Disease on EC 5.6.2.4 - DNA 3'-5' helicase
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Acquired Immunodeficiency Syndrome
The B. subtilis Accessory Helicase PcrA Facilitates DNA Replication through Transcription Units.
Adenocarcinoma
Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival.
Adenocarcinoma
Werner's syndrome as a hereditary risk factor for exocrine pancreatic cancer: Potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy.
Adrenal Insufficiency
MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.
alpha-Thalassemia
A point mutation in the XNP gene, associated with an ATR-X phenotype without alpha-thalassemia.
Alzheimer Disease
FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease.
Anemia
Identification of the NLS and NES motifs of VP2 from chicken anemia virus and the interaction of VP2 with mini-chromosome maintenance protein 3.
Ataxia Telangiectasia
ATM activation is impaired in human cells defective in RecQL4 helicase activity.
Ataxia Telangiectasia
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
Ataxia Telangiectasia
Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts.
Ataxia Telangiectasia
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Ataxia Telangiectasia
The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.
Bloom Syndrome
A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint.
Bloom Syndrome
A novel frameshift mutation in BLM gene associated with high sister chromatid exchanges (SCE) in heterozygous family members.
Bloom Syndrome
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Bloom Syndrome
Aberrant BLM cytoplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer.
Bloom Syndrome
Acute myeloid leukaemia after treatment for acute lymphoblastic leukaemia in girl with Bloom syndrome.
Bloom Syndrome
Analysis of m6A RNA Methylation-Related Genes in Liver Hepatocellular Carcinoma and Their Correlation with Survival.
Bloom Syndrome
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.
Bloom Syndrome
ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation.
Bloom Syndrome
Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.
Bloom Syndrome
BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54.
Bloom Syndrome
BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes.
Bloom Syndrome
BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination.
Bloom Syndrome
BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.
Bloom Syndrome
BLM unfolds G-quadruplexes in different structural environments through different mechanisms.
Bloom Syndrome
Bloom syndrome and Fanconi's anemia: rate and ethnic origin of mutation carriers in Israel.
Bloom Syndrome
Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks.
Bloom Syndrome
Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.
Bloom Syndrome
Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition.
Bloom Syndrome
Bloom's Syndrome: Clinical Spectrum, Molecular Pathogenesis, and Cancer Predisposition.
Bloom Syndrome
Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.
Bloom Syndrome
Characterization and mutational analysis of the RecQ core of the bloom syndrome protein.
Bloom Syndrome
Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.
Bloom Syndrome
Chk1-dependent constitutive phosphorylation of BLM helicase at serine 646 decreases after DNA damage.
Bloom Syndrome
Clinical features of Bloom syndrome and function of the causative gene, BLM helicase.
Bloom Syndrome
Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription.
Bloom Syndrome
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.
Bloom Syndrome
Defining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis.
Bloom Syndrome
Delineation of WRN helicase function with EXO1 in the replicational stress response.
Bloom Syndrome
Dephosphorylation and subcellular compartment change of the mitotic Bloom's syndrome DNA helicase in response to ionizing radiation.
Bloom Syndrome
Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors.
Bloom Syndrome
Diagnosis of Bloom Syndrome in a Patient with Short Stature, Recurrence of Malignant Lymphoma, and Consanguineous Origin.
Bloom Syndrome
Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair.
Bloom Syndrome
DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
Bloom Syndrome
Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing.
Bloom Syndrome
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
Bloom Syndrome
FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease.
Bloom Syndrome
Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.
Bloom Syndrome
Genetic Manipulation of Homologous Recombination In Vivo Attenuates Intestinal Tumorigenesis.
Bloom Syndrome
Helicase activity is only partially required for Schizosaccharomyces pombe Rqh1p function.
Bloom Syndrome
Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases.
Bloom Syndrome
Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability.
Bloom Syndrome
In vivo analysis of Drosophila BLM helicase function during DNA double-strand gap repair.
Bloom Syndrome
Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N'-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand.
Bloom Syndrome
Interaction of replication protein A with two acidic peptides from human Bloom syndrome protein.
Bloom Syndrome
Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.
Bloom Syndrome
Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.
Bloom Syndrome
Investigating the pathogenic SNPs in BLM helicase and their biological consequences by computational approach.
Bloom Syndrome
Loss of Bloom syndrome protein destabilizes human gene cluster architecture.
Bloom Syndrome
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells.
Bloom Syndrome
miR-522-3p promotes tumorigenesis in human colorectal cancer via targeting bloom syndrome protein.
Bloom Syndrome
Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line.
Bloom Syndrome
NMR Investigation of the Interaction between the RecQ C-Terminal Domain of Human Bloom Syndrome Protein and G-Quadruplex DNA from the Human c-Myc Promoter.
Bloom Syndrome
Non-Bloom syndrome-associated partial and total loss-of-function variants of BLM helicase.
Bloom Syndrome
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.
Bloom Syndrome
PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1.
Bloom Syndrome
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
Bloom Syndrome
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Bloom Syndrome
Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome.
Bloom Syndrome
Recognition and Unfolding of c-MYC and Telomeric G-Quadruplex DNAs by the RecQ C-Terminal Domain of Human Bloom Syndrome Helicase.
Bloom Syndrome
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase.
Bloom Syndrome
RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.
Bloom Syndrome
RecQ helicase BLM regulates prostate cancer cell proliferation and apoptosis.
Bloom Syndrome
Regulation and localization of the Bloom syndrome protein in response to DNA damage.
Bloom Syndrome
Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription.
Bloom Syndrome
Removal of the Bloom Syndrome DNA Helicase Extends the Utility of Imprecise Transposon Excision for Making Null Mutations in Drosophila.
Bloom Syndrome
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.
Bloom Syndrome
Resolution of ROS-induced G-quadruplexes and R-loops at transcriptionally active sites is dependent on BLM helicase.
Bloom Syndrome
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
Bloom Syndrome
Roles of the Bloom's syndrome helicase in the maintenance of genome stability.
Bloom Syndrome
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
Bloom Syndrome
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
Bloom Syndrome
Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death.
Bloom Syndrome
Small scale genetic alterations contribute to increased mutability at the X-linked Hprt locus in vivo in Blm hypomorphic mice.
Bloom Syndrome
Small Ubiquitin-related Modifier (SUMO) Binding Determines Substrate Recognition and Paralog-selective SUMO Modification.
Bloom Syndrome
Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein.
Bloom Syndrome
Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein.
Bloom Syndrome
Structural and functional characterization of the N-terminal domain of human Rad51D.
Bloom Syndrome
Structural basis of Bloom syndrome (BS) causing mutations in the BLM helicase domain.
Bloom Syndrome
Structure and function of the regulatory HRDC domain from human Bloom syndrome protein.
