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(+/-)-10,11-dihydrolunarine
Lunaria biennis
-
0.1 mM
(1,3,5-triaza-7-phosphaadamantane)Au(saccharine)
-
-
-
(1E)-1-(2-chlorophenyl)penta-1,4-dien-3-one
-
0.1 mM, irreversible inhibition
(1E)-1-[2-chloro-10-[3-(dimethylamino)propyl]-10,10a-dihydro-4aH-phenothiazin-8-yl]ethanone O-benzyloxime
-
(1E,2E)-3-(5-nitrofuran-2-yl)prop-2-enal N-hexylsemicarbazone
-
-
(1S,3S)-3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine
-
-
(2-chloroethoxy)diphenylmethane
-
-
(22R,25R)-solasodine
-
compound is an alkaloid scaffold lead in the search for inhibitors
(22R,25S)-solanidine
-
compound is an alkaloid scaffold lead in the search for inhibitors
(22S,25S)-tomatidine
-
compound is an alkaloid scaffold lead in the search for inhibitors
(2E)-3-(5-nitrofuran-2-yl)-N-tricyclo[3.3.1.13,7]dec-1-ylprop-2-enamide
-
-
(2E)-N-hexyl-3-(5-nitrofuran-2-yl)prop-2-enamide
-
-
(2Z)-2-[(2E)-2-(3H-indol-3-ylidene)ethylidene]-1-methyl-1,2-dihydroquinoline
-
-
(3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium
(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)(phenyl)-methanone
-
-
(4'-chloro-2,2':6',2''-terpyridine)platinum(II) ammine complex
-
irreversible, altering specifically the Cys52 residue in the active center, increased oxidase activity
(4-picoline) (4'-p-bromophenyl-2,2':6',2''-terpyridine)platinum(II) complex
-
irreversible, altering specifically the Cys52 residue in the active center, increased oxidase activity
(4E)-5-(2-chlorophenyl)-N,N,2,2-tetramethyl-3-oxopent-4-en-1-aminium chloride
-
0.1 mM, reversible inhibition
(4E)-5-(2-chlorophenyl)-N,N-dimethyl-3-oxopent-4-en-1-aminium chloride
-
0.1 mM, irreversible inhibition
(6-benzyloxycarbonylamino-6-[[[methyl-(2-propylamino-ethyl)-carbamoyl]-methyl]-carbamoyl]-1-[[(3-propylamino-propylcarbamoyl)-methyl]-carbamoyl]-hex-3-enyl)-carbamic acid benzyl ester
-
-
(6-benzyloxycarbonylamino-6-[[[methyl-(2-propylamino-ethyl)-carbamoyl]-methyl]-carbamoyl]-1-[[(3-propylamino-propylcarbamoyl)-methyl]-carbamoyl]-hexyl)-carbamic acid benzyl ester
-
-
1,1'-(10-acetyl-10,10a-dihydro-4aH-phenothiazine-2,8-diyl)diethanone
-
1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide]
-
more than 90% inhibition at 0.1 mM
1,1'-[10-[3-(dimethylamino)propyl]-10,10a-dihydro-4aH-phenothiazine-2,8-diyl]diethanone
-
1,1'-[ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis(3-benzyl-1,3-dihydro-2H-benzimidazol-2-imine)
-
-
1,1'-[methanediylbis(oxyethane-2,1-diyl)]bis(3-methyl-1,3-dihydro-2H-benzimidazol-2-imine)
-
IC50: 0.1 mM
1,1'-[methanediylbis(oxyethane-2,1-diyl)]bis(3-phenyl-1,3-dihydro-2H-benzimidazol-2-imine)
-
IC50: 0.004 mM
1,3-Bis(2-chloroethyl)-1-nitrosourea
-
-
1,3-bis[3-(dimethylamino)propyl]-1,5-dihydro-2H-pyrimido[4,5-beta][1,4]benzothiazine-2,4(3H)-dione
1,6-dimethyl-3-(4-methylphenyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
linear uncompetitive mode of inhibition
1-((1-benzo[b]furan-2-yl)cyclohexyl)piperidine
-
-
1-((1-benzo[b]thiazol-2-yl)cyclohexyl)piperidine
-
-
1-((1-benzo[b]thiophen-2-yl)cyclohexyl)-4-methylpiperazine
-
-
1-((1-benzo[b]thiophen-2-yl)cyclohexyl)diethylamine
-
-
1-((1-benzo[b]thiophen-2-yl)cyclohexyl)pyrrolidine
-
-
1-((1-benzo[b]thiophen-2-yl)cyclopentyl)piperidine
-
-
1-((1-benzo[b]thiophen-3-yl)cyclohexyl)piperidine
-
-
1-((1-biphenyl-4-yl)cyclohexyl)piperidine
-
-
1-((1-naphthalen-1-yl)cyclohexyl)piperidine
-
-
1-((1-naphthalen-2-yl)cyclohexyl)piperidine
-
-
1-((1-thiophen-2-yl)cyclohexyl)piperidine
-
-
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
1-((2-benzhydryloxy)ethyl)piperazine
-
-
1-((2-benzo[b]thiophen-2-yl)propan-2-yl)piperidine
-
-
1-(1-(3-bromo-benzo[b]thiophen-2-yl)cyclohexyl)piperidine
-
-
1-(1-(5-bromo-benzo[b]thiophen-2-yl)cyclohexyl)piperidine
-
-
1-(1-(benzo(b)thien-2-yl)cyclohexyl)piperidine
-
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine
1-(1-benzo[b]thiophen-2-yl-cyclohexyl)-piperidine
-
-
1-(1-benzo[b]thiophen-2-yl-cyclohexyl)piperidine
-
competitive inhibitor
1-(1-benzylpiperidin-4-yl)-3-phenylthiourea
-
-
1-(1-benzylpiperidin-4-yl)-3-pyridin-3-ylthiourea
-
-
1-(1-methylpiperidin-3-yl)-3-(2-phenoxyethyl)-1,3-dihydro-2H-benzimidazol-2-imine
-
IC50: 0.1 mM
1-(1-phenylcyclohexyl)piperidine
-
-
1-(1-phenylpiperidin-4-yl)-3-propylthiourea
-
-
1-(10-acetyl-10,10a-dihydro-4aH-phenothiazin-2-yl)-2-chloroethanone
-
1-(10-acetyl-10,10a-dihydro-4aH-phenothiazin-2-yl)ethanone
-
1-(10-acetyl-2-chloro-10,10a-dihydro-4aH-phenothiazin-8-yl)ethanone
-
1-(1H-indol-5-yl)-N-[(4-methylpiperazin-1-yl)methyl]methanediamine
-
0.1 mM, 31% or 39% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide, respectively
1-(2,4-dichlorophenoxy)-3-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]propan-2-ol
-
IC50: 0.005 mM
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
1-(2-(benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine
-
GBR-12935
1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium
1-(2-phenoxyethyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-imine
-
IC50: 0.004 mM
1-(2-phenoxyethyl)-3-[2-(piperidin-1-yl)ethyl]-1,3-dihydro-2H-benzimidazol-2-imine
-
-
1-(3,4-dichlorobenzyl)-4-(2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-2-oxoethyl)-1-methylpiperazin-1-ium formate
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
1-(3,4-dichlorophenyl)-2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
1-(3,4-dichlorophenyl)-2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
-
IC50: 0.009 mM
