Disease on EC 5.6.2.3 - DNA 5'-3' helicase
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Acquired Immunodeficiency Syndrome
Components of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processing.
Acute Kidney Injury
Dynamic changes in Bach1 expression in the kidney of rhabdomyolysis-associated acute kidney injury.
Adenocarcinoma
Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma.
Adenocarcinoma
Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression.
Adenocarcinoma
Therapeutic effects of bach1 siRNA on human breast adenocarcinoma cell line.
Adenocarcinoma of Lung
FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling, and metastasis.
Adenocarcinoma of Lung
The Role of Upregulated DDX11 as A Potential Prognostic and Diagnostic Biomarker in Lung Adenocarcinoma.
Adenoma
Aberration of Nrf2?Bach1 pathway in colorectal carcinoma; role in carcinogenesis and tumor progression.
Adenoma
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Alzheimer Disease
A novel variation in the Twinkle linker region causing late-onset dementia.
Alzheimer Disease
Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease.
Alzheimer Disease
Bach1 Overexpression in Down Syndrome Correlates with the Alteration of the HO-1/BVR-A System: Insights for Transition to Alzheimer's Disease.
Alzheimer Disease
microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia.
Amyotrophic Lateral Sclerosis
Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly.
Anemia
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
Anemia
Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.
Anemia
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Anemia
Structure, function and evolution of the XPD family of iron-sulfur-containing 5'-->3' DNA helicases.
Anemia, Aplastic
Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.
Anthrax
An essential DnaB helicase of Bacillus anthracis: identification, characterization, and mechanism of action.
Apraxias
A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.
Apraxias
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
Apraxias
Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly.
Arthritis, Rheumatoid
Bach1 Inhibition Suppresses Osteoclastogenesis via Reduction of the Signaling via Reactive Oxygen Species by Reinforced Antioxidation.
Arthritis, Rheumatoid
RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice.
Arthrogryposis
Radiation hybrid mapping of 18 positional and physiological candidate genes for arthrogryposis multiplex congenita on porcine chromosome 5.
Astrocytoma
Analysis of difference of association between polymorphisms in the XRCC5, RPA3 and RTEL1 genes and glioma, astrocytoma and glioblastoma.
Astrocytoma
CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility.
Astrocytoma
RTEL1 and TERT polymorphisms are associated with astrocytoma risk in the Chinese Han population.
Ataxia
Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Ataxia
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Ataxia
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
Ataxia
Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease.
Ataxia
Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly.
Ataxia Telangiectasia
Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.
Ataxia Telangiectasia
Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management.
Atherosclerosis
Ablation of the bach1 gene leads to the suppression of atherosclerosis in bach1 and apolipoprotein E double knockout mice.
Atherosclerosis
Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury.
Bloom Syndrome
A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.
Bloom Syndrome
Aberrant chromosome morphology in human cells defective for Holliday junction resolution.
Bloom Syndrome
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.
Bloom Syndrome
BLM, the Bloom's syndrome protein, varies during the cell cycle in its amount, distribution, and co-localization with other nuclear proteins.
Bloom Syndrome
Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.
Bloom Syndrome
Bloom syndrome DNA helicase deficiency is associated with oxidative stress and mitochondrial network changes.
Bloom Syndrome
Cell cycle regulation of the endogenous wild type Bloom's syndrome DNA helicase.
Bloom Syndrome
Cellular defects caused by hypomorphic variants of the Bloom syndrome helicase gene BLM.
Bloom Syndrome
Characterization and mutational analysis of the RecQ core of the bloom syndrome protein.
Bloom Syndrome
Characterization of the nuclear localization signal in the DNA helicase responsible for Bloom syndrome.
Bloom Syndrome
Clinical features of Bloom syndrome and function of the causative gene, BLM helicase.
Bloom Syndrome
Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains.
Bloom Syndrome
Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.
Bloom Syndrome
Dephosphorylation and subcellular compartment change of the mitotic Bloom's syndrome DNA helicase in response to ionizing radiation.
Bloom Syndrome
Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors.
Bloom Syndrome
Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene.
Bloom Syndrome
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Bloom Syndrome
FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease.
Bloom Syndrome
Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells.
Bloom Syndrome
hRAD54 gene and 1p high-resolution deletion-mapping analyses in oligodendrogliomas.
Bloom Syndrome
Multifaceted role of the Topo III?-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection.
Bloom Syndrome
Multiple functions of Drosophila BLM helicase in maintenance of genome stability.
Bloom Syndrome
Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.
Bloom Syndrome
Point mutations causing Bloom's syndrome abolish ATPase and DNA helicase activities of the BLM protein.
Bloom Syndrome
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Bloom Syndrome
Purification of overexpressed hexahistidine-tagged BLM N431 as oligomeric complexes.
Bloom Syndrome
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
Bloom Syndrome
Regulation of homologous integration in yeast by the DNA repair proteins Ku70 and RecQ.
Bloom Syndrome
Removal of the Bloom Syndrome DNA Helicase Extends the Utility of Imprecise Transposon Excision for Making Null Mutations in Drosophila.
Bloom Syndrome
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.
Bloom Syndrome
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
Bloom Syndrome
Somatic hypermutation of immunoglobulin genes is independent of the Bloom's syndrome DNA helicase.
Bloom Syndrome
Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase.
Bloom Syndrome
The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage.
Bloom Syndrome
The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability.
Bloom Syndrome
The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans.
Bloom Syndrome
The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.
Bloom Syndrome
The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants.
Bloom Syndrome
Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates.
Bone Marrow Diseases
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Bone Marrow Failure Disorders
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.
Bone Marrow Failure Disorders
FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks.
Bone Marrow Failure Disorders
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction.
Bone Marrow Failure Disorders
Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita.
Bone Marrow Failure Disorders
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia.
Bone Marrow Failure Disorders
RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility.
Bowen's Disease
Expression of Minichromosome Maintenance Proteins in Actinic Keratosis and Squamous Cell Carcinoma.
Brain Diseases
Abnormal Glycosylation Profile and High Alpha-Fetoprotein in a Patient with Twinkle Variants.
Brain Diseases
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Brain Neoplasms
CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility.
Brain Neoplasms
Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma.
Breast Neoplasms
A novel breast cancer-associated BRIP1 (FANCJ/BACH1) germ-line mutation impairs protein stability and function.
Breast Neoplasms
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Breast Neoplasms
Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase.
Breast Neoplasms
Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer.
Breast Neoplasms
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Breast Neoplasms
BACH1 517C-->T transition impairs protein translocation to nucleus: a role in breast cancer susceptibility?
Breast Neoplasms
BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes.
Breast Neoplasms
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
Breast Neoplasms
BACH1, the master regulator gene: A novel candidate target for cancer therapy.
Breast Neoplasms
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
Breast Neoplasms
BRIP1 inhibits the tumorigenic properties of cervical cancer by regulating RhoA GTPase activity.
Breast Neoplasms
Clinical implications of germline mutations in breast cancer genes: RECQL.
Breast Neoplasms
Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature-based meta-analysis and meta-regression analysis.
Breast Neoplasms
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.
Breast Neoplasms
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
Breast Neoplasms
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Breast Neoplasms
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Breast Neoplasms
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by RPA to unwind the damaged DNA substrate in a strand-specific manner.
Breast Neoplasms
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.
Breast Neoplasms
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.
Breast Neoplasms
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact to Facilitate the DNA Damage Response.
Breast Neoplasms
Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells.
Breast Neoplasms
Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations.
Breast Neoplasms
LncRNA SNHG5 promotes the glycolysis and proliferation of breast cancer cell through regulating BACH1 via targeting miR-299.
Breast Neoplasms
Loss of the BRCA1-Interacting Helicase BRIP1 Results in Abnormal Mammary Acinar Morphogenesis.
Breast Neoplasms
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia.
Breast Neoplasms
Mutational analysis of the breast cancer susceptibility gene BRIP1 /BACH1/FANCJ in high-risk non-BRCA1/BRCA2 breast cancer families.
Breast Neoplasms
Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.
Breast Neoplasms
RECQL5: Another DNA helicase potentially involved in hereditary breast cancer susceptibility.
Breast Neoplasms
shRNA knockdown of DNA helicase ERCC6L expression inhibits human breast cancer growth.
Breast Neoplasms
Silencing of bach1 gene by small interfering RNA-mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells.
Breast Neoplasms
Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression.
Breast Neoplasms
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Breast Neoplasms
Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication.
Breast Neoplasms
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.
Breast Neoplasms
Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass.
Breast Neoplasms
The Antitumor Mechanism of Paeonol on CXCL4/CXCR3-B Signals in Breast Cancer Through Induction of Tumor Cell Apoptosis.
Breast Neoplasms
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.
Breast Neoplasms
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.
Breast Neoplasms
The Fanconi anemia/BRCA gene network in zebrafish: Embryonic expression and comparative genomics.
Breast Neoplasms
The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.
Breast Neoplasms
Therapeutic effects of bach1 siRNA on human breast adenocarcinoma cell line.
Breast Neoplasms
Transcriptional Network Analysis Identifies BACH1 as A Master Regulator of Breast Cancer Bone Metastasis.