Bloom Syndrome
Super-resolution mapping of cellular double-strand break resection complexes during homologous recombination.
Bloom Syndrome
Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry.
Bloom Syndrome
System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel SUMO target proteins and acceptor lysines relevant for genome stability.
Bloom Syndrome
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.
Bloom Syndrome
The arginine finger of the Bloom syndrome protein: its structural organization and its role in energy coupling.
Bloom Syndrome
The Bloom Syndrome Protein BLM Is Selectively Cleaved during Apoptotic Cell Death.
Bloom Syndrome
The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control.
Bloom Syndrome
The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.
Bloom Syndrome
The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
Bloom Syndrome
The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA.
Bloom Syndrome
The Bloom's syndrome helicase suppresses crossing over during homologous recombination.
Bloom Syndrome
The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage.
Bloom Syndrome
The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.
Bloom Syndrome
The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.
Bloom Syndrome
The nuclease FAN1 is involved in DNA crosslink repair in Arabidopsis thaliana independently of the nuclease MUS81.
Bloom Syndrome
The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins.
Bloom Syndrome
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.
Bloom Syndrome
The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.
Bloom Syndrome
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
Bloom Syndrome
Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.
Bloom Syndrome
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.
Bloom Syndrome
Withdrawal: Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death.
Bone Diseases, Metabolic
Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders.
Bone Diseases, Metabolic
Generalized metabolic bone disease and fracture risk in Rothmund-Thomson syndrome.
Bone Marrow Failure Disorders
ATP-dependent helicase activity is dispensable for the physiological functions of Recql4.
Bone Marrow Failure Disorders
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
Bone Marrow Failure Disorders
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Brain Neoplasms
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Breast Neoplasms
A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.
Breast Neoplasms
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice.
Breast Neoplasms
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Breast Neoplasms
Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.
Breast Neoplasms
Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.
Breast Neoplasms
Distinct prognosis of mRNA expression of the five RecQ DNA-helicase family members - RECQL, BLM, WRN, RECQL4, and RECQL5 - in patients with breast cancer.
Breast Neoplasms
Embryonic stem cells deficient for Brca2 or Blm exhibit divergent genotoxic profiles that support opposing activities during homologous recombination.
Breast Neoplasms
Genetic screen for chromosome instability in mice: Mcm4 and breast cancer.
Breast Neoplasms
Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells.
Breast Neoplasms
Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.
Breast Neoplasms
Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer.
Breast Neoplasms
Prognostic significance of minichromosome maintenance proteins in breast cancer.
Breast Neoplasms
RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner.
Breast Neoplasms
Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase.
Breast Neoplasms
Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain.
Breast Neoplasms
The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine.
Breast Neoplasms
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Breast Neoplasms
[Preparation, characterization and application of monoclonal antibody against RecQ helicase].
Carcinogenesis
Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.
Carcinogenesis
DNA end resection controls the balance between homologous and illegitimate recombination in Escherichia coli.
Carcinogenesis
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.
Carcinogenesis
Involvement of WRN helicase in immortalization and tumorigenesis by the telomeric crisis pathway (Review).
Carcinogenesis
MCM7 amplification and overexpression promote cell proliferation, colony formation and migration in esophageal squamous cell carcinoma by activating the AKT1/mTOR signaling pathway.
Carcinogenesis
miR-522-3p promotes tumorigenesis in human colorectal cancer via targeting bloom syndrome protein.
Carcinogenesis
Myc and the Replicative CMG Helicase: The Creation and Destruction of Cancer: Myc Over-Activation of CMG Helicases Drives Tumorigenesis and Creates a Vulnerability in CMGs for Therapeutic Intervention.
Carcinogenesis
Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
Carcinogenesis
RecQ helicases and genome stability: lessons from model organisms and human disease.
Carcinogenesis
Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.
Carcinogenesis
The function of RecQ helicase gene family (especially BLM) in DNA recombination and joining.
Carcinogenesis
The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer.
Carcinogenesis
The molecular role of the Rothmund-Thomson-, RAPADILINO- and Baller-Gerold-gene product, RECQL4: recent progress.
Carcinogenesis
The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism.
Carcinogenesis
The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice.
Carcinoma
Adult respiratory papillomatosis: human papillomavirus type and viral coinfections as predictors of prognosis.
Carcinoma
Analysis of oral papillomas, leukoplakias, and invasive carcinomas for human papillomavirus type related DNA.
Carcinoma
Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas.
Carcinoma
Genetic model of transformation and neoplastic progression in laryngeal epithelium.
Carcinoma
Human papilloma virus (HPV) infections related to cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma of the uterine cervix.
Carcinoma
Human papillomavirus (HPV) infections of the female genital tract and their associations with intraepithelial neoplasia and squamous cell carcinoma.
Carcinoma
Human papillomavirus and host variables as predictors of clinical course in patients with juvenile-onset recurrent respiratory papillomatosis.
Carcinoma
Human papillomavirus in penile squamous cell lesions. A comparison of an isotopic RNA and two commercial nonisotopic DNA in situ hybridization methods.
Carcinoma
Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma.
Carcinoma
Next-generation sequencing identifies recurrent copy number variations in invasive breast carcinomas from Ghana.
Carcinoma
[Urethral condyloma acuminatum with severe dysplasia in a male patient detected human papillomavirus type 11: a case report]
Carcinoma in Situ
Human papillomavirus in penile squamous cell lesions. A comparison of an isotopic RNA and two commercial nonisotopic DNA in situ hybridization methods.
Carcinoma, Bronchogenic
Malignant tumours in patients with a history of multiple laryngeal papillomas: the significance of irradiation.
Carcinoma, Hepatocellular
Increased expression of MCM4 is associated with poor prognosis in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Upregulation of RECQL4 expression predicts poor prognosis in hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Effects of RECQ1 helicase silencing on non-small cell lung cancer cells.
Carcinoma, Squamous Cell
Adult respiratory papillomatosis: human papillomavirus type and viral coinfections as predictors of prognosis.
Carcinoma, Squamous Cell
Human papillomavirus in penile squamous cell lesions. A comparison of an isotopic RNA and two commercial nonisotopic DNA in situ hybridization methods.
Cataract
Mutations in ANAPC1, Encoding a Scaffold Subunit of the Anaphase-Promoting Complex, Cause Rothmund-Thomson Syndrome Type 1.
Cataract
Successful umbilical cord blood stem cell transplantation in a patient with Rothmund-Thomson syndrome and combined immunodeficiency.
Cholera
CTX?: Exploring new alternatives in host factor-mediated filamentous phage replications.
Coinfection
Adeno-associated virus small rep proteins are modified with at least two types of polyubiquitination.
Colonic Neoplasms
Interaction between RAD51 and MCM Complex Is Essential for RAD51 Foci Forming in Colon Cancer HCT116 Cells.