1-(3,4-dichlorophenyl)-2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanone
-
IC50: 0.01 mM
1-(3,4-dichlorophenyl)-2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one
-
1-(3,4-dichlorophenyl)-3-[(4-ethylphenyl)amino]propan-1-one
-
containing two Cl groups and one NH-4-EtPh group
1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane
1-(3-bromothiophen-2-yl)-N-(pyridin-3-ylmethyl)methanediamine
-
0.1 mM, 15% or 14% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide, respectively
1-(3-nitrophenyl)-3-(phenylamino)propan-1-one
-
containing one NHPh group
1-(3-phenoxypropyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-imine
-
IC50: 0.007 mM
1-(3-phenylpropyl)piperazine
-
-
1-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)-2-(dimethyl-amino)ethanone
-
-
1-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)-2-phenyl-ethanone
-
-
1-(4'-benzo[b]thiophen-2-yl)-1,4'-(bipiperidine-1'-yl)ethanone
-
-
1-(4,6,8-trimethylquinazolin-2-yl)guanidine
-
-
1-(4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-(2-(naphthalen-2-yl)ethyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamido)butyl)guanidinium 2,2,2-trifluoroacetate
-
-
1-(4-bromophenyl)-2-(3-butyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)ethanol
-
IC50: 0.1 mM, 42% inhibition at 0.025 mM
1-(4-chlorophenyl)-3-morpholin-4-ylpropan-1-one
-
containing one Cl group and one N-morpholinyl group
1-(4-ethoxyphenyl)-2-(2-imino-3-prop-2-en-1-yl-2,3-dihydro-1H-benzimidazol-1-yl)ethanol
-
IC50: 0.1 mM, 6% inhibition at 0.025 mM
1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide
1-(4-methylquinazolin-2-yl)guanidine
-
-
1-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-2-amine
-
1-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-2-amine
-
1-(5-phenoxypentyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-imine
-
IC50: 0.008 mM
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium
1-(methylsulfanyl)-4-[3-(methylsulfanyl)-1,2,4-triazin-5-yl]-5,6,7,8-tetrahydroisoquinoline
-
-
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium
1-biphenyl-4-yl-2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanone
-
IC50: 0.025 mM
1-ethyl-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
1-ethyl-6-methyl-3-(pyridin-3-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
1-ethyl-6-methyl-3-(thiophen-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
linear uncompetitive mode of inhibition
1-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
1-ethyl-6-methyl-3-[(Z)-2-phenylethenyl]pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
1-ethyl-6-methyl-3-[4-(trifluoromethyl)phenyl]pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
1-methyl-(2-(1-piperidin-1-yl)cyclohexyl)-1H-indole
-
-
1-phenyl-3-(1-phenylpiperidin-4-yl)thiourea
-
-
1-phenyl-3-[1-(pyridin-3-yl)piperidin-4-yl]urea
-
-
1-[(4E)-5-(2-chlorophenyl)-3-oxopent-4-en-1-yl]piperidinium chloride
-
0.1 mM, irreversible inhibition
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine
-
-
1-[1-(4,5-diphenylthiophen-2-yl)cyclohexyl]pyrrolidine
-
1-[1-[4,5-bis(2H-1,3-benzodioxol-5-yl)thiophen-2-yl]cyclohexyl]pyrrolidine
-
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-4-(3-phenyl-propyl)piperazine
-
-
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-4-(E)-(3-phenyl-allyl)piperazine
-
-
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-piperazine
-
-
1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium
1-[2-(4-methylpiperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)-ferrocenylmethyl]-3-p-chloro-phenyl-urea
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-3-[2,6-bis-(trifluoromethyl)-phenyl]-urea
-
ferrocenic 4-aminoquinoline urea compound 8
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-methoxyphenyl-urea
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-tolyl-urea
-
ferrocenic 4-aminoquinoline urea compound 5
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-[2,4-bis-(trifluoromethyl)-phenyl]-urea
-
ferrocenic 4-aminoquinoline urea compound 7
1-[2-(morpholin-4-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
1-[2-(piperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
1-[2-(piperidin-4-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
1-[2-chloro-10-[3-(dimethylamino)propyl]-10,10a-dihydro-4aH-phenothiazin-8-yl]ethanone
-
1-[2-imino-3-(2-morpholin-4-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-phenoxypropan-2-ol
-
IC50: 0.1 mM
1-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3,3-dimethylbutan-2-ol
-
IC50: 0.1 mM, 66% inhibition at 0.025 mM
1-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-(4-methoxyphenoxy)propan-2-ol
-
IC50: 0.016 mM
1-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-phenoxypropan-2-ol
-
IC50: 0.005 mM
1-[2-imino-3-(morpholin-4-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-(4-methylphenoxy)propan-2-ol
-
IC50: 0.1 mM
1-[2-imino-3-(piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-(4-methylphenoxy)propan-2-ol
-
IC50: 0.009 mM
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
1-[4-(methylsulfonyl)phenyl]-3-piperidin-1-ylpropan-1-one
-
containing one N-piperidyl group
10-(bromoacetyl)-2-chloro-10,10a-dihydro-4aH-phenothiazine
-
10-butanoyl-2-chloro-10,10a-dihydro-4aH-phenothiazine
-
10-[3-(4-methylpiperidin-1-yl)propyl]-2-(trifluoromethyl)-10,10a-dihydro-4aH-phenothiazine
-
12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium
2,2'-(2-imino-1H-benzimidazole-1,3(2H)-diyl)bis(N,N-diethylethanamine)
-
IC50: 0.059 mM
