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1,4-dihydronicotinamide adenine dinucleotide + H2O
1,4-dihydronicotinamide mononucleotide + 5'-AMP
2',3''-cGAMP + H2O
?
-
-
-
?
2',3'-cAMP + H2O
adenosine monophosphate
2'-5'-ApU + H2O
adenosine + uridine 5'-phosphate
-
-
-
?
2'-5'-oligoadenylate + H2O
?
-
-
-
-
?
2-nitrophenyl phosphate + H2O
2-nitrophenol + phosphate
-
-
-
-
?
3 diadenosine 5',5''-P1,P4-tetraphosphate + 3 H2O
2 ATP + 2 ADP + 2 AMP
-
-
-
?
3',5'-cAMP + H2O
adenosine monophosphate
-
traces of activity
-
?
3'-5'-ApA + H2O
adenosine + adenosine 5'-phosphate
-
-
-
?
3'-5'-ApC + H2O
adenosine + cytidine 5'-phosphate
-
-
-
?
3'-5'-ApU + H2O
adenosine + uridine 5'-phosphate
-
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
3'-phosphoadenosine + phosphosulfate
3'-phosphoadenosine-5'-phosphosulfate + H2O
?
-
-
-
?
3-acetylpyridine adenine dinucleotide + H2O
3-acetylpyridine riboside 5'-phosphate + 5'-AMP
3-aminopyridine 1,N6-ethenoadenine dinucleotide + H2O
3-aminopyridine riboside + N6-etheneadenosine 5'-phosphate
-
-
-
?
3-aminopyridine adenine dinucleotide + H2O
3-aminopyridine riboside 5'-phosphate + 5'-AMP
3-methylpyridine adenine dinucleotide + H2O
3-methylpyridine mononucleotide + 5'-AMP
-
-
-
?
3-pyridylcarbinol adenine dinucleotide + H2O
?
-
-
-
?
4-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
4-nitrophenyl phenyl phosphate + H2O
4-nitrophenol + phenyl phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
4-nitrophenyl phosphate dianion + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate monoanion + H2O
4-nitrophenol + phosphate
-
72fold higher activity than with 4-nitrophenyl phosphate dianion
-
-
?
4-nitrophenyl-5'-adenosine monophosphate + H2O
4-nitrophenol + 5'-adenosine monophosphate
artificial substrate
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
4-nitrophenyl-TMP + H2O
4-nitrophenol + TMP
-
-
-
-
?
5',5'-diadenosine tetraphosphate + H2O
ATP + 5'-AMP
-
-
-
-
?
5',5'-diadenosine triphosphate + H2O
ADP + 5'-AMP
-
-
-
-
?
5'-adenylylimidodiphosphate + H2O
?
5'-AMP + H2O
adenosine + phosphate
5'-deoxy-5'-thioadenosine 5'-triphosphate + H2O
5'-deoxy-5'-thioadenosine 3'-monophosphate + phosphate
-
-
-
?
7-methyl 5'-guanosine 2'-O-methylguanosine triphosphate + H2O
7-methyl 5'-guanosine 2'-O-methylguanosine diphosphate + phosphate
-
-
-
-
?
7-methyl 5'-guanosine 2'-O-methylgunaosine triphosphate + H2O
7-methyl-GMP + 7-methyl-GDP + GMP + GDP
-
-
-
?
8-bromo-NAD+ + H2O
8-bromo-AMP + NMN
-
same hydrolysis rate as for NAD+
-
?
adenosine (alpha,beta-methylene) 5'-triphosphate + H2O
adenosine (alpha,beta-methylene) 5'-diphosphate + phosphate
-
-
-
?
adenosine 3'-(alpha-naphthylphosphate)
adenosine + alpha-naphthylphosphate
-
very low activity
-
?
adenosine 5'-O-(2-thiotriphosphate) + H2O
AMP + ?
adenosine 5'-O-(3-thiotriphosphate) + H2O
AMP + ?
-
-
-
?
adenosine 5'-phosphosulfate + H2O
?
adenosine 5'-phosphosulfate + H2O
adenosine + phosphosulfate
-
-
-
?
ADP + H2O
AMP + phosphate
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
ADP-glucose + H2O
AMP + alpha-D-glucose-1-phosphate
ADP-ribose + H2O
AMP + alpha-D-ribose 1-phosphate
99% of the activity with ADP-glucose
-
-
?
ADP-ribose + H2O
AMP + phosphoribose
alpha-NADH + H2O
alpha-NMNH + AMP
-
low activity
-
?
alpha-naphthylphosphate + H2O
alpha-naphthol + phosphate
-
low activity
-
?
AMP + H2O
adenosine + phosphate
-
-
-
?
ATP + 2 H2O
AMP + 2 phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
ATP + H2O
AMP + diphosphate
ATP + H2O
diphosphate + AMP
-
best substrate
-
-
?
beta,gamma-methyleneadenosine 5'-triphosphate + H2O
adenosine 5'-monophosphate + phosphomethylposphoric acid
beta-naphthylphenylphosphonate + H2O
?
-
very low activity
-
?
bis(4-nitrophenyl) phosphate + H2O
4-nitrophenylphosphate + 4-nitrophenol
-
-
-
-
?
bis(4-nitrophenyl) phosphate + H2O
?
-
-
-
?
bis(4-nitrophenyl)phosphate + H2O
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
bis-4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
2000fold higher activity than with 4-nitrophenyl phosphate dianion
-
-
?
bis-alpha-naphthylphosphate + H2O
?
-
very low activity
-
?
bis-p-nitrophenyl phosphate + H2O
p-nitrophenol + p-nitrophenyl phosphate
-
-
-
-
?
CDP + H2O
?
56% of the activity with UDP
-
-
?
CDP + H2O
CMP + phosphate
CDP-choline + H2O
CMP + phosphorylcholine
-
-
-
?
CDP-glucose + H2O
CMP + alpha-D-glucose 1-phosphate
77% of the activity with ADP-glucose
-
-
?
CDP-glucose + H2O
CMP + D-glucose-1-phosphate
coenzyme A + H2O
?
-
low activity
-
?
CTP + H2O
?
-
low activity
-
?
CTP + H2O
CDP + phosphate
CTP + H2O
CMP + diphosphate
dATP + H2O
dADP + phosphate
-
-
-
-
?
dATP + H2O
dAMP + diphosphate
-
-
-
?
dCDP + H2O
dCMP + phosphate
-
-
-
-
?
dCTP + H2O
dCDP + phosphate
-
-
-
-
?
dCTP + H2O
dCMP + diphosphate
dGDP + H2O
dGMP + phosphate
-
-
-
-
?
dGTP + H2O
dGDP + phosphate
-
-
-
-
?
dGTP + H2O
dGMP + diphosphate
dGTP is the best substrate among the deoxyribonucleoside triphosphates
-
-
?
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano + 2 H2O
?
low hydrolysis activity with the inhibitor as substrate
-
-
?
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-gamma,delta-methylene-tetraphosphate + 2 H2O
?
low hydrolysis activity with the inhibitor as substrate
-
-
?
diadenosine 5',5''-P1, P2-diphosphate + H2O
AMP + AMP
diadenosine 5',5''-P1,P3-triphosphate + H2O
5'-ADP + 5'-AMP
diadenosine 5',5''-P1,P3-triphosphate + H2O
AMP + ADP
-
-
-
?
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
ATP + 5'-AMP
diadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano + 2 H2O
?
low hydrolysis activity with the inhibitor as substrate
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
p4A + 5'-AMP
diadenosine 5',5''-P1,P5-pentaposphate + H2O
ATP + ADP + AMP + adenosine 5'-tetraphosphate
-
-
-
?
diadenosine 5'-diphosphate + H2O
adenosine 5'-monophosphate + ?
diadenosine polyphosphate + H2O
AMP + ?
-
from di- to pentaphosphates, hydrolysis rate decreases with chain length
-
?
diguanosine 5',5'''-P1,P4-tetraphosphate + H2O
GTP + 5'-GMP
diphosphate + H2O
2 phosphate
-
significant activity
-
?
diphosphate + H2O
phosphate
-
-
-
-
?
diphospho-3-acetylpyridine nucleotide + H2O
?
-
reduced form, 2fold higher activity than for NAD+
-
?
diphospho-deaminopyridine nucleotide + H2O
?
-
-
-
?
dITP + H2O
dIMP + diphosphate
at the optimal pH of 10.0, the recombinant enzyme hydrolyzes ITP, dITP, and xanthosine 5'-triphosphate to their respective monophosphates whereas activity with other nucleoside triphosphates is low. UTP, (d)CTP, TTP, and (d)ATP are hydrolyzed 10-100fold less than dITP. IDP and IMP are not hydrolyzed at all
-
-
?
DNA + H2O
adenosine 5'-monophosphate + ?
-
E. coli, low activity
-
?
dTTP + H2O
dTMP + diphosphate
dUTP + H2O
dUMP + diphosphate
weakest substrate
-
-
?
formycin 5'-triphosphate + H2O
?
-
-
-
?
GDP + H2O
?
38% of the activity with UDP
-
-
?
GDP + H2O
GMP + phosphate
GDP-glucose + H2O
GMP + D-glucose-1-phosphate
GDP-mannose + H2O
GMP + alpha-D-mannose 1-phosphate
76% of the activity with ADP-glucose
-
-
?
GDP-mannose + H2O
GMP + D-mannose-1-phosphate
GTP + H2O
GDP + phosphate
GTP + H2O
GMP + diphosphate
guanosine (alpha,beta-methylene) 5'-triphosphate + H2O
guanosine (alpha,beta-methylene) 5'-diphosphate + phosphate
-
-
-
?
IDP + H2O
?
48% of the activity with UDP
-
-
?
IDP + H2O
IMP + phosphate
ITP + H2O
IDP + phosphate
-
-
-
-
?
ITP + H2O
IMP + diphosphate
at the optimal pH of 10.0, the recombinant enzyme hydrolyzes ITP, dITP, and xanthosine 5'-triphosphate to their respective monophosphates whereas activity with other nucleoside triphosphates is low. UTP, (d)CTP, TTP, and (d)ATP are hydrolyzed 10-100fold less than dITP. IDP and IMP are not hydrolyzed at all
-
-
?
methyl 4-nitrophenyl phosphate + H2O
4-nitrophenol + methyl phosphate
-
200fold higher activity than with 4-nitrophenyl phosphate dianion
-
-
?
methyl 4-nitrophenyl phosphate diester + H2O
?
-
-
-
-
?
mRNA + H2O
7-methyl-GMP + ?
NADP+ + H2O
nicotinamide nucleotide + adenosine 2',5'-bisphosphate
NADP+ + H2O
NMN + adenosine 2',5'-bisphosphate
-
-
-
-
?
NADP+ + H2O
NMN + adenosine 2',5'-phosphate
NADPH + H2O
NMNH + adenosine 2',5'-bisphosphate
-
-
-
-
?
NADPH + H2O
NMNH + adenosine 2',5'-phosphate
nicotinamide 1,N6-ethenoadenine dinucleotide + H2O
NMN + N6-ethenoadenosine 5'-phosphate
nicotinamide guanine dinucleotide + H2O
NMN + GMP
nicotinamide hypoxanthine dinucleotide + H2O
NMN + hypoxanthine monophosphate
nicotinic acid adenine dinucleotide + H2O
nicotinic acid mononucleotide + 5'-AMP
p-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + TMP
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + phenylphosphonate
p-nitrophenyl thymidine 5'-monophosphate + H2O
?
-
-
-
?
p-nitrophenyl-dTMP + H2O
p-nitrophenol + dTMP
p-nitrophenylphosphate + H2O
p-nitrophenol + phosphate
P1,P2-di(adenosine-5') diphosphate + H2O
?
-
tetramer 3fold more active than dimer
-
?
P1,P2-di(thymidine-3') diphosphate + H2O
?
-
very low activity for both dimer and tetramer
-
?
P1,P2-di(thymidine-5') diphosphate + H2O
?
-
low activity for both dimer and tetramer
-
?
P1,P3-di(adenosine-5') triphosphate + H2O
?
-
tetramer 2fold more active than dimer
-
?
P1,P4-bis(5'-adenosyl)-alpha,beta-gamma,delta-bismethylene-tetraphosphate + 2 H2O
?
low hydrolysis activity with the inhibitor as substrate
-
-
?
P1,P5-bis(5'-adenosyl)pentaphosphate + 2 H2O
?
-
-
-
?
P1-5'-(7-methyl)-guanosine-P3-5'-guanosine triphosphate + H2O
7-methylguanosine 5'-diphosphate + GMP
-
cap analogue
-
?
poly (ADP-ribose) + H2O
phosphoribosyladenosine 5'-phosphate + ?
-
-
-
?
polyadenylate + H2O
adenosine 5'-monophosphate + ?
-
low activity
-
?
polynucleotide + H2O
nucleoside 5'-phosphate + ?
-
hardly degraded
-
?
pyridine adenine dinucleotide + H2O
pyridine riboside 5'-phosphate + 5'-AMP
RNA + H2O
adenosine 5'-monophosphate + ?
-
yeast, low activity
-
?
TDP-glucose + H2O
tMP + alpha-D-glucose 1-phosphate
TDP-glucose + H2O
TMP + D-glucose-1-phosphate
thiamine diphosphate + H2O
?
-
-
-
?
thiamine diphosphate + H2O
thiamine + diphosphate
-
-
-
?
thionicotinamide adenine dinucleotide + H2O
thionicotinamide mononucleotide + 5'-AMP
-
-
-
?
thymidine + alpha-naphthylphosphate + H2O
thymidine 3'-alpha-naphthol + phosphate
-
very low activity
-
?
thymidine 3'-alpha-naphthylphosphate + H2O
thymidine 3'-alpha-naphthol + phosphate
-
-
-
-
?
thymidine 3'-diphospho 3'-thymidine + H2O
thymidine 3'-phosphate + thymidine 3'-phosphate
thymidine 3'-monophosphate p-nitrophenyl ester + H2O
thymidine 3'-monophosphate + p-nitrophenol
thymidine 5'-6-bromo-2-hydroxy-3-naphthoic acid 2-methoxyanilide-naphthylphosphate + H2O
?
-
low activity
-
?
thymidine 5'-alpha-naphthylphosphate + H2O
thymidine + alpha-naphthylphosphate
thymidine 5'-diphospho 5'-thymidine + H2O
thymidine 5'-phosphate + thymidine 5'-phosphate
-
low activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
thymidine-5'-L-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
-
?
TTP + H2O
TDP + phosphate
TTP + H2O
TMP + diphosphate
the enzyme exhibits significant activity for TTP only when substrate concentration reaches 0.5 mM
-
-
?
UDP + H2O
UMP + phosphate
UDP-alpha-D-galactose + H2O
UMP + alpha-D-galactose-1-phosphate
UDP-glucose + H2O
UMP + alpha-D-glucose 1-phosphate
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
UDP-glucuronic acid + H2O
UMP + glucuronic acid phosphate
UDP-MurNAc-peptide + H2O
UMP + ?