Colorectal Neoplasms
Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers.
Colorectal Neoplasms
miR-522-3p promotes tumorigenesis in human colorectal cancer via targeting bloom syndrome protein.
Colorectal Neoplasms
Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.
Colorectal Neoplasms
WRN Promoter CpG Island Hypermethylation Does Not Predict More Favorable Outcomes for Patients with Metastatic Colorectal Cancer Treated with Irinotecan-Based Therapy.
Condylomata Acuminata
Human papillomavirus in penile squamous cell lesions. A comparison of an isotopic RNA and two commercial nonisotopic DNA in situ hybridization methods.
Condylomata Acuminata
Identification of human papillomavirus types in male urethral condylomata acuminata by in situ hybridization.
Congenital Abnormalities
Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.
Congenital Abnormalities
Ribosomal Protein S3 Negatively Regulates Unwinding Activity of RecQ-like Helicase 4 through Their Physical Interaction.
Congenital Abnormalities
Rothmund-Thomson syndrome and RECQL4 defect: splitting and lumping.
Craniosynostoses
Craniosynostosis, hydrocephalus, Chiari I malformation and radioulnar synostosis: probably a new syndrome.
Cysts
Determination of potential cellular proliferation in the odontogenic epithelia of the dental follicle of the asymptomatic impacted third molars.
Dengue
Dengue Virus Capsid Interacts with DDX3X-A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection.
Diabetic Nephropathies
ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with type 1 diabetes.
dna 3'-5' helicase deficiency
Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells.
dna 3'-5' helicase deficiency
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
dna 3'-5' helicase deficiency
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
dna 3'-5' helicase deficiency
Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.
dna 3'-5' helicase deficiency
Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing.
dna 3'-5' helicase deficiency
Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase.
dna 3'-5' helicase deficiency
Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome.
dna 3'-5' helicase deficiency
RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.
dna 3'-5' helicase deficiency
The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments.
dna 3'-5' helicase deficiency
Unique and important consequences of RECQ1 deficiency in mammalian cells.
dna 3'-5' helicase deficiency
WRN regulates pathway choice between classical and alternative non-homologous end joining.
dna 3'-5' helicase deficiency
[Role of RecQ5 in syncytial blastoderm of the Drosophila embryo].
dna 5'-3' helicase deficiency
Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.
Dwarfism
A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.
Esophageal Neoplasms
RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer.
Esophageal Squamous Cell Carcinoma
RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer.
Fanconi Anemia
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Fanconi Anemia
Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes.
Fanconi Anemia
Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer.
Fanconi Anemia
Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.
Fanconi Anemia
Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.
Fanconi Anemia
Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.
Fanconi Anemia
Subependymal giant cell astrocytoma-like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type-1-association.
Fanconi Anemia
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Genetic Diseases, Inborn
Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders.
Genetic Diseases, Inborn
ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation.
Genetic Diseases, Inborn
Bloom's syndrome workshop focuses on the functional specificities of RecQ helicases.
Genetic Diseases, Inborn
Characterization of the slow-growth phenotype of S. cerevisiae Whip/Mgs1 Sgs1 double deletion mutants.
Genetic Diseases, Inborn
Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.
Genetic Diseases, Inborn
Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.
Genetic Diseases, Inborn
Defining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis.
Genetic Diseases, Inborn
Differential regulation of human RecQ family helicases in cell transformation and cell cycle.
Genetic Diseases, Inborn
Drosophila homologue of the Rothmund-Thomson syndrome gene: Essential function in DNA replication during development.
Genetic Diseases, Inborn
Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation.
Genetic Diseases, Inborn
Genetic Manipulation of Homologous Recombination In Vivo Attenuates Intestinal Tumorigenesis.
Genetic Diseases, Inborn
Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases.
Genetic Diseases, Inborn
Human RECQ1 Is a DNA Damage Responsive Protein Required for Genotoxic Stress Resistance and Suppression of Sister Chromatid Exchanges.
Genetic Diseases, Inborn
Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability.
Genetic Diseases, Inborn
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.
Genetic Diseases, Inborn
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Genetic Diseases, Inborn
RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex.
Genetic Diseases, Inborn
RecQL4: a helicase linking formation and maintenance of a replication fork.
Genetic Diseases, Inborn
RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks.
Genetic Diseases, Inborn
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging.
Genetic Diseases, Inborn
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
Genetic Diseases, Inborn
Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.
Genetic Diseases, Inborn
The Human RecQ4 Helicase Contains a Functional RecQ C-terminal Region (RQC) That Is Essential for Activity.
Genetic Diseases, Inborn
The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer.
Genetic Diseases, Inborn
Unique and important consequences of RECQ1 deficiency in mammalian cells.
Genetic Diseases, Inborn
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Genetic Diseases, Inborn
Werner's syndrome as a hereditary risk factor for exocrine pancreatic cancer: Potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy.
Glioblastoma
Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells.
Glioblastoma
RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos.
Glioblastoma
RECQ1 Promotes Stress Resistance and DNA Replication Progression Through PARP1 Signaling Pathway in Glioblastoma.
Glioblastoma
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.
Glioma
Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells.
Hematologic Neoplasms
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.
Hepatitis C
Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super-families of helicases.
Hepatitis C
Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Herpes Simplex
Herpes simplex virus DNA replication: a spacer sequence directs the ATP-dependent formation of a nucleoprotein complex at oriS.
Hypersensitivity
Arabidopsis RecQsim, a plant-specific member of the RecQ helicase family, can suppress the MMS hypersensitivity of the yeast sgs1 mutant.
Hypersensitivity
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.
Hypersensitivity
Defining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis.
Hypersensitivity
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.
Hypersensitivity
Pathways of Resistance to Thymineless Death in Escherichia coli and the Function of UvrD.
Hypersensitivity
The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.
Hypertriglyceridemia
Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model.
Hypocalcemia
Craniosynostosis and radial ray defect: a rare presentation of 22q11.2 deletion syndrome.
Infections
Buschke-Löwenstein Tumour: Successful Treatment with Minimally Invasive Techniques.
Infections
Characterization of the transcription profile of adeno-associated virus type 5 reveals a number of unique features compared to previously characterized adeno-associated viruses.
Infections
Comparative analysis of chrysanthemum transcriptome in response to three RNA viruses: Cucumber mosaic virus, Tomato spotted wilt virus and Potato virus X.
Infections
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response.
Infections
Development of bladder tumour containing HPV type 11 DNA after renal transplantation.
Infections
Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses.
Infections
Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis.
Infections
Relationship between the clinical course and HPV typing of recurrent laryngeal papillomatosis. The Red Cross War Memorial Children's Hospital experience 1982-1988.
