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5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
5,10-methylenetetrahydromethanopterin + coenzyme F420
hydrogenotrophic methanogenesis pathway in class I methanogens, enzyme of the methanogenic energy metabolism that catalyzes the hydride transfer between substrate and product using coenzyme F420 as hydride carrier
-
-
r
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
additional information
?
-
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
r
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
r
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
si face specific at C5 of F420
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
the enzyme is Si-face stereospecific with respect to C5 of F420 and Re-face stereospecific with respect to the methylene group of methylenetetrahydromethanopterin, reaction needs to be performed under strict anaerobic conditions
-
-
r
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
r
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
the enzyme is Si-face stereospecific with respect to C5 of F420 and Re-face stereospecific with respect to the methylene group of methylenetetrahydromethanopterin, reaction needs to be performed under strict anaerobic conditions
-
-
r
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
r
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
absolutely dependent on coenzyme F420
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
fourth step in the CO2 reduction to methane
-
-
r
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
substrate binding site structure analysis
-
-
r
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
the enzyme is Si-face stereospecific with respect to C5 of F420 and Re-face stereospecific with respect to the methylene group of methylenetetrahydromethanopterin, reaction needs to be performed under strict anaerobic conditions
-
-
r
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
the enzyme catalyzes the fourth reaction step of CO2-reduction to methane in methanogenic archaea
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
the enzyme catalyzes the fourth reaction step of CO2-reduction to methane in methanogenic archaea
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
the enzyme is proposed to function in methanol oxidation step to CO2
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
the enzyme is Si-face stereospecific with respect to C5 of F420 and Re-face stereospecific with respect to the methylene group of methylenetetrahydromethanopterin, reaction needs to be performed under strict anaerobic conditions
-
-
r
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
r
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
r
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
r
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
equilibrium favors oxidation of methylenetetrahydromethanopterin
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
reversible stereospecific transfer of a hydride ion from the re face at C14a of N5,N10-methylenetetrahydromethanopterin to the si face at C5 of coenzyme F420
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
absolutely dependent on coenzyme F420
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
absolutely dependent on coenzyme F420
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
absolutely dependent on coenzyme F420
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
the enzyme is Si-face stereospecific with respect to C5 of F420 and Re-face stereospecific with respect to the methylene group of methylenetetrahydromethanopterin, reaction needs to be performed under strict anaerobic conditions
-
-
r
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
r
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
equilibrium favors oxidation of methylenetetrahydromethanopterin
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
absolutely dependent on coenzyme F420
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
r
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
absolutely dependent on coenzyme F420
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
absolutely dependent on coenzyme F420
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
additional information
?
-
-
enzyme is involved in CO2 reduction to CH4
-
-
?
additional information
?
-
-
enzyme is involved in CO2 reduction to CH4
-
-
?
additional information
?
-
-
enzyme is involved in CO2 reduction to CH4
-
-
?
additional information
?
-
-
enzyme is involved in CO2 reduction to CH4
-
-
?
additional information
?
-
-
enzyme is involved in CO2 reduction to CH4
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
5,10-methylenetetrahydromethanopterin + coenzyme F420
hydrogenotrophic methanogenesis pathway in class I methanogens, enzyme of the methanogenic energy metabolism that catalyzes the hydride transfer between substrate and product using coenzyme F420 as hydride carrier
-
-
r
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
additional information
?
-
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
-
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
fourth step in the CO2 reduction to methane
-
-
r
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
the enzyme catalyzes the fourth reaction step of CO2-reduction to methane in methanogenic archaea
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
the enzyme catalyzes the fourth reaction step of CO2-reduction to methane in methanogenic archaea
-
-
?
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
the enzyme is proposed to function in methanol oxidation step to CO2
-
-
?
additional information
?
-
-
enzyme is involved in CO2 reduction to CH4
-
-
?
additional information
?
-
-
enzyme is involved in CO2 reduction to CH4
-
-
?
additional information
?
-
-
enzyme is involved in CO2 reduction to CH4
-
-
?
additional information
?
-
-
enzyme is involved in CO2 reduction to CH4
-
-
?
additional information
?
-
-
enzyme is involved in CO2 reduction to CH4
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Jablonski, P.E.; DiMarco, A.A.; Bobik, T.A.; Cabell, M.C.; Ferry, J.G.