UDP-N-acetyl-alpha-D-galactosamine + H2O
N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
UMP + H2O
uridine + phosphate
-
very low activity
-
?
uridine 3'-(alpha-naphthylphosphate) + H2O
uridine + alpha-naphthylphosphate
-
very low activity
-
?
uridine 3'-(phenylphosphate) + H2O
uridine + phenylphosphate
-
very low activity
-
?
uridine diphosphoglucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
UTP + H2O
diphosphate + UMP
-
-
-
-
?
UTP + H2O
UDP + phosphate
-
highest rate of hydrolysis
-
-
?
UTP + H2O
UMP + diphosphate
xanthosine 5'-triphosphate + H2O
xanthosine 5'-monophosphate + diphosphate
at the optimal pH of 10.0, the recombinant enzyme hydrolyzes ITP, dITP, and xanthosine 5'-triphosphate to their respective monophosphates whereas activity with other nucleoside triphosphates is low. UTP, (d)CTP, TTP, and (d)ATP are hydrolyzed 10-100fold less than dITP. IDP and IMP are not hydrolyzed at all
-
-
?
additional information
?
-
1,4-dihydronicotinamide adenine dinucleotide + H2O
1,4-dihydronicotinamide mononucleotide + 5'-AMP
-
-
-
?
1,4-dihydronicotinamide adenine dinucleotide + H2O
1,4-dihydronicotinamide mononucleotide + 5'-AMP
-
-
-
?
2',3'-cAMP + H2O
adenosine monophosphate
-
low activity
-
?
2',3'-cAMP + H2O
adenosine monophosphate
-
low activity for the tetramer
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
3'-phosphoadenosine + phosphosulfate
-
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
3'-phosphoadenosine + phosphosulfate
-
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
3'-phosphoadenosine + phosphosulfate
-
-
-
?
3-acetylpyridine adenine dinucleotide + H2O
3-acetylpyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
3-acetylpyridine adenine dinucleotide + H2O
3-acetylpyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
3-aminopyridine adenine dinucleotide + H2O
3-aminopyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
3-aminopyridine adenine dinucleotide + H2O
3-aminopyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
3-aminopyridine adenine dinucleotide + H2O
3-aminopyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
4-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
-
-
-
?
4-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
-
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
-
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
artificial substrate
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
artificial substrate
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
artificial substrate
-
-
?
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
hydrolysis of pnp-TMP at the cell surface of both osteocarcinoma and colon cancer cells
-
-
?
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
a specific NPP substrate
-
-
?
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
-
-
-
-
?
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
-
-
-
-
?
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
-
-
-
?
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
-
-
-
-
?
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
-
-
-
?
5'-adenylylimidodiphosphate + H2O
?
-
-
-
?
5'-adenylylimidodiphosphate + H2O
?
-
-
-
?
5'-AMP + H2O
adenosine + phosphate
-
-
-
-
?
5'-AMP + H2O
adenosine + phosphate
-
traces of activity
-
?
adenosine 5'-O-(2-thiotriphosphate) + H2O
AMP + ?
-
-
-
?
adenosine 5'-O-(2-thiotriphosphate) + H2O
AMP + ?
-
-
-
?
adenosine 5'-phosphosulfate + H2O
?
31% of the activity with ADP
-
-
?
adenosine 5'-phosphosulfate + H2O
?
44% of the activity with ADP-glucose
-
-
?
adenosine 5'-phosphosulfate + H2O
?
81% of the activity with UDP
-
-
?
ADP + H2O
?
best substrate
-
-
?
ADP + H2O
?
40% of the activity with ADP-glucose
-
-
?
ADP + H2O
?
87% of the activity with UDP
-
-
?
ADP + H2O
AMP + phosphate
-
5fold lower activity compared to ATP
-
-
?
ADP + H2O
AMP + phosphate
-
-
-
?
ADP + H2O
AMP + phosphate
-
-
-
?
ADP + H2O
AMP + phosphate
-
low activity
-
?
ADP + H2O
AMP + phosphate
-
-
-
-
?
ADP + H2O
AMP + phosphate
-
low activity
-
?
ADP + H2O
AMP + phosphate
-
-
-
?
ADP + H2O
AMP + phosphate
-
low activity
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
-
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
best substrate
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
65% of the activity with ADP
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
-
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose-1-phosphate
-
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose-1-phosphate
-
-
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose-1-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + phosphoribose
-
-
-
?
ADP-ribose + H2O
AMP + phosphoribose
-
high activity
-
?
ADP-ribose + H2O
AMP + phosphoribose
-
-
-
?
ADP-ribose + H2O
AMP + phosphoribose
-
-
-
-
?
ADP-ribose + H2O
AMP + phosphoribose
-
low activity
-
?
ADP-ribose + H2O
AMP + phosphoribose
-
-
-
?
ADP-ribose + H2O
AMP + phosphoribose
best substrate
-
-
?
Ap3A + H2O
?
-
-
-
-
?
ATP + H2O
?
-
-
-
?
ATP + H2O
?
81% of the activity with ADP-glucose
-
-
?
ATP + H2O
ADP + phosphate
-
the specific activity of NPP for ATP is about 5fold higher than that of ADP
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
low activity
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
ADP formation as a result of adenylate kinase activity
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
little accumulation of ADP
?
ATP + H2O
AMP + diphosphate
-
accounts for 50-75% of extracellular hydrolysed ATP
-
?
ATP + H2O
AMP + diphosphate
-
extracellular ATP mainly hydrolysed by ecto-nucleotide pyrophosphatase, enzyme modulates purinoceptor-mediated signal transduction
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
-
?
ATP + H2O
AMP + diphosphate
-
-
initial product: AMP
?
ATP + H2O
AMP + diphosphate
-
-
-
?
beta,gamma-methyleneadenosine 5'-triphosphate + H2O
adenosine 5'-monophosphate + phosphomethylposphoric acid
-
-
-
?
beta,gamma-methyleneadenosine 5'-triphosphate + H2O
adenosine 5'-monophosphate + phosphomethylposphoric acid
-
-
-
?
bis(4-nitrophenyl)phosphate + H2O
?
-
-
-
?
bis(4-nitrophenyl)phosphate + H2O
?
32% of the activity with UDP
-
-
?
bis(4-nitrophenyl)phosphate + H2O
?
35% of the activity with UDP
-
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
-
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
0.31% hydrolysis rate compared to NADH as substrate
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
low activity
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
-
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
-
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
dimer nearly 4fold more active than tetramer
-
?
CDP + H2O
CMP + phosphate
-
-
-
-
?
CDP + H2O
CMP + phosphate
-
low activity
-
?
CDP-glucose + H2O
CMP + D-glucose-1-phosphate
-
-
-
?
CDP-glucose + H2O
CMP + D-glucose-1-phosphate
-
-
-
-
?
CDP-glucose + H2O
CMP + D-glucose-1-phosphate
-
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
?
CTP + H2O
CDP + phosphate
low activity
-
-
?
CTP + H2O
CMP + diphosphate
-
-
-
?
CTP + H2O
CMP + diphosphate
-
-
-
?
CTP + H2O
CMP + diphosphate
-
-
-
?
CTP + H2O
CMP + diphosphate
-
-
-
?
dCTP + H2O
dCMP + diphosphate
-
-
-
?
dCTP + H2O
dCMP + diphosphate
-
-
-
?
diadenosine 5',5''-P1, P2-diphosphate + H2O
AMP + AMP
-
-
-
?
diadenosine 5',5''-P1, P2-diphosphate + H2O
AMP + AMP
-
-
-
?
diadenosine 5',5''-P1,P3-triphosphate + H2O
5'-ADP + 5'-AMP
-
NPP1
-
-
?
diadenosine 5',5''-P1,P3-triphosphate + H2O
5'-ADP + 5'-AMP
-
NPP2
-
-
?
diadenosine 5',5''-P1,P3-triphosphate + H2O
5'-ADP + 5'-AMP
NPP3
-
-
?
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
ATP + 5'-AMP
-
NPP1
-
-
?
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
ATP + 5'-AMP
-
NPP2
-
-
?
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
ATP + 5'-AMP
NPP3
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
p4A + 5'-AMP
-
NPP1
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
p4A + 5'-AMP
-
NPP2
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
p4A + 5'-AMP
NPP3
-
-
?
diadenosine 5'-diphosphate + H2O
adenosine 5'-monophosphate + ?
-
-
-
?
diadenosine 5'-diphosphate + H2O
adenosine 5'-monophosphate + ?
-
-
-
-
?
diguanosine 5',5'''-P1,P4-tetraphosphate + H2O
GTP + 5'-GMP
-
NPP1
-
-
?
diguanosine 5',5'''-P1,P4-tetraphosphate + H2O
GTP + 5'-GMP
-
NPP2
-
-
?
diguanosine 5',5'''-P1,P4-tetraphosphate + H2O
GTP + 5'-GMP
NPP3
-
-
?
diphosphate + H2O
?
-
-
-
?
diphosphate + H2O
?
59% of the activity with ADP
-
-
?
dTTP + H2O
dTMP + diphosphate
the enzyme possesses dTTP-specific activity at a substrate concentration of 0.1 mM
-
-
?
dTTP + H2O
dTMP + diphosphate
-
-
-
?
FAD + H2O
FMN + AMP
-
-
-
?
FAD + H2O
FMN + AMP
-
-
-
-
?
FAD + H2O
FMN + AMP
-
-
-
?
FAD + H2O
FMN + AMP
-
-
-
?
FAD + H2O
FMN + AMP
-
-
-
?
FAD + H2O
FMN + AMP
-
low activity
-
?
FAD + H2O
FMN + AMP
-
-
-
?
FAD + H2O
FMN + AMP
-
-
-
?
FAD + H2O
FMN + AMP
-
-
-
?
FAD + H2O
FMN + AMP
-
-
-
?
FAD + H2O
FMN + AMP
-
-
-
?
GDP + H2O
GMP + phosphate
-
-
-
-
?
GDP + H2O
GMP + phosphate
-
low activity
-
?
GDP-glucose + H2O
GMP + D-glucose-1-phosphate
-
-
-
?
GDP-glucose + H2O
GMP + D-glucose-1-phosphate
-
-
-
?
GDP-mannose + H2O
GMP + D-mannose-1-phosphate
-
-
-
?
GDP-mannose + H2O
GMP + D-mannose-1-phosphate
-
-
-
?
GDP-mannose + H2O
GMP + D-mannose-1-phosphate
-
-
-
?
GDP-mannose + H2O
GMP + D-mannose-1-phosphate
-
-
-
?
GDP-mannose + H2O
GMP + D-mannose-1-phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
low activity
-
-
?
GTP + H2O
GMP + diphosphate
-
-
-
?
GTP + H2O
GMP + diphosphate
-
-
-
?
GTP + H2O
GMP + diphosphate
-
-
-
?
GTP + H2O
GMP + diphosphate
-
1.5fold more hydrolysis than for ATP
-
?
GTP + H2O
GMP + diphosphate
GTP is the best substrate among the ribonucleoside triphosphates
-
-
?
IDP + H2O
IMP + phosphate
-
-
-
-
?
IDP + H2O
IMP + phosphate
-
-
-
?
mRNA + H2O
7-methyl-GMP + ?
-
-
-
?
mRNA + H2O
7-methyl-GMP + ?
-
reovirus m7-G(5')p3(5')Gm-terminated intact mRNA
-
?
NAD+ + H2O
NMN + AMP
-
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
best natural substrate tested
-
?
NAD+ + H2O
NMN + AMP
-
tetramer 4fold more active than dimer
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NAD+ + H2O
NMN + AMP
-
-
-
?
NADH + H2O
NMNH + AMP
-
-
-
-
?
NADH + H2O
NMNH + AMP
-
reduced and oxidized forms, split by two different pyrophosphatase in the crude extract, oxidized form not split by the purified enzyme
-
?
NADH + H2O
NMNH + AMP
-
alpha-isomer, reduced activity for both reduced and oxidized forms
-
?
NADH + H2O
NMNH + AMP
-
-
-
?
NADH + H2O
NMNH + AMP
-
-
-
?
NADH + H2O
NMNH + AMP
-
best natural substrate, reduced form more rapidly hydrolysed than oxidized form
-
?
NADH + H2O
NMNH + AMP
-
-
-
?
NADH + H2O
NMNH + AMP
-
-
-
-
?
NADH + H2O
NMNH + AMP
-
-
-
?
NADH + H2O
NMNH + AMP
-
-
-
?
NADH + H2O
NMNH + AMP
-
-
-
?
NADH + H2O
NMNH + AMP
-
-
-
?
NADH + H2O
NMNH + AMP
-
reduced and oxidized forms
-
?
NADH + H2O
NMNH + AMP
-
-
-
?
NADP+ + H2O
nicotinamide nucleotide + adenosine 2',5'-bisphosphate
-
only reduced form hydrolysed
-
?
NADP+ + H2O
nicotinamide nucleotide + adenosine 2',5'-bisphosphate
-
-
-
?
NADP+ + H2O
nicotinamide nucleotide + adenosine 2',5'-bisphosphate
-
-
-
?
NADP+ + H2O
NMN + adenosine 2',5'-phosphate
-
-
-
?
NADP+ + H2O
NMN + adenosine 2',5'-phosphate
-
-
-
?
NADP+ + H2O
NMN + adenosine 2',5'-phosphate
-
-
-
?
NADP+ + H2O
NMN + adenosine 2',5'-phosphate
-
-
-
?
NADP+ + H2O
NMN + adenosine 2',5'-phosphate
-
-
-
?
NADPH + H2O
NMNH + adenosine 2',5'-phosphate
-
reduced form more rapidly hydrolysed than oxidized form
-
?
NADPH + H2O
NMNH + adenosine 2',5'-phosphate
-
-
-
?
NADPH + H2O
NMNH + adenosine 2',5'-phosphate
-
-
-
?
NADPH + H2O
NMNH + adenosine 2',5'-phosphate
high activity
-
-
?
nicotinamide 1,N6-ethenoadenine dinucleotide + H2O
NMN + N6-ethenoadenosine 5'-phosphate
-
-
-
?
nicotinamide 1,N6-ethenoadenine dinucleotide + H2O
NMN + N6-ethenoadenosine 5'-phosphate
-
-
-
?
nicotinamide 1,N6-ethenoadenine dinucleotide + H2O
NMN + N6-ethenoadenosine 5'-phosphate
-
-
-
?
nicotinamide guanine dinucleotide + H2O
NMN + GMP
-
-
-
?
nicotinamide guanine dinucleotide + H2O
NMN + GMP
-
-
-
?
nicotinamide hypoxanthine dinucleotide + H2O
NMN + hypoxanthine monophosphate
-
-
-
?
nicotinamide hypoxanthine dinucleotide + H2O
NMN + hypoxanthine monophosphate
-
-
-
?
nicotinic acid adenine dinucleotide + H2O
nicotinic acid mononucleotide + 5'-AMP
-
-
-
?
nicotinic acid adenine dinucleotide + H2O
nicotinic acid mononucleotide + 5'-AMP
-
-
-
?
p-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + TMP
-
-
-
-
?
p-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + TMP
-
1500000fold higher activity than with 4-nitrophenyl phosphate dianion
-
-
?
p-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + TMP
-
-
-
-
?