2,2-dimethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dione
-
2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
2,2-dimethyl-3-(prop-2-en-1-yl)-3,4-dihydro-2H-benzo[h]chromene-5,6-dione
-
2,2-dimethyl-4a,10b-dihydro-2H-benzo[h]chromene-5,6-dione
-
2,3-Bis(3-(2-amidinohydrazono)-butyl)-1,4-naphthoquinone dihydrochloride
-
-
2,5-bis(3,4,5-trimethoxyphenyl)furan
-
3% inhibition at 0.02 mg/ml
2,5-bis(3,4-dimethoxyphenyl)furan
-
7% inhibition at 0.02 mg/ml
2,5-bis(4-methoxyphenyl)furan
-
15% inhibition at 0.02 mg/ml
2,5-bis(4-nitrophenyl)furan
-
9% inhibition at 0.02 mg/ml
2,5-bis[4-(trifluoromethyl)phenyl]furan
-
10% inhibition at 0.02 mg/ml
2,5-diphenylfuran
-
4% inhibition at 0.02 mg/ml
2-(1-cyclopentylcyclohexyl)-1-benzothiophene
2-(1-[3-[2-(trifluoromethyl)-4a,10a-dihydro-10H-phenothiazin-10-yl]propyl]piperidin-4-yl)ethanol
-
2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
2-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethyl-2-oxoethanamine
-
2-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethylethanamine
-
2-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-dimethylethanamine
-
2-(3-benzyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)-1-(4-chlorophenyl)ethanol
-
IC50: 0.1 mM, 32% inhibition at 0.025 mM
2-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)-N,N-dimethylethanamine
-
-
2-(4-nitrophenyl)furan
-
34% inhibition at 0.02 mg/ml
2-(4-[4-amino-6,7-bis[2-(dimethylamino)ethoxy]quinazolin-2-yl]piperazin-1-yl)naphthalene-1,4-dione
-
non-competitive inhibition, 79% inhibition at 0.05 mM
2-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N-methylethanamine
-
2-(5-methylfuran-2-yl)-N-(2-morpholinoethyl)quinoline-4-carboxamide
-
-
2-(5-methylfuran-2-yl)-N-(pyridin-2-ylmethyl)quinoline-4-carboxamide
-
-
2-(5-nitro-2-furanylmethylidene)-N,N'-(1,4-piperazinediylbis(1,3-propanediyl))bishydrazinecarboximidamide tetrahydrobromide
-
-
2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
2-(dimethylamino)-N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]acetamide
2-(propan-2-yl)naphtho[1,2-b]furan-4,5-dione
-
2-(propan-2-yl)naphtho[2,3-b]furan-4,9-dione
-
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
2-amino-4-chlorophenyl phenyl sulfide
-
weak inhibitor
2-chloro-10-(3-(4-(3-phenylpropyl)piperazin-1-yl)propyl)-10H-phenothiazine
-
-
2-chloro-10-(chloroacetyl)-10,10a-dihydro-4aH-phenothiazine
-
2-chloro-10-[3-[(Z)-propyldiazenyl]propyl]-10,10a-dihydro-4aH-phenothiazine
-
2-ethylnaphtho[2,3-b]furan-4,9-dione
-
2-hydroxy-3-(3-methylbut-2-en-1-yl)naphthalene-1,4-dione
-
2-hydroxy-3-[(1E)-3-methylbut-1-en-1-yl]naphthalene-1,4-dione
-
2-hydroxynaphthalene-1,4-dione
-
2-methoxy-6-chloro-9-aminoacridine/2-hydroxyethanethiolate (2,2':6',2''-terpyridine)platinum(II) complex
-
4 chimeric compound variants, competitive and irreversible inhibition, probably Cys52 of the enzyme is specifically modified, 4'-substituted (terpyridine)platinum(II) containing complexes do not inhibit irreversibly
2-methylnaphtho[2,3-b]furan-4,9-dione
-
2-nitronaphtho[2,3-b]thiophene-4,9-dione
-
2-propylnaphtho[1,2-b]furan-4,5-dione
-
2-[(1E)-but-1-en-1-yl]-3-hydroxynaphthalene-1,4-dione
-
2-[(4-bromophenyl)sulfanyl]-5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]aniline
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride
2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methoxyphenyl)ethanol
-
IC50: 0.024 mM, 85% inhibition at 0.025 mM
2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium
2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methoxyphenyl)ethanone
-
IC50: 0.007 mM, 91% inhibition at 0.025 mM
2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methylphenyl)ethanol
-
IC50: 0.019 mM
2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methylphenyl)ethanol
-
IC50: 0.029 mM
2-[3-[2-(dimethylamino)propyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methylphenyl)ethanol
-
IC50: 0.035 mM
2-[4-(1H-indol-3-ylacetyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
-
23% inhibition at 0.1 mM
2-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-5-methoxycyclohexa-2,5-diene-1,4-dione
-
non-competitive inhibition, 75% inhibition at 0.1 mM
2-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]naphthalene-1,4-dione
-
mixed-type inhibition, 57% inhibition at 0.1 mM
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-N-(pentafluorobenzyl)-2-oxoethanaminium formate
2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-N-[(5-nitro-2-furyl)methyl]-2-oxoethanaminium formate
3',4'-dichlorobenzyl-[5-chloro-2-(phenylsulfanylphenylamino)-propyl]-dimethylammonium chloride
-
-
3,3'-[5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophene-2,3-diyl]dipyridine
-
3,3'-[butane-1,4-diylbis[(3-aminopropyl)imino]]bis(N-[5-chloro-2-[(4-methoxyphenyl)sulfanyl]phenyl]propanamide)
-
IC50: 0.0003 mM
3,3'-[polyaminobis(carbonylalkyl)]bis(1,4-naphthoquinone) derivatives
-
-
3,4-dichloro-N-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-N,N-dimethylanilinium
-
-
3,4-dichloro-N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium
-
-
3-((10H-phenothiazin-10-yl)methyl)-1-azoniabicyclo[2.2.2]octane
3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium
3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium
3-(2-acetyl-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
3-(2-butanoyl-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
3-(2-carbamoyl-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