Protein content and enzyme activities in methanol- and acetate-grown Methanosarcina thermophila
J. Bacteriol.
172
1271-1275
1990
Methanosarcina thermophila, Methanosarcina thermophila TM-1
brenda
Moeller-Zinkhan, D.; Boerner, G.; Thauer, R.K.
Function of methanofuran, tetramethanopterin, and coenzyme F420 in Archaeoglobus fulgidus
Arch. Microbiol.
152
362-368
1989
Archaeoglobus fulgidus
-
brenda
Mukhopadhyay, B.; Daniels, L.
Aerobic purification of N5,N10-methylenetetrahydromethanopterin dehydrogenase, separated from N5,N10-methenyltetrahydromethanopterin cyclohydrolase, from Methanobacterium thermoautotrophicum strain Marburg
Can. J. Microbiol.
35
499-507
1989
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus Marburg / DSM 2133
brenda
Hartzell, P.L.; Zvilius, G.; Escalante-Semerena, J.C.; Donnelly, M.I.
Coenzyme dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum
Biochem. Biophys. Res. Commun.
133
884-890
1985
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus DELTAH
brenda
te Broemmelstroet, B.W.; Hensgens, C.M.H.; Keltjens, J.T.; van der Drift, C.; Vogels, G.D.
Purification and characterization of coenzyme F420-dependent 5,10-methylenetetrahydromethanopterin dehydrogenase from Methanobacterium thermoautothrophicum strain DELTAH
Biochim. Biophys. Acta
1073
77-84
1991
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus DELTAH
brenda
Klein, A.R.; Thauer, R.K.
Re-face specificity at C14a of methylenetetrahydromethanopterin and si-face specificity at C5 of coenzyme F420 for coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase from methanogenic archaea
Eur. J. Biochem.
227
169-174
1995
Methanothermobacter thermautotrophicus, Methanopyrus kandleri
brenda
Klein, A.R.; Koch, J.; Stetter, K.O.; Thauer, R.K.
Two N5,N10-methylenetetrahydromethanopterin dehydrogenases in the extreme thermophile Methanopyrus kandleri: characterization of the coenzyme F420-dependent enzyme
Arch. Microbiol.
160
186-192
1993
Methanopyrus kandleri
brenda
Mukhopadhyay, B.; Purwantini, E.; Pihl, T.D.; Reeve, J.N.; Daniels, L.
Cloning, sequencing, and transcriptional analysis of the coenzyme F420-dependent methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase gene from Methanobacterium thermoautotrophicum strain Marburg and functional expression in Escherichia coli
J. Biol. Chem.
270
2827-2832
1995
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus Marburg / DSM 2133
brenda
te Brommelstroet, B.W.; Geerts, W.J.; Keltjens, J.T.; van der Drift, C.; Vogels, G.D.
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri
Biochim. Biophys. Acta
1079
293-302
1991
Methanosarcina barkeri
brenda
Kunow, J.; Schwoerer, B.; Setzke, E.; Thauer, R.K.
Si-face stereospecificity at C5 of coenzyme F420 for F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase, F420-dependent N5,N10-methylenetetrahydromethanopterin reductase and F420H2:dimethylnaphthoquinone oxidoreductase
Eur. J. Biochem.
214
641-646
1993
Archaeoglobus fulgidus
brenda
Schwrer, B.; Breitung, J.; Klein, A.R.; Stetter, K.O.; Thauer, R.K.
Formylmethanofuran:tetrahydromethanopterin formyltransferase and N5,N10-methylenetetrahydromethanopterin dehydrogenase from the sulfate-reducing Archaeoglobus fulgidus: similarities with the enzymes from methanogenic Archaea
Arch. Microbiol.
159
225-232
1993
Archaeoglobus fulgidus
brenda
Shima, S.; Thauer, R.K.
Tetrahydromethanopterin-specific enzymes from Methanopyrus kandleri
Methods Enzymol.
331
317-353
2001
Archaeoglobus fulgidus, Methanosarcina barkeri, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Methanopyrus kandleri
brenda
Hagemeier, C.H.; Shima, S.; Warkentin, E.; Thauer, R.K.; Ermler, U.
Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase from Methanopyrus kandleri: the selenomethionine-labelled and non-labelled enzyme crystallized in two different forms
Acta Crystallogr. Sect. D
59
1653-1655
2003
Methanopyrus kandleri
brenda
Warkentin, E.; Hagemeier, C.H.; Shima, S.; Thauer, R.K.; Ermler, U.
