Any feedback?
No. of entries
Information on EC 1.1.1.58 - tagaturonate reductase
for references in articles please use BRENDA:EC1.1.1.58
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.58 tagaturonate reductase
The enzyme appears in viruses and cellular organisms
showSynonyms
d-tagaturonate reductase, altronate oxidoreductase, more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
altronate dehydrogenase
-
-
-
-
altronate oxidoreductase
-
-
-
-
altronic oxidoreductase
-
-
-
-
D-tagaturonate reductase
-
-
-
-
Tagaturonate dehydrogenase
-
-
-
-
Tagaturonate reductase
-
-
-
-
tagUAR
-
-
-
-
uxaB
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-altronate + NAD+ = D-tagaturonate + NADH + H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
D-galacturonate degradation I
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
D-altronate:NAD+ 3-oxidoreductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9028-45-9
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-tagaturonate + NADPH + H+
D-altronate + NADP+
-
Substrates: -
Products: -
Products: -
r
D-altronate + NAD+
D-tagaturonate + NADH
-
Substrates: -
Products: -
Products: -
r
D-altronate + NAD+
D-tagaturonate + NADH
-
Substrates: involved in hexuronate pathway
Products: -
Products: -
r
D-altronate + NAD+
D-tagaturonate + NADH
-
Substrates: -
Products: -
Products: -
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-altronate + NAD+
D-tagaturonate + NADH
-
Substrates: -
Products: -
Products: -
r
D-altronate + NAD+
D-tagaturonate + NADH
-
Substrates: involved in hexuronate pathway
Products: -
Products: -
r
D-altronate + NAD+
D-tagaturonate + NADH
-
Substrates: -
Products: -
Products: -
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
heavy metal ions are inhibitory, can be prevented by adding chelating agents
additional information
-
heavy metal ions are inhibitory, can be prevented by adding chelating agents
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
products inhibition with all products in forward and reverse reaction
-
additional information
-
products inhibition with all products in forward and reverse reaction
-
additional information
-
products inhibition with all products in forward and reverse reaction
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
328
6.2
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.3 - 8
-
pH 5.3: about 75% of activity maximum, pH 8.0: about 50% of activity maximum
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Highest Expressing Human Cell Lines
Cell Line Links Show AA Sequence and Transmembrane Helices (847 entries)
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
A9QSF6
expression of Lactococcus lactis uxaB and uxaC genes encoding D-tagaturonate reductase and D-galacturonate isomerase, in Saccharomyces cerevisiae to investigate in vivo activity of the first steps of the D-galacturonate pathway. Although D-tagaturonate reductase could, in principle, provide an alternative means for re-oxidizing cytosolic NADH, addition of D-galacturonate does not restore anaerobic growth, possibly due to absence of a functional D-altronate exporter in Saccharomyces cerevisiae
additional information
-
expression of Lactococcus lactis uxaB and uxaC genes encoding D-tagaturonate reductase and D-galacturonate isomerase, in Saccharomyces cerevisiae to investigate in vivo activity of the first steps of the D-galacturonate pathway. Although D-tagaturonate reductase could, in principle, provide an alternative means for re-oxidizing cytosolic NADH, addition of D-galacturonate does not restore anaerobic growth, possibly due to absence of a functional D-altronate exporter in Saccharomyces cerevisiae
additional information
-
expression of Lactococcus lactis uxaB and uxaC genes encoding D-tagaturonate reductase and D-galacturonate isomerase, in Saccharomyces cerevisiae to investigate in vivo activity of the first steps of the D-galacturonate pathway. Although D-tagaturonate reductase could, in principle, provide an alternative means for re-oxidizing cytosolic NADH, addition of D-galacturonate does not restore anaerobic growth, possibly due to absence of a functional D-altronate exporter in Saccharomyces cerevisiae
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
construction of a hybrid plasmid containing the Escherichia coli uxa B gene encoding for altronate oxidoreductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
synthesis
synthesis
A9QSF6
expression of Lactococcus lactis uxaB and uxaC genes encoding D-tagaturonate reductase and D-galacturonate isomerase, in Saccharomyces cerevisiae to investigate in vivo activity of the first steps of the D-galacturonate pathway. Although D-tagaturonate reductase could, in principle, provide an alternative means for re-oxidizing cytosolic NADH, addition of D-galacturonate does not restore anaerobic growth, possibly due to absence of a functional D-altronate exporter in Saccharomyces cerevisiae
synthesis
-
expression of Lactococcus lactis uxaB and uxaC genes encoding D-tagaturonate reductase and D-galacturonate isomerase, in Saccharomyces cerevisiae to investigate in vivo activity of the first steps of the D-galacturonate pathway. Although D-tagaturonate reductase could, in principle, provide an alternative means for re-oxidizing cytosolic NADH, addition of D-galacturonate does not restore anaerobic growth, possibly due to absence of a functional D-altronate exporter in Saccharomyces cerevisiae
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hickman, J.; Ashwell, G.
Uronic acid metabolism in bacteria. II Purification and properties of D-altronic acid and D-mannonic acid dehydrogenase in Escherichia coli
J. Biol. Chem.
235
1566-1570
1960
Escherichia coli
brenda
Portalier, R.; Stoeber, F.
D-Mannonate and D-altronate-NAD dehydrogenases from Escherichia coli
Methods Enzymol.
89
210-218
1982
Escherichia coli
brenda
Portalier, R.C.; Stoeber, F.R.
Colorimetric determinations of aldonate oxidoreductases of Escherichia coli K 12: applications
Biochim. Biophys. Acta
289
19-27
1972
Escherichia coli
brenda
Gierschner, K.; Endre, H.U.
D-galacturonate and D-tagaturonate
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
6
313-320
1984
Escherichia coli, Paenibacillus polymyxa
-
brenda
Portalier, R.C.; Stoeber, F.R.
D-Altronate: NAD-oxidoreductase in Escherichia coli K12. Purification, properties, and specificity
Eur. J. Biochem.
26
50-61
1972
Escherichia coli
brenda
Blanco, C.; Mata-Gilsinger, M.; Ritzenthaler, P.
Construction of hybrid plasmids containing the Escherichia coli uxaB gene: analysis of its regulation and direction of transcription
J. Bacteriol.
153
747-755
1983
Escherichia coli
brenda
Portalier, R.C.
D-Altronate: NAD-oxidoreductase from Escherichia coli K12. Kinetic studies
Eur. J. Biochem.
30
211-219
1972
Escherichia coli
brenda
Huisjes, E.H.; Luttik, M.A.; Almering, M.J.; Bisschops, M.M.; Dang, D.H.; Kleerebezem, M.; Siezen, R.; van Maris, A.J.; Pronk, J.T.
Toward pectin fermentation by Saccharomyces cerevisiae: expression of the first two steps of a bacterial pathway for D-galacturonate metabolism
J. Biotechnol.
162
303-310
2012
Lactococcus lactis (A9QSF6), Lactococcus lactis, Lactococcus lactis KF147 (A9QSF6)
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.58)
html completed
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
About BRENDA
Social media
Help
Survey
Download
Contribution
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
