluorophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-bromophenoxy)-6-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-bromophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-bromophenoxy)-7-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-bromophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(6-bromo-3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(6-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(6-bromo-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(6-chloro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(6-fluoro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(7-bromo-3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(7-bromo-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(7-chloro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
2-(7-fluoro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | - |
Rattus norvegicus | |
3,6,7-trichloroquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
3,6-dichloroquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
3,7-dichloroquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
3-chloro-6-fluoroquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
3-chloro-6-methylquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
3-chloro-6-nitroquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
3-chloro-7-fluoroquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
3-chloro-7-methoxyquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
3-chloro-7-methylquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
3-chloroquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
6,7-dichloro-3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one | - |
Rattus norvegicus | |
6-bromo-3-chloroquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
7-bromo-3-chloroquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
epalrestat | - |
Rattus norvegicus | |
methyl 2-(2-oxo-3-((3,4,5-trifluorophenyl)amino)quinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-((2,4-difluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-((4-bromophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-((4-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-(4-bromo-2-fluorophenoxy)-6-chloro-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-(4-bromo-2-fluorophenoxy)-7-chloro-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-(4-bromo-2-fluorophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetat | - |
Rattus norvegicus | |
methyl 2-(3-(4-bromophenoxy)-6-chloro-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-(4-bromophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-(4-bromophenoxy)-7-chloro-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-(4-bromophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(6-bromo-3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(6-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(6-bromo-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(6-chloro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(6-fluoro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(7-bromo-3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(7-bromo-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(7-chloro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
methyl 2-(7-fluoro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate | - |
Rattus norvegicus | |
additional information | synthesis of quinoxalinone derivatives as potent inhibitors of aldose reductase, Structure-activity relationship and molecular docking studies, overview | Rattus norvegicus | |
rubrolide L | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NADPH + H+ | Rattus norvegicus | - |
D-sorbitol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | Rattus norvegicus Wistar | - |
D-sorbitol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Wistar | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NADPH + H+ | - |
Rattus norvegicus | D-sorbitol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | - |
Rattus norvegicus Wistar | D-sorbitol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Rattus norvegicus |
ALR1 | - |
Rattus norvegicus |
ALR2 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at, ALR2 | Rattus norvegicus |
37 | - |
assay at, ALR1 | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.2 | - |
assay at, ALR2 | Rattus norvegicus |
7.2 | - |
assay at, ALR1 | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000143 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | epalrestat | |
0.00000163 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(6-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.00000243 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-bromophenoxy)-6-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.00000431 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(6-bromo-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000047 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(7-bromo-3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.00000504 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(6-chloro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000063 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(7-bromo-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000114 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-bromophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000191 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(7-fluoro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000226 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-bromo-2-fluorophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000273 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000328 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.000033 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-bromophenoxy)-7-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000356 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-bromo-2-fluorophenoxy)-7-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000382 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(6-bromo-3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000423 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(7-chloro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000435 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.000045 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000463 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-bromo-2-fluorophenoxy)-6-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000493 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-bromophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.00007 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(6-fluoro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.0000748 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.000124 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)-acetic acid | |
0.00015 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-((4-bromophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.000494 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-((4-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetic acid | |
0.000987 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(2-oxo-3-((3,4,5-trifluorophenyl)amino)quinoxalin-1(2H)-yl)acetic acid | |
0.001204 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | 2-(3-((2,4-difluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetic acid |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes the first step in the polyol pathway of glucose metabolism | Rattus norvegicus |