The structure of F420-dependent methylenetetrahydromethanopterin dehydrogenase: a crystallographic 'superstructure' of the selenomethionine-labelled protein crystal structure
Acta Crystallogr. Sect. D
61
198-202
2005
Methanopyrus kandleri
brenda
Aufhammer, S.W.; Warkentin, E.; Ermler, U.; Hagemeier, C.H.; Thauer, R.K.; Shima, S.
Crystal structure of methylenetetrahydromethanopterin reductase (Mer) in complex with coenzyme F420: Architecture of the F420/FMN binding site of enzymes within the nonprolyl cis-peptide containing bacterial luciferase family
Protein Sci.
14
1840-1849
2005
Methanosarcina barkeri
brenda
Hendrickson, E.L.; Leigh, J.A.
Roles of coenzyme F420-reducing hydrogenases and hydrogen- and F420-dependent methylenetetrahydromethanopterin dehydrogenases in reduction of F420 and production of hydrogen during methanogenesis
J. Bacteriol.
190
4818-4821
2008
Methanococcus maripaludis
brenda
Ceh, K.; Demmer, U.; Warkentin, E.; Moll, J.; Thauer, R.K.; Shima, S.; Ermler, U.
Structural basis of the hydride transfer mechanism in F(420)-dependent methylenetetrahydromethanopterin dehydrogenase
Biochemistry
48
10098-10105
2009
Methanopyrus kandleri (P94951), Methanopyrus kandleri
brenda
Vornolt, J.; Kunow, J.; Stetter, K.; Thauer, R.
Enzymes and coenzymes of the carbon monoxide dehydrogenase pathway for autotrophic CO2 fixation in Archaeoglobus lithotrophicus and the lack of carbon monoxide dehydrogenase in the heterotrophic A. profundus
Arch. Microbiol.
163
112-118
1995
Archaeoglobus fulgidus, Archaeoglobus profundus, Archaeoglobus lithotrophicus, Archaeoglobus lithotrophicus TF-2, Archaeoglobus profundus DSM 5631
-
brenda
Vorholt, J.A.; Hafenbradl, D.; Stetter, K.O.; Thauer, R.K.
Pathways of autotrophic CO2 fixation and of dissimilatory nitrate reduction to N2O in Ferroglobus placidus
Arch. Microbiol.
167
19-23
1997
Ferroglobus placidus, Ferroglobus placidus DSM 10642
brenda
Kojima, H.; Moll, J.; Kahnt, J.; Fukui, M.; Shima, S.
A reversed genetic approach reveals the coenzyme specificity and other catalytic properties of three enzymes putatively involved in anaerobic oxidation of methane with sulfate
Environ. Microbiol.
16
3431-3442
2014
uncultured archaeon (D1JH91)
brenda
Klein, A.R.; Thauer, R.K.
Overexpression of the coenzyme-F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase gene from the hyperthermophilic Methanopyrus kandleri
Eur. J. Biochem.
245
386-391
1997
Methanopyrus kandleri (P94951), Methanopyrus kandleri, Methanopyrus kandleri DSM 6324 (P94951)
brenda
Hagemeier, C.H.; Shima, S.; Thauer, R.K.; Bourenkov, G.; Bartunik, H.D.; Ermler, U.
Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: a methanogenic enzyme with an unusual quarternary structure
J. Mol. Biol.
332
1047-1057
2003
Methanopyrus kandleri (P94951), Methanopyrus kandleri, Methanopyrus kandleri DSM 6324 (P94951)
brenda
Muskal, S.M.; Sliman, J.; Kokai-Kun, J.; Pimentel, M.; Wacher, V.; Gottlieb, K.
Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway
F1000Res.
5
606
2016
Methanobrevibacter smithii (A5UMI1), Methanobrevibacter smithii, Methanobrevibacter smithii ATCC 35061 (A5UMI1)
brenda
Costa, K.; Yoon, S.; Pan, M.; Burn, J.; Baliga, N.; Leigh, J.
Effects of H2 and formate on growth yield and regulation of methanogenesis in Methanococcus maripaludis
J. Bacteriol.
195
1456-1462
2013
Methanococcus maripaludis
brenda