Breast Neoplasms
Transcriptomic and protein expression analysis reveals clinicopathological significance of Bloom's syndrome helicase (BLM) in breast cancer.
Breast Neoplasms
Utilization of fluorescence in situ hybridization with cytokeratin discriminators in TOP2A assessment of chemotherapy-treated patients with breast cancer.
Breast Neoplasms
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins.
Carcinogenesis
Aberration of Nrf2?Bach1 pathway in colorectal carcinoma; role in carcinogenesis and tumor progression.
Carcinogenesis
Bach1 deficiency and accompanying overexpression of heme oxygenase-1 do not influence aging or tumorigenesis in mice.
Carcinogenesis
Bach1 is critical for the transformation of mouse embryonic fibroblasts by Ras(V12) and maintains ERK signaling.
Carcinogenesis
BACH1 promotes the progression of esophageal squamous cell carcinoma by inducing the epithelial-mesenchymal transition and angiogenesis.
Carcinogenesis
BRIP1 inhibits the tumorigenic properties of cervical cancer by regulating RhoA GTPase activity.
Carcinogenesis
Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma.
Carcinogenesis
FANCJ couples replication past natural fork barriers with maintenance of chromatin structure.
Carcinogenesis
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by RPA to unwind the damaged DNA substrate in a strand-specific manner.
Carcinogenesis
Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis.
Carcinogenesis
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand.
Carcinogenesis
LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription.
Carcinogenesis
Molecular and Cellular Functions of the Warsaw Breakage Syndrome DNA Helicase DDX11.
Carcinogenesis
Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.
Carcinogenesis
Overexpression of the BRIP1 ameliorates chemosensitivity to cisplatin by inhibiting Rac1 GTPase activity in cervical carcinoma HeLa cells.
Carcinogenesis
Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma.
Carcinogenesis
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Carcinogenesis
XPD-The Lynchpin of NER: Molecule, Gene, Polymorphisms, and Role in Colorectal Carcinogenesis.
Carcinoid Tumor
Down-Regulation of miR-129-5p and the let-7 Family in Neuroendocrine Tumors and Metastases Leads to Up-Regulation of Their Targets Egr1, G3bp1, Hmga2 and Bach1.
Carcinoma
Aberration of Nrf2?Bach1 pathway in colorectal carcinoma; role in carcinogenesis and tumor progression.
Carcinoma
Association between visceral adiposity and DDX11 as a predictor of aggressiveness of small clear-cell renal-cell carcinoma: a prospective clinical trial.
Carcinoma
BACH1 promotes the progression of esophageal squamous cell carcinoma by inducing the epithelial-mesenchymal transition and angiogenesis.
Carcinoma
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
Carcinoma
Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma.
Carcinoma
Expression of Minichromosome Maintenance Proteins in Actinic Keratosis and Squamous Cell Carcinoma.
Carcinoma
Expression of the oxidative stress-regulated transcription factor bach2 in differentiating neuronal cells.
Carcinoma
The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity.
Carcinoma, Hepatocellular
BACH1 is transcriptionally inhibited by TET1 in hepatocellular carcinoma in a microRNA-34a-dependent manner to regulate autophagy and inflammation.
Carcinoma, Hepatocellular
E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
Carcinoma, Hepatocellular
Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis.
Carcinoma, Hepatocellular
Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes.
Carcinoma, Hepatocellular
HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells.
Carcinoma, Hepatocellular
Heme oxygenase-1 induction by heat shock in rat hepatoma cell line is regulated by the coordinated function of HSF1, NRF2, AND BACH1.
Carcinoma, Hepatocellular
LncRNA TRG-AS1 stimulates hepatocellular carcinoma progression by sponging miR-4500 to modulate BACH1.
Carcinoma, Hepatocellular
MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins.
Carcinoma, Hepatocellular
Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor bach1 and up-regulates HO-1.
Carcinoma, Ovarian Epithelial
BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition.
Carcinoma, Ovarian Epithelial
Helicase POLQ-like (HELQ) as a novel indicator of platinum-based chemoresistance for epithelial ovarian cancer.
Carcinoma, Renal Cell
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
Carcinoma, Renal Cell
The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity.
Carcinoma, Squamous Cell
Expression of Minichromosome Maintenance Proteins in Actinic Keratosis and Squamous Cell Carcinoma.
Cardiomyopathies
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Cardiomyopathies
Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species.
Cardiomyopathies
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis.
Cataract
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Cerebellar Ataxia
Infantile onset spinocerebellar ataxia caused by compound heterozygosity for Twinkle mutations and modeling of Twinkle mutations causing recessive disease.
Cerebral Infarction
Downregulation of BACH1 Protects AGAINST Cerebral Ischemia/Reperfusion Injury through the Functions of HO-1 and NQO1.
Cockayne Syndrome
Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome.
Cockayne Syndrome
The DNA helicases acting in nucleotide excision repair, XPD, CSB and XPB, are not required for PCNA-dependent repair of abasic sites.
Cockayne Syndrome
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Coinfection
Inhibition of Bombyx mori nuclear polyhedrosis virus (NPV) replication by the putative DNA helicase gene of Autographa californica NPV.
Colitis, Ulcerative
An RTEL1 Mutation Links to Infantile-Onset Ulcerative Colitis and Severe Immunodeficiency.
Colonic Neoplasms
BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes.
Colonic Neoplasms
Long non-coding RNA NEAT1 absorbs let-7 g-5p to induce epithelial-mesenchymal transition of colon cancer cells through upregulating BACH1.
Colorectal Neoplasms
BACH1 promotes the progression of human colorectal cancer through BACH1/CXCR4 pathway.
Colorectal Neoplasms
CircBACH1/let-7a-5p axis enhances the proliferation and metastasis of colorectal cancer by upregulating CREB5 expression.
Colorectal Neoplasms
Circ_0087862 promotes the progression of colorectal cancer by sponging miR-142-3p and up-regulating BACH1 expression.
Colorectal Neoplasms
FANCJ Expression Predicts the Response to 5-Fluorouracil-Based Chemotherapy in MLH1-Proficient Colorectal Cancer.
Colorectal Neoplasms
Immunohistochemical Study of the Nrf2 Pathway in Colorectal Cancer: Nrf2 Expression is Closely Correlated to Keap1 in the Tumor and Bach1 in the Normal Tissue.
Colorectal Neoplasms
Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression.
Colorectal Neoplasms
Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1.
Colorectal Neoplasms
The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer.
Congenital Abnormalities
Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome.
Coronary Disease
Genetic analysis of the relation of telomere length-related gene (RTEL1) and coronary heart disease risk.
De Lange Syndrome
Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1.
Deglutition Disorders
A novel variation in the Twinkle linker region causing late-onset dementia.
Deglutition Disorders
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Deglutition Disorders
TWINKLE gene mutation: report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review.
Dementia
microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia.
Dementia
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Dermatitis, Atopic
Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1.
Diffuse Cerebral Sclerosis of Schilder
Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Diffuse Cerebral Sclerosis of Schilder
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
dna 5'-3' helicase deficiency
An MLH1 Mutation Links BACH1/FANCJ to Colon Cancer, Signaling, and Insight toward Directed Therapy.
dna 5'-3' helicase deficiency
Bach1 deficiency ameliorates hepatic injury in a mouse model.
dna 5'-3' helicase deficiency
Bach1 deficiency and accompanying overexpression of heme oxygenase-1 do not influence aging or tumorigenesis in mice.
dna 5'-3' helicase deficiency
Bach1 deficiency protects pancreatic ?-cells from oxidative stress injury.
dna 5'-3' helicase deficiency
Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1.
dna 5'-3' helicase deficiency
Bach1 promotes muscle regeneration through repressing Smad-mediated inhibition of myoblast differentiation.
dna 5'-3' helicase deficiency
Biochemical characterization of Warsaw breakage syndrome helicase.
dna 5'-3' helicase deficiency
Bloom syndrome DNA helicase deficiency is associated with oxidative stress and mitochondrial network changes.
dna 5'-3' helicase deficiency
Correction to: Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency.
dna 5'-3' helicase deficiency
Corrigendum: Clinical and Molecular Heterogeneity of RTEL1 Deficiency.
dna 5'-3' helicase deficiency
Deficiency of the Arabidopsis Helicase RTEL1 Triggers a SOG1-Dependent Replication Checkpoint in Response to DNA Cross-Links.
dna 5'-3' helicase deficiency
DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
dna 5'-3' helicase deficiency
Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins.
dna 5'-3' helicase deficiency
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.
dna 5'-3' helicase deficiency
Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase.
dna 5'-3' helicase deficiency
Genetic Ablation of Transcription Repressor Bach1 Reduces Neural Tissue Damage and Improves Locomotor Function after Spinal Cord Injury in Mice.
dna 5'-3' helicase deficiency
Heterozygous RTEL1 mutations are associated with familial pulmonary fibrosis.
dna 5'-3' helicase deficiency
Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability.
dna 5'-3' helicase deficiency
Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice.
dna 5'-3' helicase deficiency
Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.
dna 5'-3' helicase deficiency
Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.
dna 5'-3' helicase deficiency
RTEL1 influences the abundance and localization of TERRA RNA.
dna 5'-3' helicase deficiency
Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling.
dna 5'-3' helicase deficiency
Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency.
