Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-lysophosphatidylcholine + H2O
choline + 1-lysophosphatidate
poor substrate in comparison to glycerophosphocholine
-
-
?
2-lysophosphatidylcholine + H2O
choline + 2-lysophosphatidate
very poor substrate in comparison to glycerophosphocholine
-
-
?
bis(glycerophospho)glycerol + H2O
?
low activity
-
-
?
bis(glycerophospho)glycerol + H2O
sn-gycerol 3-phosphate + ?
bis(p-nitrophenyl) phosphate + H2O
p-nitrophenyl phosphate + p-nitrophenol
cardiolipin + H2O
?
low activity
-
-
?
cyclic sn-2,3-phosphoglycerol + H2O
?
-
-
-
-
?
demeton + H2O
?
-
-
-
-
?
ethyl p-nitrophenyl phosphate + H2O
p-nitrophenol + ethyl phosphate
-
-
-
?
glycerophosphocholine + H2O
choline + glycerol-3-phosphate
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
glycerophosphoethanolamine + H2O
ethanolamine + glycerol-3-phosphate
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
glycerophosphoinositol + H2O
?
glycerophosphoinositol + H2O
inositol + glycerol-3-phosphate
-
less than 10% of the activity with glycerophosphocholine
-
-
?
glycerophosphoinositol + H2O
sn-glycerol 3-phosphate + inositol
-
-
-
?
glycerophosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphoserine + H2O
?
glycerophosphoserine + H2O
sn-glycerol 3-phosphate + serine
-
-
-
?
L-alpha-glycerophosphocholine + H2O
choline + sn-glycerol-3-phosphate
L-alpha-glycerophosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
paraoxon + H2O
diethylphosphate + 4-nitrophenol
-
-
-
-
?
sn-glycero-3-phospho-L-serine
L-serine + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
sn-glycero-3-phosphoethanolamine + H2O
ethanolamine + sn-glycerol 3-phosphate
sn-glycero-3-phosphoglycerol + H2O
glycerol + sn-glycerol 3-phosphate
sn-glycero-3-phosphoinositol + H2O
inositol + sn-glycerol 3-phosphate
sn-glycero-3-phosphoserine
serine + sn-glycerol 3-phosphate
-
-
-
-
?
additional information
?
-
bis(glycerophospho)glycerol + H2O
sn-gycerol 3-phosphate + ?
-
-
-
-
?
bis(glycerophospho)glycerol + H2O
sn-gycerol 3-phosphate + ?
-
-
-
?
bis(p-nitrophenyl) phosphate + H2O
p-nitrophenyl phosphate + p-nitrophenol
-
-
-
-
?
bis(p-nitrophenyl) phosphate + H2O
p-nitrophenyl phosphate + p-nitrophenol
-
-
-
?
bis(p-nitrophenyl) phosphate + H2O
p-nitrophenyl phosphate + p-nitrophenol
-
-
-
?
glycerophosphocholine + H2O
choline + glycerol-3-phosphate
-
-
-
?
glycerophosphocholine + H2O
choline + glycerol-3-phosphate
-
-
-
?
glycerophosphocholine + H2O
choline + glycerol-3-phosphate
Lactobacillus delbrueckii bacteriophage Ld17
-
-
-
-
?
glycerophosphocholine + H2O
choline + glycerol-3-phosphate
-
-
-
-
?
glycerophosphocholine + H2O
choline + glycerol-3-phosphate
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
reaction provides choline which is an essential growth factor in bacteria
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
utilization of glycerophosphocholine and incorporation of choline from host cell membranes
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
maintenance of the sn-glycerol-3-phosphate concentration which is essential to enable phospholipid synthesis
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
-
?
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
-
-
-
-
?
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
-
-
-
?
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
-
-
-
?
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
-
-
-
-
?
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
-
involved in phospholipids turnover
-
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
-
sn-glycerol-3-phosphate supply is essential for the de novo synthesis of glycerophospholipids
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
important for sn-glycerol-3-phosphate uptake, which serves as carbon and phosphate source
-
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
UgpQ accumulates under conditions of phosphate starvation suggesting a role in the utilization of phosphate from glycerophosphodiesters
sn-glycerol-3-phosphate supply is essential for the de novo synthesis of glycerophospholipids
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
maintenance of the sn-glycerol-3-phosphate concentration which is essential to enable phospholipid synthesis
-
-
?
glycerophosphoethanolamine + H2O
ethanolamine + glycerol-3-phosphate
-
-
-
?
glycerophosphoethanolamine + H2O
ethanolamine + glycerol-3-phosphate
-
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
reaction provides ethanolamine which is an essential growth factor in bacteria
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
-
?
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
-
?
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
-
?
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
?
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
?
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
-
?
glycerophosphoinositol + H2O
?
-
-
-
-
?
glycerophosphoinositol + H2O
?
-
-
-
-
?
glycerophosphoserine + H2O
?
-
-
-
-
?
glycerophosphoserine + H2O
?
-
-
-
-
?
L-alpha-glycerophosphocholine + H2O
choline + sn-glycerol-3-phosphate
-
-
-
-
?
