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Information on EC 1.4.99.2 - taurine dehydrogenase
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EC Tree
1.4.99.2 taurine dehydrogenaseSpecify your search results
Word Map
- 1.4.99.2
- sulfoacetaldehyde
- acetyltransferase
- sulfonate
- sulfite
-
dissimilate
-
2-aminoethanesulfonate
-
permease
-
5-gene
-
reverse-transcription
- sulfoacetate
-
rhodobacter
- sphaeroides
- pantotrophus
-
rhodopseudomonas
- calcoaceticus
-
paracoccus
-
deaminate
- palustris
-
acinetobacter
The enzyme appears in viruses and cellular organisms
Synonyms
taurine dehydrogenase, tauxy, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
TauXY
TDH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
taurine + H2O + acceptor = 2-sulfoacetaldehyde + NH3 + reduced acceptor
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
oxidative deamination
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
taurine:acceptor oxidoreductase (deaminating)
-
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CAS REGISTRY NUMBER
COMMENTARY
50812-14-1
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
taurine + H2O + 2,6-dichlorophenol indophenol
sulfoacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
taurine + H2O + bovine heart cytochrome c
2-sulfoacetaldehyde + NH3 + reduced bovine heart cytochrome c
taurine + H2O + phenazine methosulfate
sulfoacetaldehyde + NH3 + reduced phenazine methosulfate
hypotaurine + H2O + phenazine methosulfate
? + NH3 + reduced phenazine methosulfate
-
poor substrate
-
?
hypotaurine + H2O + phenazine methosulfate
? + NH3 + reduced phenazine methosulfate
-
poor substrate
-
?
N-methyltaurine + H2O + acceptor
sulfoacetaldehyde + N-methylamine + reduced acceptor
-
-
-
?
N-methyltaurine + H2O + acceptor
sulfoacetaldehyde + N-methylamine + reduced acceptor
-
-
-
?
N-methyltaurine + H2O + acceptor
sulfoacetaldehyde + N-methylamine + reduced acceptor
-
-
-
?
N-methyltaurine + H2O + acceptor
sulfoacetaldehyde + N-methylamine + reduced acceptor
-
-
-
?
taurine + H2O + 2,6-dichlorophenol indophenol
sulfoacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
?
taurine + H2O + 2,6-dichlorophenol indophenol
sulfoacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
Paracoccus denitrificans NKNIS / DSM 15418
-
-
-
?
taurine + H2O + acceptor
sulfoacetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
taurine + H2O + acceptor
sulfoacetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
taurine + H2O + acceptor
sulfoacetaldehyde + NH3 + reduced acceptor
-
acts only with phenazine methosulfate as electron acceptor
-
?
taurine + H2O + acceptor
sulfoacetaldehyde + NH3 + reduced acceptor
-
acts only with phenazine methosulfate as electron acceptor
-
?
taurine + H2O + acceptor
sulfoacetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
taurine + H2O + bovine heart cytochrome c
2-sulfoacetaldehyde + NH3 + reduced bovine heart cytochrome c
-
-
-
-
?
taurine + H2O + bovine heart cytochrome c
2-sulfoacetaldehyde + NH3 + reduced bovine heart cytochrome c
-
-
-
-
?
taurine + H2O + bovine heart cytochrome c
2-sulfoacetaldehyde + NH3 + reduced bovine heart cytochrome c
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
-
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
-
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
-
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
enzyme is encoded within the gene cluster, comprising 9 genes, of the taurine dissimilation pathway, overview
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
specific for taurine, no activity with isethionate and acetate
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Paracoccus denitrificans NKNIS / DSM 15418
enzyme is encoded within the gene cluster, comprising 9 genes, of the taurine dissimilation pathway, overview
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Paracoccus denitrificans NKNIS / DSM 15418
specific for taurine, no activity with isethionate and acetate
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Paracoccus pantotrophus NKNCYSA / DSM 12449
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
enzyme is involved in taurine dissimilation
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Ralstonia sp. EDS1 / DSM 13640
-
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Ralstonia sp. EDS1 / DSM 13640
enzyme is involved in taurine dissimilation
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Ralstonia sp. SFCD1 / DSM 15091
-
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Ralstonia sp. SFCD1 / DSM 15091
enzyme is involved in taurine dissimilation
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
specific for taurine, no activity with isethionate and acetate
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
specific for taurine, no activity with isethionate and acetate
-
-
?