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + phenylphosphonate
-
phosphodiesterase-1 activity
-
?
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + phenylphosphonate
-
phosphodiesterase-1 activity
-
?
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + phenylphosphonate
-
low activity
-
?
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + phenylphosphonate
-
dimer 8fold more active than tetramer
-
?
p-nitrophenyl-dTMP + H2O
p-nitrophenol + dTMP
-
Ca2+-dependent
-
?
p-nitrophenyl-dTMP + H2O
p-nitrophenol + dTMP
-
-
-
?
p-nitrophenyl-dTMP + H2O
p-nitrophenol + dTMP
-
-
-
-
?
p-nitrophenyl-dTMP + H2O
p-nitrophenol + dTMP
-
-
-
?
p-nitrophenylphosphate + H2O
p-nitrophenol + phosphate
-
0.04% hydrolysis rate compared to NADH as substrate
-
?
p-nitrophenylphosphate + H2O
p-nitrophenol + phosphate
-
-
-
?
p-nitrophenylphosphate + H2O
p-nitrophenol + phosphate
-
-
-
?
pyridine adenine dinucleotide + H2O
pyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
pyridine adenine dinucleotide + H2O
pyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
TDP + H2O
?
27% of the activity with ADP
-
-
?
TDP + H2O
?
40% of the activity with UDP
-
-
?
TDP-glucose + H2O
tMP + alpha-D-glucose 1-phosphate
15% of the activity with ADP
-
-
?
TDP-glucose + H2O
tMP + alpha-D-glucose 1-phosphate
82% of the activity with ADP-glucose
-
-
?
TDP-glucose + H2O
TMP + D-glucose-1-phosphate
-
low activity
-
?
TDP-glucose + H2O
TMP + D-glucose-1-phosphate
-
-
-
?
thymidine 3'-diphospho 3'-thymidine + H2O
thymidine 3'-phosphate + thymidine 3'-phosphate
-
-
-
?
thymidine 3'-diphospho 3'-thymidine + H2O
thymidine 3'-phosphate + thymidine 3'-phosphate
-
very low activity
-
?
thymidine 3'-monophosphate p-nitrophenyl ester + H2O
thymidine 3'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 3'-monophosphate p-nitrophenyl ester + H2O
thymidine 3'-monophosphate + p-nitrophenol
-
low activity
-
?
thymidine 3'-monophosphate p-nitrophenyl ester + H2O
thymidine 3'-monophosphate + p-nitrophenol
-
dimer 10fold more active than tetramer
-
?
thymidine 5'-alpha-naphthylphosphate + H2O
thymidine + alpha-naphthylphosphate
-
very low activity
-
?
thymidine 5'-alpha-naphthylphosphate + H2O
thymidine + alpha-naphthylphosphate
-
very low activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
significant phosphodiesterase activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
faster cleavage than other substrates tested
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
significant phosphodiesterase activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
significant phosphodiesterase activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
very low activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
equal activity for dimer and tetramer
-
?
TTP + H2O
TDP + phosphate
-
-
-
-
?
TTP + H2O
TDP + phosphate
-
-
-
?
TTP + H2O
TDP + phosphate
low activity
-
-
?
UDP + H2O
?
best substrate
-
-
?
UDP + H2O
?
68% of the activity with ADP
-
-
?
UDP + H2O
UMP + phosphate
-
-
-
-
?
UDP + H2O
UMP + phosphate
-
-
-
?
UDP + H2O
UMP + phosphate
-
-
low activity
?
UDP-alpha-D-galactose + H2O
UMP + alpha-D-galactose-1-phosphate
-
-
-
?
UDP-alpha-D-galactose + H2O
UMP + alpha-D-galactose-1-phosphate
-
-
-
?
UDP-alpha-D-galactose + H2O
UMP + alpha-D-galactose-1-phosphate
-
-
-
?
UDP-alpha-D-galactose + H2O
UMP + alpha-D-galactose-1-phosphate
-
-
-
?
UDP-glucose + H2O
UMP + alpha-D-glucose 1-phosphate
25% of the activity with ADP
-
-
?
UDP-glucose + H2O
UMP + alpha-D-glucose 1-phosphate
77% of the activity with ADP-glucose
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
best substrate of nucleotide-sugars tested
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
UDP-glucuronic acid + H2O
UMP + glucuronic acid phosphate
-
-
-
?
UDP-glucuronic acid + H2O
UMP + glucuronic acid phosphate
-
-
-
?
UDP-MurNAc + H2O
UMP + ?
-
-
-
?
UDP-MurNAc + H2O
UMP + ?
-
-
-
?
UDP-MurNAc-peptide + H2O
UMP + ?
-
-
-
?
UDP-MurNAc-peptide + H2O
UMP + ?
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + H2O
N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + H2O
N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UTP + H2O
UMP + diphosphate
the enzyme exhibits significant activity for UTP only when substrate concentration reaches 0.5 mM
-
-
?
UTP + H2O
UMP + diphosphate
-
-
-
?
UTP + H2O
UMP + diphosphate
-
-
-
?
UTP + H2O
UMP + diphosphate
-
-
-
?
UTP + H2O
UMP + diphosphate
-
-
-
?
UTP + H2O
UMP + diphosphate
-
-
-
?
UTP + H2O
UMP + diphosphate
-
-
-
?
UTP + H2O
UMP + diphosphate
-
2fold higher hydrolysis rate than for ATP
-
?
UTP + H2O
UMP + diphosphate
-
2fold more hydrolysis than for ATP
-
?
UTP + H2O
UMP + diphosphate
-
-
-
?
UTP + H2O
UMP + diphosphate
-
-
-
?
additional information
?
-
-
the enzyme is not active upon AMP, GMP, dAMP, IMP, CMP, dGMP, dADP, TDP, TMP, UMP, dCMP, 3'-AMP, cAMP, and 4-nitrophenyl phosphate
-
-
?
additional information
?
-
-
the enzyme preferentially hydrolyzes nucleoside 5'-triphosphates over nucleoside 5'-diphosphates
-
-
?
additional information
?
-
-
nucleotide ester-forming alcoholytic activity
-
-
?
additional information
?
-
-
hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview
-
-
?
additional information
?
-
no activity with ATP, CTP, GTP, TDP, TMP, and dCTP
-
-
?
additional information
?
-
-
E-NPP3 is associated with carcinogenesis of human colon cancer
-
-
?
additional information
?
-
-
purine-activating enzyme
-
-
?
additional information
?
-
NPP1 hydrolyzes a wide range of phosphodiester bonds, e.g. in nucleoside triphosphates, (cyclic) dinucleotides, and nucleotide sugars yielding nucleoside 5'-monophosphates as products. Its main substrate is ATP which is cleaved to AMP and diphosphate. Purine nucleotides (ATP and GTP) are better substrates than pyrimidine nucleotides (CTP and UTP). Besides, NPP1 metabolizes other nucleotides, e.g. nicotinamide adenine dinucleotide (NAD+), 3'-phosphoadenosine-5'-phosphosulfate (PAPS), diadenosine polyphosphates like diadenosine triphosphate (AP3A) or diadenosine tetraphosphate (AP4A), and UDP-glucose
-
-
-
additional information
?
-
-
NPP1 hydrolyzes a wide range of phosphodiester bonds, e.g. in nucleoside triphosphates, (cyclic) dinucleotides, and nucleotide sugars yielding nucleoside 5'-monophosphates as products. Its main substrate is ATP which is cleaved to AMP and diphosphate. Purine nucleotides (ATP and GTP) are better substrates than pyrimidine nucleotides (CTP and UTP). Besides, NPP1 metabolizes other nucleotides, e.g. nicotinamide adenine dinucleotide (NAD+), 3'-phosphoadenosine-5'-phosphosulfate (PAPS), diadenosine polyphosphates like diadenosine triphosphate (AP3A) or diadenosine tetraphosphate (AP4A), and UDP-glucose
-
-
-
additional information
?
-
-
functional enzyme is required in carminerin-deficiency to suppress the resulting pathological endochondral ossifications
-
-
?
additional information
?
-
-
the enzyme does not hydrolyze pyridoxal 5'-phosphate
-
-
?
additional information
?
-
NPP1 hydrolyzes a wide range of phosphodiester bonds, e.g. in nucleoside triphosphates, (cyclic) dinucleotides, and nucleotide sugars yielding nucleoside 5'-monophosphates as products. Its main substrate is ATP which is cleaved to AMP and diphosphate. Purine nucleotides (ATP and GTP) are better substrates than pyrimidine nucleotides (CTP and UTP)
-
-
-
additional information
?
-
-
substrate specificity, overview. No activity with bis-4-nitrophenyl phosphate. FAD, ADP-ribose, ADPG, UDPG, some diadenosine polyphosphates (ApnAs), ATP, ADP, UDP and 3',5'-cAMP are poor or no substrates
-
-
?
additional information
?
-
-
isozyme NPP1 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP1 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP1 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
-
isozyme NPP2 does not recognize nucleotide sugars as substrates, but hydrolyzed UDP, ADP and adenosine 5'-phosphosulfate, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP2 does not recognize nucleotide sugars as substrates, but hydrolyzed UDP, ADP and adenosine 5'-phosphosulfate, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP2 does not recognize nucleotide sugars as substrates, but hydrolyzed UDP, ADP and adenosine 5'-phosphosulfate, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
-
isozyme NPP6 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP6 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP6 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
-
the enzyme is an oligomannosidic glycoprotein that may participate in neural cell communication
-
-
?
additional information
?
-
-
nucleotide ester-forming alcoholytic activity
-
-
?
additional information
?
-
NPP1 hydrolyzes a wide range of phosphodiester bonds, e.g. in nucleoside triphosphates, (cyclic) dinucleotides, and nucleotide sugars yielding nucleoside 5'-monophosphates as products. Its main substrate is ATP which is cleaved to AMP and diphosphate. Purine nucleotides (ATP and GTP) are better substrates than pyrimidine nucleotides (CTP and UTP)
-
-
-
additional information
?
-
-
nucleotide ester-forming alcoholytic activity
-
-
?
additional information
?
-
the product of the TM0913 gene, has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities
-
-
?
additional information
?
-
-
the product of the TM0913 gene, has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities
-
-
?
additional information
?
-
the product of the TM0913 gene, has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities
-
-
?
additional information
?
-
the structural requirements and the conservation of the amino acids of the catalytic site of TaNPPr and, by extension, probably of all NPPs, are very stringent
-
-
?
additional information
?
-
-
the structural requirements and the conservation of the amino acids of the catalytic site of TaNPPr and, by extension, probably of all NPPs, are very stringent
-
-
?
additional information
?
-
-
hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview
-
-
?
additional information
?
-
-
hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview
-
-
?