3-(2-carboxy-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-N-(4-methylbenzyl)propan-1-aminium
-
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-N-(pentafluorobenzyl)propan-1-aminium
-
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
-
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
3-(2-chloro-10H-phenothiazin-10-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium
-
3-(2-chloro-10H-phenothiazin-10-yl)-N-(3,4-dimethylbenzyl)-N,N-dimethylpropan-1-aminium
-
3-(2-chloro-10H-phenothiazin-10-yl)-N-(3,5-dimethoxybenzyl)-N,N-dimethylpropan-1-aminium
-
3-(2-chloro-10H-phenothiazin-10-yl)-N-[4-(cyclohexylmethyl)benzyl]-N,N-dimethylpropan-1-aminium
-
3-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethyl-3-oxopropan-1-amine
-
3-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethylpropan-1-amine
-
3-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine
-
3-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)propan-1-amine
-
3-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)propanimidamide
-
3-(2-chloro-5-oxido-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
-
3-(2-hexanoyl-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
3-(3,4-dichlorophenyl)-N,N-dimethyl-3-oxopropan-1-aminium chloride
-
containing two Cl groups and one NMe2 HCl group
3-(4-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
-
3-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
-
3-(4a,10a-dihydro-10H-phenothiazin-10-yl)propan-1-amine
-
3-(4a,10a-dihydro-10H-phenothiazin-10-yl)propanimidamide
-
3-(5-bromo-2-fluorophenyl)-1-butyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
3-(5-bromo-2-fluorophenyl)-1-cyclopentyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
3-(5-bromo-2-fluorophenyl)-1-ethyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
3-(5-bromo-2-fluorophenyl)-1-[2-(dimethylamino)ethyl]-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
3-(5-bromo-2-fluorophenyl)-6-methyl-1-(propan-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
3-(5-bromo-2-fluorophenyl)-6-methylpyrimido[5,4-e,1,2,4]triazine-5,7(1H,6H)dione
-
-
3-(5-bromo-2-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
3-(5-bromothiophen-2-yl)-1-ethyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
-
3-(dimethylamino)-1-(3-nitrophenyl)propan-1-one
-
3-(dimethylamino)-1-[4-(methylsulfonyl)phenyl]propan-1-one
-
3-(methylsulfanyl)-5-phenyl-1,2,4-triazine
-
-
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
3-([2-[(4-tert-butylphenyl)amino]-5-fluorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
mixed-type inhibition
3-([5-chloro-2-[(4'-methylbiphenyl-4-yl)thio]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
3-([5-chloro-2-[1-naphthylthio]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethyl-propan-1-ammonium chloride
3-([5-chloro-2-[2-naphthylthio]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethyl-propan-1-ammonium chloride
3-acetylpyridine adenine nucleotide
-
-
3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
3-Benzyl-1-[3-(7-chloro-quinolin-4-ylamino)-propyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
-
-
3-Benzyl-1-[4-(7-chloro-quinolin-4-ylamino)-butyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
-
-
3-Benzyl-1-[6-(7-chloro-quinolin-4-ylamino)-hexyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
-
-
3-bromo-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
3-bromo-2,2-dimethyl-2H-benzo[h]chromene-5,6-dione
-
3-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione
-
3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
3-cyano-1-azabicyclo[2.2.2]oct-3-yl acetate
-
-
3-methoxy-3'-(methylsulfanyl)-5,5'-bi-1,2,4-triazine
-
-
3-methoxycarpachromene
the potent biomolecule could be an effective strategy to solve antimony-resistant strains and represent a drug candidate as an anti-Trypanosomatidae species drug
-
3-[(2,3-dimethylphenyl)amino]-1-(3-nitrophenyl)propan-1-one
-
containing one NH-2,3-diMePh group
3-[(3-fluorophenyl)amino]-1-(3-nitrophenyl)propan-1-one
-
containing one NH-3-FPh group
3-[(5-chloro-2-[[2-(trifluoromethyl)phenyl]thio]phenyl)amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
3-[(5-chloro-2-[[3-(trifluoromethyl)phenyl]thio]phenyl)amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
3-[2-(aminomethyl)-10H-phenothiazin-10-yl]-N,N-dimethylpropan-1-aminium
-
3-[2-(hydroxymethyl)-10H-phenothiazin-10-yl]-N,N-dimethylpropan-1-aminium
-
3-[2-(methoxycarbonyl)-10H-phenothiazin-10-yl]-N,N-dimethylpropan-1-aminium
-
3-[2-[(1E)-N-benzyl-N-oxidoethanimidoyl]-10H-phenothiazin-10-yl]-N,N-dimethylpropan-1-aminium
-
3-[2-[(E)-(hydroxyimino)methyl]-10H-phenothiazin-10-yl]-N,N-dimethylpropan-1-aminium
-
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
4'-(benzo[b]thiophen-2-yl)-1'-benzyl-1,4'-bipiperidine
-
-
4'-(benzo[b]thiophen-2-yl)-1'-methyl-1,4'-bipiperidine
-
-
4'-(benzo[b]thiophen-2-yl)-[1,4']bipiperidine
-
-
4,15-iso-atriplicolide isobutyrate
-
4,15-iso-atriplicolide methacrylate
-
4,15-iso-atriplicolide tiglate
-
4,4'-bis(4-benzyloxy-3-methoxybenzimidoylamino)di-cyclohexylmethane
-
97% inhibition at 0.1 mM, in the presence of 0.1 mM trypanothione disulfide
4,4'-furan-2,5-diyldibenzonitrile
-
11% inhibition at 0.02 mg/ml
4,6,8-trimethyl-N-(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)quinazolin-2-amine
-
-
4-((1-(4-ethylphenyl)-2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-3-yl)methyl)thiomorpholine
most active inhibitor
