EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    1.8.1.12 | Acquired Immunodeficiency Syndrome |
28288415 |
Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress. |
unassigned |
0 |
| 1.8.1.12 | Chagas Disease |
2059620 |
Redox enzyme engineering: conversion of human glutathione reductase into a trypanothione reductase. |
therapeutic application
unassigned |
1
0 |
| 1.8.1.12 | Chagas Disease |
2647489 |
Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds. |
therapeutic application
unassigned |
4
0 |
| 1.8.1.12 | Chagas Disease |
3135548 |
"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease. |
therapeutic application
unassigned |
2
0 |
| 1.8.1.12 | Chagas Disease |
3549299 |
Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme. |
ongoing research
therapeutic application
unassigned |
1
1
0 |
| 1.8.1.12 | Chagas Disease |
8428618 |
Crystallization and preliminary crystallographic analysis of trypanothione reductase from Trypanosoma cruzi, the causative agent of Chagas' disease. |
therapeutic application
unassigned |
4
0 |
| 1.8.1.12 | Chagas Disease |
9879510 |
Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase. |
therapeutic application
unassigned |
4
0 |
| 1.8.1.12 | Chagas Disease |
10639286 |
Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships. |
causal interaction
therapeutic application
unassigned |
2
3
0 |
| 1.8.1.12 | Chagas Disease |
10956223 |
Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines. |
therapeutic application
unassigned |
3
0 |
| 1.8.1.12 | Chagas Disease |
11123991 |
(2,2':6',2"-Terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase. |
therapeutic application
unassigned |
4
0 |