Infections
[Detection of vaginal and cervical human papillomavirus by electronic microscope examination and polymerase chain reaction technique]
Infections
[Prevalence of human papilloma virus types and their influence on the course of the disease in children suffering from recurrent respiratory papillomatosis]
Infertility, Female
Drosophila homologue of the Rothmund-Thomson syndrome gene: Essential function in DNA replication during development.
Insulin Resistance
Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome.
Intellectual Disability
Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X.
Ketosis
Integrating RNA-Seq with GWAS reveals novel insights into the molecular mechanism underpinning ketosis in cattle.
Leukemia
BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin.
Leukemia
Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in ?-irradiation-induced DNA damage responses.
Leukemia
WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.
Leukemia, Myeloid, Acute
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.
Li-Fraumeni Syndrome
RECQL4 and p53 potentiate the activity of polymerase ? and maintain the integrity of the human mitochondrial genome.
Lipodystrophy
MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.
Lipodystrophy
Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome.
Liver Neoplasms
Upregulation of RECQL4 expression predicts poor prognosis in hepatocellular carcinoma.
Lung Neoplasms
Molecular Signature of Small Cell Lung Cancer after Treatment Failure: The MCM Complex as Therapeutic Target.
Lymphatic Metastasis
Genetic differences between primary larynx and pharynx carcinomas and their matched lymph node metastases by multiplex ligation-dependent probe amplification.
Lymphatic Metastasis
Genetic model of transformation and neoplastic progression in laryngeal epithelium.
Lymphoma
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.
Lymphoma
The interaction between ATRIP and MCM complex is essential for ATRIP chromatin loading and its phosphorylation in mantle cell lymphoma cells.
Lymphoma, Mantle-Cell
The interaction between ATRIP and MCM complex is essential for ATRIP chromatin loading and its phosphorylation in mantle cell lymphoma cells.
Malaria
Emerging importance of mismatch repair components including UvrD helicase and their cross-talk with the development of drug resistance in malaria parasite.
Medulloblastoma
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Medulloblastoma
RNA Binding Protein-Mediated Post-Transcriptional Gene Regulation in Medulloblastoma.
Melanoma
Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients.
Multiple Myeloma
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.
Multiple Myeloma
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Neoplasm Metastasis
DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1.
Neoplasm Metastasis
Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis.
Neoplasm Metastasis
Genetic differences between primary larynx and pharynx carcinomas and their matched lymph node metastases by multiplex ligation-dependent probe amplification.
Neoplasm Metastasis
Genetic model of transformation and neoplastic progression in laryngeal epithelium.
Neoplasm Metastasis
Human papillomavirus and host variables as predictors of clinical course in patients with juvenile-onset recurrent respiratory papillomatosis.
Neoplasm Metastasis
Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.
Neoplasm Metastasis
RecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway.
Neoplasm Metastasis
RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer.
Neoplasm Metastasis
The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism.
Neoplasms
A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis.
Neoplasms
A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).
Neoplasms
A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.
Neoplasms
A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.
Neoplasms
Acquisition of biologically relevant gene expression data by Affymetrix microarray analysis of archival formalin-fixed paraffin-embedded tumours.
Neoplasms
Acute myeloid leukaemia after treatment for acute lymphoblastic leukaemia in girl with Bloom syndrome.
Neoplasms
Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.
Neoplasms
ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation.
Neoplasms
BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes.
Neoplasms
BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination.
Neoplasms
BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.
Neoplasms
BLM unfolds G-quadruplexes in different structural environments through different mechanisms.
Neoplasms
Bloom's syndrome workshop focuses on the functional specificities of RecQ helicases.
Neoplasms
Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.
Neoplasms
Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.
Neoplasms
Clinical Impact of Tumor DNA Repair Expression and T-cell Infiltration in Breast Cancers.
Neoplasms
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.
Neoplasms
Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.
Neoplasms
Dephosphorylation and subcellular compartment change of the mitotic Bloom's syndrome DNA helicase in response to ionizing radiation.
Neoplasms
Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.
Neoplasms
Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization.
Neoplasms
Determination of potential cellular proliferation in the odontogenic epithelia of the dental follicle of the asymptomatic impacted third molars.
Neoplasms
Development of bladder tumour containing HPV type 11 DNA after renal transplantation.
Neoplasms
Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma.
Neoplasms
Digital imaging in the immunohistochemical evaluation of the proliferation markers Ki67, MCM2 and Geminin, in early breast cancer, and their putative prognostic value.
Neoplasms
Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma.
Neoplasms
Distinct prognosis of mRNA expression of the five RecQ DNA-helicase family members - RECQL, BLM, WRN, RECQL4, and RECQL5 - in patients with breast cancer.
Neoplasms
DNA content measurement and in situ hybridization in condylomatous cervical lesions.
Neoplasms
dRecQ4 is required for DNA synthesis and essential for cell proliferation in Drosophila.
Neoplasms
Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing.
Neoplasms
Drosophila RecQ4 has a 3'-5'DNA helicase activity that is essential for viability.
Neoplasms
Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins.
Neoplasms
Embryonic stem cells deficient for Brca2 or Blm exhibit divergent genotoxic profiles that support opposing activities during homologous recombination.
Neoplasms
Enhancement of c-Myc degradation by BLM helicase leads to delayed tumor initiation.
Neoplasms
Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma.
Neoplasms
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.
Neoplasms
Expression Profile and Prognostic Values of Mini-Chromosome Maintenance Families (MCMs) in Breast Cancer.
Neoplasms
Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.
Neoplasms
Genetic Manipulation of Homologous Recombination In Vivo Attenuates Intestinal Tumorigenesis.
Neoplasms
Genetic model of transformation and neoplastic progression in laryngeal epithelium.
Neoplasms
Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells.
Neoplasms
Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases.
Neoplasms
Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype.
Neoplasms
HPV 11, 16 and 18 DNA sequences in cervical swabs from women with cervical dysplasia: prevalence and associated risk of progression.
Neoplasms
Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity.
Neoplasms
Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway.
Neoplasms
Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.
Neoplasms
Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks.
Neoplasms
Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.
Neoplasms
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.
Neoplasms
Human RECQL4 represses the RAD52-mediated single-strand annealing pathway after ionizing radiation or cisplatin treatment.
Neoplasms
Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability.
Neoplasms
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
Neoplasms
Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families.
Neoplasms
Identification of new RECQL4 mutations in Caucasian Rothmund-Thomson patients and analysis of sensitivity to a wide range of genotoxic agents.
Neoplasms
Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.
Neoplasms
Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma.
Neoplasms
Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase.
Neoplasms
Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways.
Neoplasms
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Neoplasms
Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer.
Neoplasms
Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.
Neoplasms
Investigating the pathogenic SNPs in BLM helicase and their biological consequences by computational approach.
Neoplasms
KSHV de-regulates host cellular replication during lytic reactivation by disrupting the MCM complex through ORF59.
Neoplasms
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.
Neoplasms
Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas.