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(2E)-2-([3-methoxy-4-[(1H-tetrazol-5-yl)methoxy]phenyl]methylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2E)-2-benzylidene[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2E)-2-[(2-oxo-1,2-dihydroquinolin-3-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2E)-2-[(5-iodofuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
moderate to low inhibition
(2E)-2-[(naphthalen-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2E)-2-[[2,4-bis(4-methylpiperidin-1-yl)-5-nitrophenyl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-benzylidene[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-ethylidene[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(2E)-3-phenylprop-2-en-1-ylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(3-phenoxyphenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(4-chlorophenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(4-iodophenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(4-methylphenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(5-bromofuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(5-iodofuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
highly selective for NPP1 as compared to other human enzymes, i.e. NPP2, NPP3, NTPDases1-3, TNAP, and eN
(2Z)-2-[(5-methylfuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(5-nitrofuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(5-phenylfuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(furan-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(pyridin-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[(thiophen-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[[3-(benzyloxy)phenyl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[[4-(morpholin-4-yl)phenyl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[[5-(dimethylamino)furan-2-yl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(2Z)-2-[[5-(phenylsulfanyl)furan-2-yl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
-
(3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone
-
(3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone
-
(3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone
-
(3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone
-
(4-aminophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone
-
(4-aminophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone
-
(4-aminophenyl) (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)methanone
-
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (4-chlorophenyl)methanone
-
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone
-
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone
-
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone
-
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (p-tolyl)methanone
-
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone
-
(4-chlorophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone
-
(4-chlorophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone
-
(E)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylprop-2-en-1-one
-
(R)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-2-(4-isobutylphenyl)propan-1-one
-
1,1'-(2-(2-bromophenyl)ethene-1,1-diyl)bis(1H-indole)
1-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3(2H)-one
-
1-amino-4-[4-[(4-anilino-6-chloro-1,3,5-triazin-2-yl)amino]-3-sulfoanilino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
-
1-[(4-methoxyphenyl)methyl]-1H-benzimidazole
-
10-methoxy-6-(5-methoxy-1H-indol-1-yl)indolo[2,1-a]isoquinoline
-
12-methyl-6(3-methyl-1H-indol-1-yl)indolo[1,2-h][1,7]naphthyridine
-
12-methyl-6-(3-methyl-1H-indol-1-yl)indolo[2,1-a]isoquinoline
-
2',3'-cAMP
-
7% inhibition at 2 mM
2',3'-dialdehyde ATP
-
competitive inhibition
2,3-Butanedione
-
inactivation half-life: 21.8 min at 0.1 mM
2,3-dimercapto-1-propanol
2,3-dimethoxy-12-methyl-6-(3-methyl-1H-indol-1-yl)indolo[2,1-a]isoquinoline
-
2-(trifluoromethyl)-3,4,8-tri(4-(trifluoromethyl)phenyl)quinoline
-
2-MeSADP
competitive inhibition
2-MeSATP
competitive inhibition
2-methylthioadenosine 5'-triphosphate
-
competitive inhibition
2-[4-[(4-fluorobenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-fluorobenzene-1-sulfonate
-
2-[4-[(4-methoxybenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-methoxybenzene-1-sulfonate
-
2-[4-[(4-methylbenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-methylbenzene-1-sulfonate
38.5% inhibition
2-[4-[(4-tert-butylbenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-tert-butylbenzene-1-sulfonate
shows cytotoxicity against MCF-7 and HT-29 cell lines and shows less cytotoxicity on against A-549 cell
2-[4-[(cyclohexanesulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl cyclohexanesulfonate
30.0% inhibition
2-[4-[(dimethylsulfamoyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl dimethylsulfamate
43.7% inhibition
2-[4-[(ethanesulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl ethanesulfonate
35.1% inhibition
2-[4-[(methylsulfamoyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl methylsulfamate
36.0% inhibition
3',5'-cAMP
-
4% inhibition at 2 mM
3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate
-
competitive inhibition
3,3'-[(2-chlorophenyl)methylene]bis(4-hydroxy-3,4-dihydro-2H-1-benzopyran-2-one)
-
3,4,8-tri(4-fluorophenyl)-2-(trifluoromethyl)quinoline
-
3,4,8-tri([1,1'-biphenyl]-4-yl)-2-(trifluoromethyl)quinoline
-
3,4,8-tri-(3-chlorophenyl)-2-(trifluoromethyl)quinoline
-
3,4,8-tri-m-tolyl-2-(trifluoromethyl)quinoline
-
3,4,8-tri-p-tolyl-2-(trifluoromethyl)quinoline
-
3,4,8-tribromo-2-(trifluoromethyl)quinoline
-
3,4,8-triphenyl-2-(trifluoromethyl)quinoline
-
3,4,8-tris(3,5-dimethylphenyl)-2-(trifluoromethyl)quinoline
-
3,4,8-tris(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
-
3,5-dimethyl-4-(naphthalen-2-yloxy)-1H-pyrazole
-
3,8-dibromo-2-(trifluoromethyl)quinolin-4(1H)-one
3,8-dibromo-4-(piperidin-1-yl)-2-(trifluoromethyl)quinoline
-
3,8-dibromo-4-(pyrrolidin-1-yl)-2-(trifluoromethyl)quinoline
-
3,8-dibromo-4-chloro-2-(trifluoromethyl)quinoline
-
3,8-dibromo-4-N-butylamine-2-(trifluoromethyl)quinoline
-
3,9-difluoro-6-(6-fluoro-1H-indol-1-yl)indolo[2,1-a]isoquinoline
-
3-(3-bromo-4-chloro-2-(trifluoromethyl)quinolin-8-yl)benzonitrile
-
3-bromo-4-chloro-2-(trifluoromethyl)-8-(4-(trifluoromethyl)phenyl)quinoline
-
3-bromo-4-chloro-8-(2,5-dimethoxyphenyl)-2-(trifluoromethyl)quinoline
-
3-bromo-4-chloro-8-(3,5-difluorophenyl)-2-(trifluoromethyl)quinoline
-
3-bromo-4-chloro-8-(3,5-dimethylphenyl)-2-(trifluoromethyl)quinoline
-
3-bromo-4-chloro-8-(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
-
3-bromo-4-chloro-8-(o-tolyl)-2-(trifluoromethyl)quinoline
-
3-bromo-4-chloro-8-(thiophen-3-yl)-2-(trifluoromethyl)quinoline
-
3-bromo-4-chloro-8-phenyl-2-(trifluoromethyl)quinoline
-
3-bromo-4-N-butylamine-8-(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
-
3-chloropentane-2,4-dione
-
3-fluoro-12-methyl-6-(3-methyl-1H-indol-1-yl)indolo[2,1-a]isoquinoline
-
3-fluoro-6-(1H-pyrrolo[2,3-b]pyridin-1-yl)pyrido[3',2':4,5]pyrrolo[2,1-a]isoquinoline
-
3-methyl-2-(4-methylbenzoyl)-1,2-dihydropyrazol-5-one
-
4,4'-diisothiocyanatostilbene-2,2' disulfonic acid
-
P2-purinoceptor antagonist, less potent inhibition, IC50: 0.022 mM
4-(3,8-dibromo-2-(trifluoromethyl)quinolin-4-yl)morpholine
-
4-(3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-6-[(quinoline-8-sulfonyl)oxy]-1-benzothiophen-2-yl)phenyl quinoline-8-sulfonate
28.7 inhibition; 42.5% inhibition
4-(3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-6-[[4-(trifluoromethyl)benzene-1-sulfonyl]oxy]-1-benzothiophen-2-yl)phenyl 4-(trifluoromethyl)benzene-1-sulfonate
-
4-(4-chlorobenzamido)phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
-
4-(4-chlorobenzamido)phenyl 4-(trifluoromethyl)benzene-1-sulfonate
-
4-(4-chlorobenzamido)phenyl 4-fluorobenzene-1-sulfonate
46% inhibition at 0.1 mM
4-(4-chlorobenzamido)phenyl 4-methylbenzene-1-sulfonate
-
4-(4-chlorobenzamido)phenyl 4-tert-butylbenzene-1-sulfonate
-
4-(4-chlorobenzamido)phenyl benzenesulfonate
-
4-chloro-2-(trifluoromethyl)-3,8-bis(4-(trifluoromethyl)phenyl)quinoline
-
4-chloro-3,8-bis(3-methylphenyl)-2-(trifluoromethyl)quinoline
-
4-chloro-3,8-bis(4-(trifluoromethoxy)phenyl)-2-(trifluoromethyl)quinoline
-
4-chloro-3,8-bis(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
-
4-chloro-3,8-diphenyl-2-(trifluoromethyl)quinoline
-
4-chloro-8-(2,5-dimethoxyphenyl)-2-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)quinoline
-
4-chloro-8-phenyl-2-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)quinoline
-
4-N-butylamine-3,8-bis(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
-
4-[(cycloheptanecarbonyl)amino]phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
29% inhibition at 0.1 mM; 37% inhibition at 0.1 mM
4-[(cycloheptanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
-
4-[(cycloheptanecarbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
39.3% inhibition at 0.1 mM
4-[(cycloheptanecarbonyl)amino]phenyl 4-methylbenzene-1-sulfonate
-
4-[(cycloheptanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
-
4-[(cycloheptanecarbonyl)amino]phenyl benzenesulfonate
-
4-[(cyclohexanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
-
4-[(cyclohexanecarbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
-
4-[(cyclohexanecarbonyl)amino]phenyl 4-methylbenzene-1-sulfonate
39% inhibition at 0.1 mM+L345; 43% inhibition at 0.1 mM
4-[(cyclohexanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
-
4-[(cyclohexanecarbonyl)amino]phenyl benzenesulfonate
-
4-[(cyclohexanecarbonyl)amino]phenyl ethanesulfonate
-
4-[(cyclohexanecarbonyl)amino]phenyl methanesulfonate
-
4-[(cyclohexanecarbonyl)amino]phenyl propane-1-sulfonate
-
4-[(cyclooctanecarbonyl)amino]phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
30% inhibition at 0.1 mM; 30% inhibition at 0.1 mM
4-[(cyclooctanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
29% inhibition at 0.1 mM
4-[(cyclooctanecarbonyl)amino]phenyl 4-methylbenzene-1-sulfonate
35% inhibition at 0.1 mM; 43% inhibition at 0.1 mM
4-[(cyclooctanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
40% inhibition at 0.1 mM; 46% inhibition at 0.1 mM
4-[(cyclooctanecarbonyl)amino]phenyl benzenesulfonate
45% inhibition at 0.1 mM; 47% inhibition at 0.1 mM
4-[(cyclopentanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
-
4-[(cyclopentanecarbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
-
4-[(cyclopentanecarbonyl)amino]phenyl 4-methylbenzene-1-sulfonate
-
4-[(cyclopentanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
-
4-[(cyclopentanecarbonyl)amino]phenyl benzenesulfonate
-
4-[(naphthalene-2-carbonyl)amino]phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
-
4-[(naphthalene-2-carbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
-
4-[(naphthalene-2-carbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
-
4-[(naphthalene-2-carbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
49% inhibition at 0.1 mM
4-[(naphthalene-2-carbonyl)amino]phenyl benzenesulfonate
23% inhibition at 0.1 mM; 24% inhibition at 0.1 mM
4-[(quinoline-8-carbonyl)amino]phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
37% inhibition at 0.1 mM; 42% inhibition at 0.1 mM
5'-O-(boranyl[[hydroxy(phosphonomethyl)phosphoryl]oxy]phosphoryl)adenosine
-
5'-O-[([[dibromo(phosphono)methyl](hydroxy)phosphoryl]oxy)(hydroxy)phosphoryl]-N,N-diethyladenosine
-
5'-phosphoadenosine 3'-phosphate
-
P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.036 mM
5,5'-(propane-1,3-diyl)di(1,3,4-oxadiazole-2(3H)-thione)
-
5-(1H-pyrazol-1-yl)pyrazolo[5,1-a]isoquinoline
-
5-(1H-pyrrol-1-yl)pyrrolo[2,1-a]isoquinoline
-
6-(1H-benzo[d]imidazol-1-yl)benzo[4,5]imidazo[2,1-a]isoquinoline
-
6-(1H-indol-1-yl)indolo[2,1-a]isoquinoline
-
6-(1H-pyrrolo[2,3-b]pyridin-1-yl)pyrido[3',2':4,5]pyrrolo[2,1-a]isoquinoline
-
6-(4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)-9,10-dihydroindolo[2,1-a]isoquinolin-11(8H)-one
-
6-(5-cyano-1H-indol-1-yl)-2,3-dimethoxyindolo[2,1,-a]isoquinoline-10-carbonitrile
-
6-(5-cyano-1H-indol-1-yl)-3-fluoroindolo[2,1-a]isoquinoline-10-carbonitrile
-
6-(5-cyano-1H-indol-1-yl)indolo[2,1-a]isoquinoline-10-carbonitrile
-
8,8'-[carbonylbis[azanediyl-3,1-phenylenecarbonylazanediyl(4-methyl-3,1-phenylene)carbonylazanediyl]]di(naphthalene-1,3,5-trisulfonic acid)
-
8,9-dimethoxy-5-(1H-pyrrol-1-yl)pyrrolo[2,1-a]isoquinoline
-
8-(4-methoxyphenyl)-3,4-di-p-tolyl-2-(trifluoromethyl)quinoline
-
8-phenyl-2-(trifluoromethyl)-3,4-bis(4-(trifluoromethyl)phenyl)quinoline
-
8-phenyl-4-(p-tolyl)-2-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)quinoline
-
9-fluoro-6-(6-fluoro-1H-indol-1-yl)-2,3-dimethoxyindolo[2,1-a]isoquinoline
-
9-fluoro-6-(6-fluoro-1H-indol-1-yl)-[1,3]dioxolo[4,5-g]indolo[2,1-a]isoquinoline
-
9-fluoro-6-(6-fluoro-1H-indol-1-yl)indolo[2,1-a]isoquinoline
-
acidic fibroblast growth factor
-
potent inhibition at nearly stoichiometric concentrations, Ki: 1.3 nM
-
adenosine
-
competitive inhibition, Ki: 2.7 mM
adenosine 2'-monophosphate
-
8% inhibition at 2 mM
adenosine 3',5'-bisphosphate
-
-
adenosine 3'-monophosphate
adenosine 5'-alpha,beta-methylene-gamma-thiotriphosphate
-
Adenyl-5'-yl imidodiphosphate
adenylic acid
-
competitive inhibition, Ki: 0.036 mM
ADP-ribose
-
47% inhibition at 0.5 mM, competitive type of inhibition
alpha,beta-methylene adenosine 5'-triphosphate
alpha,beta-methylene ADP
-
mixed inhibition
alpha,beta-methylene ATP
-
competitive inhibition
alpha,beta-methyleneadenosine triphosphate
cannot be hydrolyzed and blocks both NTPase and pyrophosphatase activities
alpha-borano-beta,gamma-MetATP
-
AMP(CH)2PP
-
competitive inhibition, Ki: 25 mM
AMP-amidate
-
competitive inhibition, Ki: 30 mM
AMP-PP(S)
-
competitive inhibition, Ki: 33 mM
B4 lectin
-
from Vicia villosa, strong inhibition between 0.002-0.02 mM, specific for hydrolysis of UDP-N-acetyl-alpha-D-galactosamine, reversal by addition of N-acetyl-alpha-D-galactosamine, only weakly inhibitory towards UDP-galactose or UDP-GlcNAc
-
beta,gamma-methyleneadenosine 5'-triphosphate
-
competitive inhibition of formycin 5'-triphosphate hydrolysis, Ki: 0.1 mM
Borate
-
strong inhibition at pH 8.5, not at pH 7.4
CDP-choline
-
62% inhibition at 0.2 mM
coenzyme A
-
90% inhibition at 0.2 mM
CTP
-
potent inhibition at 0.1 mM
cytidine 5'-diphosphate
-
competitive inhibition, Ki: 0.0085 mM
dAMP
-
16% inhibition at 17 mM
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-gamma,delta-methylene-tetraphosphate
-
diadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
-
dialADP
noncompetitive inhibition
diethyldiphosphate
-
inactivation follows apparent first-order kinetics, completely restored by hydroxylamine
EGTA
-
strong inhibition at 1 mM, partially reversed by Mg2+, complete reactivation at 10 mM Ca2+
F-
-
0.01 mM, 54% inhibition
FeSO4
-
42% inhibition at 1 mM in the presence of 0.1 mM o-phenanthroline
gamma-S-adenosine 5'-(alpha,beta-methylene)triphosphate
competitive inhibition
GDP
-
competitive inhibition, Ki: 0.0025 mM
GDP-mannose
-
competitive inhibition of phosphodiesterase activity
GSH
-
40% inhibition at 1 mM
GSSG
-
25% inhibition at 1 mM
guanidine hydrochloride
-
85% inhibition at 4.2 M, complete recovery of activity after dialysis
ITP
-
potent inhibition at 0.1 mM
L-ascorbic acid
-
8% inhibition at 16 mM
L-phenylalanine
-
5 mM, 10% loss of activity
lectin
-
from Wistaria floribunda, inhibition for hydrolysis of UDP-N-acetyl-alpha-D-galactosamine, reversal by addition of N-acetyl-alpha-D-galactosamine
-
N-(3,4-dimethoxyphenyl)-2-[(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]acetamide
-
N-ethyl-5-phenylisoxazolium-3'-sulfonate
-
Woodward's reagent, inactivation half-life: 16 min at 0.05 mM
N-omega-nitro-L-arginine methyl ester
-
enzyme activity is decreased in serum and platelets from N-omega-nitro-L-arginine methyl ester -treated rats
N-[2-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl] sulfuric diamide
i.e. SAR 03004
N-[2-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide
-
N1-butylnicotinamide chloride
-
competitive inhibition, Ki: 0.408 mM
N1-heptylnicotinamide chloride
-
competitive inhibition, Ki: 0.48 mM
N1-hexylnicotinamide chloride
-
competitive inhibition, Ki: 0.629 mM
N1-octylnicotinamide chloride
-
competitive inhibition, Ki: 0.287 mM
N1-pentylnicotinamide chloride
-
competitive inhibition, Ki: 0.297 mM
nicotinamide
-
19% inhibition at 100 mM
NMN
