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S-adenosyl-L-methionine + (+/-)beta-methylhistamine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + (R)-alpha-methylhistamine
S-adenosyl-L-homocysteine + ?
S-adenosyl-L-methionine + (S)-alpha-methylhistamine
S-adenosyl-L-homocysteine + ?
S-adenosyl-L-methionine + BI 187004
S-adenosyl-L-homocysteine + 1-(1-methyl-1H-benzimidazole-6-carbonyl)-1,2,3,4,5,5a,10,10a-octahydroindeno[2,1-b]azepine-7-carbonitrile
BI 187004, i.e. an 11beta-hydroxysteroid dehydrogenase 1 inhibitor
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + N-methylhistamine
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
S-adenosyl-L-methionine + homohistamine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
additional information
?
-
S-adenosyl-L-methionine + (R)-alpha-methylhistamine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + (R)-alpha-methylhistamine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + (S)-alpha-methylhistamine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + (S)-alpha-methylhistamine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + N-methylhistamine
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + N-methylhistamine
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
highly specific for histamine
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
highly specific for histamine
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
highly specific for histamine
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
-
-
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
highly specific for histamine
-
?
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
given a negative correlation between diamine oxidase and HMT activities, the fraction of catabolized histamine decreases with increasing HMT activity
-
-
?
additional information
?
-
-
major pathway of histamine metabolism in mammals
-
-
?
additional information
?
-
-
major pathway of histamine metabolism in mammals
-
-
?
additional information
?
-
-
possible role in modulation of histamine mediated reactions in skin
-
-
?
additional information
?
-
-
major enzyme for histamine inactivation in mammalian tissues
-
-
?
additional information
?
-
-
major pathway of histamine metabolism in mammals
-
-
?
additional information
?
-
-
major pathway of histamine metabolism in mammals
-
-
?
additional information
?
-
-
major enzyme for histamine inactivation in mammalian tissues
-
-
?
additional information
?
-
-
major pathway of histamine metabolism in mammals
-
-
?
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(5'-amino-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-[4-(3-piperidin-1-yl-propoxy)-phenyl]-methanone
-
50% inhibition at 0.0020 mM, simultaneously a highly potent H3 receptor ligand
(5'-nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-[4-(3-piperidin-1-yl-propoxy)-phenyl]-methanone
-
50% inhibition at 0.0015 mM, simultaneously a highly potent H3 receptor ligand
(5-nitro-pyridin-2-yl)-[4-(3-piperidin-1-yl-propoxy)-benzyl]-amine
-
50% inhibition at 0.0042 mM, simultaneously a highly potent H3 receptor ligand
(5-nitro-pyridin-2-yl)-{2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-ethyl}-amine
-
50% inhibition at 0.0028 mM, simultaneously a highly potent H3 receptor ligand
(5-nitro-pyridin-2-yl)-{3-[4-(3-piperidin-1-yl-propoxy)-phenyl]-propyl}-amine
-
50% inhibition at 0.0017 mM, simultaneously a highly potent H3 receptor ligand
(5-nitro-pyridin-2-yl)-{4-[4-(3-piperidin-1-yl-propoxy)-phenyl]-butyl}-amine
-
50% inhibition at 0.0017 mM, simultaneously a highly potent H3 receptor ligand
(R)-chloroquine
-
