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IUBMB Comments The enzyme from Corynebacterium cyclohexanicum is highly specific for the trans -4-hydroxy derivative. cf . EC 1.1.1.438 , cis -4-hydroxycyclohexanecarboxylate dehydrogenase.
Reaction Schemes
+
=
4-oxocyclohexane-1-carboxylate
+
+
Synonyms
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4-hydroxycyclohexanecarboxylate dehydrogenase
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ambiguous
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trans-4-hydroxycyclohexanecarboxylate dehydrogenase
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-
-
-
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trans-4-hydroxycyclohexane-1-carboxylate + NAD+ = 4-oxocyclohexane-1-carboxylate + NADH + H+
-
-
-
-
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trans-4-hydroxycyclohexane-1-carboxylate:NAD+ 4-oxidoreductase
The enzyme from Corynebacterium cyclohexanicum is highly specific for the trans-4-hydroxy derivative. cf. EC 1.1.1.438, cis-4-hydroxycyclohexanecarboxylate dehydrogenase.
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
-
Substrates: -
?
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
-
Substrates: enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway
?
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
-
Substrates: -
?
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
-
Substrates: enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway
?
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
-
Substrates: higher specific activities assayed for reverse reaction
r
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
-
Substrates: highly specific for trans isomer
r
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
-
Substrates: -
r
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
-
Substrates: enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway
?
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
-
Substrates: enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway
?
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
-
Substrates: -
r
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NAD+
-
very specific, no activity with NADP+
NAD+
-
very specific, no activity with NADP+
NADH
-
very specific, no activity with NADPH
NADH
-
very specific, no activity with NADPH
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iodoacetamide
-
slight inhibition
iodoacetic acid
-
slight inhibition
N-bromosuccinimide
-
strong inhibition
p-hydroxymercuribenzoate
-
slight inhibition
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0.5
4-Oxocyclohexanecarboxylate
-
-
0.51
trans-4-hydroxycyclohexanecarboxylate
-
-
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1.48
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crude extract, NADH oxidation
104.1
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purified enzyme, NADH oxidation
40
-
purified enzyme, NAD reduction
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5.8 - 7.2
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NADH oxidation, depending on the buffer system
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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CHCB1_SINCY
259
0
27076
Swiss-Prot
-
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dimer
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2 * 27600, gel filtration, SDS-PAGE
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Obata, H.; Uebayasi, M.; Kaneda, T.
Purification and properties of 4-hydroxycyclohexanecarboxylate dehydrogenase from Corynebacterium cyclohexanicum
Eur. J. Biochem.
174
451-458
1988
Sinomonas cyclohexanicum
brenda
Taylor, D.G.; Trudgill, P.
Metabolism of cyclohexane caroxylic acid by Alcaligenes strain W1
J. Bacteriol.
5
401-411
1978
Alcaligenes sp., Alcaligenes sp. W1
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brenda
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