Neoplasms
Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
Neoplasms
Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion.
Neoplasms
Molecular differentiation of early and late stage laryngeal squamous cell carcinoma: an exploratory analysis.
Neoplasms
Multigene panel testing beyond BRCA1/2 in breast/ovarian cancer Spanish families and clinical actionability of findings.
Neoplasms
Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line.
Neoplasms
Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer.
Neoplasms
Mutations in ANAPC1, Encoding a Scaffold Subunit of the Anaphase-Promoting Complex, Cause Rothmund-Thomson Syndrome Type 1.
Neoplasms
Mutations in conserved functional domains of human RecQ helicases are associated with diseases and cancer: A review.
Neoplasms
Myc and the Replicative CMG Helicase: The Creation and Destruction of Cancer: Myc Over-Activation of CMG Helicases Drives Tumorigenesis and Creates a Vulnerability in CMGs for Therapeutic Intervention.
Neoplasms
Next-generation sequencing identifies recurrent copy number variations in invasive breast carcinomas from Ghana.
Neoplasms
Novel Insights into the Biochemical Mechanism of CK1? and its Functional Interplay with DDX3X.
Neoplasms
Novel physiological RECQL4 alternative transcript disclosed by molecular characterisation of Rothmund-Thomson Syndrome sibs with mild phenotype.
Neoplasms
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Neoplasms
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
Neoplasms
Prognostic value of minichromosome maintenance mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy.
Neoplasms
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Neoplasms
Rare Presentation of a Rare Disease: Signet-Ring Cell Gastric Adenocarcinoma in Rothmund-Thomson Syndrome.
Neoplasms
RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.
Neoplasms
RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner.
Neoplasms
RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos.
Neoplasms
RECQ1 Promotes Stress Resistance and DNA Replication Progression Through PARP1 Signaling Pathway in Glioblastoma.
Neoplasms
RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA).
Neoplasms
RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription.
Neoplasms
RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers.
Neoplasms
RECQL4 and p53 potentiate the activity of polymerase ? and maintain the integrity of the human mitochondrial genome.
Neoplasms
RecQL4 cytoplasmic localization: Implications in mitochondrial DNA oxidative damage repair.
Neoplasms
RECQL4, Negatively Regulated by miR-10a-5p, Facilitates Cell Proliferation and Invasion via MAFB in Ovarian Cancer.
Neoplasms
Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma.
Neoplasms
Replication protein A stimulates the werner syndrome protein branch migration activity.
Neoplasms
Resection Activity of the Sgs1 Helicase Alters the Affinity of DNA Ends for Homologous Recombination Proteins in Saccharomyces cerevisiae.
Neoplasms
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging.
Neoplasms
Rothmund-Thomson syndrome helicase, RECQ4: on the crossroad between DNA replication and repair.
Neoplasms
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
Neoplasms
Rothmund-Thomson Syndrome: Insights from New Patients on the Genetic Variability Underpinning Clinical Presentation and Cancer Outcome.
Neoplasms
Screening and identification of genes associated with cell proliferation in cholangiocarcinoma.
Neoplasms
Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.
Neoplasms
Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain.
Neoplasms
Somatic and germline analysis of a familial Rothmund-Thomson syndrome in two siblings with osteosarcoma.
Neoplasms
Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.
Neoplasms
Successful umbilical cord blood stem cell transplantation in a patient with Rothmund-Thomson syndrome and combined immunodeficiency.
Neoplasms
Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer.
Neoplasms
Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein.
Neoplasms
The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
Neoplasms
The Bloom's syndrome helicase suppresses crossing over during homologous recombination.
Neoplasms
The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.
Neoplasms
The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients.
Neoplasms
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.
Neoplasms
The Human RecQ4 Helicase Contains a Functional RecQ C-terminal Region (RQC) That Is Essential for Activity.
Neoplasms
The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.
Neoplasms
The MCM complex: its role in DNA replication and implications for cancer therapy.
Neoplasms
The molecular role of the Rothmund-Thomson-, RAPADILINO- and Baller-Gerold-gene product, RECQL4: recent progress.
Neoplasms
The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress.
Neoplasms
The Set2-RPB1-interaction domain of human RECQ5 is important for transcription-associated genome stability.
Neoplasms
The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism.
Neoplasms
The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage.
Neoplasms
Understanding the roles of RecQ helicases in the maintenance of genome integrity and suppression of tumorigenesis.
Neoplasms
Upregulation of RECQL4 expression predicts poor prognosis in hepatocellular carcinoma.
Neoplasms
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.
Neoplasms
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Neoplasms
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
Neoplasms
Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.
Neoplasms
Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.
Neoplasms
Werner's syndrome as a hereditary risk factor for exocrine pancreatic cancer: Potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy.
Neoplasms
When transcription meets recombination: a lesson from the human RECQ protein complexes.
Neoplasms
[Preparation, characterization and application of monoclonal antibody against RecQ helicase].
Neuroblastoma
Minichromosome Maintenance Complex Is a Critical Node in the miR-183 Signaling Network of MYCN-Amplified Neuroblastoma Cells.
Neurodegenerative Diseases
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Neutropenia
Absence of RECQL4 mutations in poikiloderma with neutropenia in Navajo and non-Navajo patients.
Nijmegen Breakage Syndrome
Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.
Orofaciodigital Syndromes
Copy Number Variations of Four Y-Linked Genes in Swamp Buffaloes.
Osteosarcoma
Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome.
Osteosarcoma
Clinicopathologic features of osteosarcoma in patients with Rothmund-Thomson syndrome.
Osteosarcoma
Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma.
Osteosarcoma
Does ATRX germline variation predispose to osteosarcoma? Three additional cases of osteosarcoma in two ATR-X syndrome patients.
Osteosarcoma
Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma.
Osteosarcoma
Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation.
Osteosarcoma
Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases.
Osteosarcoma
Novel physiological RECQL4 alternative transcript disclosed by molecular characterisation of Rothmund-Thomson Syndrome sibs with mild phenotype.
Osteosarcoma
Radiographic abnormalities in Rothmund-Thomson syndrome and genotype-phenotype correlation with RECQL4 mutation status.
Osteosarcoma
RECQL4-deficient cells are hypersensitive to oxidative stress/damage: Insights for osteosarcoma prevalence and heterogeneity in Rothmund-Thomson syndrome.
Osteosarcoma
Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma.
Osteosarcoma
Ribosomal Protein S3 Negatively Regulates Unwinding Activity of RecQ-like Helicase 4 through Their Physical Interaction.
Osteosarcoma
Second Osteosarcoma in a 16-Year-Old Woman Diagnosed With Rothmund-Thomson Syndrome.
Osteosarcoma
The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.
Ovarian Neoplasms
PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells.