50% inhibition at 0.018 mM, liver enzyme, 50% inhibition at 0.0022 mM, brain enzyme
(S)-chloroquine
-
50% inhibition at 0.005 mM, liver enzyme, 50% inhibition at 0.007 mM, brain enzyme
1-(3-(4-(3,4-dihydro-2H-pyrrol-5-yl)phenoxy)propyl)piperidine
-
50% inhibition at 0.0090 mM, simultaneously a highly potent H3 receptor ligand
2-(3-piperidin-1-ylpropoxy)-1,3-benzothiazole quinoline
-
50% inhibition at 0.021 mM, simultaneously a highly potent H3 receptor ligand
-
2-(4-hydroperoxyphenyl)-6-methyl-4H-chromen-4-one
-
-
2-Bromolysergic acid diethylamide
-
-
2-Methylhistamine
-
strong
3,6-dimethyl-2-phenyl-4H-chromen-4-one
-
-
3-bromo-6-chloro-2-phenyl-4H-chromen-4-one
-
-
3-bromo-6-methyl-2-phenyl-4H-chromen-4-one
-
-
3-chloro-6-methyl-2-phenyl-4H-chromen-4-one
-
-
3-Methylhistamine
-
strong
4-(dimethylamino)butyl carbamimidothioate
-
SKF-91488
5-nitro-2-(3-piperidin-1-ylpropoxy)pyridine
-
50% inhibition at 0.034 mM, simultaneously a highly potent H3 receptor ligand
5-nitro-N-(4-(3-piperidin-1-ylpropoxy)phenyl)pyridin-2-amine
-
50% inhibition at 0.0038 mM, simultaneously a highly potent H3 receptor ligand
6-(3-piperidin-1-ylpropoxy)pyridin-3-amine
-
50% inhibition at 0.053 mM, simultaneously a potent H3 receptor ligand
6-chloro-2-phenyl-4H-chromen-4-one
-
-
6-methyl-2-phenyl-4H-chromen-4-one
-
-
6-piperidin-1-yl-1-[4-(3-piperidin-1-yl-propoxy)-phenyl]-hexan-1-one
-
50% inhibition at 0.0089 mM, simultaneously a highly potent H3 receptor ligand
7-chloro-4-(3-piperidin-1-ylpropoxy)quinoline
-
50% inhibition at 0.0026 mM, simultaneously a potent H3 receptor ligand
8-(3-(1H-imidazol-4-yl)propoxy)-5-nitroquinoline
-
50% inhibition at 0.0117 mM, simultaneously a highly potent H3 receptor ligand
8-bromo-6-chloro-2-phenyl-4H-chromen-4-one
-
-
8-bromo-6-methyl-2-phenyl-4H-chromen-4-one
-
-
bromo-lysergic acid diethylamide
-
55% inhibition at 0.005 mM
diphenhydramine
potent HNMT inhibitor, occupies the histamine-binding site, thus blocks access to the enzymes active site
Impromidine
-
competitive, reversible
N-(2-(1H-imidazol-4-yl)ethyl)-1,2,3,4-tetrahydroacridin-9-amine
-
50% inhibition at 0.000086 mM, simultaneously a highly potent H3 receptor ligand
N-(2-(1H-imidazol-4-yl)ethyl)-N-methylquinolin-4-amine
-
50% inhibition at 0.000079 mM, simultaneously a highly potent H3 receptor ligand
N-(2-(1H-imidazol-4-yl)ethyl)quinolin-4-amine
-
50% inhibition at 0.000055 mM, simultaneously a highly potent H3 receptor ligand
N-(3-(1H-imidazol-4-yl)propyl)-1,2,3,4-tetrahydroacridin-9-amine
-
50% inhibition at 0.000035 mM, simultaneously a highly potent H3 receptor ligand
N-(3-(1H-imidazol-4-yl)propyl)-2-methylquinolin-4-amine
-
50% inhibition at 0.000054 mM, simultaneously a highly potent H3 receptor ligand
N-(3-(1H-imidazol-4-yl)propyl)-N-methylquinolin-4-amine
-
50% inhibition at 0.000035 mM, simultaneously a highly potent H3 receptor ligand
N-(3-(1H-imidazol-4-yl)propyl)quinolin-4-amine
-
50% inhibition at 0.000024 mM, simultaneously a highly potent H3 receptor ligand
N-[2(benzhydryloxy)ethyl] N N-dimethylamine
-
diphenhydramine, competitive inhibitor
N2-[2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-ethyl]-pyridine-2,5-diamine
-
50% inhibition at 0.00031 mM, simultaneously a highly potent H3 receptor ligand
N2-[3-[4-(3-piperidin-1-yl-propoxy)-phenyl]-propyl]-pyridine-2,5-diamine
-
50% inhibition at 0.0013 mM, simultaneously a highly potent H3 receptor ligand
N2-[4-[4-(3-piperidin-1-yl-propoxy)-phenyl]-butyl]-pyridine-2,5-diamine
-
50% inhibition at 0.00034 mM, simultaneously a highly potent H3 receptor ligand
Nalpha-methylhistamine
-
weak
p-hydroxymercuribenzoate
-
complete inhibition at 0.1 mM
tryptamine
-
and the hydroxyl derivative
tyramine
-
