Disease on EC 2.7.1.67 - 1-phosphatidylinositol 4-kinase
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1-phosphatidylinositol 4-kinase deficiency
PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome.
22q11 Deletion Syndrome
An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia.
Adenocarcinoma
Membrane-associated phosphatidylinositol kinase of R3230AC mammary tumors and normal mammary glands and effects of insulin on tumor enzyme activity.
Alzheimer Disease
Effects of Alzheimer's disease-related beta amyloid protein fragments on enzymes metabolizing phosphoinositides in brain.
Alzheimer Disease
Evidence for a selective decrease in type 1 phosphatidylinositol kinase activity in brains of patients with Alzheimer's disease.
Alzheimer Disease
Pathophysiological concentrations of amyloid beta proteins directly inhibit rat brain and recombinant human type II phosphatidylinositol 4-kinase activity.
Alzheimer Disease
Platelet phosphatidylinositol kinase activity is not altered in Alzheimer disease.
Alzheimer Disease
Reduced phosphatidylinositol kinase activity in Alzheimer's disease: effects of age and onset.
Alzheimer Disease
Reductions in brain phosphatidylinositol kinase activities in Alzheimer's disease.
Anemia
A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis.
Anemia
Red cell membrane phosphatidylinositol kinase activity in hemolytic anemias and myeloproliferative diseases.
Anemia, Hemolytic, Congenital
Red cell membrane phosphatidylinositol kinase activity in hemolytic anemias and myeloproliferative diseases.
Arthrogryposis
Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis.
Breast Neoplasms
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer.
Breast Neoplasms
Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells.
Breast Neoplasms
Quercetin down-regulates signal transduction in human breast carcinoma cells.
Breast Neoplasms
Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells.
Breast Neoplasms
Using Phosphatidylinositol Phosphorylation as Markers for Hyperglycemic Related Breast Cancer.
Carcinogenesis
Murine pancreatic ductal adenocarcinoma produced by in vitro transduction of polyoma middle T oncogene into the islets of Langerhans.
Carcinogenesis
Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.
Carcinogenesis
Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organisation and lateral diffusion of PI4KIIalpha at the trans-Golgi Network.
Carcinogenesis
Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.
Carcinoma
Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells.
Carcinoma
Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells.
Carcinoma
Evidence for tight coupling of gonadotropin-releasing hormone receptors to phosphatidylinositol kinase in plasma membrane from ovarian carcinomas.
Carcinoma
Linkage of reduction in 1-phosphatidylinositol 4-kinase activity and inositol 1,4,5-trisphosphate concentration in human ovarian carcinoma cells treated with quercetin.
Carcinoma, Hepatocellular
1-Phosphatidylinositol 4-kinase: an enzyme linked with proliferation and malignancy.
Carcinoma, Hepatocellular
Enhanced phosphatidylinositol kinase activity is associated with early stages of hepatocarcinogenesis and hepatocellular carcinoma.
Carcinoma, Hepatocellular
Intracellular signalling: phosphatidylinositol lipid metabolism in cancer cells.
Carcinoma, Hepatocellular
The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells.
Carcinoma, Hepatocellular
Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.
Cholera
Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells.
Contracture
Dependence of cyclopiazonic-acid-induced muscle contractures on extracellular Ca2+.
Cutis Laxa
Novel defect in phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) at the membrane-enzyme interface is associated with metabolic cutis laxa.
Deafness
Phosphatidylinositol 4-kinase ? mutations cause nonsyndromic sensorineural deafness and inner ear malformation.
DiGeorge Syndrome
Accurate diagnosis of spinal muscular atrophy and 22q11.2 deletion syndrome using limited deoxynucleotide triphosphates and high-resolution melting.
DiGeorge Syndrome
Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome.
DiGeorge Syndrome
Failure to confirm association between PIK4CA and psychosis in 22q11.2 deletion syndrome.
Enterovirus Infections
ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites.
Epilepsy
PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome.
Glioblastoma
Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme.
Hemangioma
Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src.
Hepatitis A
ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.
Hepatitis C
Activity-Based Phosphatidylinositol Kinase Probes Detect Changes to Protein-Protein Interactions During Hepatitis C Virus Replication.
Hepatitis C
Anti-Hepatitis C Virus Activity and Toxicity of Type III Phosphatidylinositol-4-Kinase Beta Inhibitors.
Hepatitis C
Discovery of Selective Small Molecule Type III Phosphatidylinositol 4-Kinase Alpha (PI4KIII?) Inhibitors as Anti Hepatitis C (HCV) Agents.
Hepatitis C
Evaluation of phosphatidylinositol-4-kinase III? as a hepatitis C virus drug target.
Hepatitis C
Hepatitis C virus NS5A competes with PI4KB for binding to ACBD3 in a genotype-dependent manner.
Hepatitis C
Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication.
Hepatitis C
Hepatitis C Virus Subverts Human Choline Kinase-? To Bridge Phosphatidylinositol-4-Kinase III? (PI4KIII?) and NS5A and Upregulates PI4KIII? Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication.
Hepatitis C
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase III? (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Hepatitis C
Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication.
Hepatitis C
The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.
Hepatitis C
The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement.
Hermanski-Pudlak Syndrome
Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells.
Hermanski-Pudlak Syndrome
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type II?.