Down Syndrome
Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease.
Down Syndrome
Analysis of mtDNA, miR-155 and BACH1 expression in hearts from donors with and without Down syndrome.
Down Syndrome
Bach1 Overexpression in Down Syndrome Correlates with the Alteration of the HO-1/BVR-A System: Insights for Transition to Alzheimer's Disease.
Drug Hypersensitivity
DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects.
Ductus Arteriosus, Patent
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Dysarthria
Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Dysarthria
TWINKLE gene mutation: report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review.
Dyskeratosis Congenita
Complex phenotype of dyskeratosis congenita and mood dysregulation with novel homozygous RTEL1 and TPH1 variants.
Dyskeratosis Congenita
Constitutional Mutations in RTEL1 Cause Severe Dyskeratosis Congenita.
Dyskeratosis Congenita
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.
Dyskeratosis Congenita
Generation of an Rtel1-CreERT2 knock-in mouse model for lineage tracing RTEL1+ stem cells during development.
Dyskeratosis Congenita
Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita.
Dyskeratosis Congenita
Mutant mice lacking the p53 C-terminal domain model telomere syndromes.
Dyskeratosis Congenita
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Dyskeratosis Congenita
Telomere shortening by mutations in the RTEL1 helicase cause severe form of dyskeratosis congenita, Hoyerall-Hreidarsson syndrome.
Dyskeratosis Congenita
The C-terminal extension of human RTEL1, mutated in Hoyeraal-Hreidarsson syndrome, contains Harmonin-N-like domains.
Dyskeratosis Congenita
[RTEL1 (regulator of telomere elongation helicase 1), a DNA helicase essential for genome stability].
Dysphonia
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Dysplastic Nevus Syndrome
Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.
Epidermal Cyst
Twinkle artefact in the ultrasound diagnosis of superficial epidermoid cysts.
Epilepsy
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Epilepsy
Migraine and epilepsy: A focus on overlapping clinical, pathophysiological, molecular, and therapeutic aspects.
Epilepsy
Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Esophageal Squamous Cell Carcinoma
BACH1 promotes the progression of esophageal squamous cell carcinoma by inducing the epithelial-mesenchymal transition and angiogenesis.
Fanconi Anemia
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Fanconi Anemia
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.
Fanconi Anemia
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
Fanconi Anemia
Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism.
Fanconi Anemia
Chl1 DNA Helicase Regulates Scc2 Deposition Specifically during DNA-Replication in Saccharomyces cerevisiae.
Fanconi Anemia
Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ? (POLN).
Fanconi Anemia
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Fanconi Anemia
Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells.
Fanconi Anemia
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
Fanconi Anemia
FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway.
Fanconi Anemia
FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex.
Fanconi Anemia
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Fanconi Anemia
FANCJ Expression Predicts the Response to 5-Fluorouracil-Based Chemotherapy in MLH1-Proficient Colorectal Cancer.
Fanconi Anemia
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.
Fanconi Anemia
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Fanconi Anemia
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress.
Fanconi Anemia
FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks.
Fanconi Anemia
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by RPA to unwind the damaged DNA substrate in a strand-specific manner.
Fanconi Anemia
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.
Fanconi Anemia
FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.
Fanconi Anemia
FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.
Fanconi Anemia
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.
Fanconi Anemia
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction.
Fanconi Anemia
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact to Facilitate the DNA Damage Response.
Fanconi Anemia
Helicase-inactivating mutations as a basis for dominant negative phenotypes.
Fanconi Anemia
HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks.
Fanconi Anemia
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand.
Fanconi Anemia
Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations.
Fanconi Anemia
Investigation of the core binding regions of human Werner syndrome and Fanconi anemia group J helicases on replication protein A.
Fanconi Anemia
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia.
Fanconi Anemia
Mustard Seed (Brassica nigra) Extract Exhibits Antiproliferative Effect against Human Lung Cancer Cells through Differential Regulation of Apoptosis, Cell Cycle, Migration, and Invasion.
Fanconi Anemia
Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans.
Fanconi Anemia
Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress.
Fanconi Anemia
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Fanconi Anemia
Subependymal giant cell astrocytoma-like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type-1-association.
Fanconi Anemia
The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J.
Fanconi Anemia
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.
Fanconi Anemia
The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization.
Fanconi Anemia
The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.
Fanconi Anemia
Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion.
Fanconi Anemia
Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1.
Fanconi Anemia
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins.
Fragile X Syndrome
Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n.
GATA2 Deficiency
A homozygous mutation of RTEL1 in a child presenting with an apparently isolated natural killer cell deficiency.
Genetic Diseases, Inborn
An E2F1/DDX11/EZH2 Positive Feedback Loop Promotes Cell Proliferation in Hepatocellular Carcinoma.
Genetic Diseases, Inborn
Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING.
Genetic Diseases, Inborn
Biochemical characterization of Warsaw breakage syndrome helicase.
Genetic Diseases, Inborn
Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients.
Genetic Diseases, Inborn
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.
Genetic Diseases, Inborn
Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways.
Genetic Diseases, Inborn
Molecular and Cellular Functions of the Warsaw Breakage Syndrome DNA Helicase DDX11.
Genetic Diseases, Inborn
RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks.
Genetic Diseases, Inborn
The Genome Stability Maintenance DNA Helicase DDX11 and Its Role in Cancer.
Genetic Diseases, Inborn
The Q Motif Is Involved in DNA Binding but Not ATP Binding in ChlR1 Helicase.
Glioblastoma
Analysis of difference of association between polymorphisms in the XRCC5, RPA3 and RTEL1 genes and glioma, astrocytoma and glioblastoma.
Glioblastoma
Association between RTEL1, PHLDB1, and TREH Polymorphisms and Glioblastoma Risk: A Case-Control Study.
Glioblastoma
Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a chinese population.
Glioblastoma
BACH1 Promotes Temozolomide Resistance in Glioblastoma through Antagonizing the Function of p53.
Glioblastoma
Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma.
Glioblastoma
Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival.
Glioma
A functional variant on 20q13.33 related to glioma risk alters enhancer activity and modulates expression of multiple genes.
Glioma
Adult Diffuse Glioma GWAS by Molecular Subtype Identifies Variants in D2HGDH and FAM20C.
Glioma
Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies.
Glioma
Analysis of difference of association between polymorphisms in the XRCC5, RPA3 and RTEL1 genes and glioma, astrocytoma and glioblastoma.
Glioma
Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population.
Glioma
Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies.
Glioma
Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a chinese population.
Glioma
Associations between the rs6010620 polymorphism in RTEL1 and risk of glioma: a meta-analysis of 20,711 participants.
Glioma
Cancer susceptibility variants and the risk of adult glioma in a US case-control study.
Glioma
Fine mapping analysis of a region of 20q13.33 identified five independent susceptibility loci for glioma in a Chinese Han population.
Glioma
Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma.
Glioma
miR-4530 inhibits the malignant biological behaviors of human glioma cells by directly targeting RTEL1.
Glioma
Regulator of telomere elongation helicase 1 (RTEL1) rs6010620 polymorphism contribute to increased risk of glioma.
Glioma
Replication of GWAS identifies RTEL1, CDKN2A/B, and PHLDB1 SNPs as risk factors in Portuguese gliomas patients.
Glioma
The Genetic Architecture of Gliomagenesis-Genetic Risk Variants Linked to Specific Molecular Subtypes.
Glioma
The role of the RTEL1 rs2297440 polymorphism in the risk of glioma development: a meta-analysis.
Glioma
The RTEL1 rs6010620 polymorphism and glioma risk: a meta-analysis based on 12 case-control studies.
Glioma
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
Hearing Loss
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Hearing Loss, Sensorineural
Study of carrier frequency of Warsaw breakage syndrome in the Ashkenazi Jewish population and presentation of two cases.
Heart Defects, Congenital
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Diseases
The overexpression of Twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in mice.
Heart Failure
The overexpression of Twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in mice.
Heart Rupture
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis.
Heart Septal Defects, Atrial
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Septal Defects, Ventricular
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Hepatitis B
Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.
Hepatitis C
Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super-families of helicases.
Hepatitis C
Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Hepatitis C
MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins.
Hepatitis C
MicroRNA-let-7c suppresses hepatitis C virus replication by targeting Bach1 for induction of heme oxygenase-1 expression.
Hepatitis C
Structurally conserved amino Acid w501 is required for RNA helicase activity but is not essential for DNA helicase activity of hepatitis C virus NS3 protein.
Hepatitis C
The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding.
Hepatitis C
The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.
Herpes Simplex
A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.
Herpes Simplex
Association of DNA helicase and primase activities with a subassembly of the herpes simplex virus 1 helicase-primase composed of the UL5 and UL52 gene products.
Herpes Simplex
Complex of the herpes simplex virus type 1 origin binding protein UL9 with DNA as a platform for the design of a new type of antiviral drugs.
Herpes Simplex
Functional properties of the herpes simplex virus type I origin-binding protein are controlled by precise interactions with the activated form of the origin of DNA replication.