L-alpha-glycerophosphocholine + H2O
choline + sn-glycerol-3-phosphate
-
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
isozyme At-GDPD1
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
preferred substrate
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
the brain enzyme is specific for
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoethanolamine + H2O
ethanolamine + sn-glycerol 3-phosphate
-
isozyme At-GDPD1
-
-
?
sn-glycero-3-phosphoethanolamine + H2O
ethanolamine + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoethanolamine + H2O
ethanolamine + sn-glycerol 3-phosphate
-
-
-
-
?
sn-glycero-3-phosphoethanolamine + H2O
ethanolamine + sn-glycerol 3-phosphate
-
-
-
-
?
sn-glycero-3-phosphoglycerol + H2O
glycerol + sn-glycerol 3-phosphate
-
isozyme At-GDPD1
-
-
?
sn-glycero-3-phosphoglycerol + H2O
glycerol + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoglycerol + H2O
glycerol + sn-glycerol 3-phosphate
-
-
-
-
?
sn-glycero-3-phosphoinositol + H2O
inositol + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoinositol + H2O
inositol + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoinositol + H2O
inositol + sn-glycerol 3-phosphate
-
-
-
-
?
additional information
?
-
-
recombinant isozyme AtGPDPL1 shows limited enzymatic activity toward glycerophosphodiesters
-
-
?
additional information
?
-
-
the enzyme is active towards more complex substrates, even if their final product is always glycerol 3-phosphate. It hydrolyzes phosphodiester bonds between adjacent glycerol units. Substrates are polyglycerophosphates, such as purified cell-wall teichoic acid, as well as deacylated, unsubstituted lipoteichoic acid, di(glycerophospho)glycerol (deacylated cardiolipin) and mono(glycerophospho)glycerol
-
-
?
additional information
?
-
-
the enzyme is active towards more complex substrates, even if their final product is always glycerol 3-phosphate. It hydrolyzes phosphodiester bonds between adjacent glycerol units. Substrates are polyglycerophosphates, such as purified cell-wall teichoic acid, as well as deacylated, unsubstituted lipoteichoic acid, di(glycerophospho)glycerol (deacylated cardiolipin) and mono(glycerophospho)glycerol
-
-
?
additional information
?
-
-
no substrates are bis-p-nitrophenylphosphate, ADP, ADP-ribose, ADP-glucose, UDP-glucose
-
-
?
additional information
?
-
-
catabolism of glycerophosphocholine by higher plant cells
-
-
?
additional information
?
-
-
not: bis(4-nitrophenyl)phosphate
-
-
?
additional information
?
-
the enzyme has a broad substrate specificity. It hydrolyzes glycerophosphodiester bonds through its recognition of the glycerophospho moiety, but it does not hydrolyze other types of bonds, such as that of bis(p-nitrophenyl)phosphate. No activity towards phosphatidyl-DL-glycerol or lysophosphatidyl-DL-glycerol
-
-
?
additional information
?
-
the enzyme has a broad substrate specificity. It hydrolyzes glycerophosphodiester bonds through its recognition of the glycerophospho moiety, but it does not hydrolyze other types of bonds, such as that of bis(p-nitrophenyl)phosphate. No activity towards phosphatidyl-DL-glycerol or lysophosphatidyl-DL-glycerol
-
-
?
additional information
?
-
-
enzyme responsible for interaction with immunoglobulin D, important virulence factor
-
-
?
additional information
?
-
high substrate specificity
-
-
?
additional information
?
-
high substrate specificity
-
-
?
additional information
?
-
protein may act as a negative regulator in gene transcription mediated by the MAPK signaling pathways
-
-
?
additional information
?
-
-
protein may act as a negative regulator in gene transcription mediated by the MAPK signaling pathways
-
-
?
additional information
?
-
isozyme GDE2-mediated hydrolysis of the RECK GPI anchor is not a phospholipase D-like hydrolysis, which suggests a different attack of the phosphodiester bond compared to that reported for the other GDE2 substrate sn-glycero-3-phosphocholine
-
-
?
additional information
?
-
isozyme GDE2-mediated hydrolysis of the RECK GPI anchor is not a phospholipase D-like hydrolysis, which suggests a different attack of the phosphodiester bond compared to that reported for the other GDE2 substrate sn-glycero-3-phosphocholine
-
-
?
additional information
?
-
-
the enzyme has a very broad substrate specificity, it catalyzes the hydrolysis not only of glycerophosphoethanolamine, but also of phosphomonoesters, diesters and triesters, in addition to phosphothiolates. The enzyme can hydrolyze several organophosphates
-
-
?
additional information
?
-
-
the metal-bound hydroxide nucleophile is formed in the resting inactive mononuclear form, which becomes catalytically competent upon binding the second metal ion
-
-
?
additional information
?
-
-
high substrate specificity
-
-
?
additional information
?
-
enzyme may be involved in morphological changes of cells
-
-
?
additional information
?
-
-
enzyme may be involved in morphological changes of cells
-
-
?
additional information
?
-
-
important role in neurite growth, a loss of function mutant of Neuro2A fails to form neurites upon retinoic acid treatment
-
-
?
additional information
?
-
-
high substrate specificity
-
-
?
additional information
?
-
-
the enzyme catalyzes cleavage of phosphatidylglycerol to diacylglycerol and glycerophosphate
-
-
?
additional information
?
