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Information on EC 1.17.1.5 - nicotinate dehydrogenase

for references in articles please use BRENDA:EC1.17.1.5

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IUBMB Comments

A flavoprotein containing non-heme iron. The enzyme is capable of acting on a variety of nicotinate analogues to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3-dicarboxylate, trigonelline and 6-methylnicotinate. The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide.

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
nicotinate dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
nicotinate + H2O + NADP+ = 6-hydroxynicotinate + NADPH + H+
show the reaction diagram
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