4-(2-(([1,1'-biphenyl]-4-ylmethyl)amino)-N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-7Hpyrrolo[2,3-d]pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
-
-
4-(2-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidin-1'-yl)ethyl)morpholine
-
-
4-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-4-oxo-N'-phenylbutanehydrazide
-
4-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-4-oxobutanoic acid
-
4-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethyl-4-oxobutan-1-amine
-
4-(2-chlorobenzyl)cyclopent-2-en-1-one
-
0.1 mM, reversible inhibition
4-(2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-2-oxoethyl)-1-methyl-1-(pentafluorobenzyl)piperazin-1-ium formate
4-(azepan-1-ylmethyl)-2,6-di-tert-butylphenol
-
containing one Bu group and one N-homopiperidylde group
4-(benzofuroxan-5-ylmethyloxy)benzaldehyde amidinohydrazone
-
50% of inhibition at a inhibitor dose of 0.1 mM, 30% of inhibition at a inhibitor dose of 0.04 mM
4-(benzyloxy)-N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium
-
-
4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-((2-(naphthalen-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
-
-
4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-((3-phenylpropyl)amino)-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
-
-
4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-(phenethylamino)-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
-
-
4-chloromercuribenzoic acid
-
-
4-furan-2-ylbenzenesulfonamide
-
8% inhibition at 0.02 mg/ml
4-furan-2-ylbenzonitrile
-
5% inhibition at 0.02 mg/ml
4-[(4E)-5-(2-chlorophenyl)-3-oxopent-4-en-1-yl]morpholin-4-ium chloride
-
0.1 mM, irreversible inhibition
4-[(7-chloro-4-nitro-2,1,3-benzothiadiazol-5-yl)sulfanyl]quinazoline
-
reversible. Compound inhibits parasite proliferation with EC50 values between 50 and 5 microM
4-[(dimethylamino)methyl]-2,6-bis(1-methylethyl)phenol
-
containing one Pr group and one NMe2 group
4-[1-(1-benzothiophen-2-yl)cyclohexyl]morpholine
-
-
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium
4-[[bis(2-hydroxyethyl)amino]methyl]-2,6-dibutylphenol
-
5,5'-dithiobis(N-[3-(4-methylpiperazin-1-yl)propyl]-2-nitrobenzamide)
-
recombinant enzyme
5,6-dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4-ol
-
-
5,7-dichloro-4-nitro-2,1,3-benzothiadiazole
-
reversible. Compound inhibits parasite proliferation with EC50 values between 50 and 5 microM
5,7-dimethoxynaphtho[2,3-b]thiophene-4,9-dione
-
5-(2-chloroethoxy)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
-
-
5-(5-(1-(pyrrolidin-1-yl)cyclohexyl)-1,3-thiazol-2-yl)-1H-indole
competitive inhibition
-
5-chloro-2-[(4-chlorophenyl)sulfanyl]-N-[3-(4-methylpiperazin-1-yl)propyl]aniline
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-(phenylsulfanyl)aniline
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-naphthalen-1-ylphenyl)sulfanyl]aniline
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-naphthalen-2-ylphenyl)sulfanyl]aniline
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-pyridin-2-ylphenyl)sulfanyl]aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[2-(trifluoromethyl)phenyl]sulfanyl]aniline
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[3-(trifluoromethyl)phenyl]sulfanyl]aniline
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[4-(trifluoromethyl)phenyl]sulfanyl]aniline
5-methoxynaphtho[2,3-b]furan-4,9-dione
-
5-nitro-furan-2-carboxylic acid (3-dimethylamino-propyl)-amide
reversible uncompetitive inhibition regarding substrate trypanothione disulfide, IC50 value for Trypanooma cruzi growth inhibition 0.0019 microM, EC50 value for toxicity against HeLa cells 0.074 microM
5-nitrofuran-2-carbaldehyde N-butylsemicarbazone
-
-
5-nitrofuran-2-carboxylic acid benzylamide
reversible uncompetitive inhibition regarding substrate trypanothione disulfide, IC50 value for Trypanooma cruzi growth inhibition 0.0015 microM, EC50 value for toxicity against HeLa cells 0.123 microM
5-nitrofuran-2-carboxylic acid dibenzylamide
reversible uncompetitive inhibition regarding substrate trypanothione disulfide, IC50 value for Trypanooma cruzi growth inhibition 0.0001 microM, EC50 value for toxicity against HeLa cells 0.078 microM
5-[2-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
-
5-[2-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
-
5-[3-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
5-[3-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
6,7-bis[2-(dimethylamino)ethoxy]-2-[4-(1H-indol-3-ylacetyl)piperazin-1-yl]quinazolin-4-amine
-
44% inhibition at 0.05 mM
6,7-dimethoxy-2-[4-[(3R)-1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl]piperazin-1-yl]quinazolin-4-amine
-
complete inhibition at 0.1 mM
6,7-dimethoxy-2-[4-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl]piperazin-1-yl]quinazolin-4-amine
-
complete inhibition at 0.1 mM
6-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethyl-6-oxohexan-1-amine
-
6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium
6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine
i.e. RD 777. IC50 value 0.029 microM for promastigote assay. Competitive with respect to substrate trypanothione disulfide
6-bromo-2-(5-methylfuran-2-yl)-N-(2-morpholinoethyl)quinoline-4-carboxamide
-
linear mixed-type inhibition
6-bromo-2-(5-methylfuran-2-yl)-N-(4-sulfamoylbenzyl)quinoline-4-carboxamide
-
-
6-bromo-2-(5-methylfuran-2-yl)-N-(morpholin-4-yl)quinoline-4-carboxamide
-
-
6-bromo-2-(5-methylfuran-2-yl)-N-(pyridin-2-ylmethyl)quinoline-4-carboxamide
-
linear mixed-type inhibition
