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Information on EC 1.1.1.393 - 3beta-hydroxycholanate 3-dehydrogenase (NADP+)

for references in articles please use BRENDA:EC1.1.1.393

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IUBMB Comments

This bacterial enzyme is involved, along with EC 1.1.1.52, 3α-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3α-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3β-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391, 3β-hydroxycholanate 3-dehydrogenase (NAD+).

The enzyme appears in viruses and cellular organisms

Synonyms
3beta-HSDH, 3beta-hydroxysteroid dehydrogenase, 3beta-hyoxysteroid dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
isolithocholate + NADP+ = 3-oxo-5beta-cholan-24-oate + NADPH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
bile acids 3-O-epimerization, iso-bile acids biosynthesis II
Highest Expressing Human Cell Lines
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