-
10% inhibition at 40 mM
nucleoside monophosphates
-
-
p-hydroxymercuribenzoate
-
60% inhibition at 1 mM, reversal by GSH
p-nitrophenyl 3'-thymidylate
-
15% inhibition at 0.2 mM
p-nitrophenyl 5'-thymidylate
-
15% inhibition at 0.2 mM
P1,P4-bis(5'-adenosyl)-alpha,beta-gamma,delta-bismethylene-tetraphosphate
-
polyoxymetalate PSB-POM141
-
-
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid
pyridoxal phosphate-6-azophenyl-2',4'disulfonic acid
PZB08513136A
the most potent thioacetamide derivative
SDS
-
partial inactivation at 0.1%, w/v, complete inactivation at 1%, w/v
Sodium fluoride
-
about 30% residual activity at 40 mM sodium fluoride using ATP as substrate, less than 60% residual activity at 40 mM sodium fluoride using ADP or bis(4-nitrophenyl) phosphate as substrate
thiamine diphosphate
-
17% inhibition at 0.2 mM
thiazolobenzimidazolone
and derivatives
TTP
-
70% inhibition at 1 mM
UDP-galactose
-
competitive inhibition, Ki: 29 mM
uridine 5'-diphosphate
-
competitive inhibition, Ki: 0.0012 mM
UTP
-
potent inhibition at 0.1 mM
[TiW11CoO40]8-
i.e. PSB-POM141
-
1,1'-(2-(2-bromophenyl)ethene-1,1-diyl)bis(1H-indole)
-
1,1'-(2-(2-bromophenyl)ethene-1,1-diyl)bis(1H-indole)
-
2,3-dimercapto-1-propanol
-
nearly complete inactivation at 3 mM
2,3-dimercapto-1-propanol
-
complete inhibition at 5 mM
2-mercaptoethanol
-
80% inhibition at 5 mM
2-mercaptoethanol
-
19% inhibition at 4 mM
2-mercaptoethanol
-
90% inhibition at 16 mM
3,8-dibromo-2-(trifluoromethyl)quinolin-4(1H)-one
-
3,8-dibromo-2-(trifluoromethyl)quinolin-4(1H)-one
-
5'-ADP
-
54% inhibition at 2 mM
5'-ADP
-
competitive inhibition, Ki: 0.0019 mM
5'-ADP
-
complete inhibition at 1 mM
5'-ADP
-
inhibition of monomer
5'-ADP
-
less potent inhibitor
5'-AMP
-
73% inhibition at2 mM
5'-AMP
-
competitive inhibition, Ki: 0.037 mM
5'-AMP
-
biphasic kinetics abolished in the presence of 0.2 mM, Ki: 0.015 mM
5'-AMP
-
sigmoid type of inhibition, phosphate abolishes sigmoidal response
5'-AMP
-
29% inhibition at 12 mM
5'-AMP
-
56% inhibition at 2 mM
5'-AMP
-
effective inhibitor, Ki: 0.5 mM
5'-AMP
-
49% inhibition at 40 mM
5'-AMP
-
complete inhibition at 1 mM for monomer, dimer, tetramer, only dimer inhibits at 0.01 mM to 25%
5'-AMP
-
biphasic inhibition, increasing Km, decreasing Vm
adenosine 3'-monophosphate
-
8% inhibition at 2 mM
adenosine 3'-monophosphate
-
Ki: 1 mM
adenosine 5'-sulfate
-
46% inhibition at 2 mM
adenosine 5'-sulfate
-
Ki: 0.052 mM
Adenyl-5'-yl imidodiphosphate
-
competitive inhibition of formycin 5'-triphosphate hydrolysis, Ki: 0.22 mM
Adenyl-5'-yl imidodiphosphate
-
61-78% inhibition at 1 mM
ADP
-
-
ADP
-
competitive inhibition
alpha,beta-metADP
competitive inhibition
alpha,beta-metADP
mixed inhibition type
alpha,beta-metATP
competitive inhibition
alpha,beta-metATP
competitive inhibition
alpha,beta-methylene adenosine 5'-triphosphate
-
61-78% inhibition at 0.3 mM
alpha,beta-methylene adenosine 5'-triphosphate
-
competitive inhibition, Ki: 25 mM
alpha,beta-methylene adenosine 5'-triphosphate
-
25% inhibition at 2 mM
AMP
-
-
AMP
-
competitive inhibition
ATP
-
competitive inhibition of formycin 5'-triphosphate hydrolysis, Ki: 0.1 mM
ATP
-
potent inhibition at 0.1 mM
ATP
-
competitive inhibition
ATP
-
44% inhibition at 2 mM
ATP
-
inhibition of monomer
ATP
-
non-competitive inhibition
benzoyl-ATP
-
benzoyl-ATP
competitive inhibition
Cibacron blue
-
0.1 mM, substrate Ap4A, strong inhibition, NPP1; 0.1 mM, substrate Ap4A, strong inhibition, NPP2
Cibacron blue
0.1 mM, substrate Ap4A, strong inhibition, NPP1
Cu2+
-
1 mM, more than 95% inhibition
Cu2+
-
inhibition at 5 mM
Cu2+
-
50% inhibition at 1.5 mM
Cu2+
-
45% inhibition at 1 mM
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
-
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
-
dialATP
uncompetitive inhibition
diphosphate
-
complete inhibition above 0.1 mM
diphosphate
-
26% inhibition at 10 mM
diphosphate
-
8% inhibition at 2 mM
diphosphate
-
strong inhibition at pH 8.5, not at pH 7.4
dithiothreitol
-
less than 20% residual activity at 40 mM dithiothreitol using ATP as substrate, less than 10% residual activity at 40 mM dithiothreitol using ADP as substrate, less than 50% residual activity at 40 mM dithiothreitol using bis(4-nitrophenyl) phosphate as substrate
dithiothreitol
-
50% inhibition at 2.3 mM
dithiothreitol
-
92% inhibition at 4 mM, reversal to 92% of initial activity by addition of Zn2+
dithiothreitol
-
complete inactivation at 4 mM
EDTA
-
less than 20% residual activity at 40 mM EDTA using ATP as substrate, less than 10% residual activity at 40 mM EDTA using ADP as substrate, about 40% residual activity at 40 mM EDTA using bis(4-nitrophenyl) phosphate as substrate
EDTA
-
abolishes activity and makes enzyme unstable
EDTA
-
50% inhibition at 0.2 mM
EDTA
-
strong inhibition at 1 mM, partially reversed by Mg2+, complete reactivation at 10 mM Ca2+
EDTA
activity can be restored by addition of 2-5 mM ZnCl2 or CaCl2, but only partially by 2-5 mM MgCl2
EDTA
-
EDTA is not able to remove the bound metal ions in ONPP
EDTA
-
0.1 mM, complete inhibition
EDTA
-
at 0.5 mM, EDTA greatly reduces the catalytic activity
EDTA
-
enhanced inhibition at 0.005 mM in the presence of 5 mM glycine
EDTA
-
complete inhibition at 1 mM
EDTA
-
inactivation after 30 min preincubation at 6 mM
EDTA
-
complete inactivation, partially restored by Mg2+, Ca2+
EDTA
-
50% inhibition at 1 mM
EDTA
-
complete inactivation at 2 mM, no reversal by addition of metals
EDTA
-
complete inhibition at 2 mM, partial reactivation by divalent cations
EDTA
activity is restorable by Zn2+
EDTA
-
complete inhibition, reversal for dimer and tetramer by Zn2+
FAD+
-
50% inhibition at 1-2 mM
FAD+
-
79% inhibition at 0.2 mM
GMP
-
Ki: 0.022 mM
GMP
-
complete inhibition at 1 mM
heparin
-
NPP1
Hg2+
-
inhibition at 5 mM
Hg2+
-
25% inhibition at 1 mM
L-cysteine
-
complete inhibition at 4 mM, reversal to 95% of initial activity by addition of Zn2+
L-cysteine
-
complete inactivation at 4 mM
NAD+
-
82% inhibition at 0.2 mM
NAD+
-
competitive inhibition of phosphodiesterase activity
NAD+
-
84% inhibition at 2 mM
NADH
-
14% inhibition at 2 mM
NADH
-
effective inhibition of DPN splitting
NaF
-
82% inhibition at 10 mM
NaF
-
22% inhibition at 45 mM
Ni2+
-
1 mM, more than 95% inhibition
Ni2+
-
inhibition at 5 mM
Ni2+
-
50% inhibition at 2 mM
o-phenanthroline
-
60-90% inhibition at 0.1 mM, reversal by FeSO4
o-phenanthroline
-
complete inactivation at 2 mM, no reversal by addition of metal ions, m-phenanthroline no effect
o-phenanthroline
-
complete inactivation at 2 mM, partial reactivation by divalent cations
phosphate
-
18% inhibition at 2 mM
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid
-
0.1 mM, substrate p4A, 42% inhibition, NPP2; 0.1 mM, substrate p4A, about 85% inhibition, NPP1
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid
0.1 mM, substrate Ap4A, about 85% inhibition, NPP3
pyridoxal phosphate-6-azophenyl-2',4'disulfonic acid
-
P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM
pyridoxal phosphate-6-azophenyl-2',4'disulfonic acid
-
complete inhibition above 0.02 mM
Reactive blue 2
-
-
Reactive blue 2
-
P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM
Sodium diphosphate
-
competitive inhibition, Ki: 0.41 mM
Sodium diphosphate
-
66% inhibition at 25 mM
suramin
-
0.1 mM, substrate Ap4A, about 77% inhibition, NPP2; 0.1 mM, substrate p4A, about 70% inhibition, NPP1
suramin
-
0.25 mM, inhibition
suramin
-
a P2 receptor antagonist and an inhibitor of E-NTPDase and NPP1-2 activities
suramin
-
P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.072 mM
UDP-glucose
-
competitive inhibition of phosphodiesterase activity
UDP-glucose
-
competitive inhibition, Ki: 18 mM
UMP
-
competitive inhibition, Ki: 26 mM
UMP
-
11% inhibition at 56 mM
Urea
-
complete inhibition at 4.5 M for monomer, tetramer inactivated at 6 M
Urea
-
progressive inhibition greater 1 M, 80% inhibition at 6 M, dilution or dialysis results in complete restoration of activity
Zn2+
-
1 mM, more than 95% inhibition
Zn2+
-
inhibition at 5 mM
Zn2+
-
50% inhibition at 20 mM
Zn2+
-
above 1-2 mM of EDTA-concentration optimal in restorage, greater values inhibitory
additional information
-
phenylmethylsulfonyl fluoride does not modify the catalytic activity of NPP
-
additional information
-
diadenosine 5,5-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, synthesis, overview; diadenosine 5,5-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, synthesis, overview; diadenosine 5,5-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, synthesis, overview
-
additional information
diadenosine 5,5-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, synthesis, overview; diadenosine 5,5-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, synthesis, overview; diadenosine 5,5-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, synthesis, overview
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additional information
diadenosine 5,5-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, synthesis, overview; diadenosine 5,5-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, synthesis, overview; diadenosine 5,5-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, synthesis, overview
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structure-activity relationships of thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives as selective nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitors. Inhibition mechanism, overview
-
additional information
structure-activity relationships of thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives as selective nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitors. Inhibition mechanism, overview
-
additional information
-
structure-activity relationships of thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives as selective nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitors. Inhibition mechanism, overview
-
additional information
synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors, structure-activity relationships, molecular docking study and analysis, overview; synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors, structure-activity relationships, molecular docking study and analysis, overview
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additional information
synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors, structure-activity relationships, molecular docking study and analysis, overview; synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors, structure-activity relationships, molecular docking study and analysis, overview
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design and synthesis of arylated 2-trifluoromethylquinolines derivatives by site-selective, chemo-selective amination reactions following regioselective Suzuki-Miyaura coupling reactions. Evaluation of their potential to inhibit two families of ecto-nucleotidases, i.e. NPPs (EC 3.6.1.9) and nucleoside triphosphate diphosphohydrolases (NTPDases, EC 3.6.1.15), docking studies to analyze the active binding site of the molecules, overview. The compounds all show negligible inhibition of NTPDases1-3; design and synthesis of arylated 2-trifluoromethylquinolines derivatives by site-selective, chemo-selective amination reactions following regioselective Suzuki-Miyaura coupling reactions. Evaluation of their potential to inhibit two families of ecto-nucleotidases, i.e. NPPs (EC 3.6.1.9) and nucleoside triphosphate diphosphohydrolases (NTPDases, EC 3.6.1.15), docking studies to analyze the active binding site of the molecules, overview. The compounds all show negligible inhibition of NTPDases1-3
-
additional information
design and synthesis of arylated 2-trifluoromethylquinolines derivatives by site-selective, chemo-selective amination reactions following regioselective Suzuki-Miyaura coupling reactions. Evaluation of their potential to inhibit two families of ecto-nucleotidases, i.e. NPPs (EC 3.6.1.9) and nucleoside triphosphate diphosphohydrolases (NTPDases, EC 3.6.1.15), docking studies to analyze the active binding site of the molecules, overview. The compounds all show negligible inhibition of NTPDases1-3; design and synthesis of arylated 2-trifluoromethylquinolines derivatives by site-selective, chemo-selective amination reactions following regioselective Suzuki-Miyaura coupling reactions. Evaluation of their potential to inhibit two families of ecto-nucleotidases, i.e. NPPs (EC 3.6.1.9) and nucleoside triphosphate diphosphohydrolases (NTPDases, EC 3.6.1.15), docking studies to analyze the active binding site of the molecules, overview. The compounds all show negligible inhibition of NTPDases1-3
-
additional information
synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile, structure activity and structure selectivity relationship of 2-benzoyl-5-methyl-1H-pyrazol-3(2H)-one derivatives, overview. The cytotoxic potential of the synthesized pyrazole derivatives is scrutinized against three different cancer cell lines i.e. breast cancer cells (MCF-7), cervical cancer cells (HeLa), and bone marrow lymphoblast cells (K-562). The assay is performed by using MTT (dimethyl-2-thiazolyl-2,5-diphenyl-2H-tetrazolium bromide)-based cell viability assay; synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile, structure activity and structure selectivity relationship of 2-benzoyl-5-methyl-1H-pyrazol-3(2H)-one derivatives, overview. The cytotoxic potential of the synthesized pyrazole derivatives is scrutinized against three different cancer cell lines i.e. breast cancer cells (MCF-7), cervical cancer cells (HeLa), and bone marrow lymphoblast cells (K-562). The assay is performed by using MTT (dimethyl-2-thiazolyl-2,5-diphenyl-2H-tetrazolium bromide)-based cell viability assay
-
additional information
synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile, structure activity and structure selectivity relationship of 2-benzoyl-5-methyl-1H-pyrazol-3(2H)-one derivatives, overview. The cytotoxic potential of the synthesized pyrazole derivatives is scrutinized against three different cancer cell lines i.e. breast cancer cells (MCF-7), cervical cancer cells (HeLa), and bone marrow lymphoblast cells (K-562). The assay is performed by using MTT (dimethyl-2-thiazolyl-2,5-diphenyl-2H-tetrazolium bromide)-based cell viability assay; synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile, structure activity and structure selectivity relationship of 2-benzoyl-5-methyl-1H-pyrazol-3(2H)-one derivatives, overview. The cytotoxic potential of the synthesized pyrazole derivatives is scrutinized against three different cancer cell lines i.e. breast cancer cells (MCF-7), cervical cancer cells (HeLa), and bone marrow lymphoblast cells (K-562). The assay is performed by using MTT (dimethyl-2-thiazolyl-2,5-diphenyl-2H-tetrazolium bromide)-based cell viability assay
-
additional information
a series of raloxifene sulfonate/sulfamate derivatives are designed, synthesized, and tested for inhibitory effect against nucleotide pyrophosphatase/phosphodiesterase-1 and -3 (NPP1 and NPP3) enzymes. The compounds are subjected to cytotoxic studies on various cancer cell lines, and the most potent derivatives are explored for their potency against these cancer cell lines, e.g. HT-29 cells, as well as F180 fibroblasts, inhibition values in percent per 0.01 mM. Structure-activity relationships, molecular modeling of inhibitor binding, overview. Pi-Pi stacking interactions and metal interactions with zinc inside the active site are noticed and contributed towards the inhibitory activity; a series of raloxifene sulfonate/sulfamate derivatives are designed, synthesized, and tested for inhibitory effect against nucleotide pyrophosphatase/phosphodiesterase-1 and -3 (NPP1 and NPP3) enzymes. The compounds are subjected to cytotoxic studies on various cancer cell lines, and the most potent derivatives are explored for their potency against these cancer cell lines, e.g. HT-29 cells, as well as F180 fibroblasts. Structure-activity relationships, molecular modeling of inhibitor binding, overview. Pi-Pi stacking interactions and metal interactions with zinc inside the active site are noticed and contributed towards the inhibitory activity
-
additional information