6-bromo-2-(5-methylfuran-2-yl)-N-(pyridin-3-yl)quinoline-4-carboxamide
-
-
6-bromo-2-(5-methylfuran-2-yl)-N-phenethylquinoline-4-carboxamide
-
-
6-bromo-N,N,N-trimethyl-2-(2-(5-methylfuran-2-yl)quinoline-4-carboxamido)ethanaminium iodide
-
-
6-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
-
linear mixed-type inhibition
6-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylthiophen-2-yl)-quinoline-4-carboxamide
-
-
6-bromo-N-(2-(dimethylamino)ethyl)-2-(furan-2-yl)quinoline-4-carboxamide
-
-
6-bromo-N-(2-(methylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
-
-
6-bromo-N-(furan-2-ylmethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
-
-
6-bromo-N-[2-(dimethylamino)ethyl]-2-(pyridin-4-yl)quinoline-4-carboxamide
-
-
6-bromo-N-[2-(dimethylamino)ethyl]-2-phenylquinoline-4-carboxamide
-
-
6-bromo-N-[3-(1H-imidazol-1-ylamino)propyl]-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
-
-
6-chloro-2-(5-methylfuran-2-yl)-N-[3-(morpholin-4-yl)propyl]quinoline-4-carboxamide
-
-
6-chloro-2-methoxyacridin-9-amine
-
6-chloro-3-[3-(3-hydroxy-2-piperidyl)-2-oxo-propyl]-7-(4-pyridyl) quinazolin-4-one
-
febrifugine analogue, putative inhibitor identified by molecular docking
6-chloro-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
-
-
6-chloro-N-[2-(dimethylamino)ethyl]-3-methyl-2-(4-methylphenyl)quinoline-4-carboxamide
-
-
6-chlorotacrine
-
competitive inhibition
6-methoxynaphtho[2,3-b]furan-4,9-dione
-
7,8-dimethoxynaphtho[2,3-b]thiophene-4,9-dione
-
7-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
-
-
7-ethoxy-4-methyl-N-(4,4,6-trimethyl-4,5-dihydropyrimidin-2-yl)quinazolin-2-amine
-
-
7-ethyl-4-methyl-N-(4,4,6-trimethyl-4,5-dihydropyrimidin-2-yl)quinazolin-2-amine
-
-
7-methoxy-N-[2-([[2-(4-methylpiperazin-1-yl)ethyl]amino]methyl)-3-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl]-4a,9a-dihydroacridin-2-amine
8-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
-
-
8-methoxynaphtho[2,3-b]furan-4,9-dione
-
9-Amino-1,2,3,4-tetrahydroacridine
-
i.e. tacrine, competitive inhibition
9-aminoacridine derivatives
-
competitive inhibition
9-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione
-
9-thioacridine derivatives
-
mixed-type inhibition
Ac-PAIIQSVGISNLKNL-NH2
about 30% residual activity at 0.025 mM
Ac-PKAIQSVGISNLKNL-NH2
about 18% residual activity at 0.025 mM
Ac-PKIIASVGISNLKNL-NH2
about 65% residual activity at 0.025 mM
Ac-PKIIQAVGISNLKNL-NH2
about 10% residual activity at 0.025 mM
Ac-PKIIQSAGISNLKNL-NH2
about 19% residual activity at 0.025 mM
Ac-PKIIQSVAISNLKNL-NH2
about 20% residual activity at 0.025 mM
Ac-PKIIQSVGASNLKNL-NH2
about 22% residual activity at 0.025 mM
Ac-PKIIQSVGIANLKNL-NH2
about 15% residual activity at 0.025 mM
Ac-PKIIQSVGISAKNL-NH2
about 30% residual activity at 0.025 mM
Ac-PKIIQSVGISMKM-NH2
the enzyme is almost completely inactivated after 50 min (3000 s) in the presence of 0.025 mM
Ac-PKIIQSVGISNLANL-NH2
about 31% residual activity at 0.025 mM
Ac-PKIIQSVGISNLKA-NH2
about 31% residual activity at 0.025 mM
Ac-PKIIQSVGISNLKNL-NH2
about 20% residual activity at 0.025 mM
acylspermines and acylspermidines
-
-
alternariol
-
no inhibitory activity
alternariol methyl ether
-
no inhibitory activity
Amphotericin B
-
0.0346 mM, 100% inhibition
antimony chloride
-
assay containing 10% vol. methanol
arsenite
-
+ NADPH, slightly
Au(2-(2'-pyridyl)benzimidazole)Cl2
-
-
-
Au-(N-(1-hydroxy-3-methylbutan-2-yl)pyridine-2-carboxamide)Cl
-
-
-
benznidazole
-
growth inhibition
benzofuroxan-5-carboxaldehyde thiosemicarbazone
-
19% of inhibition at a inhibitor dose of 0.1 mM, 9% of inhibition at a inhibitor dose of 0.04 mM
benzoyl-Gly-L-Arg-L-Arg-L-Leu-beta-naphthylamide
reversible and competitive inhibition
benzoyl-L-Arg-p-nitroanilide
reversible and competitive inhibition
benzoyl-L-Leu-L-Arg-L-Arg-beta-naphthylamide
reversible and competitive inhibition
benzoyl-L-Phe-L-Val-L-Arg-7-amido-4-methylcoumarin
reversible and competitive inhibition
benzoyl-Lys-Phe-Arg-p-nitroanilide
reversible and competitive inhibition
benzo[b]thiophen-2-yl(1-(piperidin-1-yl)cyclohexyl)methanone
-
-
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide
reversible and competitive inhibition
benzyloxycarbonyl-Gly-Gly-L-Arg-7-amido-4-methylcoumarin
reversible and competitive inhibition
benzyloxycarbonyl-L-Arg-L-Arg-4-methoxy-beta-naphthylamide
reversible and competitive inhibition
benzyloxycarbonyl-L-Arg-L-Arg-p-nitroanilide
reversible and competitive inhibition
benzyloxycarbonyl-L-Arg-p-nitroanilide
reversible and competitive inhibition
benzyloxycarbonyl-L-Lys-4-methoxy-beta-naphthylamide
reversible and competitive inhibition
bis(9H-fluoren-9-ylmethyl) [(18S,23S)-3,14,17,24-tetraoxo-1,4,8,13,16-pentaazacyclotetracosane-18,23-diyl]biscarbamate
-
lack the disulfide and trypanothione's gamma-glutamyl groups have been replaced by hydrophobic aromatic moieties
bis(tetrahydrocinnamoyl)spermine
-
i.e. kukoamine A
bisbenzylisoquinoline alkaloids
-
e.g. cepharanthine, (-)curine, daphnoline, antioquine, limacine, cycleanine
-
bromoacetyl alprenolol menthane
-
-
butyl 4-[[3-(3-nitrophenyl)-3-oxopropyl]amino]benzoate
-
containing one NH-4-(CO2-nBu)Ph group
cephalotaxine
-
compound is an alkaloid scaffold lead in the search for inhibitors
cis-3-(1,3-dioxolan-2-yl)-8-bromo-9b-(trans-acrylic acid)-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
0.1 mM
cis-3-oxo-8,9b-bis-(trans-N-(acrylamidospermidyl))-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
IC50: 0.029 mM