-
the enzyme catalyzes cleavage of phosphatidylglycerol to diacylglycerol and glycerophosphate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
glycerophosphocholine + H2O
choline + glycerol-3-phosphate
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
?
glycerophosphoinositol + H2O
sn-glycerol 3-phosphate + inositol
-
-
-
?
glycerophosphoserine + H2O
sn-glycerol 3-phosphate + serine
-
-
-
?
L-alpha-glycerophosphocholine + H2O
choline + sn-glycerol-3-phosphate
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
sn-glycero-3-phosphoethanolamine + H2O
ethanolamine + sn-glycerol 3-phosphate
sn-glycero-3-phosphoglycerol + H2O
glycerol + sn-glycerol 3-phosphate
-
isozyme At-GDPD1
-
-
?
sn-glycero-3-phosphoinositol + H2O
inositol + sn-glycerol 3-phosphate
-
-
-
?
additional information
?
-
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
reaction provides choline which is an essential growth factor in bacteria
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
utilization of glycerophosphocholine and incorporation of choline from host cell membranes
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
maintenance of the sn-glycerol-3-phosphate concentration which is essential to enable phospholipid synthesis
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
-
?
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
-
-
-
-
?
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
-
-
-
?
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
-
-
-
?
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
-
-
-
-
?
glycerophosphodiester + H2O
glycerol 3-phosphate + alcohol
-
involved in phospholipids turnover
-
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
-
sn-glycerol-3-phosphate supply is essential for the de novo synthesis of glycerophospholipids
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
important for sn-glycerol-3-phosphate uptake, which serves as carbon and phosphate source
-
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
UgpQ accumulates under conditions of phosphate starvation suggesting a role in the utilization of phosphate from glycerophosphodiesters
sn-glycerol-3-phosphate supply is essential for the de novo synthesis of glycerophospholipids
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
maintenance of the sn-glycerol-3-phosphate concentration which is essential to enable phospholipid synthesis
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
reaction provides ethanolamine which is an essential growth factor in bacteria
-
-
?
L-alpha-glycerophosphocholine + H2O
choline + sn-glycerol-3-phosphate
-
-
-
-
?
L-alpha-glycerophosphocholine + H2O
choline + sn-glycerol-3-phosphate
-
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
isozyme At-GDPD1
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoethanolamine + H2O
ethanolamine + sn-glycerol 3-phosphate
-
isozyme At-GDPD1
-
-
?
sn-glycero-3-phosphoethanolamine + H2O
ethanolamine + sn-glycerol 3-phosphate
-
-
-
-
?
additional information
?
-
-
catabolism of glycerophosphocholine by higher plant cells
-
-
?
additional information
?
-
-
enzyme responsible for interaction with immunoglobulin D, important virulence factor
-
-
?
additional information
?
-
protein may act as a negative regulator in gene transcription mediated by the MAPK signaling pathways
-
-
?
additional information
?
-
-
protein may act as a negative regulator in gene transcription mediated by the MAPK signaling pathways
-
-
?
additional information
?
-
isozyme GDE2-mediated hydrolysis of the RECK GPI anchor is not a phospholipase D-like hydrolysis, which suggests a different attack of the phosphodiester bond compared to that reported for the other GDE2 substrate sn-glycero-3-phosphocholine
-
-
?
additional information
?
-
isozyme GDE2-mediated hydrolysis of the RECK GPI anchor is not a phospholipase D-like hydrolysis, which suggests a different attack of the phosphodiester bond compared to that reported for the other GDE2 substrate sn-glycero-3-phosphocholine
-
-
?
additional information
?
-
enzyme may be involved in morphological changes of cells
-
-
?
additional information
?
-
-
enzyme may be involved in morphological changes of cells
-
-
?
additional information
?
-
-
important role in neurite growth, a loss of function mutant of Neuro2A fails to form neurites upon retinoic acid treatment
-
-
?
additional information
?
-
-
the enzyme catalyzes cleavage of phosphatidylglycerol to diacylglycerol and glycerophosphate
-
-
?
additional information
?