Herpes Simplex
Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products.
Herpes Simplex
Herpes simplex virus helicase-primase: the UL8 protein is not required for DNA-dependent ATPase and DNA helicase activities.
Herpes Simplex
Identification of residues within the herpes simplex virus type 1 origin-binding protein that contribute to sequence-specific DNA binding.
Herpes Simplex
Inhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complex.
Herpes Simplex
Inhibition of herpes simplex virus type 1 DNA replication by mutant forms of the origin-binding protein.
Herpes Simplex
Interactions of a subassembly of the herpes simplex virus type 1 helicase-primase with DNA.
Herpes Simplex
Modulation of the herpes simplex virus type-1 UL9 DNA helicase by its cognate single-strand DNA-binding protein, ICP8.
Herpes Simplex
Sequence of the HindIII T fragment of human cytomegalovirus, which encodes a DNA helicase.
Herpes Simplex
The DNA ligands influence the interactions between the herpes simplex virus 1 origin binding protein and the single strand DNA-binding protein, ICP-8.
Herpes Simplex
The herpes simplex virus type 1 origin-binding protein carries out origin specific DNA unwinding and forms stem-loop structures.
Herpes Simplex
The herpes simplex virus type 1 origin-binding protein interacts specifically with the viral UL8 protein.
Herpes Simplex
The herpes simplex virus type-1 origin binding protein. DNA helicase activity.
Herpes Simplex
The herpes simplex virus type-1 single-strand DNA-binding protein, ICP8, increases the processivity of the UL9 protein DNA helicase.
Herpes Simplex
The origin-binding domain of the herpes simplex virus type 1 UL9 protein is not required for DNA helicase activity.
Herpes Simplex
[Complex of the herpes simplex virus initiator protein UL9 with DNA as a platform for the design of a new type of antiviral drugs]
Hypokalemia
Age-related changes in renal function, membrane protein metabolism, and Na,K-ATPase activity and abundance in hypokalemic F344 x BNF(1) rats.
Ichthyosis
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Ichthyosis
Trypanosoma brucei harbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms.
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways.
Infarction, Middle Cerebral Artery
MicroRNA-532-5p upregulation protects neurological deficits after ischemic stroke through inhibition of BTB and CNC homology 1.
Infections
Abortive infection of the baculovirus Autographa californica nuclear polyhedrosis virus in Sf-9 cells after mutation of the putative DNA helicase gene.
Infections
Differential gene expression profile from haematopoietic tissue stem cells of red claw crayfish, Cherax quadricarinatus, in response to WSSV infection.
Infections
Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products.
Infections
High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms.
Infections
Interaction of the bacteriophage T4 gene 59 helicase loading protein and gene 41 helicase with each other and with fork, flap, and cruciform DNA.
Infections
Let-7c overexpression inhibits dengue virus replication in human hepatoma Huh-7 cells.
Infections
MOV10 interacts with Enterovirus 71 genomic 5'UTR and modulates viral replication.
Insulin Resistance
Bach1 deficiency protects pancreatic ?-cells from oxidative stress injury.
Intellectual Disability
Human DNA Helicase B as a Candidate for Unwinding Secondary CGG Repeat Structures at the Fragile X Mental Retardation Gene.
Intellectual Disability
Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome.
Intellectual Disability
Novel mutations in WWOX, RARS2, and C10orf2 genes in consanguineous Arab families with intellectual disability.
Intellectual Disability
Study of carrier frequency of Warsaw breakage syndrome in the Ashkenazi Jewish population and presentation of two cases.
Intellectual Disability
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Intellectual Disability
The Genome Stability Maintenance DNA Helicase DDX11 and Its Role in Cancer.
Intervertebral Disc Degeneration
Therapeutic effect of co-culture of rat bone marrow mesenchymal stem cells and degenerated nucleus pulposus cells on intervertebral disc degeneration.
Intestinal Pseudo-Obstruction
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Iron Deficiencies
Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency.
Iron Deficiencies
Loss of mitochondrial localization of human FANCG causes defective FANCJ helicase.
Keratosis, Actinic
Expression of Minichromosome Maintenance Proteins in Actinic Keratosis and Squamous Cell Carcinoma.
Kidney Calculi
Acoustic shadowing in pediatric kidney stone ultrasound: a retrospective study with non-enhanced computed tomography as reference standard.
Kidney Calculi
Relationship between Twinkle Artefacts and in vivo Biochemical Composition of Kidney Stones.
Kidney Neoplasms
ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers.
Kidney Neoplasms
microRNA-155 silencing inhibits proliferation and migration and induces apoptosis by upregulating BACH1 in renal cancer cells.
Leukemia
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
Leukemia
MOV10 interacts with Enterovirus 71 genomic 5'UTR and modulates viral replication.
Leukemia
Regulatory heme and trichloroethylene intoxication: A possible explanation of the case of "A Civil Action".
Leukemia, Erythroblastic, Acute
Heme induces ubiquitination and degradation of the transcription factor Bach1.
Leukemia, Erythroblastic, Acute
Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.
Leukemia, Erythroblastic, Acute
Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network.
Leukemia, Erythroblastic, Acute
Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells.
Leukopenia
Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: A prospective clinical study.
Liver Diseases
Mitochondrial DNA Depletion Syndromes: Review and Updates of Genetic Basis, Manifestations, and Therapeutic Options.
Liver Diseases
Myelodysplasia and liver disease extend the spectrum of RTEL1 related telomeropathies.
Liver Failure
Next Generation Sequencing Facilitates The Diagnosis In A Child With Twinkle Mutations Causing Cholestatic Liver Failure.
Loeys-Dietz Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Lung Diseases
Pulmonary phenotypes associated with genetic variation in telomere-related genes.
Lung Diseases
The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis.
Lung Diseases, Interstitial
Rare Variants in RTEL1 Are Associated with Familial Interstitial Pneumonia.
Lung Diseases, Interstitial
Regulator of telomere length 1 (RTEL1) mutations are associated with heterogeneous pulmonary and extra-pulmonary phenotypes.
Lung Diseases, Interstitial
Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia.
Lung Injury
Genetic ablation of Bach1 gene enhances recovery from hyperoxic lung injury in newborn mice via transient upregulation of inflammatory genes.
Lung Injury
Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: role of IL-6.
Lung Neoplasms
Analysis of RTEL1 and PCDHGB6 promoter methylation in circulating-free DNA of lung cancer patients using liquid biopsy: A pilot study.
Lung Neoplasms
beta-Carotene and cigarette smoke condensate regulate heme oxygenase-1 and its repressor factor Bach1: relationship with cell growth.
Lung Neoplasms
Chronic intermittent hypoxia promoted lung cancer stem cell-like properties via enhancing Bach1 expression.
Lung Neoplasms
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
Lung Neoplasms
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.
Lung Neoplasms
Telomere structure and maintenance gene variants and risk of five cancer types.
Lung Neoplasms
[miR-155/BACH1 Signaling Pathway in Human Lung Adenocarcinoma Cell Death Induced by Arsenic Trioxide].
Lupus Erythematosus, Systemic
Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
Lupus Nephritis
Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons.
Lymphatic Metastasis
Construction and selection of subtracted cDNA library of mouse hepatocarcinoma cell lines with different lymphatic metastasis potential.
Lymphoma
FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.
Lymphoma
RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an E?-myc/Bcl-2 mouse model.
Lymphoma
The novel lncRNA BlackMamba controls the neoplastic phenotype of ALK- anaplastic large cell lymphoma by regulating the DNA helicase HELLS.
Lymphoma, Large-Cell, Anaplastic
The novel lncRNA BlackMamba controls the neoplastic phenotype of ALK- anaplastic large cell lymphoma by regulating the DNA helicase HELLS.
Lymphoma, Non-Hodgkin
Telomerase activity in B-cell non-Hodgkin lymphomas is regulated by hTERT transcription and correlated with telomere-binding protein expression but uncoupled from proliferation.
Malaria
Plasmodium falciparum DNA helicase 60. dsRNA- and antibody-mediated inhibition of malaria parasite growth and downregulation of its enzyme activities by DNA-interacting compounds.
Malaria
Replication fork-stimulated eIF-4A from Plasmodium cynomolgi unwinds DNA in the 3' to 5' direction and is inhibited by DNA-interacting compounds.
Melanoma
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.
Melanoma
Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.
Melanoma
The DEAD/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas.
Meningioma
Search for mutations of the hRAD54 gene in sporadic meningiomas with deletion at 1p32.
Microcephaly
Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome.
Microcephaly
Study of carrier frequency of Warsaw breakage syndrome in the Ashkenazi Jewish population and presentation of two cases.
Migraine Disorders
Migraine and epilepsy: A focus on overlapping clinical, pathophysiological, molecular, and therapeutic aspects.
Mitochondrial Diseases
A mitochondrial implication in a Tunisian patient with Friedreich's ataxia-like.
Mitochondrial Diseases
Adults with RRM2B-related mitochondrial disease have distinct clinical and molecular characteristics.
Mitochondrial Diseases
Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number.
Mitochondrial Diseases
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Mitochondrial Diseases
Mitochondrial DNA homeostasis is essential for nigrostriatal integrity.
Mitochondrial Diseases
Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.
Mitochondrial Diseases
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.
Mitochondrial Diseases
POLG1 p.R722H mutation associated with multiple mtDNA deletions and a neurological phenotype.
Mitochondrial Diseases
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number.
Mitochondrial Diseases
Twinkle, the mitochondrial replicative DNA helicase, is widespread in the eukaryotic radiation and may also be the mitochondrial DNA primase in most eukaryotes.
Mitochondrial Encephalomyopathies
Revisiting mitochondrial ocular myopathies: a study from the Italian Network.
Mitochondrial Myopathies
Affection of immune cells by a C10orf2 mutation manifesting as mitochondrial myopathy and transient sensory transverse syndrome.
Mitochondrial Myopathies
Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.
Mitochondrial Myopathies
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Mitochondrial Myopathies
Reply to the letter by Finsterer et al. concerning the paper: "Affection of immune-cells by a C10orf2 mutation manifesting as mitochondrial myopathy and transient sensory transverse syndrome" by Galassi G. et al.
Mitochondrial Myopathies
The hexameric structure of the human mitochondrial replicative helicase Twinkle.
Motor Neuron Disease
A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.
Motor Neuron Disease
Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease.
Muscle Weakness
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Muscular Diseases
A novel variation in the Twinkle linker region causing late-onset dementia.
Muscular Diseases
Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice.
Muscular Diseases
Mild ocular myopathy associated with a novel mutation in mitochondrial twinkle helicase.
Muscular Diseases
Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.
Muscular Diseases
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Muscular Diseases
Recessive C10orf2 mutations in a family with infantile-onset spinocerebellar ataxia, sensorimotor polyneuropathy, and myopathy.
Muscular Diseases
Revisiting mitochondrial ocular myopathies: a study from the Italian Network.
Myelodysplastic Syndromes
Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.
Myocardial Infarction
Bach1-induced suppression of angiogenesis is dependent on the BTB domain.
Myocardial Infarction
Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1.
Myocardial Infarction
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis.
Neoplasm Metastasis
A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.
Neoplasm Metastasis
Aberration of Nrf2?Bach1 pathway in colorectal carcinoma; role in carcinogenesis and tumor progression.
Neoplasm Metastasis
Associations between the Nrf2/Keap1 pathway and mitochondrial functions in colorectal cancer are affected by metastasis.
Neoplasm Metastasis
BACH1 Promotes Pancreatic Cancer Metastasis by Repressing Epithelial Genes and Enhancing Epithelial-Mesenchymal Transition.
Neoplasm Metastasis
BACH1 promotes the progression of esophageal squamous cell carcinoma by inducing the epithelial-mesenchymal transition and angiogenesis.
Neoplasm Metastasis
BACH1 promotes the progression of human colorectal cancer through BACH1/CXCR4 pathway.
Neoplasm Metastasis
BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes.
Neoplasm Metastasis
BACH1, the master regulator gene: A novel candidate target for cancer therapy.
Neoplasm Metastasis
BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition.
Neoplasm Metastasis
CircBACH1/let-7a-5p axis enhances the proliferation and metastasis of colorectal cancer by upregulating CREB5 expression.
Neoplasm Metastasis
Down-Regulation of miR-129-5p and the let-7 Family in Neuroendocrine Tumors and Metastases Leads to Up-Regulation of Their Targets Egr1, G3bp1, Hmga2 and Bach1.
Neoplasm Metastasis
FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling, and metastasis.
Neoplasm Metastasis
Limited inhibition of multiple nodes in a driver network blocks metastasis.
Neoplasm Metastasis
MALAT1 and BACH1 are prognostic biomarkers for triple-negative breast cancer.
Neoplasm Metastasis
Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.
Neoplasm Metastasis
Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.
Neoplasm Metastasis
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
Neoplasm Metastasis
Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1.
Neoplasm Metastasis
Regulatory mechanisms of heme regulatory protein BACH1: a potential therapeutic target for cancer.
Neoplasm Metastasis
Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.
Neoplasm Metastasis
Silencing of bach1 gene by small interfering RNA-mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells.
Neoplasm Metastasis
Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression.
Neoplasm Metastasis
The transcription factor BACH1 at the crossroads of cancer biology: From epithelial-mesenchymal transition to ferroptosis.
Neoplasm Metastasis
Transcriptional Network Analysis Identifies BACH1 as A Master Regulator of Breast Cancer Bone Metastasis.
Neoplasms
A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (review).
Neoplasms
A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.
Neoplasms
Aberration of Nrf2?Bach1 pathway in colorectal carcinoma; role in carcinogenesis and tumor progression.
Neoplasms
An E2F1/DDX11/EZH2 Positive Feedback Loop Promotes Cell Proliferation in Hepatocellular Carcinoma.
Neoplasms
Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies.
Neoplasms
Association between visceral adiposity and DDX11 as a predictor of aggressiveness of small clear-cell renal-cell carcinoma: a prospective clinical trial.
Neoplasms
Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population.
Neoplasms
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.
Neoplasms
Associations between the Nrf2/Keap1 pathway and mitochondrial functions in colorectal cancer are affected by metastasis.
Neoplasms
BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression.
Neoplasms
Bach1 is critical for the transformation of mouse embryonic fibroblasts by Ras(V12) and maintains ERK signaling.
Neoplasms
BACH1 promotes the progression of esophageal squamous cell carcinoma by inducing the epithelial-mesenchymal transition and angiogenesis.
Neoplasms
BACH1 promotes the progression of human colorectal cancer through BACH1/CXCR4 pathway.
Neoplasms
BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes.
Neoplasms
Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM2.
Neoplasms
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer.
Neoplasms
Bloom helicase explicitly unwinds 3'-tailed G4DNA structure in prostate cancer cells.
Neoplasms
Bloom syndrome DNA helicase deficiency is associated with oxidative stress and mitochondrial network changes.
Neoplasms
Bovine papillomavirus type 1 E1 and simian virus 40 large T antigen share regions of sequence similarity required for multiple functions.
Neoplasms
BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.
Neoplasms
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
Neoplasms
BRIP1 inhibits the tumorigenic properties of cervical cancer by regulating RhoA GTPase activity.
Neoplasms
BRIP1/FANCJ Mutation Analysis in a Family with History of Male and Female Breast Cancer in India.
Neoplasms
BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition.
Neoplasms
Cancer-related mutations in BRCA1-BRCT cause long-range structural changes in protein-protein binding sites: a molecular dynamics study.
Neoplasms
Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion.
Neoplasms
Chromosome instability and tumor predisposition inversely correlate with BLM protein levels.
Neoplasms
CircBACH1/let-7a-5p axis enhances the proliferation and metastasis of colorectal cancer by upregulating CREB5 expression.
Neoplasms
Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1.
Neoplasms
DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects.
Neoplasms
Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells.
Neoplasms
Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments.
Neoplasms
Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma.
Neoplasms
Dimerization of simian virus 40 T-antigen hexamers activates T-antigen DNA helicase activity.
Neoplasms
DNA helicase and nucleoside-5'-triphosphatase activities of polyoma virus large tumor antigen.
Neoplasms
DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
Neoplasms
Does Bach1 & c-Myc dependent redox dysregulation of Nrf2 & adaptive homeostasis decrease cancer risk in ageing?
Neoplasms
Does Natural Killer Cell Deficiency (NKD) Increase the Risk of Cancer? NKD May Increase the Risk of Some Virus Induced Cancer.
Neoplasms
E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
Neoplasms
Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins.
Neoplasms
Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc(min) mice.
Neoplasms
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.
Neoplasms
Effects of in vitro dephosphorylation on DNA-binding and DNA helicase activities of simian virus 40 large tumor antigen.
Neoplasms
Efficacy of Acylfulvene Illudin analogues against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents: retention of activity against various mdr phenotypes and unusual cytotoxicity against ERCC2 and ERCC3 DNA helicase-deficient cells.
Neoplasms
Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma.
Neoplasms
ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers.
Neoplasms
Expression of Ku86 and presence of Ku86 antibody as biomarkers of hepatitis B virus related hepatocellular carcinoma.
Neoplasms
FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links.
Neoplasms
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.
Neoplasms
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction.
Neoplasms
Functional role of BTB and CNC Homology 1 gene in pancreatic cancer and its association with survival in patients treated with gemcitabine.
Neoplasms
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility.
Neoplasms
Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis.
Neoplasms
HELQ reverses the malignant phenotype of osteosarcoma cells via CHK1-RAD51 signaling pathway.
Neoplasms
Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population.
Neoplasms
hRAD54 gene and 1p high-resolution deletion-mapping analyses in oligodendrogliomas.
Neoplasms
Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution.
Neoplasms
Identification of putative pathogenic microRNA and its downstream targets in anaplastic lymphoma kinase-negative anaplastic large cell lymphoma.
Neoplasms
Immunohistochemical Study of the Nrf2 Pathway in Colorectal Cancer: Nrf2 Expression is Closely Correlated to Keap1 in the Tumor and Bach1 in the Normal Tissue.
Neoplasms
Isolation of human DNA-unwinding elements as sites of DNA polymerase alpha/primase entry.