Ovarian Neoplasms
RECQL4, Negatively Regulated by miR-10a-5p, Facilitates Cell Proliferation and Invasion via MAFB in Ovarian Cancer.
Ovarian Neoplasms
Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value.
Pancreatic Neoplasms
Prognostic value of minichromosome maintenance mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy.
Pancreatic Neoplasms
RECQ1 A159C Polymorphism Is Associated With Overall Survival of Patients With Resected Pancreatic Cancer: A Replication Study in NRG Oncology Radiation Therapy Oncology Group 9704.
Pancreatic Neoplasms
Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.
Papilloma
Association of DNA aneuploidy with human papillomavirus-induced malignant transformation of sinonasal transitional papillomas.
Papilloma
Children and partners of patients with recurrent respiratory papillomatosis have no evidence of the disease during long-term observation.
Papilloma
Conjunctival papilloma caused by human papillomavirus type 11 treated with systemic interferon in a five-year-old boy.
Papilloma
Detection and typing of papillomavirus DNA in formaldehyde-fixed paraffin-embedded tissue.
Papilloma
Human papillomavirus and host variables as predictors of clinical course in patients with juvenile-onset recurrent respiratory papillomatosis.
Papilloma
Human papillomavirus in normal conjunctival tissue and in conjunctival papilloma: types and frequencies in a large series.
Papilloma
Integration of human papillomavirus type 11 in recurrent respiratory papilloma-associated cancer.
Papilloma
Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation.
Papilloma
Malignant tumours in patients with a history of multiple laryngeal papillomas: the significance of irradiation.
Papilloma
Oral Papillomatosis in Immunocompromised Patients: A Case Series of Kidney Transplant Recipients and Myelodysplastic Syndrome.
Papilloma
The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase.
Papilloma
[Prevalence of human papilloma virus types and their influence on the course of the disease in children suffering from recurrent respiratory papillomatosis]
Papillomavirus Infections
Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses.
Papillomavirus Infections
In inverted papillomas HPV more likely represents incidental colonization than an etiological factor.
Pneumonia
Successful umbilical cord blood stem cell transplantation in a patient with Rothmund-Thomson syndrome and combined immunodeficiency.
Pneumonia, Pneumocystis
Successful umbilical cord blood stem cell transplantation in a patient with Rothmund-Thomson syndrome and combined immunodeficiency.
Progeria
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks.
Progeria
Werner complex deficiency in cells disrupts the Nuclear Pore Complex and the distribution of lamin B1.
Prostatic Neoplasms
Bloom helicase explicitly unwinds 3'-tailed G4DNA structure in prostate cancer cells.
Prostatic Neoplasms
Bloom Syndrome Protein Activates AKT and PRAS40 in Prostate Cancer Cells.
Prostatic Neoplasms
MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer.
Prostatic Neoplasms
RecQ helicase BLM regulates prostate cancer cell proliferation and apoptosis.
Prostatic Neoplasms
Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.
Protein Deficiency
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
Protein Deficiency
WRN regulates pathway choice between classical and alternative non-homologous end joining.
Pulmonary Disease, Chronic Obstructive
RecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway.
rada recombinase deficiency
The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.
Rothmund-Thomson Syndrome
A patient with Rothmund-Thomson syndrome and all features of RAPADILINO.
Rothmund-Thomson Syndrome
A rare RECQL4 indel mutation in a Chinese patient with Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders.
Rothmund-Thomson Syndrome
An unusual mutation in RECQ4 gene leading to Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
ATM activation is impaired in human cells defective in RecQL4 helicase activity.
Rothmund-Thomson Syndrome
Atypical Rothmund-Thomson syndrome in a patient with compound heterozygous mutations in RECQL4 gene and phenotypic features in RECQL4 syndromes.
Rothmund-Thomson Syndrome
Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.
Rothmund-Thomson Syndrome
Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.
Rothmund-Thomson Syndrome
Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
Clericuzio type poikiloderma with neutropenia is distinct from Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
Clinicopathologic features of osteosarcoma in patients with Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RecQ helicase protein-like 4.
Rothmund-Thomson Syndrome
Direct and indirect roles of RECQL4 in modulating base excision repair capacity.
Rothmund-Thomson Syndrome
Disease-causing missense mutations in human DNA helicase disorders.
Rothmund-Thomson Syndrome
DNA helicases associated with genetic instability, cancer, and aging.
Rothmund-Thomson Syndrome
Drosophila homologue of the Rothmund-Thomson syndrome gene: Essential function in DNA replication during development.
Rothmund-Thomson Syndrome
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4.
Rothmund-Thomson Syndrome
Early blistering, poikiloderma, hypohidrosis, alopecia and exocrine pancreatic hypofunction: a peculiar variant of Rothmund-Thomson syndrome?
Rothmund-Thomson Syndrome
Elevated incidence of loss of heterozygosity (LOH) in an sgs1 mutant of Saccharomyces cerevisiae: roles of yeast RecQ helicase in suppression of aneuploidy, interchromosomal rearrangement, and the simultaneous incidence of both events during mitotic growth.
Rothmund-Thomson Syndrome
Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma.
Rothmund-Thomson Syndrome
Four novel RECQL4 mutations in four Chinese patients with Rothmund-Thomson syndrome and analysis of RECQL4 mRNA expression level in one typical patient.
Rothmund-Thomson Syndrome
Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation.
Rothmund-Thomson Syndrome
Growth retardation and skin abnormalities of the Recql4-deficient mouse.
Rothmund-Thomson Syndrome
Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases.
Rothmund-Thomson Syndrome
Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis.
Rothmund-Thomson Syndrome
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.
Rothmund-Thomson Syndrome
Human RECQL4 represses the RAD52-mediated single-strand annealing pathway after ionizing radiation or cisplatin treatment.
Rothmund-Thomson Syndrome
Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability.
Rothmund-Thomson Syndrome
Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase.
Rothmund-Thomson Syndrome
Intron-size constraint as a mutational mechanism in Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.
Rothmund-Thomson Syndrome
Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion.
Rothmund-Thomson Syndrome
Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases.
Rothmund-Thomson Syndrome
Multiple malignant diseases in a patient with Rothmund-Thomson syndrome with RECQL4 mutations: Case report and literature review.
Rothmund-Thomson Syndrome
Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
Novel pathogenic RECQL4 variants in Chinese patients with Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
Novel pathogenic variants in the RECQL4 gene causing Rothmund-Thomson syndrome in three Chinese patients.
Rothmund-Thomson Syndrome
Novel physiological RECQL4 alternative transcript disclosed by molecular characterisation of Rothmund-Thomson Syndrome sibs with mild phenotype.
Rothmund-Thomson Syndrome
Nuclear import and retention domains in the amino terminus of RECQL4.
Rothmund-Thomson Syndrome
Pili annulati in a case of Rothmund-Thomson syndrome with a novel frameshift mutation in RECQL4.