and the hydroxyl derivative
[4-(3-piperidin-1-yl-propoxy)-phenyl]-(1-quinolin-4-yl-piperidin-4-yl)-methanone
-
50% inhibition at 0.00031 mM, simultaneously a highly potent H3 receptor ligand
1-Methylhistamine
-
-
1-Methylhistamine
-
strong
amodiaquine
-
-
amodiaquine
potent HNMT inhibitor, occupies the histamine-binding site, thus blocks access to the enzymes active site
amodiaquine
inhibits the reaction with BI 187004
chlorpromazine
-
60% inhibition at o.oo5 mM
histamine
-
not
iodoacetamide
-
complete inhibition at 0.01 mM
iodoacetamide
-
activation
Methylhistamine
-
40% inhibition at 0.1 mM
Metoprine
-
-
Metoprine
potent HNMT inhibitor, occupies the histamine-binding site, thus blocks access to the enzymes active site
p-chloromercuribenzoate
-
90% inhibition at 0.01 mM
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
S-adenosylhomocysteine
-
-
S-adenosylhomocysteine
-
-
S-adenosylhomocysteine
-
-
serotonin
-
33% inhibition at 0.005 mM
SKF 91488
-
-
tacrine
-
50% inhibition at 0.00046 mM for enzyme of embryonic kidney, at 0.0007 mM for recombinant brain enzyme
tacrine
potent HNMT inhibitor, occupies the histamine-binding site, thus blocks access to the enzymes active site
tacrine
-
50% inhibition at 0.00029 mM
additional information
-
overview: adenosine analogs bearing a lipophilic side chain
-
additional information
-
not inhibitory: S-adenosyl-L-methionine
-
additional information
-
not inhibitory: galanthamine up to 0.001 mM
-
additional information
near the N-terminus of HNMT, several aromatic residues (Phe9, Tyr15, and Phe19) adopt different rotamer conformations or become disordered in the enzyme-inhibitor complexes, accommodating the diverse, rigid hydrophobic groups of the inhibitors, maximized shape complementarity between the protein aromatic side-chains and aromatic rings of the inhibitors are responsible for the tight binding of the different inhibitors
-
additional information
-
not inhibitory: galanthamine up to 0.001 mM
-
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Brown, D.D.; Tomchick, R.; Axelrod, J.
The distribution and properties of a histamine-methylating enzyme
J. Biol. Chem.
234
2948-2950
1959
Cavia porcellus, Oryctolagus cuniculus, Felis catus, Mus musculus, Rattus norvegicus
brenda
Axelrod, J.
Histamine N-methyltransferase (pig liver)
Methods Enzymol.
17
766-769
1971
Cavia porcellus, Sus scrofa
-
brenda
Barth, H.; Lorenz, W.; Niemeyer, I.
Inhibition and activation of histamine methyltransferase by methylated histamines
Hoppe-Seyler's Z. Physiol. Chem.
354
1021-1026
1973
Sus scrofa
brenda
Francis, D.M.; Thompson, M.F.; Greaves, M.W.
The kinetic properties and reaction mechanism of histamine methyltransferase from human skin
Biochem. J.
187
819-828
1980
Homo sapiens
brenda
Bowsher, R.R.; Verburg, K.M.; Henry, D.P.
Rat histamine N-methyltransferase. Quantification, tissue distribution, purification, and immunologic properties
J. Biol. Chem.
258
12215-12220
1983
Rattus norvegicus
brenda
Harvima, R.J.; Kajander, E.O.; Harvima, I.T.; Fraki, J.E.
Purification and partial characterization of rat kidney histamine-N-methyltransferase
Biochim. Biophys. Acta
841
42-49
1985
Rattus norvegicus
brenda
Fukuda, H.; Yamatodani, A.; Imamura, I.; Maeyama, K.; Watanabe, T.; Wada, H.
High-performance liquid chromatographic determination of histamine N-methyltransferase activity
J. Chromatogr.
567
459-464
1991
Rattus norvegicus
brenda
Nishibori, M.; Oishi, R.; Itoh, Y.; Saeki, K.
Purification and partial characterization of histamine N-methyltransferase from bovine brain
Neurochem. Int.
19
135-141
1991
Bos taurus
-
brenda
Scott, M.C.; Guerciolini, R.; Szumlanski, C.; Weinshilboum, R.M.
