Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2,4-dichloro-6-hydroxyphenyl)(1,3-dihydro-2H-isoindol-2-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(2,3-dihydro-1H-indol-1-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,3-dihydro-1H-indol-1-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,6-diazaspiro[3.4]octan-6-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(2-oxa-6-azaspiro[3.4]octan-6-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(3,3-dimethylpyrrolidin-1-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(3-fluoro-3-methylpyrrolidin-1-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(3-phenylpyrrolidin-1-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(4-phenylpiperidin-1-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)(pyrrolidin-1-yl)methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)[3-(1-methyl-1H-pyrazol-4-yl)pyrrolidin-1-yl]methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)[3-(2-phenylethyl)pyrrolidin-1-yl]methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-2-yl)pyrrolidin-1-yl]methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-3-yl)pyrrolidin-1-yl]methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-4-yl)pyrrolidin-1-yl]methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)[3-(trifluoromethyl)pyrrolidin-1-yl]methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)methyl]pyrrolidin-1-yl]methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)oxy]pyrrolidin-1-yl]methanone | - |
Homo sapiens | |
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-4-yl)methyl]pyrrolidin-1-yl]methanone | - |
Homo sapiens | |
(2-azaspiro[3.4]octan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(2-azaspiro[4.4]nonan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(2-azaspiro[4.5]decan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(3-anilinopyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(3-benzylpyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(4-benzylpiperidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(5-azaspiro[2.4]heptan-5-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-aza-spiro[3.4]oct-6-yl)-(2,4-difluoro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2,3-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-3-fluoro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-methoxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2-chloro-4-fluoro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methoxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methylphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxy-4-methylphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(2-hydroxypyridin-3-yl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(3,4-dichloro-2-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(3,6-dichloro-2-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(3-chloro-5-hydroxypyridin-4-yl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-2-yl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-4-yl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(4,5-dichloro-2-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-fluoro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxy-6-methylphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(4-fluoro-2-hydroxyphenyl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(4-hydroxypyridin-3-yl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(5-chloro-3-hydroxypyridin-2-yl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(5-fluoro-3-hydroxypyridin-2-yl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)(5-hydroxypyrimidin-4-yl)methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)[2-chloro-4-(dimethylamino)-6-hydroxyphenyl]methanone | - |
Homo sapiens | |
(6-azaspiro[3.4]octan-6-yl)[2-chloro-6-hydroxy-4-(trifluoromethyl)phenyl]methanone | - |
Homo sapiens | |
(6-azaspiro[3.5]nonan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens | |
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-dichlorophenol | - |
Homo sapiens | |
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-difluorophenol | - |
Homo sapiens | |
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3-fluorophenol | - |
Homo sapiens | |
2-(6-azaspiro[3.4]octane-6-sulfonyl)-5-fluorophenol | - |
Homo sapiens | |
4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzamide | - |
Homo sapiens | |
4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzonitrile | - |
Homo sapiens | |
N-acetylserotonine | - |
Homo sapiens | |
SPRi3 | - |
Homo sapiens | |
sulfapyridine | - |
Homo sapiens | |
sulfasalazine | - |
Homo sapiens | |
xanthurenic acid | - |
Homo sapiens | |
[4-(benzenesulfonyl)piperidin-1-yl](2,4-dichloro-6-hydroxyphenyl)methanone | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sepiapterin + NADPH + H+ | Homo sapiens | - |
7,8-dihydrobiopterin + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35270 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sepiapterin + NADPH + H+ | - |
Homo sapiens | 7,8-dihydrobiopterin + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SPR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00003 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | 2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-difluorophenol | |
0.00004 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | 2-(6-azaspiro[3.4]octane-6-sulfonyl)-5-fluorophenol | |
0.000057 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-aza-spiro[3.4]oct-6-yl)-(2,4-difluoro-6-hydroxyphenyl)methanone | |
0.000083 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | 2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-dichlorophenol | |
0.00012 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(2,3-dihydro-1H-indol-1-yl)methanone | |
0.00021 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone | |
0.00024 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(4-phenylpiperidin-1-yl)methanone | |
0.00028 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (3-anilinopyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | |
0.00029 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxyphenyl)methanone | |
0.00031 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)oxy]pyrrolidin-1-yl]methanone | |
0.00031 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (4-benzylpiperidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | |
0.00031 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(5-chloro-3-hydroxypyridin-2-yl)methanone | |
0.00035 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(5-fluoro-3-hydroxypyridin-2-yl)methanone | |
0.00037 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-3-yl)pyrrolidin-1-yl]methanone | |
0.00038 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)[3-(2-phenylethyl)pyrrolidin-1-yl]methanone | |
0.00046 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.5]nonan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | |
0.00052 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(3-phenylpyrrolidin-1-yl)methanone | |
0.00055 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-4-yl)methyl]pyrrolidin-1-yl]methanone | |
0.00058 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | |
0.0006 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)[3-(1-methyl-1H-pyrazol-4-yl)pyrrolidin-1-yl]methanone | |
0.0006 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | [4-(benzenesulfonyl)piperidin-1-yl](2,4-dichloro-6-hydroxyphenyl)methanone | |
0.00061 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)methyl]pyrrolidin-1-yl]methanone | |
0.00061 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-2-yl)methanone | |
0.00062 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-4-yl)pyrrolidin-1-yl]methanone | |
0.00067 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2-chloro-4-fluoro-6-hydroxyphenyl)methanone | |
0.00068 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone | |
0.00074 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (3-benzylpyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | |
0.00079 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-2-yl)pyrrolidin-1-yl]methanone | |
0.00098 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (5-azaspiro[2.4]heptan-5-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | |
0.00131 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)[3-(trifluoromethyl)pyrrolidin-1-yl]methanone | |
0.00145 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxyphenyl)methanone | |
0.00155 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(5-hydroxypyrimidin-4-yl)methanone | |
0.00157 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-3-fluoro-6-hydroxyphenyl)methanone | |
0.00168 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(2-oxa-6-azaspiro[3.4]octan-6-yl)methanone | |
0.00199 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(pyrrolidin-1-yl)methanone | |
0.00232 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)[2-chloro-4-(dimethylamino)-6-hydroxyphenyl]methanone | |
0.0024 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2-azaspiro[4.4]nonan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | |
0.00244 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,3-dihydro-1H-indol-1-yl)methanone | |
0.00256 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(1,3-dihydro-2H-isoindol-2-yl)methanone | |
0.00404 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxyphenyl)methanone | |
0.00478 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2-azaspiro[3.4]octan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | |
0.0051 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(3,3-dimethylpyrrolidin-1-yl)methanone | |
0.00527 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(3-fluoro-3-methylpyrrolidin-1-yl)methanone | |
0.00585 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (2-azaspiro[4.5]decan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone | |
0.00748 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2,3-dichloro-6-hydroxyphenyl)methanone | |
0.00772 | - |
at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(4-chloro-2-fluoro-6-hydroxyphenyl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,6-diazaspiro[3.4]octan-6-yl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-methoxyphenyl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methoxyphenyl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methylphenyl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxy-4-methylphenyl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(2-hydroxypyridin-3-yl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(3,4-dichloro-2-hydroxyphenyl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(3,6-dichloro-2-hydroxyphenyl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(3-chloro-5-hydroxypyridin-4-yl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-4-yl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(4,5-dichloro-2-hydroxyphenyl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxy-6-methylphenyl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(4-fluoro-2-hydroxyphenyl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)(4-hydroxypyridin-3-yl)methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | (6-azaspiro[3.4]octan-6-yl)[2-chloro-6-hydroxy-4-(trifluoromethyl)phenyl]methanone | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | 2-(6-azaspiro[3.4]octane-6-sulfonyl)-3-fluorophenol | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | 4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzamide | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication | Homo sapiens | 4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzonitrile |