Disease on EC 2.1.1.367 - [histone H3]-lysine9 N-methyltransferase
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Adenocarcinoma of Lung
Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma.
Arrhythmias, Cardiac
Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
Astrocytoma
miR-101 reverses hypomethylation of the PRDM16 promoter to disrupt mitochondrial function in astrocytoma cells.
Atherosclerosis
PRDM16 Upregulation Induced by MicroRNA-448 Inhibition Alleviates Atherosclerosis via the TGF-? Signaling Pathway Inactivation.
Bone Diseases, Metabolic
Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease.
Bone Diseases, Metabolic
Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.
Bone Marrow Failure Disorders
Congenital hypoplastic bone marrow failure associated with a de novo partial deletion of the MECOM gene at 3q26.2.
Bone Marrow Failure Disorders
Somatic MECOM mosaicism in a patient with congenital bone marrow failure without a radial abnormality.
Breast Neoplasms
Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice.
Carcinogenesis
Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis.
Carcinogenesis
PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.
Carcinoma
PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.
Cardiomegaly
Prdm16 Deficiency Leads to Age-Dependent Cardiac Hypertrophy, Adverse Remodeling, Mitochondrial Dysfunction, and Heart Failure.
Cardiomyopathies
Cardiomyopathy due to PRDM16 mutation: First description of a fetal presentation, with possible modifier genes.
Cardiomyopathies
Co-occurrence of orofacial clefts and clubfoot phenotypes in a sub-Saharan African cohort: Whole-exome sequencing implicates multiple syndromes and genes.
Cardiomyopathies
Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy.
Cardiomyopathies
Loss of PRDM16 is unlikely to cause cardiomyopathy in 1p36 deletion syndrome.
Cardiomyopathy, Dilated
Cardiac-specific inactivation of Prdm16 effects cardiac conduction abnormalities and cardiomyopathy-associated phenotypes.
Cardiomyopathy, Dilated
Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
Cleft Lip
[Associations among PRDM16 polymorphisms, environmental exposure factors during mother's pregnancy, and nonsyndromic cleft lip with or without cleft palate].
Cleft Palate
A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development.
Cleft Palate
[Associations among PRDM16 polymorphisms, environmental exposure factors during mother's pregnancy, and nonsyndromic cleft lip with or without cleft palate].
Colorectal Neoplasms
Intratumoral Heterogeneity of Frameshift Mutations in MECOM Gene is Frequent in Colorectal Cancers with High Microsatellite Instability.
Congenital Abnormalities
Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.
Coronary Artery Disease
Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure.
Coronary Artery Disease
Type 2 diabetes is associated with decreased PGC1? expression in epicardial adipose tissue of patients with coronary artery disease.
Death, Sudden, Cardiac
Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
Diabetes Mellitus
Type 2 diabetes is associated with decreased PGC1? expression in epicardial adipose tissue of patients with coronary artery disease.
Diabetes Mellitus, Type 2
The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1? signalling pathway.
Diabetes Mellitus, Type 2
Type 2 diabetes is associated with decreased PGC1? expression in epicardial adipose tissue of patients with coronary artery disease.
Epilepsy
Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis.
Epilepsy
Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility.
Essential Hypertension
[Association study of PRDM16 gene polymorphisms with essential hypertension in Xinjiang Uygur population].
Fanconi Anemia
Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling.
Fatty Liver
Gain of Metabolic Benefit with Ablation of miR-149-3p from Subcutaneous Adipose Tissue in Diet-Induced Obese Mice.
Glioblastoma
Expression of MECOM is associated with unfavorable prognosis in glioblastoma multiforme.
Granulomatous Disease, Chronic
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Heart Diseases
Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy.
Heart Failure
Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure.
Heart Failure
Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
Heart Failure
Prdm16 Deficiency Leads to Age-Dependent Cardiac Hypertrophy, Adverse Remodeling, Mitochondrial Dysfunction, and Heart Failure.
Heart Septal Defects, Ventricular
Genome-wide methylation analysis identifies novel CpG loci for perimembranous ventricular septal defects in human.
Hemangioblastoma
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
Hematologic Diseases
[Expression of HOXB4, PRDM16 and HOXA9 in Patients with Acute Myeloid Leukemia and Its Clinical Significance].
Hematologic Neoplasms
Retroviral gene therapy for X-linked chronic granulomatous disease: results from phase I/II trial.
Hydrocephalus
Prdm16 is required for the maintenance of neural stem cells in the postnatal forebrain and their differentiation into ependymal cells.
Hypertension
Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure.
Hypogonadism
Co-occurrence of orofacial clefts and clubfoot phenotypes in a sub-Saharan African cohort: Whole-exome sequencing implicates multiple syndromes and genes.
Infections
QTL Mapping for Resistance to Iridovirus in Asian Seabass Using Genotyping-by-Sequencing.
Insulin Resistance
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Ppar?.
Insulin Resistance
Gain of Metabolic Benefit with Ablation of miR-149-3p from Subcutaneous Adipose Tissue in Diet-Induced Obese Mice.
Insulin Resistance
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Insulin Resistance
Ononitol monohydrate enhances PRDM16 & UCP-1 expression, mitochondrial biogenesis and insulin sensitivity via STAT6 and LTB
Insulin Resistance
PRDM16 sustains white fat gene expression profile in human adipocytes in direct relation with insulin action.
Insulin Resistance
Reprogrammed Functional Brown Adipocytes Ameliorate Insulin Resistance and Dyslipidemia in Diet-Induced Obesity and Type 2 Diabetes.
Lecithin Cholesterol Acyltransferase Deficiency
Novel metabolic phenotypes in lecithin cholesterol acyltyransferase-deficient mice.
Leukemia
Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo.
Leukemia
Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells.
Leukemia
Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition.
Leukemia
MECOM (EVI1) Rearrangements: A Review and Case Report of Two MDS Patients with Complex 3q Inversion/Deletions.
Leukemia
Novel RUNX1-PRDM16 fusion transcripts in a patient with acute myeloid leukemia showing t(1;21)(p36;q22).
Leukemia
PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.
Leukemia
PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity.
Leukemia
Selection for Evi1 activation in myelomonocytic leukemia induced by hyperactive signaling through wild-type NRas.
Leukemia
SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.
Leukemia
[Expression of HOXB4, PRDM16 and HOXA9 in Patients with Acute Myeloid Leukemia and Its Clinical Significance].
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cryptic and partial deletions of PRDM16 and RUNX1 without t(1;21)(p36;q22) and/or RUNX1-PRDM16 fusion in a case of progressive chronic myeloid leukemia: a complex chromosomal rearrangement of underestimated frequency in disease progression?
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
MECOM: A Very Interesting Gene Involved also in Lymphoid Malignancies.
Leukemia, Myeloid
Overexpression of PRDM16 in the presence and absence of the RUNX1/PRDM16 fusion gene in myeloid leukemias.
Leukemia, Myeloid, Acute
Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia.
Leukemia, Myeloid, Acute
Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo.
Leukemia, Myeloid, Acute
H2AFY is a novel fusion partner of MECOM in acute myeloid leukemia.
Leukemia, Myeloid, Acute
High PRDM16 expression predicts poor outcomes in adult acute myeloid leukemia patients with intermediate cytogenetic risk: a comprehensive cohort study from a single Chinese center.
Leukemia, Myeloid, Acute
Lenalidomide Plus Hypomethylating Agent as a Treatment Option in Acute Myeloid Leukemia With Recurrent Genetic Abnormalities-AML With inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM.
Leukemia, Myeloid, Acute
MECOM: A Very Interesting Gene Involved also in Lymphoid Malignancies.
Leukemia, Myeloid, Acute
Molecular characterization of the rare translocation t(3;10)(q26;q21) in an acute myeloid leukemia patient.
Leukemia, Myeloid, Acute
PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.
Leukemia, Myeloid, Acute
The closely related rare and severe acute myeloid leukemias carrying EVI1 or PRDM16 rearrangements share singular biological features.
Leukemia, Myeloid, Acute
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.
Leukemia, Myeloid, Acute
The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
The subtype-specific features of EVI1 and PRDM16 in acute myeloid leukemia.