a series of raloxifene sulfonate/sulfamate derivatives are designed, synthesized, and tested for inhibitory effect against nucleotide pyrophosphatase/phosphodiesterase-1 and -3 (NPP1 and NPP3) enzymes. The compounds are subjected to cytotoxic studies on various cancer cell lines, and the most potent derivatives are explored for their potency against these cancer cell lines, e.g. HT-29 cells, as well as F180 fibroblasts, inhibition values in percent per 0.01 mM. Structure-activity relationships, molecular modeling of inhibitor binding, overview. Pi-Pi stacking interactions and metal interactions with zinc inside the active site are noticed and contributed towards the inhibitory activity; a series of raloxifene sulfonate/sulfamate derivatives are designed, synthesized, and tested for inhibitory effect against nucleotide pyrophosphatase/phosphodiesterase-1 and -3 (NPP1 and NPP3) enzymes. The compounds are subjected to cytotoxic studies on various cancer cell lines, and the most potent derivatives are explored for their potency against these cancer cell lines, e.g. HT-29 cells, as well as F180 fibroblasts. Structure-activity relationships, molecular modeling of inhibitor binding, overview. Pi-Pi stacking interactions and metal interactions with zinc inside the active site are noticed and contributed towards the inhibitory activity
-
additional information
synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation, potent inhibition of nucleotide pyrophosphatase-1, docking study, overview. Various N-fused isoquinoline derivatives are synthesized using a one-pot reaction of 1-bromo-2-(2,2-difluorovinyl)benzenes with N-H group containing heterocycles followed by intramolecular palladium-catalyzed C-H arylation. The method described gives convenient access to diverse structures of N-fused polycyclic isoquinolines; synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation, potent inhibition of nucleotide pyrophosphatase-3, docking study, overview. Various N-fused isoquinoline derivatives are synthesized using a one-pot reaction of 1-bromo-2-(2,2-difluorovinyl)benzenes with N-H group containing heterocycles followed by intramolecular palladium-catalyzed C-H arylation. The method described gives convenient access to diverse structures of N-fused polycyclic isoquinolines
-
additional information
synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation, potent inhibition of nucleotide pyrophosphatase-1, docking study, overview. Various N-fused isoquinoline derivatives are synthesized using a one-pot reaction of 1-bromo-2-(2,2-difluorovinyl)benzenes with N-H group containing heterocycles followed by intramolecular palladium-catalyzed C-H arylation. The method described gives convenient access to diverse structures of N-fused polycyclic isoquinolines; synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation, potent inhibition of nucleotide pyrophosphatase-3, docking study, overview. Various N-fused isoquinoline derivatives are synthesized using a one-pot reaction of 1-bromo-2-(2,2-difluorovinyl)benzenes with N-H group containing heterocycles followed by intramolecular palladium-catalyzed C-H arylation. The method described gives convenient access to diverse structures of N-fused polycyclic isoquinolines
-
additional information
-
synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation, potent inhibition of nucleotide pyrophosphatase-1, docking study, overview. Various N-fused isoquinoline derivatives are synthesized using a one-pot reaction of 1-bromo-2-(2,2-difluorovinyl)benzenes with N-H group containing heterocycles followed by intramolecular palladium-catalyzed C-H arylation. The method described gives convenient access to diverse structures of N-fused polycyclic isoquinolines; synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation, potent inhibition of nucleotide pyrophosphatase-3, docking study, overview. Various N-fused isoquinoline derivatives are synthesized using a one-pot reaction of 1-bromo-2-(2,2-difluorovinyl)benzenes with N-H group containing heterocycles followed by intramolecular palladium-catalyzed C-H arylation. The method described gives convenient access to diverse structures of N-fused polycyclic isoquinolines
-
additional information
NPP3 is not affected by 0.1 mM suramin
-
additional information
there is a decrease in relative expression of NPP3 in brain through rat aging
-
additional information
there is a decrease in relative expression of NPP3 in brain through rat aging
-
additional information
-
no inhibition by gadolinium chloride, levamisole, heparin, and lysophosphatidic acid in the soluble and microsomal fractions
-
additional information
poor inhibition by imidazole at 2 mM
-
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0.01
(2E)-2-([3-methoxy-4-[(1H-tetrazol-5-yl)methoxy]phenyl]methylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2E)-2-benzylidene[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2E)-2-[(2-oxo-1,2-dihydroquinolin-3-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2E)-2-[(naphthalen-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.00856
(2E)-2-[[2,4-bis(4-methylpiperidin-1-yl)-5-nitrophenyl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.01
(2Z)-2-benzylidene[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-ethylidene[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(2E)-3-phenylprop-2-en-1-ylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(3-phenoxyphenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(4-chlorophenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(4-iodophenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(4-methylphenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.00061
(2Z)-2-[(5-bromofuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.000467
(2Z)-2-[(5-iodofuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.00211
(2Z)-2-[(5-methylfuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.00107
(2Z)-2-[(5-nitrofuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(5-phenylfuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.000981
(2Z)-2-[(furan-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(pyridin-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(thiophen-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[[3-(benzyloxy)phenyl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.00891
(2Z)-2-[[4-(morpholin-4-yl)phenyl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.00421
(2Z)-2-[[5-(dimethylamino)furan-2-yl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[[5-(phenylsulfanyl)furan-2-yl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.00052
1-amino-4-[4-[(4-anilino-6-chloro-1,3,5-triazin-2-yl)amino]-3-sulfoanilino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
versus ATP, pH 9.0, 37°C, NPP1
0.01
1-[(4-methoxyphenyl)methyl]-1H-benzimidazole
above, pH 9.0, 37°C, NPP1
0.00218 - 0.0354
2-MeSADP
0.00447 - 0.0399
2-MeSATP
0.05
3,3'-[(2-chlorophenyl)methylene]bis(4-hydroxy-3,4-dihydro-2H-1-benzopyran-2-one)
versus p-nitrophenyl phenyl phosphate, pH 9.0, 37°C, NPP1
0.0005
5'-O-(boranyl[[hydroxy(phosphonomethyl)phosphoryl]oxy]phosphoryl)adenosine
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
0.012
5'-O-[([[dibromo(phosphono)methyl](hydroxy)phosphoryl]oxy)(hydroxy)phosphoryl]-N,N-diethyladenosine
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
0.15
5,5'-(propane-1,3-diyl)di(1,3,4-oxadiazole-2(3H)-thione)
versus p-nitrophenyl phenyl phosphate, pH 9.0, 37°C, NPP1
0.00026
8,8'-[carbonylbis[azanediyl-3,1-phenylenecarbonylazanediyl(4-methyl-3,1-phenylene)carbonylazanediyl]]di(naphthalene-1,3,5-trisulfonic acid)
versus ATP, pH 9.0, 37°C, NPP1
0.0000013
acidic fibroblast growth factor
-
potent inhibition at nearly stoichiometric concentrations
-
2.7
adenosine
-
competitive inhibition
1
adenosine 3'-monophosphate
-
-
0.00002
adenosine 5'-alpha,beta-methylene-gamma-thiotriphosphate
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
0.052
adenosine 5'-sulfate
-
-
0.036
adenylic acid
-
competitive inhibition
0.00128 - 0.0243
alpha,beta-metADP
0.0022 - 0.0269
alpha,beta-metATP
25
alpha,beta-methylene adenosine 5'-triphosphate
-
-
0.0005 - 0.056
alpha-borano-beta,gamma-MetATP
pH and temperature not specified in the publication, membrane enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.00296 - 0.0205
benzoyl-ATP
0.1
beta,gamma-methyleneadenosine 5'-triphosphate
-
competitive inhibition of formycin 5'-triphosphate hydrolysis
0.0085
cytidine 5'-diphosphate
-
competitive inhibition
0.009
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
0.051
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-gamma,delta-methylene-tetraphosphate
with NPP1, pH 7.3, 37°C
0.02
diadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
with NPP1, pH 7.3, 37°C
0.00342 - 0.00562
dialADP
0.002 - 0.0045
gamma-S-adenosine 5'-(alpha,beta-methylene)triphosphate
pH and temperature not specified in the publication, membrane enzyme
0.0025
GDP
-
competitive inhibition
0.00534
N-(3,4-dimethoxyphenyl)-2-[(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]acetamide
versus ATP, pH 9.0, 37°C, NPP1
0.000059
N-[2-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
0.408
N1-butylnicotinamide chloride
-
competitive inhibition
0.48
N1-heptylnicotinamide chloride
-
competitive inhibition
0.629
N1-hexylnicotinamide chloride
-
competitive inhibition
0.287
N1-octylnicotinamide chloride
-
competitive inhibition
0.297
N1-pentylnicotinamide chloride
-
competitive inhibition
0.013
P1,P4-bis(5'-adenosyl)-alpha,beta-gamma,delta-bismethylene-tetraphosphate
with NPP1, pH 7.3, 37°C
0.000005
polyoxymetalate PSB-POM141
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
-
0.00052 - 0.00071
Reactive blue 2
0.00004 - 0.00026
suramin
29
UDP-galactose
-
competitive inhibition
0.0012
uridine 5'-diphosphate
-
competitive inhibition
additional information
additional information
-
0.00218
2-MeSADP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.0237 - 0.0328
2-MeSADP
pH and temperature not specified in the publication, soluble enzyme, versus ATP
0.0354
2-MeSADP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-adenosine monophosphate
0.00447
2-MeSATP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.0213 - 0.0253
2-MeSATP
pH and temperature not specified in the publication, soluble enzyme, versus ATP
0.0399
2-MeSATP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-adenosine monophosphate
0.00128
alpha,beta-metADP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.0096
alpha,beta-metADP
pH and temperature not specified in the publication, versus 4-nitrophenyl-5'-thymidine monophosphate
0.0165
alpha,beta-metADP
pH and temperature not specified in the publication, membrane enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.0165 - 0.0243
alpha,beta-metADP
pH and temperature not specified in the publication, soluble enzyme, versus ATP
0.0022
alpha,beta-metATP
pH and temperature not specified in the publication, versus 4-nitrophenyl-5'-thymidine monophosphate
0.00332
alpha,beta-metATP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.00819
alpha,beta-metATP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-adenosine monophosphate
0.013 - 0.0269
alpha,beta-metATP
pH and temperature not specified in the publication, soluble enzyme, versus ATP
0.00296
benzoyl-ATP
pH and temperature not specified in the publication, membrane enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.0146
benzoyl-ATP
pH and temperature not specified in the publication, soluble enzyme, versus ATP
0.0205
benzoyl-ATP
pH and temperature not specified in the publication
0.009
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
with NPP1, pH 7.3, 37°C
0.009
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
0.00342
dialADP
pH and temperature not specified in the publication, membrane enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.00503
dialADP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.00509
dialADP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-adenosine monophosphate
0.00514 - 0.00562
dialADP
pH and temperature not specified in the publication, soluble enzyme, versus ATP
0.00409
dialATP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.00508
dialATP
pH and temperature not specified in the publication, soluble enzyme, versus 4-nitrophenyl-5'-adenosine monophosphate
0.00682 - 0.00696
dialATP
pH and temperature not specified in the publication, soluble enzyme, versus ATP
0.0098
dialATP
pH and temperature not specified in the publication
0.00052
Reactive blue 2
-
E-NPP1, in 10 mM HEPES, 1 mM MgCl2, and 2 mM CaCl2, pH 7.4, at 37°C
0.00071
Reactive blue 2
-
E-NPP3, in 10 mM HEPES, 1 mM MgCl2, and 2 mM CaCl2, pH 7.4, at 37°C
0.00004
suramin
-
E-NPP3, in 10 mM HEPES, 1 mM MgCl2, and 2 mM CaCl2, pH 7.4, at 37°C
0.00026
suramin
-
E-NPP1, in 10 mM HEPES, 1 mM MgCl2, and 2 mM CaCl2, pH 7.4, at 37°C
additional information
additional information
inhibition kinetics
-
additional information
additional information
inhibition kinetics
-
additional information
additional information
-
inhibition kinetics
-
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0.00322 - 0.1
(3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone
0.00181 - 0.1
(3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone
0.00342 - 0.1
(3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone
0.00035 - 0.1
(3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone
0.00315 - 0.1
(4-aminophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone
0.00051 - 0.1
(4-aminophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone
0.00122 - 0.00435
(4-aminophenyl) (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)methanone
0.00063 - 0.00534
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (4-chlorophenyl)methanone
0.00153 - 0.1
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone
0.00226 - 0.1
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone
0.00032 - 0.1
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone
0.1 - 0.23
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (p-tolyl)methanone
0.00542 - 0.00598
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone
0.00115 - 0.1
(4-chlorophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone
0.00237 - 0.00253
(4-chlorophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone
0.00225 - 0.1
(E)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylprop-2-en-1-one
0.0124 - 0.1
(R)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-2-(4-isobutylphenyl)propan-1-one
0.00041 - 0.1
1-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3(2H)-one
0.00181 - 0.00888
2-[4-[(4-fluorobenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-fluorobenzene-1-sulfonate
0.00042 - 0.00124
2-[4-[(4-methoxybenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-methoxybenzene-1-sulfonate
0.00045
2-[4-[(4-methylbenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-methylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C
0.00029 - 0.00071
2-[4-[(4-tert-butylbenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-tert-butylbenzene-1-sulfonate
0.00049
2-[4-[(cyclohexanesulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl cyclohexanesulfonate
Homo sapiens
pH 9.5, 37°C
0.00151
2-[4-[(ethanesulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl ethanesulfonate
Homo sapiens
pH 9.5, 37°C
0.00155
2-[4-[(methylsulfamoyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl methylsulfamate
Homo sapiens
pH 9.5, 37°C
0.00051 - 0.1
3,4,8-tri(4-fluorophenyl)-2-(trifluoromethyl)quinoline
0.0207 - 0.1
3,4,8-tri-m-tolyl-2-(trifluoromethyl)quinoline
0.00073 - 0.1
3,4,8-tri-p-tolyl-2-(trifluoromethyl)quinoline
0.00018 - 0.1
3,4,8-triphenyl-2-(trifluoromethyl)quinoline
0.00987 - 0.1
3,4,8-tris(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
0.00126 - 0.00804
3,5-dimethyl-4-(naphthalen-2-yloxy)-1H-pyrazole
0.00063 - 0.00242
3,8-dibromo-2-(trifluoromethyl)quinolin-4(1H)-one
0.00039 - 0.00765
3,8-dibromo-4-chloro-2-(trifluoromethyl)quinoline
0.00035 - 0.1
3-(3-bromo-4-chloro-2-(trifluoromethyl)quinolin-8-yl)benzonitrile
0.00031 - 0.1
3-bromo-4-chloro-2-(trifluoromethyl)-8-(4-(trifluoromethyl)phenyl)quinoline
0.00025 - 0.00036
3-bromo-4-chloro-8-(2,5-dimethoxyphenyl)-2-(trifluoromethyl)quinoline
0.00039 - 0.00114
3-bromo-4-chloro-8-(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
0.00576 - 0.1
3-bromo-4-chloro-8-(thiophen-3-yl)-2-(trifluoromethyl)quinoline
0.00126 - 0.1
3-methyl-2-(4-methylbenzoyl)-1,2-dihydropyrazol-5-one
0.022
4,4'-diisothiocyanatostilbene-2,2' disulfonic acid
Rattus sp.