-
the enzyme catalyzes cleavage of phosphatidylglycerol to diacylglycerol and glycerophosphate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
metabolism
the isozyme GDPD5 is a glycerophosphodiester phosphodiesterase that likely participates in regulating choline phospholipid metabolism in breast cancer, which possibly occurs in cooperation with choline kinase alpha and phosphatidylcholine-specific phospholipase D1
evolution
-
phylogenetic analysis, overview
evolution
-
phylogenetic analysis, overview
evolution
-
phylogenetic analysis, overview
evolution
-
phylogenetic analysis, overview
evolution
-
phylogenetic analysis, overview
evolution
-
phylogenetic analysis, overview
evolution
-
phylogenetic analysis, overview
evolution
-
phylogenetic analysis, overview
evolution
phylogenetic analysis, overview
evolution
phylogenetic analysis, overview
evolution
phylogenetic analysis, overview
evolution
phylogenetic analysis, overview
evolution
phylogenetic analysis, overview
evolution
phylogenetic analysis, overview
evolution
phylogenetic analysis, overview
evolution
phylogenetic analysis, overview
evolution
phylogenetic analysis, overview
evolution
phylogenetic analysis, overview
evolution
-
phylogenetic analysis, overview. A common feature of this enzyme family is the presence of the classical triosephosphate isomerase barrel fold
evolution
phylogenetic analysis, overview. Escherichia coli GlpQ and UgpQ possess a significant similarity, suggesting a common evolutionary origin
evolution
-
phylogenetic analysis, overview. PfGDPD shows clear homology with bacterial GP-PDEs
evolution
phylogenetic analysis, overview. The enzyme Pgc1p belongs to the superfamily of phospholipase-C-like enzymes
evolution
-
phylogenetic analysis, overview. The enzyme shows a structure unusual for the enzyme family, the T2047enzyme of Agrobacterium tumefaciens forms a hexamer and, in particular, a trimer of dimers, with a channel passing through the center of the assembly
evolution
-
phylogenetic analysis, overview. The phosphodiesterase GpdQ is unrelated to the Escherichia coli enzyme UgpQ. The crystal structure of GpdQ emphasizes its difference compared to all other bacterial GP-PDEs with respect to the absence of the conserved triosephosphate isomerase barrel fold in the catalytic site. GpdQ is clustered separately in the phylogenetic tree and appears as a structurally distinct GP-PDE, its secondary structure prediction suggests that it more properly belongs to the alpha/beta-sandwich metallo-dependent phosphoesterase family
evolution
the human glycerophosphodiester phosphodiesterase domain (GDPD) containing family consists of 5 isozymes, GDPD1-5
evolution
-
phylogenetic analysis, overview
-
evolution
-
phylogenetic analysis, overview
-
malfunction
-
abrogation of nontypeable Haemophilus influenzae protein D function reduces phosphorylcholine decoration, adherence to airway epithelial A549 cells, and fitness in a chinchilla, Chinchilla lanigera, model of otitis media. Exposure of NTHI to antibodies directed against the vaccine formulation recapitulates the phosphorylcholine decoration and NTHI adherence phenotypes exhibite by PD/GlpQ-deficient NTHI, mechanism(s) of anti-PD/GlpQ antibody-mediated protection from NTHI-induced otitis media, overview
malfunction
ablating GDE2 expression in the spinal cord using small-interfering RNAs results in the loss of post-mitotic motor neurons and an increase in cell death
malfunction
deletion of the YPL110c gene leads to the massive accumulation of glycero-3-phosphocholine
malfunction
deletion of the yqiHIK operon impairs the growth of Bacillus subtilis at high salinity
malfunction
inactivation of gene glpQ results in reduced bacteria growth, loss of hydrogen peroxide production and a complete loss of Mycoplasma pneumoniae cytotoxicity towards HeLa cells
malfunction
isozyme GDE5 expression down-regulation in several types of skeletal muscle atrophies is induced by aging and denervation
malfunction
-
loss-of-function of the plastid-localized isozyme AtGDPD1 induces a decrease of enzyme activity, glycerol 3-phosphate and inorganic phosphate content, and seedling growth rate compared to the wild-type plant
malfunction
the enzyme encoded by glycerophosphodiester phosphodiesterase domain containing 5 is associated with breast cancer malignancy
malfunction
-
abrogation of nontypeable Haemophilus influenzae protein D function reduces phosphorylcholine decoration, adherence to airway epithelial A549 cells, and fitness in a chinchilla, Chinchilla lanigera, model of otitis media. Exposure of NTHI to antibodies directed against the vaccine formulation recapitulates the phosphorylcholine decoration and NTHI adherence phenotypes exhibite by PD/GlpQ-deficient NTHI, mechanism(s) of anti-PD/GlpQ antibody-mediated protection from NTHI-induced otitis media, overview
-
physiological function
-
PD/GlpQ enzymatic activity is predicted to facilitate choline and sn-glycerol-3-phosphate acquisition via the cleavage of L-alpha-glycerophosphocholine, an abundant catabolite of host phospholipids
physiological function
enzyme Pgc1p controls the phosphatidylglycerol content of the cell membranes by cleavage of phosphatidylglycerol to diacylglycerol and glycerophosphate
physiological function
isozyme GDE2 is directly linked to cell differentiation, which triggers motor neuron differentiation, and it acts as an osmoregulated enzyme. GDE2 promotion of neurogenesis follows a different molecular mechanism compared to that postulated for GDE2 osmoregulation of kidney cells, overview. GDE2 up-regulation upon retinoic-acid treatment is sufficient to induce neurite formation that is blocked upon GDE2 downregulation by siRNAs. Isozmye GDE2 is involved in the regulation of neuronal transcriptional programs
physiological function
isozyme GDE5 inhibits skeletal muscle development independent of its enzymatic activity. Isozyme GDE5 expression in brain can contribute to variations in cortical surface area. Decreased isozyme GDE5 expression might represent an adaptation response to counteract the pathology, overview
physiological function
lipoprotein D is not surface-exposed and is not a virulence factor useful for vaccine design
