Also acts on related alkaloids with an endo-aldehyde group as vellosimine (same stereochemistry at C-16) but only slight activity with exo-aldehydes. Detected in many cell suspension cultures of plants from the family Apocynaceae.
The enzyme appears in viruses and cellular organisms
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SYSTEMATIC NAME
IUBMB Comments
10-deoxysarpagine:NADP+ oxidoreductase
Also acts on related alkaloids with an endo-aldehyde group as vellosimine (same stereochemistry at C-16) but only slight activity with exo-aldehydes. Detected in many cell suspension cultures of plants from the family Apocynaceae.
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
highly instable enzyme, in crude extracts, half-life of activity is 25 h at 4°C, 0.25% activity remains after 7 d, activity depends completely on the presence of 2-mercaptoethanol
Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine
Tetrahedron
40
1691-1699
1984
Catharanthus roseus, no activity in Alstonia scholaris, no activity in Carissa macrocarpa, no activity in Catharanthus roseus, no activity in Coleus blumei, no activity in Malus sylvestris, no activity in Nicotiana sylvestris, no activity in Picralima nitida, no activity in Rhazya stricta, no activity in Stemmadenia tomentosa, no activity in Tabernanthe iboga, no activity in Voacanga africana, Rauvolfia serpentina, Rauvolfia verticillata, Rauvolfia vomitoria, Vinca herbacea, Vinca minor
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