Immune System Diseases
Biallelic PI4KA variants cause neurological, intestinal and immunological disease.
Infections
ANXA2 Facilitates Enterovirus 71 Infection by Interacting with 3D Polymerase and PI4KB to Assist the Assembly of Replication Organelles.
Infections
Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.
Infections
Enterovirus 3A facilitates viral replication by promoting PI4KB-ACBD3 interaction.
Infections
Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication.
Infections
Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening.
Infections
Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase III? or oxysterol binding protein.
Infections
Phosphatidylinositol 4-Kinase III? Is Required for Severe Acute Respiratory Syndrome Coronavirus Spike-mediated Cell Entry.
Infections
West Nile virus replication requires fatty acid synthesis but is independent on phosphatidylinositol-4-phosphate lipids.
Influenza, Human
Multiple roles for phosphatidylinositol 4-kinase in biosynthetic transport in polarized Madin-Darby canine kidney cells.
Insulin Resistance
Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity.
Intellectual Disability
PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome.
Kidney Diseases
APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.
Leukemia
Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity.
Leukemia
The role of phosphatidylinositol 4-kinase type IIalpha in degranulation of RBL-2H3 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Puncta intended: connecting the dots between autophagy and cell stress networks.
Malaria
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.
Medulloblastoma
A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110{gamma} Isoform in Medulloblastoma Cell Proliferation and Chemoresistance.
Myeloproliferative Disorders
Red cell membrane phosphatidylinositol kinase activity in hemolytic anemias and myeloproliferative diseases.
Myocardial Ischemia
Association of the phosphatidylinositol signal pathway with prolonged myocardial ischemia.
Myoclonus
PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome.
Neoplasm Metastasis
Identification of genes related to invasion and metastasis in pancreatic cancer by cDNA representational difference analysis.
Neoplasms
1-Phosphatidylinositol 4-kinase: an enzyme linked with proliferation and malignancy.
Neoplasms
A complex between phosphatidylinositol 4 kinase II? and integrin ?3?1 is required for N-glycan sialylation in cancer cells.
Neoplasms
A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis.
Neoplasms
Aegle marmelos differentially affects hepatic markers of glycolysis, insulin signalling pathway, hypoxia, and inflammation in HepG2 cells grown in fructose versus glucose-rich environment.
Neoplasms
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer.
Neoplasms
Analysis of the microarray gene expression for breast cancer progression after the application modified logistic regression.
Neoplasms
Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme.
Neoplasms
Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells.
Neoplasms
Enhanced phosphatidylinositol kinase activity is associated with early stages of hepatocarcinogenesis and hepatocellular carcinoma.
Neoplasms
Membrane-associated phosphatidylinositol kinase of R3230AC mammary tumors and normal mammary glands and effects of insulin on tumor enzyme activity.
Neoplasms
PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation.
Neoplasms
Polyoma virus middle tumor antigen stimulates membrane-associated protein kinase C at lower levels than required for phosphatidylinositol kinase activation and neoplastic transformation.
Neoplasms
Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase ?- but not ?-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation.
Neoplasms
Silencing of type II phosphatidylinositol 4-kinase ? stabilizes prostate apoptosis response-4 and induces apoptosis in cancer cells.
Neoplasms
The Many Roles of Type II Phosphatidylinositol 4-Kinases in Membrane Trafficking: New Tricks for Old Dogs.
Neoplasms
Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells.
Neoplasms
Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity.
Nervous System Diseases
PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome.
Ovarian Neoplasms
Puncta intended: connecting the dots between autophagy and cell stress networks.
Paramyxoviridae Infections
PI4KB on Inclusion Bodies Formed by ER Membrane Remodeling Facilitates Replication of Human Parainfluenza Virus Type 3.
Paraplegia
Biallelic PI4KA variants cause a novel neurodevelopmental syndrome with hypomyelinating leukodystrophy.
Paraplegia
Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation.
Parkinson Disease
Effects of Alzheimer's disease-related beta amyloid protein fragments on enzymes metabolizing phosphoinositides in brain.
Polycystic Kidney Diseases
Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease.
Polymicrogyria
Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis.
Psychomotor Agitation
PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome.
Sarcoma
1-Phosphatidylinositol 4-kinase: an enzyme linked with proliferation and malignancy.
Sarcoma, Avian
Elevated phosphatidylinositol kinase activity in Rous sarcoma virus-transformed cells. Lack of evidence for enzyme translocation.
Sarcoma, Avian
Phosphatidylinositol kinase activities in normal and Rous sarcoma virus-transformed cells.
Sarcoma, Avian
Phosphatidylinositol kinase activity in virus-transformed and nontransformed cells.
Sarcoma, Avian
Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.
Spastic Paraplegia, Hereditary
Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation.
Starvation
Microautophagy in the yeast vacuole depends on the activities of phosphatidylinositol 4-kinases, Stt4p and Pik1p.
Starvation
Regulation of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae by CDP-diacylglycerol.
Triple Negative Breast Neoplasms
Puncta intended: connecting the dots between autophagy and cell stress networks.
Vesicular Stomatitis
Multiple roles for phosphatidylinositol 4-kinase in biosynthetic transport in polarized Madin-Darby canine kidney cells.
Vesicular Stomatitis
Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex.
Vesicular Stomatitis
Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex.
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