physiological function
-
plastid-localized isozyme AtGDPD1 is devoted to the glycerophosphodiester degradation pathway as a source of inorganic phosphate
physiological function
the enzyme activity contributes to bacterial pathogenicity, overview. The enzyme has all of the properties necessary for its application as an antigenically active carrier protein for conjugate vaccines, mainly because it is a surface-exposed membrane lipoprotein that is highly conserved among different Haemophilus influenzae strains
physiological function
-
the enzyme is considered to be essential during the phase of metamorphosis, when the larvae enter the pupal stage and the organism extensively hydrolyzes its cellular constituents and reassembles the components into the tissues of the adult organism
physiological function
the enzyme is required for glycerol 3-phosphate production starting from deacylated phospholipids. This metabolic pathway appears to contribute to cell proliferation during host infection, which leads to an increased cell density of Borrelia hermsii in the host blood
physiological function
the enzyme is responsible for glycero-3-phosphocholine hydrolysis, which is used as a phosphate source. It might also act by binding potential partners involved in phosphate metabolism
physiological function
the enzyme might contribute to the damage to the human host cell membranes by Mycoplasma hyorhinis, that is involved in human gastric cancer
physiological function
the enzyme might have a role in osmoprotection
physiological function
the functional glycerophosphodiester phosphodiesterase also controls the expression of a set of genes that encode lipoproteins, the glycerol facilitator and a metal ion ABC transporter
physiological function
the primary physiological function of UgpQ is the use of glycerophosphodiesters as a source of phosphate, an activity that is performed more efficiently by UgpQ than by homologue GlpQ. The enzyme might have a role in bacterial pathogenicity
physiological function
the primary physiological function of UgpQ is the use of glycerophosphodiesters as a source of phosphate, an activity that is performed more efficiently by UgpQ than by homologue GlpQ. The ugp-encoded transport system represents another Escherichia coli transport system for sn-glycerol 3-phosphate
physiological function
-
the two isozymes are phosphate-deprivation induced and regulate root hair development and density, suggesting their role in plant acclimation to phosphate deprivation
physiological function
Lactobacillus delbrueckii bacteriophage Ld17
-
GDPD activity is involved in phage adsorption and/or phage genome injection. The GDPD homotrimer is present in the viral baseplate structure involved in phage-host interaction
physiological function
-
GlpQ is essential for growth on glycerolphosphodiesters. Cleavage of glycerophosphorylcholine and its product glycerol 3-phosphate occurs extracellularly allowing other bacteria to benefit from this metabolism
physiological function
GlpQ is essential for growth on glycerolphosphodiesters. Cleavage of glycerophosphorylcholine and its product glycerol 3-phosphate occurs extracellularly allowing other bacteria to benefit from this metabolism
physiological function
-
overexpression lines show higher GDPD activity, phosphate content, root growth, and biomass accumulation as compared with wild type. Silencing of GDPD2 leads to decreased GDPD activity and phosphate content. Most of the phosphate-containing metabolites and fatty acids are elevated in transgenic lines and in overexpression lines higher accumulation of several classes of phospholipids and galactolipids is observed
physiological function
-
GlpQ is essential for growth on glycerolphosphodiesters. Cleavage of glycerophosphorylcholine and its product glycerol 3-phosphate occurs extracellularly allowing other bacteria to benefit from this metabolism
-
physiological function
-
GlpQ is essential for growth on glycerolphosphodiesters. Cleavage of glycerophosphorylcholine and its product glycerol 3-phosphate occurs extracellularly allowing other bacteria to benefit from this metabolism
-
physiological function
-
PD/GlpQ enzymatic activity is predicted to facilitate choline and sn-glycerol-3-phosphate acquisition via the cleavage of L-alpha-glycerophosphocholine, an abundant catabolite of host phospholipids
-
physiological function
-
the enzyme activity contributes to bacterial pathogenicity, overview. The enzyme has all of the properties necessary for its application as an antigenically active carrier protein for conjugate vaccines, mainly because it is a surface-exposed membrane lipoprotein that is highly conserved among different Haemophilus influenzae strains
-
additional information
-
absence of the conserved triosephosphate isomerase barrel fold in the catalytic site, the secondary structure shows an alpha/beta-sandwich
additional information
lipoprotein D has enzyme activity similar to other bacterial enzyme, which is modulated by, but not dependent on, its N-terminal lipidation
additional information
-
proposal of a mechanism of catalysis through two reaction steps, with the glycerol and the phosphate moieties forming a cyclic phosphate intermediate that is stabilized by the calcium ion
additional information
-
the brain enzyme is regionally and developmentally regulated
additional information
-
the enzyme TM1621 structure suggests that the biologically relevant form is a monomer composed of 11 beta-strands, 10 alpha-helices and four 310-helices
additional information
-
the GP-PDE domain localized at the C terminus
additional information
the GP-PDE domain localized at the C terminus
additional information
the organism encodes two potential enzymes (MPN420 or GlpQ, and MPN566), although only GlpQ is functional. MPN566 has no enzymatic activity, and inactivation of its gene does not result in any detectable phenotype
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Larson, T.J.; Ehrmann, M.; Boos, W.
Periplasmic glycerophosphodiester phosphodiesterase of Escherichia coli, a new enzyme of the glp regulon
J. Biol. Chem.
258
5428-5432
1983
Escherichia coli
brenda
Kasahara, M.; Makino, K.; Amemura, M.; Nakata, A.