taurine + H2O + ferricyanide
2-sulfoacetaldehyde + NH3 + ferrocyanide
-
-
-
-
?
taurine + H2O + ferricyanide
2-sulfoacetaldehyde + NH3 + ferrocyanide
-
-
-
-
?
taurine + H2O + ferricyanide
2-sulfoacetaldehyde + NH3 + ferrocyanide
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
-
-
-
?
taurine + H2O + phenazine methosulfate
sulfoacetaldehyde + NH3 + reduced phenazine methosulfate
-
only acts with phenazine methosulfate as electron acceptor
-
?
taurine + H2O + phenazine methosulfate
sulfoacetaldehyde + NH3 + reduced phenazine methosulfate
-
only acts with phenazine methosulfate as electron acceptor
-
?
additional information
?
-
no activity with FAD, FMN, riboflavin, PQQ, 1,4-naphthoquinone, ubiquinone, menadione, and K3Fe(CN)6 as acceptors
-
-
?
additional information
?
-
no activity with FAD, FMN, riboflavin, PQQ, 1,4-naphthoquinone, ubiquinone, menadione, and K3Fe(CN)6 as acceptors
-
-
?
additional information
?
-
-
no activity with FAD, FMN, riboflavin, PQQ, 1,4-naphthoquinone, ubiquinone, menadione, and K3Fe(CN)6 as acceptors
-
-
?
additional information
?
-
Paracoccus denitrificans NKNIS / DSM 15418
no activity with FAD, FMN, riboflavin, PQQ, 1,4-naphthoquinone, ubiquinone, menadione, and K3Fe(CN)6 as acceptors
-
-
?
additional information
?
-
Paracoccus denitrificans NKNIS / DSM 15418
no activity with FAD, FMN, riboflavin, PQQ, 1,4-naphthoquinone, ubiquinone, menadione, and K3Fe(CN)6 as acceptors
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
taurine + H2O + bovine heart cytochrome c
2-sulfoacetaldehyde + NH3 + reduced bovine heart cytochrome c
taurine + H2O + acceptor
sulfoacetaldehyde + NH3 + reduced acceptor
-
acts only with phenazine methosulfate as electron acceptor
-
?
taurine + H2O + acceptor
sulfoacetaldehyde + NH3 + reduced acceptor
-
acts only with phenazine methosulfate as electron acceptor
-
?
taurine + H2O + bovine heart cytochrome c
2-sulfoacetaldehyde + NH3 + reduced bovine heart cytochrome c
-
-
-
-
?
taurine + H2O + bovine heart cytochrome c
2-sulfoacetaldehyde + NH3 + reduced bovine heart cytochrome c
-
-
-
-
?
taurine + H2O + bovine heart cytochrome c
2-sulfoacetaldehyde + NH3 + reduced bovine heart cytochrome c
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
-
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
enzyme is encoded within the gene cluster, comprising 9 genes, of the taurine dissimilation pathway, overview
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Paracoccus denitrificans NKNIS / DSM 15418
enzyme is encoded within the gene cluster, comprising 9 genes, of the taurine dissimilation pathway, overview
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Paracoccus pantotrophus NKNCYSA / DSM 12449
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
enzyme is involved in taurine dissimilation
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Ralstonia sp. EDS1 / DSM 13640
enzyme is involved in taurine dissimilation
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
Ralstonia sp. SFCD1 / DSM 15091
enzyme is involved in taurine dissimilation
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + cytochrome c
sulfoacetaldehyde + NH3 + reduced cytochrome c
-
enzyme is encoded within a gene cluster
-
-
?
taurine + H2O + ferricyanide
2-sulfoacetaldehyde + NH3 + ferrocyanide
-
-
-
-
?