cis-3-oxo-8,9b-bis-(trans-N1-(acrylamidospermidyl))-1,2,3,4,4a,9b-hexahydrodibenzofuran
-
cis-3-oxo-8,9b-bis-(trans-N3-(dimethylamino)propylacrylamido)-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
0.1 mM
cis-3-oxo-8-trans-(N-acrylamidospermidyl)-9b-trans-ethylacrylyl-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
IC50: 0.056 mM
cis-3-oxo-8-trans-(N1-acrylamidospermidyl)-9b-trans-ethylacrylyl-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
-
connesine
-
97% growth inhibition
crude extract of Lentinus strigosus
-
100% inhibition of trypanothione reductase
-
cryptolepine
-
compound is an alkaloid scaffold lead in the search for inhibitors
dethiotrypanothione
-
trypanothione disulfide analogue 2, lack the disulfide
dibenzyl [(18S,23S)-3,14,17,24-tetraoxo-1,4,8,13,16-pentaazacyclotetracosane-18,23-diyl]biscarbamate
-
lack the disulfide and trypanothione's gamma-glutamyl groups have been replaced by hydrophobic aromatic moieties
dihydrohypnophilin
-
no inhibitory activity
diphenyl(1-(piperidin-1-yl)cyclohexyl)methanol
-
-
ethyl 2-acetyl-5-[4-butyl-2-(3-hydroxypentyl)-5-nitro-1H-imidazol-1-yl]pent-2-enoate
-
putative drug candidate for the treatment of visceral leishmaniasis
eupomatenoid-5
-
eupomatenoid-5 decreases enzyme activity, leading to a relative increase in reactive oxygen species that triggers mitochondrial depolarization followed by an absolute increase in mitochondrial reactive oxygen and nitrogen species production through the electron transport chain. This increase in reactive oxygen and nitro-gen species induces oxidative damage, leading to parasite death
Gentian violet
-
wild-type and recombinant enzyme overexpressing cells
H2O2
-
wild-type and recombinant enzyme overexpressing cells
heptyl (2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinecarboxylate
-
-
hexyl (2E)-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarboxylate
-
-
hypnophilin
-
100% inhibition of trypanothione reductase, reduces the proliferation of human peripheral blood monocluear cells, not cytotoxic for lymphocytes and monocytes
isopropyl 2-isobutyryl-3-trifluoromethylquinoxaline-7-carboxylate 1,4-di-N-oxide
noncompetitive. IC50 values against strains NINOA and INC-5 are 0.060 microM and 0.073 microM, respectively, IC50 against human glutathione reductase is 0.050 microM
kukoamine A
-
mixed inhibitor
L-Arg-beta-naphthylamide
reversible and competitive inhibition
L-His-L-Trp-L-His
reversible and competitive inhibition
L-His-L-Trp-L-Lys
reversible and competitive inhibition
L-Phe-L-Arg-L-Trp
reversible and competitive inhibition
L-Phe-L-Met-L-Arg-L-Phe-NH2
reversible and competitive inhibition
L-Phe-L-Pro-L-Arg-4-methoxy-beta-naphthylamide
reversible and competitive inhibition
L-Trp
reversible and competitive inhibition
L-Trp-beta-naphthylamide
reversible and competitive inhibition
lunarinol
Lunaria biennis
-
0.1 mM
masticadienonic acid
the potent biomolecule could be an effective strategy to solve antimony-resistant strains and represent a drug candidate as an anti-Trypanosomatidae species drug
-
melarsen-trypanothione disulfide adduct
melarsen-trypanothione disulfide-adduct
melarsoprol
-
+ NADPH, slightly
MelT
-
adduct of melarsen oxide with dihydrotrypanothione
miconazole
-
0.064 mM, 100% inhibition
N'-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N,N-dimethylethane-1,2-diamine
N'-(5-chloro-2-[[2-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
N'-(5-chloro-2-[[3-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
-
-
N'-(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
N'-[2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]-N,N-dimethylpropane-1,3-diamine
N'-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-N,N-dimethyl-1,2-ethanediamine
N'-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N,N-dimethylethane-1,2-diamine
N'-[5-chloro-2-(naphthalen-1-ylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
N'-[5-chloro-2-(naphthalen-2-ylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
N'-[5-chloro-2-(phenylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
N'-[5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]-N,N-dimethylpropane-1,3-diamine
N,N'-(4,4'-diselanediylbis[4,1-phenylene])bisadamantamide
-
-
N,N'-(4,4'-diselanediylbis[4,1-phenylene])bisfuran-2-carboxamide
-
-
N,N'-(4,4'-diselanediylbis[4,1-phenylene])bisnaphthamide
-
-
N,N'-(furan-2,5-diyldibenzene-4,1-diyl)diacetamide
-
IC50: 0.0485 mM, 54% inhibition at 0.02 mg/ml
N,N-diethyl-2-(2-imino-3-prop-2-en-1-yl-2,3-dihydro-1H-benzimidazol-1-yl)ethanamine
-
IC50: 0.1 mM, 31% inhibition at 0.025 mM
N,N-diethyl-2-[2-imino-3-(2-phenoxyethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanamine
-
IC50: 0.008 mM
N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-aminium
-
N,N-dimethyl-3-(2-propanoyl-10H-phenothiazin-10-yl)propan-1-aminium
-
N,N-dimethyl-3-(3-nitrophenyl)-3-oxopropan-1-aminium chloride
-
containing one NMe2 HCl group
N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-aminium
-
N,N-dimethyl-3-[2-[(1E)-N-methyl-N-oxidoethanimidoyl]-10H-phenothiazin-10-yl]propan-1-aminium
-
N,N-dimethyl-3-[4-(methylsulfonyl)phenyl]-3-oxopropan-1-aminium chloride
-
containing one NMe2 HCl group
N,N-dimethyl-N-[3-(7-methoxy-1-methyl-3,4-dihydro-9H-beta-carbolin-9-yl)propyl]amine
N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
-
-
N-(2-(dimethylamino)ethyl)-6-fluoro-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
-
-
N-(2-phenoxyethyl)-N'-(2-piperidin-1-ylethyl)benzene-1,2-diamine
