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Information on EC 1.3.1.45 - 2'-hydroxyisoflavone reductase

for references in articles please use BRENDA:EC1.3.1.45

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IUBMB Comments

In the reverse reaction, a 2′-hydroxyisoflavone is reduced to an isoflavanone; 2′-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
isoflavone reductase, osirl, isoflavone reductase-like protein, gbirl1, ole e 12, cairl, gmifr, pvifr1, 2'-hydroxyisoflavone reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
(-)-maackiain biosynthesis, (-)-medicarpin biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links