-
P2-purinoceptor antagonist, less potent inhibition, IC50: 0.022 mM
0.00023 - 0.00401
4-(3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-6-[[4-(trifluoromethyl)benzene-1-sulfonyl]oxy]-1-benzothiophen-2-yl)phenyl 4-(trifluoromethyl)benzene-1-sulfonate
0.000975 - 0.001203
4-(4-chlorobenzamido)phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
0.003424 - 0.02157
4-(4-chlorobenzamido)phenyl 4-(trifluoromethyl)benzene-1-sulfonate
0.002897
4-(4-chlorobenzamido)phenyl 4-fluorobenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP29
0.001437 - 0.001624
4-(4-chlorobenzamido)phenyl 4-methylbenzene-1-sulfonate
0.001525 - 0.001799
4-(4-chlorobenzamido)phenyl 4-tert-butylbenzene-1-sulfonate
0.002772 - 0.009614
4-(4-chlorobenzamido)phenyl benzenesulfonate
0.00281 - 0.1
4-chloro-3,8-diphenyl-2-(trifluoromethyl)quinoline
0.000431 - 0.002578
4-[(cycloheptanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
0.002267
4-[(cycloheptanecarbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP20
0.000255 - 0.000422
4-[(cycloheptanecarbonyl)amino]phenyl 4-methylbenzene-1-sulfonate
0.001493 - 0.04701
4-[(cycloheptanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
0.006602 - 0.01384
4-[(cycloheptanecarbonyl)amino]phenyl benzenesulfonate
0.000387 - 0.00179
4-[(cyclohexanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
0.000254 - 0.000564
4-[(cyclohexanecarbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
0.000807 - 0.00255
4-[(cyclohexanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
0.001079 - 0.01185
4-[(cyclohexanecarbonyl)amino]phenyl benzenesulfonate
0.000369 - 0.001629
4-[(cyclohexanecarbonyl)amino]phenyl ethanesulfonate
0.001354 - 0.001918
4-[(cyclohexanecarbonyl)amino]phenyl methanesulfonate
0.002409 - 0.003461
4-[(cyclohexanecarbonyl)amino]phenyl propane-1-sulfonate
0.000214
4-[(cyclooctanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP26
0.001134 - 0.003963
4-[(cyclopentanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
0.001014 - 0.00576
4-[(cyclopentanecarbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
0.000856 - 0.008137
4-[(cyclopentanecarbonyl)amino]phenyl 4-methylbenzene-1-sulfonate
0.001648 - 0.002675
4-[(cyclopentanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
0.001724 - 0.04667
4-[(cyclopentanecarbonyl)amino]phenyl benzenesulfonate
0.002892 - 0.003429
4-[(naphthalene-2-carbonyl)amino]phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
0.001118 - 0.005426
4-[(naphthalene-2-carbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
0.001487 - 0.01352
4-[(naphthalene-2-carbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
0.002195
4-[(naphthalene-2-carbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP33
0.009296 - 0.02051
4-[(naphthalene-2-carbonyl)amino]phenyl benzenesulfonate
0.036
5'-phosphoadenosine 3'-phosphate
Rattus sp.
-
P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.036 mM
0.013
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
Homo sapiens
with NPP1, pH 7.3, 37°C
0.05
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-gamma,delta-methylene-tetraphosphate
Homo sapiens
with NPP1, pH 7.3, 37°C
0.063
diadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
Homo sapiens
with NPP1, pH 7.3, 37°C
0.033
P1,P4-bis(5'-adenosyl)-alpha,beta-gamma,delta-bismethylene-tetraphosphate
Homo sapiens
with NPP1, pH 7.3, 37°C
0.012
pyridoxal phosphate-6-azophenyl-2',4'disulfonic acid
Rattus sp.
-
P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM
0.002 - 0.017
Reactive blue 2
0.00322
(3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00181
(3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00342
(3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00035
(3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00315
(4-aminophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(4-aminophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00051
(4-aminophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(4-aminophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00122
(4-aminophenyl) (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.00435
(4-aminophenyl) (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00063
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (4-chlorophenyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.00534
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (4-chlorophenyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00153
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00226
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00032
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.1
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (p-tolyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.23
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (p-tolyl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.00542
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00598
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.00115
(4-chlorophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(4-chlorophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00237
(4-chlorophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP3
0.00253
(4-chlorophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone
Homo sapiens
pH 9.5, 37°C, NPP1
0.00225
(E)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylprop-2-en-1-one
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(E)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylprop-2-en-1-one
Homo sapiens
pH 9.5, 37°C, NPP1
0.0124
(R)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-2-(4-isobutylphenyl)propan-1-one
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
(R)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-2-(4-isobutylphenyl)propan-1-one
Homo sapiens
pH 9.5, 37°C, NPP1
0.00041
1-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3(2H)-one
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
1-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3(2H)-one
Homo sapiens
pH 9.5, 37°C, NPP1
0.00181
2-[4-[(4-fluorobenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-fluorobenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C
0.00888
2-[4-[(4-fluorobenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-fluorobenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C
0.00042
2-[4-[(4-methoxybenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-methoxybenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C
0.00124
2-[4-[(4-methoxybenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-methoxybenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C
0.00029
2-[4-[(4-tert-butylbenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C
0.00071
2-[4-[(4-tert-butylbenzene-1-sulfonyl)oxy]phenyl]-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-1-benzothiophen-6-yl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C
0.00051
3,4,8-tri(4-fluorophenyl)-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.1
3,4,8-tri(4-fluorophenyl)-2-(trifluoromethyl)quinoline
Homo sapiens
above, pH 9.5, 37°C, NPP3
0.0207
3,4,8-tri-m-tolyl-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.1
3,4,8-tri-m-tolyl-2-(trifluoromethyl)quinoline
Homo sapiens
above, pH 9.5, 37°C, NPP3
0.00073
3,4,8-tri-p-tolyl-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.1
3,4,8-tri-p-tolyl-2-(trifluoromethyl)quinoline
Homo sapiens
above, pH 9.5, 37°C, NPP3
0.00018
3,4,8-triphenyl-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.1
3,4,8-triphenyl-2-(trifluoromethyl)quinoline
Homo sapiens
above, pH 9.5, 37°C, NPP3
0.00987
3,4,8-tris(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.1
3,4,8-tris(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
Homo sapiens
above, pH 9.5, 37°C, NPP3
0.00126
3,5-dimethyl-4-(naphthalen-2-yloxy)-1H-pyrazole
Homo sapiens
pH 9.5, 37°C, NPP3
0.00804
3,5-dimethyl-4-(naphthalen-2-yloxy)-1H-pyrazole
Homo sapiens
pH 9.5, 37°C, NPP1
0.00063
3,8-dibromo-2-(trifluoromethyl)quinolin-4(1H)-one
Homo sapiens
pH 9.5, 37°C, NPP1
0.00242
3,8-dibromo-2-(trifluoromethyl)quinolin-4(1H)-one
Homo sapiens
pH 9.5, 37°C, NPP3
0.00039
3,8-dibromo-4-chloro-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP3
0.00765
3,8-dibromo-4-chloro-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.00035
3-(3-bromo-4-chloro-2-(trifluoromethyl)quinolin-8-yl)benzonitrile
Homo sapiens
pH 9.5, 37°C, NPP1
0.1
3-(3-bromo-4-chloro-2-(trifluoromethyl)quinolin-8-yl)benzonitrile
Homo sapiens
above, pH 9.5, 37°C, NPP3
0.00031
3-bromo-4-chloro-2-(trifluoromethyl)-8-(4-(trifluoromethyl)phenyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.1
3-bromo-4-chloro-2-(trifluoromethyl)-8-(4-(trifluoromethyl)phenyl)quinoline
Homo sapiens
above, pH 9.5, 37°C, NPP3
0.00025
3-bromo-4-chloro-8-(2,5-dimethoxyphenyl)-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.00036
3-bromo-4-chloro-8-(2,5-dimethoxyphenyl)-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP3
0.00039
3-bromo-4-chloro-8-(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.00114
3-bromo-4-chloro-8-(4-methoxyphenyl)-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP3
0.00576
3-bromo-4-chloro-8-(thiophen-3-yl)-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.1
3-bromo-4-chloro-8-(thiophen-3-yl)-2-(trifluoromethyl)quinoline
Homo sapiens
above, pH 9.5, 37°C, NPP3
0.00126
3-methyl-2-(4-methylbenzoyl)-1,2-dihydropyrazol-5-one
Homo sapiens
pH 9.5, 37°C, NPP3
0.1
3-methyl-2-(4-methylbenzoyl)-1,2-dihydropyrazol-5-one
Homo sapiens
pH 9.5, 37°C, NPP1
0.00023
4-(3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-6-[[4-(trifluoromethyl)benzene-1-sulfonyl]oxy]-1-benzothiophen-2-yl)phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C
0.00401
4-(3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-6-[[4-(trifluoromethyl)benzene-1-sulfonyl]oxy]-1-benzothiophen-2-yl)phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C
0.000975
4-(4-chlorobenzamido)phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP28
0.001203
4-(4-chlorobenzamido)phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP30
0.003424
4-(4-chlorobenzamido)phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP32
0.02157
4-(4-chlorobenzamido)phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP30
0.001437
4-(4-chlorobenzamido)phenyl 4-methylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP26
0.001624
4-(4-chlorobenzamido)phenyl 4-methylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP28
0.001525
4-(4-chlorobenzamido)phenyl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP29
0.001799
4-(4-chlorobenzamido)phenyl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP27
0.002772
4-(4-chlorobenzamido)phenyl benzenesulfonate
Homo sapiens
pH 9.5, 37°C, NPP27
0.009614
4-(4-chlorobenzamido)phenyl benzenesulfonate
Homo sapiens
pH 9.5, 37°C, NPP25
0.00281
4-chloro-3,8-diphenyl-2-(trifluoromethyl)quinoline
Homo sapiens
pH 9.5, 37°C, NPP1
0.1
4-chloro-3,8-diphenyl-2-(trifluoromethyl)quinoline
Homo sapiens
above, pH 9.5, 37°C, NPP3
0.000431
4-[(cycloheptanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP19
0.002578
4-[(cycloheptanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP21
0.000255
4-[(cycloheptanecarbonyl)amino]phenyl 4-methylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP17
0.000422
4-[(cycloheptanecarbonyl)amino]phenyl 4-methylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP15
0.001493
4-[(cycloheptanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP16
0.04701
4-[(cycloheptanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP18
0.006602
4-[(cycloheptanecarbonyl)amino]phenyl benzenesulfonate
Homo sapiens
pH 9.5, 37°C, NPP16
0.01384
4-[(cycloheptanecarbonyl)amino]phenyl benzenesulfonate
Homo sapiens
pH 9.5, 37°C, NPP14
0.000387
4-[(cyclohexanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP13
0.00179
4-[(cyclohexanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP15
0.000254
4-[(cyclohexanecarbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP14
0.000564
4-[(cyclohexanecarbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP12
0.000807
4-[(cyclohexanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP13
0.00255
4-[(cyclohexanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP11
0.001079
4-[(cyclohexanecarbonyl)amino]phenyl benzenesulfonate
Homo sapiens
pH 9.5, 37°C, NPP11
0.01185
4-[(cyclohexanecarbonyl)amino]phenyl benzenesulfonate
Homo sapiens
pH 9.5, 37°C, NPP9
0.000369
4-[(cyclohexanecarbonyl)amino]phenyl ethanesulfonate
Homo sapiens
pH 9.5, 37°C, NPP9
0.001629
4-[(cyclohexanecarbonyl)amino]phenyl ethanesulfonate
Homo sapiens
pH 9.5, 37°C, NPP7
0.001354
4-[(cyclohexanecarbonyl)amino]phenyl methanesulfonate
Homo sapiens
pH 9.5, 37°C, NPP8
0.001918
4-[(cyclohexanecarbonyl)amino]phenyl methanesulfonate
Homo sapiens
pH 9.5, 37°C, NPP6
0.002409
4-[(cyclohexanecarbonyl)amino]phenyl propane-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP10
0.003461
4-[(cyclohexanecarbonyl)amino]phenyl propane-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP8
0.001134
4-[(cyclopentanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP5
0.003963
4-[(cyclopentanecarbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP7
0.001014
4-[(cyclopentanecarbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP6
0.00576
4-[(cyclopentanecarbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP4
0.000856
4-[(cyclopentanecarbonyl)amino]phenyl 4-methylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP4
0.008137
4-[(cyclopentanecarbonyl)amino]phenyl 4-methylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP2
0.001648
4-[(cyclopentanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP3
0.002675
4-[(cyclopentanecarbonyl)amino]phenyl 4-tert-butylbenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP5
0.001724
4-[(cyclopentanecarbonyl)amino]phenyl benzenesulfonate
Homo sapiens
pH 9.5, 37°C, NPP3
0.04667
4-[(cyclopentanecarbonyl)amino]phenyl benzenesulfonate
Homo sapiens
pH 9.5, 37°C, NPP1
0.002892
4-[(naphthalene-2-carbonyl)amino]phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP36
0.003429
4-[(naphthalene-2-carbonyl)amino]phenyl 2,4,6-tri(propan-2-yl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP34
0.001118
4-[(naphthalene-2-carbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP36
0.005426
4-[(naphthalene-2-carbonyl)amino]phenyl 4-(trifluoromethyl)benzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP38
0.001487
4-[(naphthalene-2-carbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP35
0.01352
4-[(naphthalene-2-carbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate
Homo sapiens
pH 9.5, 37°C, NPP37
0.009296
4-[(naphthalene-2-carbonyl)amino]phenyl benzenesulfonate
Homo sapiens
pH 9.5, 37°C, NPP31
0.02051
4-[(naphthalene-2-carbonyl)amino]phenyl benzenesulfonate
Homo sapiens
pH 9.5, 37°C, NPP33
0.002
Reactive blue 2
Homo sapiens
-
E-NPP3, in 10 mM HEPES, 1 mM MgCl2, and 2 mM CaCl2, pH 7.4, at 37°C
0.012
Reactive blue 2
Rattus sp.