Neoplasms
Long noncoding RNA DDX11-AS1 induced by YY1 accelerates colorectal cancer progression through targeting miR-873/CLDN7 axis.
Neoplasms
Loss of RBMS3 Confers Platinum-resistance in Epithelial Ovarian Cancer via Activation of miR-126-5p/?-catenin/CBP signaling.
Neoplasms
MCM3 Protein Expression in Follicular and Classical Variants of Papillary Thyroid Carcinoma.
Neoplasms
MCM8 is regulated by EGFR signaling and promotes the growth of glioma stem cells through its interaction with DNA-replication-initiating factors.
Neoplasms
Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.
Neoplasms
Model system for DNA replication of a plasmid DNA containing the autonomously replicating sequence from Saccharomyces cerevisiae.
Neoplasms
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia.
Neoplasms
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome.
Neoplasms
Multiple functions of Drosophila BLM helicase in maintenance of genome stability.
Neoplasms
Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans.
Neoplasms
Mutation of the murine Bloom's syndrome gene produces global genome destabilization.
Neoplasms
Mutational analysis of the breast cancer susceptibility gene BRIP1 /BACH1/FANCJ in high-risk non-BRCA1/BRCA2 breast cancer families.
Neoplasms
Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.
Neoplasms
Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma.
Neoplasms
Overexpression of the BRIP1 ameliorates chemosensitivity to cisplatin by inhibiting Rac1 GTPase activity in cervical carcinoma HeLa cells.
Neoplasms
Oxidative stress in Fanconi anaemia: from cells and molecules toward prospects in clinical management.
Neoplasms
Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management.
Neoplasms
Partial proteolysis of simian virus 40 T antigen reveals intramolecular contacts between domains and conformation changes upon hexamer assembly.
Neoplasms
Pif1 helicase and Pol? promote recombination-coupled DNA synthesis via bubble migration.
Neoplasms
Prediction of High-Grade Clear Cell Renal Cell Carcinoma Based on Plasma mRNA Profiles in Patients with Localized Pathologic T1N0M0 Stage Disease.
Neoplasms
Problem-solving test: analysis of DNA damage recognizing proteins in yeast and human cells.
Neoplasms
Protein expression of BLM gene and its apoptosis sensitivity in hematopoietic tumor cell strains.
Neoplasms
Regulatory mechanisms of heme regulatory protein BACH1: a potential therapeutic target for cancer.
Neoplasms
Relationships between level of lipid peroxidation products and expression of Nrf2 and its activators/ inhibitors in non-small cell lung cancer tissue.
Neoplasms
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Neoplasms
RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication.
Neoplasms
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.
Neoplasms
Search for mutations of the hRAD54 gene in sporadic meningiomas with deletion at 1p32.
Neoplasms
shRNA knockdown of DNA helicase ERCC6L expression inhibits human breast cancer growth.
Neoplasms
Significance of DNA Replication Licensing Proteins (MCM2, MCM5 and CDC6), p16 and p63 as Markers of Premalignant Lesions of the Uterine Cervix: Its Usefulness to Predict Malignant Potential
Neoplasms
Silencing of bach1 gene by small interfering RNA-mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells.
Neoplasms
Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replication.
Neoplasms
SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations.
Neoplasms
Sorafenib and docosahexaenoic acid act in synergy to suppress cancer cell viability: a role of heme oxygenase 1.
Neoplasms
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.
Neoplasms
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.
Neoplasms
Suppression of Reserve MCM Complexes Chemosensitizes to Gemcitabine and 5-Fluorouracil.
Neoplasms
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated.
Neoplasms
Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass.
Neoplasms
Termination complex in Escherichia coli inhibits SV40 DNA replication in vitro by impeding the action of T antigen helicase.
Neoplasms
The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype.
Neoplasms
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.
Neoplasms
The conserved core enzymatic activities and the distinct dynamics of polyomavirus large T antigens.
Neoplasms
The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity.
Neoplasms
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.
Neoplasms
The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer.
Neoplasms
The Role of Upregulated DDX11 as A Potential Prognostic and Diagnostic Biomarker in Lung Adenocarcinoma.
Neoplasms
The Set2-RPB1-interaction domain of human RECQ5 is important for transcription-associated genome stability.
Neoplasms
The transcription factor BACH1 at the crossroads of cancer biology: From epithelial-mesenchymal transition to ferroptosis.
Neoplasms
The unwinding of duplex regions in DNA by the simian virus 40 large tumor antigen-associated DNA helicase activity.
Neoplasms
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins.
Neoplasms
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Nervous System Diseases
A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.
Nervous System Diseases
Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae.
Neuroblastoma
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
Neuroblastoma
Differentiation impairs Bach1 dependent HO-1 activation and increases sensitivity to oxidative stress in SH-SY5Y neuroblastoma cells.
Neurodegenerative Diseases
Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.
Neurodegenerative Diseases
Novel Autosomal Recessive c10orf2 Mutations Causing Infantile-Onset Spinocerebellar Ataxia.
Neurodegenerative Diseases
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
Neurodegenerative Diseases
Senataxin: A New Guardian of the Female Germline Important for Delaying Ovarian Aging.
Neuroendocrine Tumors
Down-Regulation of miR-129-5p and the let-7 Family in Neuroendocrine Tumors and Metastases Leads to Up-Regulation of Their Targets Egr1, G3bp1, Hmga2 and Bach1.
Neurologic Manifestations
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Neurologic Manifestations
Twinkle-associated familial parkinsonism with Lewy pathology: Cause or predisposition?
Neuromuscular Diseases
The Human Mitochondrial DNA helicase TWINKLE is both an unwinding and an annealing helicase.
Nevus
Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.
Non-alcoholic Fatty Liver Disease
Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor.
Ophthalmoplegia
Encephalomyopathies caused by abnormal nuclear-mitochondrial intergenomic cross-talk.
Ophthalmoplegia
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.
Ophthalmoplegia
Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Ophthalmoplegia
Twinkle mutation in an Italian family with external progressive ophthalmoplegia and parkinsonism: A case report and an update on the state of art.
Ophthalmoplegia
Twinkle-associated familial parkinsonism with Lewy pathology: Cause or predisposition?
Ophthalmoplegia, Chronic Progressive External
A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family.
Ophthalmoplegia, Chronic Progressive External
A novel Twinkle gene mutation in autosomal dominant progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
A novel variation in the Twinkle linker region causing late-onset dementia.
Ophthalmoplegia, Chronic Progressive External
Abnormal Glycosylation Profile and High Alpha-Fetoprotein in a Patient with Twinkle Variants.
Ophthalmoplegia, Chronic Progressive External
Autosomal dominant mutations in POLG and C10orf2: association with late onset chronic progressive external ophthalmoplegia and Parkinsonism in two patients.
Ophthalmoplegia, Chronic Progressive External
C10ORF2 mutation associated with progressive external ophthalmoplegia and clinically isolated syndrome.
Ophthalmoplegia, Chronic Progressive External
Clinical and molecular features of adPEO due to mutations in the Twinkle gene.
Ophthalmoplegia, Chronic Progressive External
Clinical phenotype of autosomal dominant progressive external ophthalmoplegia in a family with a novel mutation in the C10orf2 gene.
Ophthalmoplegia, Chronic Progressive External
Defects of intergenomic communication: autosomal disorders that cause multiple deletions and depletion of mitochondrial DNA.
Ophthalmoplegia, Chronic Progressive External
Differential phenotypes of active site and human autosomal dominant progressive external ophthalmoplegia mutations in Drosophila mitochondrial DNA helicase expressed in Schneider cells.
Ophthalmoplegia, Chronic Progressive External
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Ophthalmoplegia, Chronic Progressive External
Extraocular Muscle Reveals Selective Vulnerability of Type IIB Fibers to Respiratory Chain Defects Induced by Mitochondrial DNA Alterations.
Ophthalmoplegia, Chronic Progressive External
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.
Ophthalmoplegia, Chronic Progressive External
Finding twinkle in the eyes of a 71-year-old lady: a case report and review of the genotypic and phenotypic spectrum of TWINKLE-related dominant disease.
Ophthalmoplegia, Chronic Progressive External
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.
Ophthalmoplegia, Chronic Progressive External
Investigation on mtDNA deletions and twinkle gene mutation (G1423C) in Iranian patients with chronic progressive external opthalmoplagia.
Ophthalmoplegia, Chronic Progressive External
Levodopa response in Parkinsonism with multiple mitochondrial DNA deletions.
Ophthalmoplegia, Chronic Progressive External
Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.
Ophthalmoplegia, Chronic Progressive External
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.
Ophthalmoplegia, Chronic Progressive External
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Ophthalmoplegia, Chronic Progressive External
Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance.
Ophthalmoplegia, Chronic Progressive External
Mutations of ANT1, Twinkle, and POLG1 in sporadic progressive external ophthalmoplegia (PEO).
Ophthalmoplegia, Chronic Progressive External
Neurodegenerative parkinsonism and progressive external ophthalmoplegia with a Twinkle mutation.
Ophthalmoplegia, Chronic Progressive External
Novel mutation in C10orf2 associated with multiple mtDNA deletions, chronic progressive external ophthalmoplegia and premature aging.