Leukemia, Myeloid, Acute
[Expression of HOXB4, PRDM16 and HOXA9 in Patients with Acute Myeloid Leukemia and Its Clinical Significance].
Lymphocytosis
Persistent polyclonal binucleated B-cell lymphocytosis and MECOM gene amplification.
Lymphoma, Non-Hodgkin
MECOM: A Very Interesting Gene Involved also in Lymphoid Malignancies.
Metabolic Syndrome
Association of genetic variations of PRDM16 with metabolic syndrome in a general Xinjiang Uygur population.
Migraine Disorders
Association between PRDM16, MEF2D, TRPM8, LRP1 gene polymorphisms and migraine susceptibility in the She ethnic population in China.
Migraine Disorders
Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis.
Migraine Disorders
Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses.
Migraine Disorders
Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility.
Migraine Disorders
PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients.
Migraine Disorders
rs2651899 variant is associated with risk for migraine without aura from North Indian population.
Migraine with Aura
Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis.
Migraine without Aura
Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis.
Migraine without Aura
Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility.
Migraine without Aura
PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients.
Myelodysplastic Syndromes
MECOM: A Very Interesting Gene Involved also in Lymphoid Malignancies.
Myelodysplastic Syndromes
PRDM16 (1p36) translocations define a distinct entity of myeloid malignancies with poor prognosis but may also occur in lymphoid malignancies.
Myelodysplastic Syndromes
PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.
Neoplasms
Complex chromosomal rearrangements leading to MECOM overexpression are recurrent in myeloid malignancies with various 3q abnormalities.
Neoplasms
Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies.
Neoplasms
Deciphering the complexities of MECOM rearrangement-driven chromosomal aberrations.
Neoplasms
Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.
Neoplasms
EVI1, a target gene for amplification at 3q26, antagonizes transforming growth factor-?-mediated growth inhibition in hepatocellular carcinoma.
Neoplasms
Expression of MECOM is associated with unfavorable prognosis in glioblastoma multiforme.
Neoplasms
Genetic heterogeneity after first-line chemotherapy in high-grade serous ovarian cancer.
Neoplasms
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms.
Neoplasms
Genome-wide identification of transcription factors that are critical to non-small cell lung cancer.
Neoplasms
Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer.
Neoplasms
Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis.
Neoplasms
Intratumoral Heterogeneity of Frameshift Mutations in MECOM Gene is Frequent in Colorectal Cancers with High Microsatellite Instability.
Neoplasms
MECOM (EVI1) Rearrangements: A Review and Case Report of Two MDS Patients with Complex 3q Inversion/Deletions.
Neoplasms
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions.
Neoplasms
MECOM, HBS1L-MYB, THRB-RARB, JAK2, and TERT polymorphisms defining the genetic predisposition to myeloproliferative neoplasms: A study on 939 patients.
Neoplasms
Molecular approaches identify a cryptic MECOM rearrangement in a child with a rapidly progressive myeloid neoplasm.
Neoplasms
PRDM16 (1p36) translocations define a distinct entity of myeloid malignancies with poor prognosis but may also occur in lymphoid malignancies.
Neoplasms
PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity.
Neoplasms
PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.
Neoplasms
Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer.
Neoplasms
Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies.
Neoplasms
SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells.
Neoplasms
t(3;8)(q26.2;q24) Often Leads to MECOM/MYC Rearrangement and Is Commonly Associated with Therapy-Related Myeloid Neoplasms and/or Disease Progression.
Neoplasms
Transcription analysis of a histones modifiers panel coupled with critical tumor suppressor genes displayed frequent changes in patients with AML.: mRNA levels of histones modifiers and TSGs in AML.
Neoplasms
Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first-line platinum chemotherapy in high grade serous ovarian cancer.
Obesity
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
Obesity
CCAAT/enhancer binding protein ? (C/EBP?) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice.
Obesity
Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice.
Obesity
Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure.
Obesity
Gain of Metabolic Benefit with Ablation of miR-149-3p from Subcutaneous Adipose Tissue in Diet-Induced Obese Mice.
Obesity
Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue.
Obesity
Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice.
Obesity
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Obesity
MiR-499/PRDM16 axis modulates the adipogenic differentiation of mouse skeletal muscle satellite cells.