Mouse kidney histamine N-methyltransferase: assay conditions, biochemical properties and strain variation
Agents Actions
32
194-202
1991
Homo sapiens, Mus musculus
brenda
Crooks, P.A.; Hassan, S.F.; Benghiat, E.; Hemrick-Luecke, S.K.; Fuller, R.W.
5'-Thioadenosine derivatives as potent and selective inhibitors of histamine N-methyltransferase
Drug Metabol. Drug Interact.
7
111-141
1989
Cavia porcellus
brenda
Rhim, H.; Choi, M.U.
Purification and general characterization of rat brain histamine N-methyltransferase
Hanguk Saenghwahakhoe Chi
22
455-461
1989
Rattus norvegicus
-
brenda
Gitomer, W.L.; Tipton, K.F.
Purification and kinetic properties of ox brain histamine N-methyltransferase
Biochem. J.
233
669-676
1986
Bos taurus
brenda
Fuhr, N.; Kownatzki, E.
Inhibition of rat kidney histamine-N-methyltransferase by biogenic amines
Pharmacology
32
114-120
1986
Rattus norvegicus
brenda
Barth, H.; Schunack, W.; Crombach, M.; Lorenz, W.
Gastric histamine methyltransferase: different methylation rates for enantiomers of side-chain methylated histamine analogues using a highly purified enzyme preparation
Agents Actions
14
346-350
1984
Sus scrofa
brenda
Matuszewska, B.; Borchardt, R.T.
Guinea pig brain histamine N-methyltransferase: purification and partial characterization
J. Neurochem.
41
113-118
1983
Cavia porcellus
brenda
Dent, C.; Nilam, F.; Smith, I.R.
Sidechain-modified histamine analogues as substrates for histamine N-methyltransferase
Biochem. Pharmacol.
31
2297-2300
1982
Cavia porcellus
brenda
Beaven, M.A.; Roderick, N.B.
Impromidine, a potent inhibitor of histamine methyltransferase (HMT) and diamine oxidase (DAO)
Biochem. Pharmacol.
29
2897-2900
1980
Rattus norvegicus
brenda
Thithapandha, A.; Cohn, V.H.
Brain histamine N-methyltransferase purification, mechanism of action, and inhibition by drugs
Biochem. Pharmacol.
27
263-271
1978
Cavia porcellus
brenda
Matuszewska, B.; Borchardt, R.T.
Rat kidney histamine N-methyltransferase: purification and partial characterization
Prep. Biochem.
15
145-157
1985
Rattus norvegicus
brenda
Borchardt, R.T.; Matuszewska, B.
S-adenosylmethionine dependent transmethylation of histamine: Purification and partial characterization of guinea pig brain and rat kidney histamine N-methyltransferase
Adv. Biosci.
51
163-172
1985
Cavia porcellus, Rattus norvegicus
-
brenda
Horton, J.R.; Sawada, K.; Nishibori, M.; Zhang, X.; Cheng, X.
Two polymorphic forms of human histamine methyltransferase. Structural, thermal, and kinetic comparisons
Structure
9
837-849
2001
Homo sapiens (P50135), Homo sapiens
brenda
Takemura, M.; Imamura, I.; Mizuguchi, H.; Fukui, H.; Yamatodani, A.
Tissue distribution of histamine N-methyltransferase-like immunoreactivity in rodents
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54
1059-1071
1994
Cavia porcellus, Mus musculus, Rattus norvegicus
brenda
Yamauchi, K.; Sekizawa, K.; Suzuki, H.; Nakazawa, H.; Ohkawara, Y.; Katayose, D.; Ohtsu, H.; Tamura, G.; Shibahara, S.; et al.
Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway
Am. J. Physiol.
267
L342-L349
1994
Homo sapiens
brenda
Tahara, A.; Nishibori, M.; Ohtsuka, A.; Sawada, K.; Sakiyama, J.; Saeki, K.
Immunohistochemical localization of histamine N-methyltransferase in guinea pig tissues
J. Histochem. Cytochem.
48
943-954
2000
Cavia porcellus
brenda
Preuss, C.V.; Wood, T.C.; Szumlanski, C.L.; Raftogianis, R.B.; Otterness, D.M.; Girard, B.; Scott, M.C.; Weinshilboum, R.M.
Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity
Mol. Pharmacol.
53
708-717
1998
Homo sapiens
brenda
Donatelli, P.; Marchi, G.; Giuliani, L.; Gustafsson, L.L.; Pacifici, G.M.
Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain
Eur. J. Clin. Pharmacol.
47
345-349
1994
Homo sapiens
brenda
Pang, Y.P.; Zheng, X.E.; Weinshilboum, R.M.
Theoretical 3D model of histamine N-methyltransferase: Insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability
Biochem. Biophys. Res. Commun.
287
204-208
2001
Homo sapiens (P50135), Homo sapiens
brenda
Schwelberger, H.G.; Drasche, A.
Structure and expression of porcine histamine N-methyltransferase
Inflamm. Res.
51
S85-S86
2002
Sus scrofa
-
brenda
Oroszi, G.; Enoch, M.A.; Chun, J.; Virkkunen, M.; Goldman, D.
Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations
Alcohol. Clin. Exp. Res.
29
303-309
2005
Homo sapiens
brenda
Grassmann, S.; Apelt, J.; Sippl, W.; Ligneau, X.; Pertz, H.H.; Zhao, Y.H.; Arrang, J.M.; Ganellin, C.R.; Schwartz, J.C.; Schunack, W.; Stark, H.
Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities
Bioorg. Med. Chem.
11
2163-2174
2003
Rattus norvegicus
brenda
Huetz, G.N.; Schwelberger, H.G.
Simultaneous purification of the histamine degrading enzymes diamine oxidase and histamine N-methyltransferase from the same tissue
Inflamm. Res.
52
S65-S66
2003
Sus scrofa
-
brenda
Kuefner, M.A.; Schwelberger, H.G.; Weidenhiller, M.; Hahn, E.G.; Raithel, M.
Both catabolic pathways of histamine via histamine-N-methyl-transferase and diamine oxidase are diminished in the colonic mucosa of patients with food allergy
Inflamm. Res.
53
S31-S32
2004
Homo sapiens
-
brenda
Taraschenko, O.D.; Barnes, W.G.; Herrick-Davis, K.; Yokoyama, Y.; Boyd, D.L.; Hough, L.B.
Actions of tacrine and galanthamine on histamine-N-methyltransferase
Methods Find. Exp. Clin. Pharmacol.
27
161-165
2005
Homo sapiens, Rattus norvegicus
brenda
Apelt, J.; Grassmann, S.; Ligneau, X.; Pertz, H.H.; Ganellin, C.R.; Arrang, J.M.; Schwartz, J.C.; Schunack, W.; Stark, H.
Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives
Pharmazie
60
97-106
2005
Rattus norvegicus
brenda
Feurle, J.; Rajtar, S.; Irman-Florjanc, T.; Schwelberger, H.G.
Molecular cloning of guinea-pig diamine oxidase and histamine N-methyltransferase
Inflamm. Res.
55
S59-S60
2006
Cavia porcellus
-
brenda
Horton, J.R.; Sawada, K.; Nishibori, M.; Cheng, X.
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs
J. Mol. Biol.
353
334-344
2005
Homo sapiens (P50135)
brenda
Aschenbach, J.R.; Schwelberger, H.G.; Ahrens, F.; Fuerll, B.; Gaebel, G.
Histamine inactivation in the colon of pigs in relationship to abundance of catabolic enzymes
Scand. J. Gastroenterol.
41
712-719
2006
Sus scrofa
brenda
Rutherford, K.; Parson, W.W.; Daggett, V.
The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics
Biochemistry
47
893-901
2008
Homo sapiens (P50135), Homo sapiens
brenda
Cao, H.; Mei, Q.; Zhang, L.; Xu, J.
C314T polymorphism in histamine N-methyltransferase gene and susceptibility to duodenal ulcer in Chinese population.
Clin. Chim. Acta
391
130
2008
Homo sapiens
-
brenda
Reuter, M.; Jeste, N.; Klein, T.; Hennig, J.; Goldman, D.; Enoch, M.; Oroszi, G.
Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians
Drug Alcohol Depend.
87
69-75
2007
Homo sapiens
brenda
Yokoyama, A.; Mori, S.; Takahashi, H.K.; Kanke, T.; Wake, H.; Nishibori, M.
Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice
Eur. J. Pharmacol.
558
179-184
2007
Mus musculus
brenda
Rajtar, S.; Irman-Florjanc, T.
Amitriptyline affects histamine-N-methyltransferase and diamine oxidase activity in rats and guinea pigs
Eur. J. Pharmacol.