Ophthalmoplegia, Chronic Progressive External
Novel Twinkle (PEO1) gene mutations in mendelian progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Novel Twinkle gene mutation in autosomal dominant progressive external ophthalmoplegia and multisystem failure.
Ophthalmoplegia, Chronic Progressive External
Orthostatic Tremor, Progressive External Ophthalmoplegia, and Twinkle.
Ophthalmoplegia, Chronic Progressive External
POLG1, C10ORF2, and ANT1 mutations are uncommon in sporadic progressive external ophthalmoplegia with multiple mitochondrial DNA deletions.
Ophthalmoplegia, Chronic Progressive External
Progressive external ophthalmoplegia (PEO) due to a mutation in the C10orf2 (PEO1) gene mimicking a myasthenic crisis.
Ophthalmoplegia, Chronic Progressive External
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Ophthalmoplegia, Chronic Progressive External
Reconstitution of a minimal mtDNA replisome in vitro.
Ophthalmoplegia, Chronic Progressive External
Remarkable infidelity of polymerase gammaA associated with mutations in POLG1 exonuclease domain.
Ophthalmoplegia, Chronic Progressive External
Sensory ataxic neuropathy due to a novel C10Orf2 mutation with probable germline mosaicism.
Ophthalmoplegia, Chronic Progressive External
SLC25A4 and C10ORF2 Mutations in Autosomal Dominant Progressive External Ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Structure-function defects of the twinkle amino-terminal region in progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Structure-function defects of the TWINKLE linker region in progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function.
Ophthalmoplegia, Chronic Progressive External
The clinical, histochemical, and molecular spectrum of PEO1 (Twinkle)-linked adPEO.
Ophthalmoplegia, Chronic Progressive External
TWINKLE gene mutation: report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review.
Ophthalmoplegia, Chronic Progressive External
TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein.
Ophthalmoplegia, Chronic Progressive External
Twinkle helicase (PEO1) gene mutation causes mitochondrial DNA depletion.
Ophthalmoplegia, Chronic Progressive External
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number.
Ophthalmoplegia, Chronic Progressive External
Twinkle mutation in an Italian family with external progressive ophthalmoplegia and parkinsonism: A case report and an update on the state of art.
Ophthalmoplegia, Chronic Progressive External
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.
Ophthalmoplegia, Chronic Progressive External
Twinkle mutations in two Chinese families with autosomal dominant progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Twinkle, the mitochondrial replicative DNA helicase, is widespread in the eukaryotic radiation and may also be the mitochondrial DNA primase in most eukaryotes.
Ophthalmoplegia, Chronic Progressive External
[Mitochondrial dysfunction in bipolar disorder]
Osteoarthritis
Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1.
Osteoporosis
Bach1 Inhibition Suppresses Osteoclastogenesis via Reduction of the Signaling via Reactive Oxygen Species by Reinforced Antioxidation.
Osteoporosis
Downregulation of Bach1 protects osteoblasts against hydrogen peroxide-induced oxidative damage in vitro by enhancing the activation of Nrf2/ARE signaling.
Osteoporosis
RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice.
Osteosarcoma
Circ_0081001 down-regulates miR-494-3p to enhance BACH1 expression and promotes osteosarcoma progression.
Osteosarcoma
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
Osteosarcoma
The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.
Ovarian Neoplasms
Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.
Ovarian Neoplasms
BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition.
Ovarian Neoplasms
Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism.
Ovarian Neoplasms
Chl1 DNA Helicase Regulates Scc2 Deposition Specifically during DNA-Replication in Saccharomyces cerevisiae.
Ovarian Neoplasms
Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1.
Ovarian Neoplasms
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Ovarian Neoplasms
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.
Ovarian Neoplasms
FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks.
Ovarian Neoplasms
Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics.
Ovarian Neoplasms
HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks.
Ovarian Neoplasms
Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations.
Ovarian Neoplasms
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia.
Ovarian Neoplasms
No evidence of involvement of germline BACH1 mutations in Finnish breast and ovarian cancer families.
Ovarian Neoplasms
Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress.
Ovarian Neoplasms
RECQL1 DNA Repair Helicase: A Potential Therapeutic Target and a Proliferative Marker against Ovarian Cancer.
Ovarian Neoplasms
Structure-function analysis of DNA helicase HELQ: A new diagnostic marker in ovarian cancer.
Ovarian Neoplasms
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.
Pancreatic Neoplasms
BACH1 Promotes Pancreatic Cancer Metastasis by Repressing Epithelial Genes and Enhancing Epithelial-Mesenchymal Transition.
Parkinson Disease
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.
Parkinson Disease
Twinkle-associated familial parkinsonism with Lewy pathology: Cause or predisposition?
Parkinsonian Disorders
Autosomal dominant mutations in POLG and C10orf2: association with late onset chronic progressive external ophthalmoplegia and Parkinsonism in two patients.
Parkinsonian Disorders
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.
Parkinsonian Disorders
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Parkinsonian Disorders
Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression.
Parkinsonian Disorders
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Parkinsonian Disorders
Neurodegenerative parkinsonism and progressive external ophthalmoplegia with a Twinkle mutation.
Parkinsonian Disorders
Tau Pathology Associated With Parkinsonism and Mutation of Mitochondrial DNA Helicase Gene TWNK.
Parkinsonian Disorders
Twinkle mutation in an Italian family with external progressive ophthalmoplegia and parkinsonism: A case report and an update on the state of art.
Parkinsonian Disorders
Twinkle-associated familial parkinsonism with Lewy pathology: Cause or predisposition?
Periodontitis
Bach1 Inhibition Suppresses Osteoclastogenesis via Reduction of the Signaling via Reactive Oxygen Species by Reinforced Antioxidation.
Peripheral Arterial Disease
Bach1 plays an important role in angiogenesis through regulation of oxidative stress.
Peripheral Nervous System Diseases
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Polyneuropathies
Recessive C10orf2 mutations in a family with infantile-onset spinocerebellar ataxia, sensorimotor polyneuropathy, and myopathy.
Progeria
Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells.
Progeria
p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes.
Prostatic Neoplasms
Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk.
Prostatic Neoplasms
Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression.
Protein Deficiency
Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins.
Pulmonary Disease, Chronic Obstructive
Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population.
Pulmonary Disease, Chronic Obstructive
Expression of nuclear factor erythroid-2-related factor 2, broad complex-tramtrack-bric a brac and Cap'n'collar homology 1 and ?-glutamic acid cysteine synthase in peripheral blood of patients with chronic obstructive pulmonary disease and its clinical significance.
Pulmonary Disease, Chronic Obstructive
miR-330 Regulates Colorectal Cancer Oncogenesis by Targeting BACH1.
Pulmonary Disease, Chronic Obstructive
Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.
Pulmonary Fibrosis
Bach1 siRNA attenuates bleomycin-induced pulmonary fibrosis by modulating oxidative stress in mice.
Pulmonary Fibrosis
BTB and CNC homology 1 inhibition ameliorates fibrosis and inflammation via blocking ERK pathway in pulmonary fibrosis.
Pulmonary Fibrosis
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.
Pulmonary Fibrosis
Heterozygous RTEL1 mutations are associated with familial pulmonary fibrosis.
Pulmonary Fibrosis
Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium.
Pulmonary Fibrosis
Regulator of telomere length 1 (RTEL1) mutations are associated with heterogeneous pulmonary and extra-pulmonary phenotypes.
Reperfusion Injury
MiR-27a-5p regulates apoptosis of liver ischemia-reperfusion injury in mice by targeting Bach1.
Reperfusion Injury
Regulation of heme oxygenase-1 by transcription factor Bach1 in the mouse brain.
Respiratory Insufficiency
TWINKLE gene mutation: report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review.
Rheumatic Diseases
Clinical and serological associations of autoantibodies to the Ku70/Ku80 heterodimer determined by a novel chemiluminescent immunoassay.
Rothmund-Thomson Syndrome
Drosophila melanogaster RECQ5/QE DNA helicase: stimulation by GTP binding.
Rothmund-Thomson Syndrome
Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma.
Rothmund-Thomson Syndrome
Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase.
Rothmund-Thomson Syndrome
Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity.
Rothmund-Thomson Syndrome
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
Scleroderma, Systemic
Altered MCM Protein Levels and Autophagic Flux in Aged and Systemic Sclerosis Dermal Fibroblasts.
Scleroderma, Systemic
Significant elevation of IgG anti-WRN (RecQ3 RNA/DNA helicase) antibody in systemic sclerosis.
Sick Sinus Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Skin Diseases
Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1.
Skin Neoplasms
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.
Skin Neoplasms
G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.
Spinal Cord Injuries
Genetic Ablation of Transcription Repressor Bach1 Reduces Neural Tissue Damage and Improves Locomotor Function after Spinal Cord Injury in Mice.
Spinocerebellar Ataxias
Abnormal Glycosylation Profile and High Alpha-Fetoprotein in a Patient with Twinkle Variants.
Spinocerebellar Ataxias
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Spinocerebellar Ataxias
Identification of a novel twinkle mutation in a family with infantile onset spinocerebellar ataxia by whole exome sequencing.