Obesity
PPAR? agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein.
Obesity
PRDM16 Gene DNA Methylation Levels in the Placenta Are Associated With Maternal Overweight and Obesity at First Trimester of Pregnancy.
Obesity
PRDM16 Gene Polymorphism Is Associated with Obesity and Blood Lipids Profiles in Saudi Population.
Obesity
PRDM16 sustains white fat gene expression profile in human adipocytes in direct relation with insulin action.
Obesity
Reprogrammed Functional Brown Adipocytes Ameliorate Insulin Resistance and Dyslipidemia in Diet-Induced Obesity and Type 2 Diabetes.
Obesity
Role of PRDM16 in the activation of brown fat programming. Relevance to the development of obesity.
Obesity
The relationship between PRDM16 promoter methylation in abdominal subcutaneous and omental adipose tissue and obesity.
Obesity
Trans-anethole ameliorates obesity via induction of browning in white adipocytes and activation of brown adipocytes.
Overweight
PRDM16 Gene DNA Methylation Levels in the Placenta Are Associated With Maternal Overweight and Obesity at First Trimester of Pregnancy.
Pancreatitis
PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.
Pancreatitis, Chronic
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions.
Pancytopenia
Congenital hypoplastic bone marrow failure associated with a de novo partial deletion of the MECOM gene at 3q26.2.
Paratuberculosis
Identification of loci associated with susceptibility to bovine paratuberculosis and with the dysregulation of the MECOM, eEF1A2, and U1 spliceosomal RNA expression.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
MECOM: A Very Interesting Gene Involved also in Lymphoid Malignancies.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.
Primary Myelofibrosis
Diagnosis of rare subtypes of acute myeloid leukaemia and related neoplasms.
Prostatic Neoplasms
PRDM16 is associated with evasion of apoptosis by prostatic cancer cells according to RNA interference screening.
Psoriasis
Novel factors in the pathogenesis of psoriasis and potential drug candidates are found with systems biology approach.
Pulmonary Disease, Chronic Obstructive
Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls.
Rhabdoid Tumor
Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors.
Stomach Neoplasms
Hypoxia-induced miR-214 expression promotes tumour cell proliferation and migration by enhancing the Warburg effect in gastric carcinoma cells.
Synostosis
A MECOM variant in an African American child with radioulnar synostosis and thrombocytopenia.
Synostosis
A novel mutation in the MECOM gene causing radioulnar synostosis with amegakaryocytic thrombocytopenia (RUSAT-2) in an infant.
Synostosis
Mutations in MECOM, Encoding Oncoprotein EVI1, Cause Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia.
Thrombocytopenia
A MECOM variant in an African American child with radioulnar synostosis and thrombocytopenia.
Thrombocytopenia
A novel mutation in the MECOM gene causing radioulnar synostosis with amegakaryocytic thrombocytopenia (RUSAT-2) in an infant.
Thrombocytopenia
Congenital thrombocytopenia in a neonate with an interstitial microdeletion of 3q26.2q26.31.
Thrombocytopenia
Mutations in MECOM, Encoding Oncoprotein EVI1, Cause Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia.
Thrombocytopenia
Utility of platelet cross-matching in a case of neonatal alloimmune thrombocytopenia associated with a de novo MECOM variant.
Thrombocytopenia, Neonatal Alloimmune
Utility of platelet cross-matching in a case of neonatal alloimmune thrombocytopenia associated with a de novo MECOM variant.
Tooth, Supernumerary
[Genetic studies of a Chilean family with three different dental anomalies]
Wilms Tumor
Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice.
[histone h3]-lysine9 n-methyltransferase deficiency
PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.
[histone h3]-lysine9 n-methyltransferase deficiency
Prdm16 Deficiency Leads to Age-Dependent Cardiac Hypertrophy, Adverse Remodeling, Mitochondrial Dysfunction, and Heart Failure.
[histone h3]-lysine9 n-methyltransferase deficiency
Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
[histone h3]-lysine9 n-methyltransferase deficiency
Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress.
[histone h3]-lysine9 n-methyltransferase deficiency
The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.
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