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Literature summary for 1.1.1.21 extracted from

  • Brown, K.E.; Broadhurst, K.A.; Mathahs, M.M.; Kladney, R.D.; Fimmel, C.J.; Srivastava, S.K.; Brunt, E.M.
    Immunodetection of aldose reductase in normal and diseased human liver (2005), Histol. Histopathol., 20, 429-436.
    View publication on PubMed
Search for more literature for 1.1.1.21

Activating Compound

Activating Compound Comment Organism Structure
additional information induction of enzyme expression inliver by toxic metabolites generated by rapidly proliferating cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NADPH + H+ Homo sapiens first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation alditol + NADP+
-
 ?
additional information Homo sapiens the enzyme is involved in pathogenesis of diabetic disease ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 female and male
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell increased expression of the enzyme in sinusoidal lining cells of the tumor Homo sapiens
-
liver healthy and diabetic livers, enzyme expression analysis, distribution in liver, expression is increased in acute and chromic liver disease, overview Homo sapiens
-
macrophage in inflamed temporal arteries Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aldose + NADPH + H+ first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation Homo sapiens alditol + NADP+
-
 ?
aldose + NADPH + H+
-
 Homo sapiens alditol + NADP+
-
 ?
additional information the enzyme is involved in pathogenesis of diabetic disease Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
alditol:NAD(P)+1oxidoreductase
-
 Homo sapiens
aldose reductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Homo sapiens