Spinocerebellar Ataxias
Infantile onset spinocerebellar ataxia caused by compound heterozygosity for Twinkle mutations and modeling of Twinkle mutations causing recessive disease.
Spinocerebellar Ataxias
Infantile onset spinocerebellar ataxia is caused by recessive mutations in mitochondrial proteins Twinkle and Twinky.
Spinocerebellar Ataxias
Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.
Spinocerebellar Ataxias
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Spinocerebellar Ataxias
Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.
Spinocerebellar Ataxias
Novel Autosomal Recessive c10orf2 Mutations Causing Infantile-Onset Spinocerebellar Ataxia.
Spinocerebellar Ataxias
Recessive C10orf2 mutations in a family with infantile-onset spinocerebellar ataxia, sensorimotor polyneuropathy, and myopathy.
Spinocerebellar Ataxias
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Spinocerebellar Ataxias
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.
Squamous Cell Carcinoma of Head and Neck
Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma.
Starvation
Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts.
Stomach Neoplasms
Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells.
Stomach Neoplasms
Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma.
Stomach Neoplasms
The long non-coding RNA DDX11-AS1 facilitates cell progression and oxaliplatin resistance via regulating miR-326/IRS1 axis in gastric cancer.
Tetralogy of Fallot
The expanding phenotypes of cohesinopathies: one ring to rule them all!
thymidine kinase deficiency
Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances.
Thymoma
BTB and CNC homology 1 inhibition ameliorates fibrosis and inflammation via blocking ERK pathway in pulmonary fibrosis.
Trichothiodystrophy Syndromes
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy.
Trichothiodystrophy Syndromes
DNA helicases associated with genetic instability, cancer, and aging.
Trichothiodystrophy Syndromes
Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy.
Trichothiodystrophy Syndromes
Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH.
Trichothiodystrophy Syndromes
Mutations in XPD helicase prevent its interaction and regulation by p44, another subunit of TFIIH, resulting in Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) phenotypes.
Trichothiodystrophy Syndromes
Premature aging in mice deficient in DNA repair and transcription.
Trichothiodystrophy Syndromes
Structure, function and evolution of the XPD family of iron-sulfur-containing 5'-->3' DNA helicases.
Trichothiodystrophy Syndromes
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.
Trichothiodystrophy Syndromes
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Triple Negative Breast Neoplasms
MALAT1 and BACH1 are prognostic biomarkers for triple-negative breast cancer.
Tuberculosis
Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB.
Tuberculosis
Characterization of physical interaction between replication initiator protein DnaA and replicative helicase from Mycobacterium tuberculosis H37Rv.
Tuberculosis
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.
Tuberculosis
Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase.
Tuberculosis
Mycobacterium tuberculosis UvrB is a robust DNA-stimulated ATPase that also possesses structure-specific ATP-dependent DNA helicase activity.
Uterine Cervical Neoplasms
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer.
Uterine Cervical Neoplasms
First evidence for the contribution of the genetic variations of BRCA1-interacting protein 1 (BRIP1) to the genetic susceptibility of cervical cancer.
Uterine Cervical Neoplasms
PIF1 Affects the Proliferation and Apoptosis of Cervical Cancer Cells by Influencing TERT.
Vaccinia
Stimulation of vaccinia virion DNA helicase I8R, but not A18R, by a vaccinia core protein L4R, an ssDNA binding protein.
Vaccinia
The vaccinia virus A18R DNA helicase is a postreplicative negative transcription elongation factor.
Vaccinia
Vaccinia virion protein I8R has both DNA and RNA helicase activities: implications for vaccinia virus transcription.
Vascular Diseases
Bach1 Induces Endothelial Cell Apoptosis and Cell-Cycle Arrest through ROS Generation.
Virus Diseases
The origin-binding domain of the herpes simplex virus type 1 UL9 protein is not required for DNA helicase activity.
Werner Syndrome
A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (review).
Werner Syndrome
A case of Werner syndrome without metabolic abnormality: implications for the early pathophysiology.
Werner Syndrome
A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in Arabidopsis.
Werner Syndrome
Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair.
Werner Syndrome
Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein.
Werner Syndrome
Biochemical characterization of an exonuclease from Arabidopsis thaliana reveals similarities to the DNA exonuclease of the human Werner syndrome protein.
Werner Syndrome
C. elegans orthologs MUT-7/CeWRN-1 of Werner syndrome protein regulate neuronal plasticity.
Werner Syndrome
Characterization of the nuclear localization signal in the DNA helicase involved in Werner's syndrome.
Werner Syndrome
Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A.
Werner Syndrome
Cognitive deficit in hippocampal-dependent tasks in Werner syndrome mouse model.
Werner Syndrome
Crosstalk among DNA Damage, Mitochondrial Dysfunction, Impaired Mitophagy, Stem Cell Attrition, and Senescence in the Accelerated Ageing Disorder Werner Syndrome.
Werner Syndrome
Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization.
Werner Syndrome
DNA damage-induced translocation of the Werner helicase is regulated by acetylation.
Werner Syndrome
DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.
Werner Syndrome
Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.
Werner Syndrome
Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients.
Werner Syndrome
Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1.
Werner Syndrome
Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n.
Werner Syndrome
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.
Werner Syndrome
Interruption of the fragile X syndrome expanded sequence d(CGG)(n) by interspersed d(AGG) trinucleotides diminishes the formation and stability of d(CGG)(n) tetrahelical structures.
Werner Syndrome
Investigation of the core binding regions of human Werner syndrome and Fanconi anemia group J helicases on replication protein A.
Werner Syndrome
Loss of Bloom syndrome protein destabilizes human gene cluster architecture.
Werner Syndrome
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
Werner Syndrome
Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase ?-double knockdown cells.
Werner Syndrome
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.
Werner Syndrome
Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome.
Werner Syndrome
Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
Werner Syndrome
p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes.
Werner Syndrome
Requirement of yeast SGS1 and SRS2 genes for replication and transcription.
Werner Syndrome
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
Werner Syndrome
Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein.
Werner Syndrome
Significant elevation of IgG anti-WRN (RecQ3 RNA/DNA helicase) antibody in systemic sclerosis.
Werner Syndrome
Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases.
Werner Syndrome
Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A.
Werner Syndrome
The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.
Werner Syndrome
The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro.
Werner Syndrome
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.
Werner Syndrome
Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein.
Werner Syndrome
Werner syndrome (WRN) DNA helicase and base excision repair (BER) factors maintain endothelial homeostasis.
Werner Syndrome
Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome.
Werner Syndrome
Werner syndrome protein prevents DNA breaks upon chromatin structure alteration.
Werner Syndrome
Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.
Werner Syndrome
Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease.
Werner Syndrome
What can we learn from Werner syndrome? A biased view from a rheumatologist.
Xeroderma Pigmentosum
A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome.
Xeroderma Pigmentosum
Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila.
Xeroderma Pigmentosum
Cloning of a cDNA from Arabidopsis thaliana homologous to the human XPB gene.
Xeroderma Pigmentosum
Conformational effects of a common codon 751 polymorphism on the C-terminal domain of the xeroderma pigmentosum D protein.
Xeroderma Pigmentosum
Differential developmental expression of the rep B and rep D xeroderma pigmentosum related DNA helicase genes from Dictyostelium discoideum.
Xeroderma Pigmentosum
Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality.
Xeroderma Pigmentosum
DNA helicases associated with genetic instability, cancer, and aging.
Xeroderma Pigmentosum
Effect of polymorphisms in XPD on clinical outcomes of platinum-based chemotherapy for Chinese non-small cell lung cancer patients.
Xeroderma Pigmentosum
Evidence for sub-functionalization of tandemly duplicated XPB nucleotide excision repair genes in Arabidopsis thaliana.
Xeroderma Pigmentosum
Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy.
Xeroderma Pigmentosum
Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population.
Xeroderma Pigmentosum
Human JC virus small tumour antigen inhibits nucleotide excision repair and sensitises cells to DNA-damaging agents.
Xeroderma Pigmentosum
Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function.
Xeroderma Pigmentosum
Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy.
Xeroderma Pigmentosum
Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH.
Xeroderma Pigmentosum
Mutations in XPD helicase prevent its interaction and regulation by p44, another subunit of TFIIH, resulting in Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) phenotypes.
Xeroderma Pigmentosum
Nucleotide excision repair is a potential therapeutic target in multiple myeloma.
Xeroderma Pigmentosum
Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome.
Xeroderma Pigmentosum
Structure, function and evolution of the XPD family of iron-sulfur-containing 5'-->3' DNA helicases.
Xeroderma Pigmentosum
Telomere attrition and genomic instability in xeroderma pigmentosum type-B deficient fibroblasts under oxidative stress.
Xeroderma Pigmentosum
The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.
Xeroderma Pigmentosum
The DNA helicases acting in nucleotide excision repair, XPD, CSB and XPB, are not required for PCNA-dependent repair of abasic sites.
Xeroderma Pigmentosum
The xeroderma pigmentosum group B protein ERCC3 produced in the baculovirus system exhibits DNA helicase activity.
Xeroderma Pigmentosum
Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene.
Xeroderma Pigmentosum
Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1.
Xeroderma Pigmentosum
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
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