Nucleotide sequence of the ugpQ gene encoding glycerophosphoryl diester phosphodiesterase of Escherichia coli K-12
Nucleic Acids Res.
17
2854
1989
Escherichia coli
brenda
Brzoska, P.; Boos, W.
Characteristics of a ugp-encoded and phoB-dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the ugp transport system of Escherichia coli
J. Bacteriol.
170
4125-4135
1988
Escherichia coli
brenda
Tommassen, J.; Eiglmeier, K.; Cole, S.T.; Overduin, P.; Larson, T.J.; Boos, W.
Characterization of two genes, glpQ and ugpQ, encoding glycerophosphoryl diester phosphodiesterases of Escherichia coli
Mol. Gen. Genet.
226
321-327
1991
Escherichia coli
brenda
Munson, R.S.; Sasaki, K.
Protein D, a putative immunoglobulin D-binding protein produced by Haemophilus influenzae, is glycerophosphodiester phosphodiesterase
J. Bacteriol.
175
4569-4571
1993
Haemophilus influenzae
brenda
Brzoskia, P.; Boos, W.
The ugp-encoded glycerophosphoryldiester phosphodiesterase, a transport-related enzyme of Escherichia coli
FEMS Microbiol. Rev.
63
115-124
1989
Escherichia coli
-
brenda
McLoughlin, S.Y.; Jackson, C.; Liu, J.W.; Ollis, D.L.
Growth of Escherichia coli coexpressing phosphotriesterase and glycerophosphodiester phosphodiesterase, using paraoxon as the sole phosphorus source
Appl. Environ. Microbiol.
70
404-412
2004
Klebsiella aerogenes
brenda
Porcella, S.F.; Raffel, S.J.; Schrumpf, M.E.; Schriefer, M.E.; Dennis, D.T.; Schwan, T.G.
Serodiagnosis of Louse-Borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis
J. Clin. Microbiol.
38
3561-3571
2000
Borrelia recurrentis
brenda
Shevchenko, D.V.; Sellati, T.J.; Cox, D.L.; Shevchenko, O.V.; Robinson, E.J.; Radolf, J.D.
Membrane topology and cellular location of the Treponema pallidum glycerophosphodiester phosphodiesterase (GlpQ) ortholog
Infect. Immun.
67
2266-2276
1999
Treponema pallidum
brenda
Schwan, T.G.; Battisti, J.M.; Porcella, S.F.; Raffel, S.J.; Schrumpf, M.E.; Fischer, E.R.; Carroll, J.A.; Stewart, P.E.; Rosa, P.; Somerville, G.A.
Glycerol-3-phosphate acquisition in spirochetes: distribution and biological activity of glycerophosphodiester phosphodiesterase (GlpQ) among Borrelia species
J. Bacteriol.
185
1346-1356
2003
Borrelia hermsii, Borrelia sp.
brenda
Van Der Rest, B.; Rolland, N.; Boisson, A.M.; Ferro, M.; Bligny, R.; Douce, R.
Identification and characterisation of plant glycerophosphodiester phosphodiesterase
Biochem. J.
379
601-607
2004
Daucus carota, Arabidopsis thaliana (Q9C907), Arabidopsis thaliana
brenda
Van der Rest, B.; Boisson, A.M.; Gout, E.; Bligny, R.; Douce, R.
Glycerophosphocholine metabolism in higher plant cells. Evidence of a new glyceryl-phosphodiester phosphodiesterase
Plant Physiol.
130
244-255
2002
Daucus carota
brenda
Yanaka, N.; Imai, Y.; Kawai, E.; Akatsuka, H.; Wakimoto, K.; Nogusa, Y.; Kato, N.; Chiba, H.; Kotani, E.; Omori, K.; Sakurai, N.
Novel membrane protein containing glycerophosphodiester phosphodiesterase motif is transiently expressed during osteoblast differentiation
J. Biol. Chem.
278
43595-43602
2003
Homo sapiens (Q9HCC8), Mus musculus (Q640M6), Mus musculus
brenda
Nogusa, Y.; Fujioka, Y.; Komatsu, R.; Kato, N.; Yanaka, N.
Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6
Gene
337
173-179
2004
Mus musculus (Q640M6), Mus musculus
brenda
Fernandez-Murray, J.P.; McMaster, C.R.
Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway
J. Biol. Chem.
280
38290-38296
2005
Saccharomyces cerevisiae
brenda
Bacon, R.M.; Pilgard, M.A.; Johnson, B.J.; Raffel, S.J.; Schwan, T.G.
Glycerophosphodiester phosphodiesterase gene (glpQ) of Borrelia lonestari identified as a target for differentiating Borrelia species associated with hard ticks (Acari:Ixodidae)
J. Clin. Microbiol.
42
2326-2328
2004
Borrelia miyamotoi (Q6UK58), Borrelia lonestari (Q6UK59), Borrelia lonestari, Borrelia miyamotoi FR64B (Q6UK58)
brenda
Santelli, E.; Schwarzenbacher, R.; McMullan, D.; Biorac, T.; Brinen, L.S.; Canaves, J.M.; Cambell, J.; Dai, X.; Deacon, A.M.; Elsliger, M.A.; et.al.