taurine + H2O + ferricyanide
2-sulfoacetaldehyde + NH3 + ferrocyanide
-
-
-
-
?
taurine + H2O + ferricyanide
2-sulfoacetaldehyde + NH3 + ferrocyanide
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
-
-
-
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
9
optimized assay with beef heart cytochrome c as acceptor
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
quantitative excretion of sulfoacetaldehyde during growth with taurine as sole source of nitrogen
-
-
brenda
quantitative excretion of sulfoacetaldehyde during growth with taurine as sole source of nitrogen
-
-
brenda
putative large subunit; growth on N-methyltaurine as sole source of carbon and energy or as sole source of fixed nitrogen for aerobic growth. Secretion of stoichiometric amounts of methylamine
SwissProt
brenda
putative large subunit; growth on N-methyltaurine as sole source of carbon and energy or as sole source of fixed nitrogen for aerobic growth. Secretion of stoichiometric amounts of methylamine
SwissProt
brenda
exponential growth with taurine as sole source of energy and carbon. Enzyme is inducible by growth on substrate
-
-
brenda
upon growth on N-acetyltaurine as sole carbon source, excretion of stoichiometric amounts of sulfate and ammonium. Proposal of degradative pathway
-
-
brenda
Paracoccus denitrificans NKNIS / DSM 15418
Paracoccus pantotrophus NKNCYSA / DSM 12449
putative large subunit; growth on N-methyltaurine as sole source of fixed nitrogen for aerobic growth. Secretion of stoichiometric amounts of methylamine
SwissProt
brenda
putative large subunit; growth on N-methyltaurine as sole source of fixed nitrogen for aerobic growth. Secretion of stoichiometric amounts of methylamine
SwissProt
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
inducible enzyme, organism can grow on taurine as sole carbon source
brenda
Paracoccus denitrificans NKNIS / DSM 15418
-
inducible enzyme, organism can grow on taurine as sole carbon source
-
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
individual deletion mutants of tauR, tauC, and tauY, show growth defects. Growth is restored when each mutant is complemented with the appropriate gene on a plasmid, suggesting that the individual deletions do not deter expression of downstream genes, they are not polar mutations. Induced or uninduced DELTAtauY mutant displays the highest levels of reporter expression compared to other strains grown under similar conditions. Increased accumulation of taurine, and thus enhanced expression, occurs in the DELTAtauY mutant due to its inability to degrade the sulfonate compound
physiological function
-
the genes of the tau region, tauR, tauC, and tauY, are each required for taurine dissimilation in Sinorhizobium meliloti. Enzyme TauY is involved in the degradation of taurine, most likely by forming part of the taurine dehydrogenase
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Q6NDJ2_RHOPA
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
464
0
51148
TrEMBL
-
Q16BZ1_ROSDO
Roseobacter denitrificans (strain ATCC 33942 / OCh 114)
464
0
51527
TrEMBL
-
Q16BZ0_ROSDO
Roseobacter denitrificans (strain ATCC 33942 / OCh 114)
128
0
14035
TrEMBL
-
A0A212KDG1_9DELT
126
0
13742
TrEMBL
-
Q6NDV4_RHOPA
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
135
0
14708
TrEMBL
-
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
2 inducible proteins of MW 14 and 50 kDa detected in the particulate fraction
?
Paracoccus denitrificans NKNIS / DSM 15418
-
2 inducible proteins of MW 14 and 50 kDa detected in the particulate fraction
-
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
in-frame deletion of gene tauY. Individual deletion mutants of tauR, tauC, and tauY, show growth defects. Growth is restored when each mutant is complemented with the appropriate gene on a plasmid, suggesting that the individual deletions do not deter expression of downstream genes, they are not polar mutations. Induced or uninduced DELTAtauY mutant displays the highest levels of reporter expression compared to other strains grown under similar conditions. Increased accumulation of taurine, and thus enhanced expression, occurs in the DELTAtauY mutant due to its inability to degrade the sulfonate compound
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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