Rothmund-Thomson Syndrome
Poikiloderma with neutropenia: a novel C16orf57 mutation and clinical diagnostic criteria.
Rothmund-Thomson Syndrome
Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts.
Rothmund-Thomson Syndrome
Radiographic abnormalities in Rothmund-Thomson syndrome and genotype-phenotype correlation with RECQL4 mutation status.
Rothmund-Thomson Syndrome
RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity.
Rothmund-Thomson Syndrome
Rare presentation of Rothmund-Thomson syndrome with novel compound heterozygous mutations of the RECQL4 gene.
Rothmund-Thomson Syndrome
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase.
Rothmund-Thomson Syndrome
RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.
Rothmund-Thomson Syndrome
RecQ helicases and PARP1 team up in maintaining genome integrity.
Rothmund-Thomson Syndrome
RecQ helicases: suppressors of tumorigenesis and premature aging.
Rothmund-Thomson Syndrome
RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA).
Rothmund-Thomson Syndrome
RECQL4 and p53 potentiate the activity of polymerase ? and maintain the integrity of the human mitochondrial genome.
Rothmund-Thomson Syndrome
RECQL4 helicase has oncogenic potential in sporadic breast cancers.
Rothmund-Thomson Syndrome
RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress.
Rothmund-Thomson Syndrome
RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity.
Rothmund-Thomson Syndrome
RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.
Rothmund-Thomson Syndrome
RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
Rothmund-Thomson Syndrome
RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.
Rothmund-Thomson Syndrome
RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity.
Rothmund-Thomson Syndrome
RECQL4-deficient cells are hypersensitive to oxidative stress/damage: Insights for osteosarcoma prevalence and heterogeneity in Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
RecQL4: a helicase linking formation and maintenance of a replication fork.
Rothmund-Thomson Syndrome
Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma.
Rothmund-Thomson Syndrome
Report of Two Novel Mutations in Indian Patients with Rothmund-Thomson Syndrome.
Rothmund-Thomson Syndrome
Ribosomal Protein S3 Negatively Regulates Unwinding Activity of RecQ-like Helicase 4 through Their Physical Interaction.
Rothmund-Thomson Syndrome
Roles of the Bloom's syndrome helicase in the maintenance of genome stability.
Rothmund-Thomson Syndrome
Rothmund-Thomson syndrome and osteoma cutis in a patient previously diagnosed as COPS syndrome.
Rothmund-Thomson Syndrome
Rothmund-Thomson syndrome and RECQL4 defect: splitting and lumping.
Rothmund-Thomson Syndrome
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
Rothmund-Thomson Syndrome
Rothmund-Thomson syndrome helicase, RECQ4: on the crossroad between DNA replication and repair.
Rothmund-Thomson Syndrome
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
Rothmund-Thomson Syndrome
Rothmund-Thomson Syndrome: novel pathogenic mutations and frequencies of variants in the RECQL4 and USB1 (C16orf57) gene.
Rothmund-Thomson Syndrome
Second Osteosarcoma in a 16-Year-Old Woman Diagnosed With Rothmund-Thomson Syndrome.
Rothmund-Thomson Syndrome
Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.
Rothmund-Thomson Syndrome
Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents.
Rothmund-Thomson Syndrome
Spontaneous chromosomal instability in peripheral blood lymphocytes from two molecularly confirmed Italian patients with Hereditary Fibrosis Poikiloderma: insights into cancer predisposition.
Rothmund-Thomson Syndrome
Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity.
Rothmund-Thomson Syndrome
Successful umbilical cord blood stem cell transplantation in a patient with Rothmund-Thomson syndrome and combined immunodeficiency.
Rothmund-Thomson Syndrome
The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.
Rothmund-Thomson Syndrome
The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability.
Rothmund-Thomson Syndrome
The involvement of human RECQL4 in DNA double-strand break repair.
Rothmund-Thomson Syndrome
The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.
Rothmund-Thomson Syndrome
The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions.
Rothmund-Thomson Syndrome
The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress.
Rothmund-Thomson Syndrome
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
Rothmund-Thomson Syndrome
[Rothmund-Thomson syndrome, trisomy 8 mosaicism and RECQ4 gene mutation]
Skin Abnormalities
Bloom's syndrome workshop focuses on the functional specificities of RecQ helicases.
Skin Diseases
Whole Genome Sequencing in an Acrodermatitis Enteropathica Family from the Middle East.
Small Cell Lung Carcinoma
Molecular Signature of Small Cell Lung Cancer after Treatment Failure: The MCM Complex as Therapeutic Target.
Squamous Cell Carcinoma of Head and Neck
Gene-environment interactions of novel variants associated with head and neck cancer.
Starvation
RecQ helicases and genome stability: lessons from model organisms and human disease.
Stomach Neoplasms
Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway.
Stomach Neoplasms
Overexpression of RECQL4 is associated with poor prognosis in patients with gastric cancer.
Triple Negative Breast Neoplasms
The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine.
Tuberculosis
Deciphering the essentiality and function of SxSx motif in Mycobacterium tuberculosis UvrB.
Tuberculosis
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.
Tuberculosis
Mycobacterium tuberculosis UvrB is a robust DNA-stimulated ATPase that also possesses structure-specific ATP-dependent DNA helicase activity.
Urinary Bladder Neoplasms
Development of bladder tumour containing HPV type 11 DNA after renal transplantation.
Uterine Cervical Neoplasms
A comparative meta-genomic analysis of HPV strains: A step towards the design, synthesis and characterization of noval quenazoline derivative for antiviral activity.
Uterine Cervical Neoplasms
Gene expression profiles in squamous cell cervical carcinoma using array-based comparative genomic hybridization analysis.
Uterine Cervical Neoplasms
Over expression of minichromosome maintenance genes is clinically correlated to cervical carcinogenesis.
Virus Diseases
Novel Insights into the Biochemical Mechanism of CK1? and its Functional Interplay with DDX3X.
Virus Diseases
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Werner Syndrome
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.
Werner Syndrome
A gene encoding an RNase D exonuclease-like protein is required for post-transcriptional silencing in Arabidopsis.
Werner Syndrome
A lack of telomeric non-reciprocal recombination (TENOR) may account for the premature proliferation blockade of Werner's syndrome fibroblasts.
Werner Syndrome
ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with type 1 diabetes.
Werner Syndrome
Action-at-a-Distance Mutagenesis Induced by Oxidized Guanine in Werner Syndrome Protein-Reduced Human Cells.
Werner Syndrome
Active Control of Repetitive Structural Transitions between Replication Forks and Holliday Junctions by Werner Syndrome Helicase.
Werner Syndrome
Age related expression of Werner's syndrome protein in selected tissues and coexpression of transcription factors.
Werner Syndrome
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
Werner Syndrome
Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin.