-
P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM
0.017
Reactive blue 2
Homo sapiens
-
E-NPP1, in 10 mM HEPES, 1 mM MgCl2, and 2 mM CaCl2, pH 7.4, at 37°C
0.0012
suramin
Homo sapiens
-
E-NPP3, in 10 mM HEPES, 1 mM MgCl2, and 2 mM CaCl2, pH 7.4, at 37°C
0.0086
suramin
Homo sapiens
-
E-NPP1, in 10 mM HEPES, 1 mM MgCl2, and 2 mM CaCl2, pH 7.4, at 37°C
0.072
suramin
Rattus sp.
-
P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.072 mM
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Belli, S.I.; Goding, J.W.
Biochemical characterization of human PC-1, an enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities
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Homo sapiens, Mus musculus
brenda
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Rattus sp.
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brenda
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Purification and properties of nucleotide pyrophosphatase from human placenta
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Rattus sp.
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2000
Lens culinaris
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Molecular cloning of cDNAs for human fibroblast nucleotide pyrophosphatase
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295
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1992
Homo sapiens
brenda
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2000
Rattus sp.
brenda
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An ecto-nucleotide pyrophosphatase is one of the main enzymes involved in the extracellular metabolism of ATP in rat C6 glioma
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72
826-834
1999
Rattus sp.
brenda
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Vicia villosa B4 lectin inhibits nucleotide pyrophosphatase activity toward UDP-GalNAc specifically
Biochim. Biophys. Acta
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215-223
1998
Bos taurus, Crotalus adamanteus
brenda
Masuda, I.; Halligan, B.D.; Barbieri, J.T.; Haas, A.L.; Ryan, L.M.; McCarty, D.J.
Molecular cloning and expression of a porcine chondrocyte nucleotide pyrophosphohydrolase
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197
277-287
1997
Sus scrofa
brenda
Salvucci, M.E.; Crafts-Brandner, S.J.
Purification and properties of a unique nucleotide pyrophosphatase/phosphodiesterase I that accumulates in soybean leaves in response to fruit removal
Plant Physiol.
108
1269-1276
1995
Glycine max
brenda
Wise, D.J.; Anderson, C.D.; Anderson, B.M.
Characterization of H. parasuis periplasmic nucleotide pyrophosphatase as a potential target enzyme for inhibition of growth
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58
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1997
Glaesserella parasuis
brenda
Yano, T.; Horie, K.; Kanamoto, R.; Kitagawa, H; Funakoshi, I.; Yamashina, I.
Immunoaffinity purification and characterization of nucleotide pyrophosphatase from human placenta
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1987
Homo sapiens
brenda
Bartkiewicz, M.; Grzybowska, E.; Sierakowska, H.; Shugar, D.
Reassociable dimer subunit of potato nucleotide pyrophosphatase; specificity and stability
Biochim. Biophys. Acta
830
313-319
1985
Solanum tuberosum
-
brenda
Kahn, D.W.; Anderson, B.M.
Characterization of Haemophilus influenzae nucleotide pyrophosphatase. An enzyme of critical importance for growth of the organism
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261
6016-6025
1996
Haemophilus influenzae
brenda
Bartkiewicz, M.; Sierakowska, H.; Shugar, D.
Nucleotide pyrophosphatase from potato tubers. Purification and properties
Eur. J. Biochem.
143
419-426
1984
Solanum tuberosum
brenda
Rossomando, E.F.; Hodge Jahngen, J.
Solubilization and substrate specificity of membrane-bound nucleotide phosphodiesterase-pyrophosphohydrolase activities from Dictyostelium discoideum
J. Biol. Chem.
258
7653-7660
1983
Dictyostelium discoideum
brenda
Buckon, M.E.; Anderson, B.M.
Studies of bovine seminal fluid nucleotide pyrophosphatase
Arch. Biochem. Biophys.
202
396-404
1980
Bos taurus
brenda
Pellon, G.; Michel, G.
Identification d'une nucleotide pyrophosphatase exocellulaire dans le milieu de culture de Streptomyces mediterranei ME/R 17 [Identification of an extracellular nucleotide pyrophosphatase in the culture media of Streptomyces mediterranei ME/R 17]
Can. J. Microbiol.
25
53-60
1979
Amycolatopsis mediterranei, Amycolatopsis mediterranei ME/R17
brenda
Twu, J.S.; Haroz, R.K.; Bretthauer, R.K.
Nucleotide pyrophosphatase from yeast. The presence of bound zinc
Arch. Biochem. Biophys.
184
249-256
1977
Saccharomyces cerevisiae
brenda
Balakrishnan, C.V.; Vaidyanathan, C.S.; Rao, N.A.
Studies on nucleotidases in plants. Isolation and properties of the monomeric form of the crystalline and homogeneous mung bean nucleotide pyrophosphatase
Eur. J. Biochem.
78
95-102
1977
Vigna radiata var. radiata
brenda
Abney, E.R.; Evans, W.H.; Parkhouse, R.M.E.
Location of nucleotide pyrophosphatase and alkaline phosphodiesterase activities on the lymphocyte surface membrane
Biochem. J.
159
293-299
1976
Mus musculus
brenda
Kole, R.; Sierakowska, H.; Shugar, D.
Novel activity of potato nucleotide pyrophosphatase
Biochim. Biophys. Acta
438
540-550
1976
Solanum tuberosum
brenda
Bischof, E.; Tran-Thi, T.A.; Decker, K.F.A.
Nucleotide pyrophosphatase of rat liver. A comparative study on the enzymes solubilized and purified from plasma membrane and endoplasmic reticulum
Eur. J. Biochem.
51
353-361
1975
Rattus sp.
brenda
Balakrishnan, C.V.; Ravindranath, S.D.; Appaji Rao, N.
Studies on nucleotidases in plants. Reversible denaturation of the crystalline mung bean nucleotide pyrophosphatase and the effect of adenylates on the native and renatured enzyme
Arch. Biochem. Biophys.
164
156-164
1974
Vigna radiata var. radiata
brenda
Evans, W.H.; Hood, D.; Gurd, J.W.
Purification and properties of a mouse liver plasma-membrane glycoprotein hydrolysing nucleotide pyrophosphate and phosphodiester bonds
Biochem. J.
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819-826
1973
Mus musculus
brenda
Haroz, R.K.; Twu, J.S.; Bretthauer, R.K.
Purification and properties of a yeast nucleotide pyrophosphatase
J. Biol. Chem.
247
1452-1457
1972
Saccharomyces sp.
brenda
Krishnan, N.; Appaji Rao, N.
Studies on nucleotide pyrophosphatase I. Partial purification and properties of a sheep liver enzyme that catalyses the hydrolysis of dinucleotides
Arch. Biochem. Biophys.
149
336-348
1972
Ovis aries aries
brenda
Decker, K.; Bischoff, E.
Purification and properties of nucleotide pyrophosphatase from rat liver plasma membranes
FEBS Lett.
21
95-98
1972
Rattus sp.
brenda
Bachorik, P.S.; Dietrich, L.S.
The purification and properties of detergent-solubilized rat liver nucleotide pyrophosphatase
J. Biol. Chem.
247
5071-5078
1972
Rattus sp.
brenda
Swartz, M.N.; Kaplan, N.O.; Lamborg, M.F.
A "heat-activated" diphosphopyridine nucleotide pyrophosphatase from Proteus vulgaris
J. Biol. Chem.
232
1051-1063
1958
Proteus vulgaris
brenda
Jacobson, K.B.; Kaplan, N.O.
A reduced pyridine nucleotide pyrophosphatase
J. Biol. Chem.
226
427-437
1957
Columba livia
brenda
Kornberg, A.; Pricer, W.E.
Nucleotide pyrophosphatase
J. Biol. Chem.
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763-778
1950
Solanum tuberosum
-
brenda
Ohe, Y.; Ohnishi, H.; Okazawa, H.; Tomizawa, K.; Kobayashi, H.; Okawa, K.; Matozaki, T.
Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain
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Rattus norvegicus
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Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1
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Mus musculus (P06802)
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Purification of a plant nucleotide pyrophosphatase as a protein that interferes with nitrate reductase and glutamine synthetase assays
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Brassica oleracea
brenda
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Hydrolysis of diadenosine polyphosphates by nucleotide pyrophosphatases/phosphodiesterases
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2971-2978
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Homo sapiens, Rattus norvegicus (P97675)
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Soluble purine-converting enzymes circulate in human blood and regulate extracellular ATP level via counteracting pyrophosphatase and phosphotransfer reactions
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2003
Homo sapiens
brenda
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Two isoforms of a nucleotide-sugar pyrophosphatase/phosphodiesterase from barley leaves (Hordeum vulgare L.) are distinct oligomers of HvGLP1, a germin-like protein
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44-48
2001
Hordeum vulgare
brenda
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Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma
Int. J. Mol. Med.
12
763-766
2003
Homo sapiens
brenda
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Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases
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276
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Mus musculus (Q9EQG7)
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Cameselle, J.C.; Agudo, A.; Canales, J.; Costas, M.J.; Fernandez, A.; Flores, A.; Garcia-Diaz, M.; Gonzalez-Santiago, S.; Lopez-Gomez, J.; Ribeiro, J.M.; Vergeles, J.M.
Nucleotide ester-forming alcoholytic activities of nucleotide pyrophosphatases: implications for practical biotransformation, enzyme mechanisms and biological function
J. Mol. Catal. B
11
469-485
2001
Rattus norvegicus, Solanum tuberosum, Crotalus durissus
-
brenda
Vaingankar, S.M.; Fitzpatrick, T.A.; Johnson, K.; Goding, J.W.; Maurice, M.; Terkeltaub, R.
Subcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1
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286
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Homo sapiens, Mus musculus
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Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2
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Mus musculus (P06802)
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Structural and functional comparisons of nucleotide pyrophosphatase/phosphodiesterase and alkaline phosphatase: implications for mechanism and evolution
Biochemistry
45
9788-9803
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Mus musculus
brenda
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Mus musculus
brenda
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Ecto-nucleotide pyrophosphatase/phosphodiesterase as part of a multiple system for nucleotide hydrolysis by platelets from rats: kinetic characterization and biochemical properties
Platelets
17
84-91
2006
Rattus norvegicus
brenda
Yegutkin, G.G.
Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
Biochim. Biophys. Acta
1783
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2008
Homo sapiens (O14638), Homo sapiens (P22413)
brenda
Fuerstenau, C.R.; Trentin, D.d.a..S.; Gossenheimer, A.N.; Ramos, D.B.; Casali, E.A.; Barreto-Chaves, M.L.; Sarkis, J.J.
Ectonucleotidase activities are altered in serum and platelets of L-NAME-treated rats
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Rattus norvegicus
brenda
Keene, K.L.; Mychaleckyj, J.C.; Smith, S.G.; Leak, T.S.; Perlegas, P.S.; Langefeld, C.D.; Freedman, B.I.; Rich, S.S.; Bowden, D.W.; Sale, M.M.
Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy
Diabetes
57
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2008
Homo sapiens (P22413)
brenda
Iqbal, J.; Levesque, S.A.; Sevigny, J.; Mueller, C.E.
A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions
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2008
Homo sapiens
brenda
Cognato, G.d.e..P.; Czepielewski, R.S.; Sarkis, J.J.; Bogo, M.R.; Bonan, C.D.
Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development
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26
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2008
Rattus norvegicus (P97675), Rattus norvegicus (Q924C3)
brenda
Henz, S.L.; Cognato, G.d.e..P.; Vuaden, F.C.; Bogo, M.R.; Bonan, C.D.; Sarkis, J.J.
Influence of antidepressant drugs on ecto-nucleotide pyrophosphatase/phosphodiesterases (E-NPPs) from salivary glands of rats
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2009
Rattus norvegicus (P97675), Rattus norvegicus (Q924C3)
brenda
Lopez-Canut, V.; Roca, M.; Bertran, J.; Moliner, V.; Tunon, I.
Theoretical study of phosphodiester hydrolysis in nucleotide pyrophosphatase/phosphodiesterase. Environmental effects on the reaction mechanism
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Xanthomonas citri
brenda
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Proteoliposomes harboring alkaline phosphatase and nucleotide pyrophosphatase as matrix vesicle biomimetics
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7598-7609
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Mus musculus
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Buffon, A.; Casali, E.A.; Cardoso, V.V.; Zerbini, L.F.; Robson, S.C.; Sarkis, J.J.; Wink, M.R.
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Rattus norvegicus
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Biochemical characterization of soluble nucleotide pyrophosphatase/phosphodiesterase activity in rat serum
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Rattus norvegicus
brenda
Santoro, M.L.; Vaquero, T.S.; Leme, A.F.; Serrano, S.M.
NPP-BJ, a nucleotide pyrophosphatase/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation
Toxicon
54
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Bothrops jararaca
brenda
Joye, I.J.; Belien, T.; Brijs, K.; Soetaert, W.; Delcour, J.A.
Mutational analysis of wheat (Triticum aestivum L.) nucleotide pyrophosphatase/phosphodiesterase shows the role of six amino acids in the catalytic mechanism
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90
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Triticum aestivum (D9YT79), Triticum aestivum
brenda
Jaemsen, J.; Baykov, A.A.; Lahti, R.
Fast kinetics of nucleotide binding to Clostridium perfringens family II pyrophosphatase containing CBS and DRTGG domains
Biochemistry (Moscow)
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2012
Clostridium perfringens
brenda
Spano, D.; Pintus, F.; Pes, R.; Medda, R.; Floris, G.
Purification and characterisation of a soluble nucleotide pyrophosphatase/phosphodiesterase from prickly pear (Opuntia ficus indica) fruits
Food Res. Int.
44
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2011
Opuntia ficus-indica
brenda
Hou, G.; Cui, Q.
QM/MM analysis suggests that alkaline phosphatase (AP) and nucleotide pyrophosphatase/phosphodiesterase slightly tighten the transition state for phosphate diester hydrolysis relative to solution: implication for catalytic promiscuity in the AP superfamil
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Escherichia coli, Xanthomonas citri, Xanthomonas citri 306
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Joye, I.; Belien, T.; Brijs, K.; Proost, P.; Soetaert, W.; Delcour, J.
Characterisation of the first wheat (Triticum aestivum L.) nucleotide pyrophosphatase/phosphodiesterase resembling mammalian counterparts
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Triticum aestivum (D9YT79)
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Pochmann, D.; Innocente, A.M.; Buffon, A.; Freitas Sarkis, J.J.; de Oliveira Porciuncula, L.
Biochemical characterization of an ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. 3.1.4.1) from rat cardiac soluble and microsomal fractions
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Rattus norvegicus, Rattus norvegicus Wistar
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Eliahu, S.; Lecka, J.; Reiser, G.; Haas, M.; Bigonnesse, F.; Levesque, S.A.; Pelletier, J.; Sevigny, J.; Fischer, B.
Diadenosine 5,5-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors
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Homo sapiens, Homo sapiens (O14638), Homo sapiens (P22413)
brenda
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