574
201-208
2007
Cavia porcellus, Rattus norvegicus
brenda
Ledesma, M.C.; Garcia-Martin, E.; Alonso-Navarro, H.; Martinez, C.; Jimenez-Jimenez, F.J.; Benito-Leon, J.; Puertas, I.; Rubio, L.; Lopez-Alburquerque, T.; Agundez, J.A.
The Nonsynonymous Thr105Ile Polymorphism of the Histamine N-Methyltransferase is Associated to the Risk of Developing Essential Tremor
Neuromolecular Med.
10
356-361
2008
Homo sapiens
brenda
Huang, C.C.; Huang, C.W.; Cheng, Y.S.; Yu, J.
Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants
BMC Dev. Biol.
8
31
2008
Danio rerio
brenda
Kim, S.H.; Kang, Y.M.; Kim, S.H.; Cho, B.Y.; Ye, Y.M.; Hur, G.Y.; Park, H.S.
Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria
Allergy
64
213-221
2009
Homo sapiens
brenda
Dave, S.; Rahatgaonkar, A.
Computational evaluation of 2-phenyl-4H-chromen-4-one analogues as antihistamines: Potential histamine N-methyltransferase (HMT) inhibitors
E-J. Chem.
6
1009-1016
2009
Homo sapiens
-
brenda
von Mach-Szczypi?ski, J.; Stanosz, S.; Sieja, K.; Stanosz, M.
Histamine and its metabolizing enzymes in tissues of primary ductal breast cancer
Eur. J. Gynaecol. Oncol.
30
509-511
2009
Homo sapiens
brenda
Osredkar, D.; Burnik-Papler, T.; Pecavar, B.; Kralj-Iglic, V.; Krzan, M.
Kinetic and pharmacological properties of [(3)H]-histamine transport into cultured type 1 astrocytes from neonatal rats
Inflamm. Res.
58
94-102
2009
Rattus norvegicus
brenda
Agundez, J.; Luengo, A.; Herraez, O.; Martinez, C.; Alonso-Navarro, H.; Jimenez-Jimenez, F.; Garcia-Martin, E.
Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinsons disease
Neuromolecular Med.
10
10-16
2008
Homo sapiens (P50135), Homo sapiens
brenda
Palada, V.; Terzi?, J.; Mazzulli, J.; Bwala, G.; Hagenah, J.; Peterlin, B.; Hung, A.Y.; Klein, C.; Krainc, D.
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinsons disease
Neurobiol. Aging
33
836.e1-3
2012
Homo sapiens
brenda
Kuefner, M.A.; Feurle, J.; Petersen, J.; Uder, M.; Schwelberger, H.G.
Influence of iodinated contrast media on the activities of histamine inactivating enzymes diamine oxidase and histamine N-methyltransferase in vitro
Allergol. Immunopathol. (Madr.)
42
324-328
2014
Homo sapiens (P50135), Homo sapiens
brenda
Tongsook, C.; Niederhauser, J.; Kronegger, E.; Straganz, G.; Macheroux, P.
Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability
Biochim. Biophys. Acta
1863
188-199
2017
Homo sapiens (P50135), Homo sapiens
brenda
Jia, H.Z.; Liu, S.L.; Zou, Y.F.; Chen, X.F.; Yu, L.; Wan, J.; Zhang, H.Y.; Chen, Q.; Xiong, Y.; Yu, B.; Zhang, W.
MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase
Cell. Mol. Biol. (Noisy-le-grand)
64
103-107
2018
Homo sapiens (P50135), Homo sapiens
brenda
Maw, H.H.; Zeng, X.; Campbell, S.; Taub, M.E.; Teitelbaum, A.M.
N-Methylation of BI 187004 by thiol S-methyltransferase
Drug Metab. Dispos.
46
770-778
2018
Homo sapiens (P50135), Homo sapiens
brenda
Naganuma, F.; Nakamura, T.; Yoshikawa, T.; Iida, T.; Miura, Y.; Karpati, A.; Matsuzawa, T.; Yanai, A.; Mogi, A.; Mochizuki, T.; Okamura, N.; Yanai, K.
Histamine N-methyltransferase regulates aggression and the sleep-wake cycle
Sci. Rep.
7
15899
2017
Mus musculus (Q91VF2)
brenda