Crystal structure of a glycerophosphodiester phosphodiesterase from Thermotoga maritima (TM1621) at 1.60 A resolution
Proteins
56
167-170
2004
Thermotoga maritima (Q9X1V6), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9X1V6)
brenda
Jackson, C.J.; Carr, P.D.; Kim, H.K.; Liu, J.W.; Ollis, D.L.
The purification, crystallization and preliminary diffraction of a glycerophosphodiesterase from Enterobacter aerogenes
Acta Crystallogr. Sect. F
62
659-661
2006
Klebsiella aerogenes (Q6XBH1)
brenda
Halperin, T.; Orr, N.; Cohen, R.; Hasin, T.; Davidovitch, N.; Klement, E.; Kayouf, R.; Baneth, G.; Cohen, D.; Yavzori, M.
Detection of relapsing fever in human blood samples from Israel using PCR targeting the glycerophosphodiester phosphodiesterase (GlpQ) gene
Acta Trop.
98
189-195
2006
Borrelia persica (Q1EGY6), Borrelia persica
brenda
Patton-Vogt, J.
Transport and metabolism of glycerophosphodiesters produced through phospholipid deacylation
Biochim. Biophys. Acta
1771
337-342
2007
Saccharomyces cerevisiae
brenda
Yanaka, N.
Mammalian glycerophosphodiester phosphodiesterases
Biosci. Biotechnol. Biochem.
71
1811-1818
2007
Haemophilus influenzae, Escherichia coli (P09394), Escherichia coli (P10908)
brenda
Yanaka, N.; Nogusa, Y.; Fujioka, Y.; Yamashita, Y.; Kato, N.
Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells
FEBS Lett.
581
712-718
2007
Mus musculus
brenda
Ohshima, N.; Yamashita, S.; Takahashi, N.; Kuroishi, C.; Shiro, Y.; Takio, K.
Escherichia coli cytosolic glycerophosphodiester phosphodiesterase (UgpQ) requires Mg2+, Co2+, or Mn2+ for its enzyme activity
J. Bacteriol.
190
1219-1223
2008
Escherichia coli K-12, Escherichia coli (P09394), Escherichia coli (P10908), Escherichia coli
brenda
Lang, Q.; Zhang, H.; Li, J.; Yin, H.; Zhang, Y.; Tang, W.; Wan, B.; Yu, L.
Cloning and characterization of a human GDPD domain-containing protein GDPD5
Mol. Biol. Rep.
35
351-359
2007
Homo sapiens (Q8WTR4), Homo sapiens
brenda
Rao, K.N.; Bonanno, J.B.; Burley, S.K.; Swaminathan, S.
Crystal structure of glycerophosphodiester phosphodiesterase from Agrobacterium tumefaciens by SAD with a large asymmetric unit
Proteins Struct. Funct. Bioinform.
65
514-518
2006
Agrobacterium tumefaciens
brenda
Toropainen, M.; Raitolehto, A.; Henckaerts, I.; Wauters, D.; Poolman, J.; Lestrate, P.; Kaeyhty, H.
Pneumococcal Haemophilus influenzae protein D conjugate vaccine induces antibodies that inhibit glycerophosphodiester phosphodiesterase activity of protein D
Infect. Immun.
76
4546-4553
2008
Haemophilus influenzae
brenda
Chang, P.A.; Shao, H.B.; Long, D.X.; Sun, Q.; Wu, Y.J.
Isolation, characterization and molecular 3D model of human GDE4, a novel membrane protein containing glycerophosphodiester phosphodiesterase domain
Mol. Membr. Biol.
25
557-566
2008
Homo sapiens (Q8N9F7), Homo sapiens
brenda
Shi, L.; Liu, J.F.; An, X.M.; Liang, D.C.
Crystal structure of glycerophosphodiester phosphodiesterase (GDPD) from Thermoanaerobacter tengcongensis, a metal ion-dependent enzyme: insight into the catalytic mechanism
Proteins
72
280-288
2008
Caldanaerobacter subterraneus subsp. tengcongensis (Q8RB32), Caldanaerobacter subterraneus subsp. tengcongensis
brenda
Jackson, C.J.; Hadler, K.S.; Carr, P.D.; Oakley, A.J.; Yip, S.; Schenk, G.; Ollis, D.L.
Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference
Acta Crystallogr. Sect. F
64
681-685
2008
Klebsiella aerogenes (Q6XBH1)
brenda
Hadler, K.S.; Mitic, N.; Yip, S.H.; Gahan, L.R.; Ollis, D.L.; Schenk, G.; Larrabee, J.A.
Electronic structure analysis of the dinuclear metal center in the bioremediator glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes
Inorg. Chem.
49
2727-2734
2010
Klebsiella aerogenes (Q6XBH1)
brenda
Hadler, K.S.; Tanifum, E.A.; Yip, S.H.; Mitic, N.; Guddat, L.W.; Jackson, C.J.; Gahan, L.R.; Nguyen, K.; Carr, P.D.; Ollis, D.L.; Hengge, A.C.; Larrabee, J.A.; Schenk, G.
Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes
J. Am. Chem. Soc.
130
14129-14138
2008
Klebsiella aerogenes (Q6XBH1)
brenda
Hadler, K.S.; Gahan, L.R.; Ollis, D.L.; Schenk, G.