Werner Syndrome
ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.
Werner Syndrome
Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.
Werner Syndrome
Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase.
Werner Syndrome
Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans.
Werner Syndrome
Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.
Werner Syndrome
Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.
Werner Syndrome
Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal.
Werner Syndrome
Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure.
Werner Syndrome
Characterization of the slow-growth phenotype of S. cerevisiae Whip/Mgs1 Sgs1 double deletion mutants.
Werner Syndrome
Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.
Werner Syndrome
Clinical outcome and mechanism of soft tissue calcification in werner syndrome.
Werner Syndrome
Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.
Werner Syndrome
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.
Werner Syndrome
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.
Werner Syndrome
Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes.
Werner Syndrome
Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.
Werner Syndrome
Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.
Werner Syndrome
DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease.
Werner Syndrome
DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
Werner Syndrome
DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA.
Werner Syndrome
Elevated incidence of loss of heterozygosity (LOH) in an sgs1 mutant of Saccharomyces cerevisiae: roles of yeast RecQ helicase in suppression of aneuploidy, interchromosomal rearrangement, and the simultaneous incidence of both events during mitotic growth.
Werner Syndrome
Evidence for a replication function of FFA-1, the Xenopus orthologue of Werner syndrome protein.
Werner Syndrome
Expression differences by continent of origin point to the immortalization process.
Werner Syndrome
Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.
Werner Syndrome
Fibroblasts from Werner syndrome patients: cancer cells derived by experimental introduction of oncogenes maintain malignant properties despite entering crisis.
Werner Syndrome
Folate modulates guanine-quadruplex frequency and DNA damage in Werner syndrome.
Werner Syndrome
Helicase activity is only partially required for Schizosaccharomyces pombe Rqh1p function.
Werner Syndrome
Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases.
Werner Syndrome
Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and Ataxia.
Werner Syndrome
Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability.
Werner Syndrome
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.
Werner Syndrome
Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.
Werner Syndrome
Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends.
Werner Syndrome
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication.
Werner Syndrome
Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase.
Werner Syndrome
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Werner Syndrome
Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N'-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand.
Werner Syndrome
Inhibition of Werner Syndrome Helicase Activity by Benzo[a]pyrene Diol Epoxide Adducts Can Be Overcome by Replication Protein A.
Werner Syndrome
Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent.
Werner Syndrome
Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence.
Werner Syndrome
Involvement of WRN helicase in immortalization and tumorigenesis by the telomeric crisis pathway (Review).
Werner Syndrome
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.
Werner Syndrome
Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains.
Werner Syndrome
Loss of Bloom syndrome protein destabilizes human gene cluster architecture.
Werner Syndrome
Loss of Werner syndrome protein function promotes aberrant mitotic recombination.
Werner Syndrome
Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase.
Werner Syndrome
Mechanistic analysis of a DNA end processing pathway mediated by the Xenopus Werner syndrome protein.
Werner Syndrome
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
Werner Syndrome
Modulation of telomeres in alternative lengthening of telomeres type I like human cells by the expression of werner protein and telomerase.
Werner Syndrome
Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage.
Werner Syndrome
Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.
Werner Syndrome
Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome.
Werner Syndrome
Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
Werner Syndrome
Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome.
Werner Syndrome
Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN.
Werner Syndrome
Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors.
Werner Syndrome
Physical and Functional Interactions of Caenorhabditis elegansWRN-1 Helicase with RPA-1.
Werner Syndrome
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.
Werner Syndrome
Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in ?-irradiation-induced DNA damage responses.
Werner Syndrome
Quantitative analysis of Werner helicase activity using the single-molecule fluorescence detection system MF10S.
Werner Syndrome
Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts.
Werner Syndrome
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase.
Werner Syndrome
RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.
Werner Syndrome
Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription.
Werner Syndrome
Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity.
Werner Syndrome
Replication protein A stimulates the werner syndrome protein branch migration activity.
Werner Syndrome
Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA.
Werner Syndrome
Resveratrol Improves Insulin Resistance Hyperglycemia and Hepatosteatosis But Not Hypertriglyceridemia, Inflammation, and Life Span in a Mouse Model for Werner Syndrome.
Werner Syndrome
Role for the Werner syndrome protein in the promotion of tumor cell growth.
Werner Syndrome
Roles of the Bloom's syndrome helicase in the maintenance of genome stability.
Werner Syndrome
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
Werner Syndrome
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
Werner Syndrome
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks.
Werner Syndrome
Severe toxicity following induction chemotherapy for acute myelogenous leukemia in a patient with Werner's syndrome.
Werner Syndrome
Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding.
Werner Syndrome
Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein.
Werner Syndrome
Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.
Werner Syndrome
Targeted inhibition of WRN helicase by external guide sequence and RNase P RNA.
Werner Syndrome
Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A.
Werner Syndrome
Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.
Werner Syndrome
Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.
Werner Syndrome
The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.
Werner Syndrome
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.
Werner Syndrome
The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events.
Werner Syndrome
The effect of resveratrol on the werner syndrome RecQ helicase gene and telomerase activity.
Werner Syndrome
The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage.
Werner Syndrome
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity.
Werner Syndrome
The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.
Werner Syndrome
The ophthalmic diagnosis and management of four siblings with Werner syndrome.
Werner Syndrome
The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions.
Werner Syndrome
The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress.
Werner Syndrome
The Werner Protein Acts as a Coactivator of Nuclear Factor ?B (NF-?B) on HIV-1 and Interleukin-8 (IL-8) Promoters.
Werner Syndrome
The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase ?
Werner Syndrome
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.
Werner Syndrome
The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase ? Elongation.
Werner Syndrome
The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication.
Werner Syndrome
The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice.
Werner Syndrome
The Werner syndrome protein has separable recombination and survival functions.
Werner Syndrome
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.
Werner Syndrome
The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa.
Werner Syndrome
The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.
Werner Syndrome
Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.
Werner Syndrome
Werner complex deficiency in cells disrupts the Nuclear Pore Complex and the distribution of lamin B1.
Werner Syndrome
Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome.
Werner Syndrome
Werner syndrome helicase activity is essential in maintaining fragile site stability.
Werner Syndrome
Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding.
Werner Syndrome
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Werner Syndrome
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
Werner Syndrome
Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.
Werner Syndrome
Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.
Werner Syndrome
Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion.
Werner Syndrome
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Werner Syndrome
Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.
Werner Syndrome
Werner's syndrome as a hereditary risk factor for exocrine pancreatic cancer: Potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy.
Werner Syndrome
WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3.
Werner Syndrome
WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts.
Werner Syndrome
WRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts.
Werner Syndrome
WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome.
Werner Syndrome
WRN regulates pathway choice between classical and alternative non-homologous end joining.
Xeroderma Pigmentosum
RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA).
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