The bioremediator glycerophosphodiesterase employs a non-processive mechanism for hydrolysis
J. Inorg. Biochem.
104
211-213
2010
Klebsiella aerogenes
brenda
Santos-Beneit, F.; Rodriguez-Garcia, A.; Apel, A.K.; Martin, J.F.
Phosphate and carbon source regulation of two PhoP-dependent glycerophosphodiester phosphodiesterase genes of Streptomyces coelicolor
Microbiology
155
1800-1811
2009
Streptomyces coelicolor (Q8CJI8), Streptomyces coelicolor (Q93JJ3), Streptomyces coelicolor
brenda
Johnson, R.W.; McGillivary, G.; Denoel, P.; Poolman, J.; Bakaletz, L.O.
Abrogation of nontypeable Haemophilus influenzae protein D function reduces phosphorylcholine decoration, adherence to airway epithelial cells, and fitness in a chinchilla model of otitis media
Vaccine
29
1211-1221
2011
Haemophilus influenzae, Haemophilus influenzae 86-028NP
brenda
Corda, D.; Mosca, M.; Ohshima, N.; Grauso, L.; Yanaka, N.; Mariggio, S.
The emerging physiological roles of the glycerophosphodiesterase family
FEBS J.
281
998-1016
2014
Klebsiella aerogenes, Agrobacterium tumefaciens, Arabidopsis thaliana, Bacillus pumilus, Saccharomyces cerevisiae, Saccharomyces cerevisiae (Q02979), Lupinus albus, Mus musculus, Musca domestica, Plasmodium falciparum, Rattus norvegicus, Streptomyces coelicolor, Thermotoga maritima, Caldanaerobacter subterraneus subsp. tengcongensis, Mycoplasma hyorhinis (E0TL71), Treponema pallidum (O30405), Escherichia coli (P09394), Escherichia coli (P10908), Bacillus subtilis (P54527), Mycoplasma pneumoniae (P75367), Haemophilus influenzae (Q06282), Borrelia hermsii (Q45201), Pasteurella multocida (Q79LP3), Homo sapiens (Q8WTR4), Homo sapiens (Q9NPB8), Staphylococcus aureus (Q99387), Bacillus pumilus DSM 27, Haemophilus influenzae DSM 11121 (Q06282)
brenda
Cao, M.D.; Doepkens, M.; Krishnamachary, B.; Vesuna, F.; Gadiya, M.M.; Loenning, P.E.; Bhujwalla, Z.M.; Gribbestad, I.S.; Glunde, K.
Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer
NMR Biomed.
25
1033-1042
2012
Homo sapiens (Q8WTR4)
brenda
Pedroso, M.M.; Ely, F.; Carpenter, M.C.; Mitic, N.; Gahan, L.R.; Ollis, D.L.; Wilcox, D.E.; Schenk, G.
Mechanistic insight from calorimetric measurements of the assembly of the binuclear metal active site of glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes
Biochemistry
56
3328-3336
2017
Klebsiella aerogenes
brenda
Wang, F.; Lai, L.; Liu, Y.; Yang, B.; Wang, Y.
Expression and characterization of a novel glycerophosphodiester phosphodiesterase from Pyrococcus furiosus DSM 3638 that possesses lysophospholipase D activity
Int. J. Mol. Sci.
17
831
2016
Pyrococcus furiosus (Q8TZI9)
brenda
Cornelissen, A.; Sadovskaya, I.; Vinogradov, E.; Blangy, S.; Spinelli, S.; Casey, E.; Mahony, J.; Noben, J.P.; Dal Bello, F.; Cambillau, C.; van Sinderen, D.
The baseplate of Lactobacillus delbrueckii bacteriophage Ld17 harbors a glycerophosphodiesterase
J. Biol. Chem.
291
16816-16827
2016
Lactobacillus delbrueckii bacteriophage Ld17
brenda
Mehra, P.; Pandey, B.K.; Verma, L.; Giri, J.
A novel glycerophosphodiester phosphodiesterase improves phosphate deficiency tolerance in rice
Plant Cell Environ.
42
1167-1179
2018
Oryza sativa
brenda
Mehra, P.; Giri, J.
Rice and chickpea GDPDs are preferentially influenced by low phosphate and CaGDPD1 encodes an active glycerophosphodiester phosphodiesterase enzyme
Plant Cell Rep.
35
1699-1717
2016
Cicer arietinum (A0A1S2XQM1), Cicer arietinum
brenda
Lidbury, I.D.E.A.; Murphy, A.R.J.; Fraser, T.D.; Bending, G.D.; Jones, A.M.E.; Moore, J.D.; Goodall, A.; Tibbett, M.; Hammond, J.P.; Scanlan, D.J.; Wellington, E.M.H.
Identification of extracellular glycerophosphodiesterases in Pseudomonas and their role in soil organic phosphorus remineralisation
Sci. Rep.
7
2179
2017
Pseudomonas stutzeri, Pseudomonas fluorescens (C3JZ29), Pseudomonas fluorescens SBW25 (C3JZ29), Pseudomonas stutzeri DSM 4166
brenda