-
IC50: 0.1 mM
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-2-(4-methylpiperazin-1-yl)acetamide
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N2,N2-dimethylglycinamide
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
N-(3,4-dichlorobenzyl)-2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-2-oxoethanaminium
N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(pentafluoro-l6-sulfanyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride
mixed-type inhibition
N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(trifluoromethyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride
competitive inhibition
N-(3,5-di-tert-butyl-4-hydroxybenzyl)-2-hydroxyethanaminium chloride
-
containing one Bu group and one N((CH2)2OH) HCl group
N-(3-chlorobenzyl)-3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
N-(3-chlorophenyl)-N',N'-dimethyl-N-phenylpropane-1,3-diamine
-
-
N-(3-dimethylamino-propyl)-O-[(E)-3-(3-[(E)-3-[N-(3-dimethylamino-propyl)aminooxy]-propenyl]-benzofuran-5-yl)-allyl]-hydroxylamine
-
benzofuranyl-based acyclic bis-polyamine analogue of lunarine with a planar bicyclic benzofuranyl scaffold, inhibition mechanism
N-(4,6-dimethylpyrimidin-2-yl)-4,5,7-trimethylquinazolin-2-amine
-
-
N-(4,6-dimethylpyrimidin-2-yl)-4,6-dimethylquinazolin-2-amine
-
-
N-(4-bromobenzyl)-3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
N-(4-chlorobenzyl)-3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
N-(4-tert-butylbenzyl)-3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-butane-1,4-diamine
-
-
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-ethane-1,2-diamine
-
enzyme and growth inhibition
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-hexane-1,6-diamine
-
-
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-propane-1,3-diamine
-
-
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethylaminomethyl)ferrocenylmethyl]-ethane-1,2-diamine
N-(pyridin-3-ylmethyl)-1-thiophen-2-ylmethanediamine
-
0.1 mM, 10% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
N-benzyl-3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
N-benzyl-4-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-4-oxobutanamide
-
N-benzyl-6-bromo-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
-
-
N-benzyolxycarbonyl-L-glutamyl(-benzoyl)-L-Leu-Ala
-
glutathione analogue, ASC-I-74B, inhibition of parasite growth and trypanothione reductase activity
N-benzyolxycarbonyl-L-glutamyl(-benzoyl)-L-Leu-Gly
-
glutathione analogue, ASC-I-74A, inhibition of parasite growth and trypanothione reductase activity
N-benzyolxycarbonyl-L-glutamyl(-benzoyl)-L-Val-Ala
-
glutathione analogue, ASC-I-75B, inhibition of parasite growth and trypanothione reductase activity
N-benzyolxycarbonyl-L-glutamyl(-benzoyl)-L-Val-Gly
-
glutathione analogue, ASC-I-75A, inhibition of parasite growth and trypanothione reductase activity
N-methyl-N-(2-oxo-2-(2-(phenylthio)phenylamino)ethyl)cyclohexanaminium
N-[(2E)-1-(2-phenoxyethyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]acetamide
-
IC50: 0.1 mM
N-[(4-chlorophenyl)(phenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octan-3-imine
-
-
N-[(4-methylpiperazin-1-yl)methyl]-1-thiophen-2-ylmethanediamine
-
0.1 mM, 10% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide
N-[2-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-2-oxoethyl]aniline
-
N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide
N-[2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]-3-(4-methylpiperazin-1-yl)propanamide
-
5% inhibition at 0.1 mM
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-phenylacetamide
-
IC50: 0.0368 mM
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-4-nitrobenzamide
-
IC50: 0.0445 mM
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]benzamide
-
IC50: 0.0496 mM
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]butanamide
-
IC50: 0.0305 mM
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]propanamide
-
IC50: 0.0316 mM
N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-2-(4-methyl-1-piperazinyl)acetamide
N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-2-(4-methyl-1-piperazinyl)ethanimidamide
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
N-[2-[(naphthalen-1-ylacetyl)amino]ethyl]-4-[[(3-nitrophenyl)(oxo)acetyl]amino]piperidine-4-carboxamide
-
0.1 mM
N-[3-(4-amino-butylamino)-propyl]-O-[(E)-3-[3-((E)-3-[N-[3-(4-amino-butylamino)-propyl]aminooxy]-propenyl)-benzofuran-5-yl]-allyl]-hydroxylamine
-
benzofuranyl-based acyclic bis-polyamine analogue of lunarine with a planar bicyclic benzofuranyl scaffold, inhibition mechanism
N-[3-(4-methyl-piperazin-1-yl)-propyl]-O-[(E)-3-[3-((E)-3-[N-[3-(4-methyl-piperazin-1-yl)-propyl]aminooxy]-propenyl)-benzofuran-5-yl]-allyl]-hydroxylamine
-
benzofuranyl-based acyclic bis-polyamine analogue of lunarine with a planar bicyclic benzofuranyl scaffold, inhibition mechanism
N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-4-(diphenylmethoxy)-N,N-dimethylanilinium
-
-
N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium
-
-
N-[4-(benzyloxy)benzyl]-3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
N-[5-chloro-2-(phenylsulfanyl)phenyl]-3-(4-methylpiperazin-1-yl)propanamide
-
0% inhibition at 0.04 mM
N-[5-chloro-2-(phenylthio)phenyl]-3-(4-methylpiperazine-1-yl)-propanamidine
N1,N4-bis(3-aminopropyl)-N1-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-yl)-N4-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)butane-1,4-diamine
-
-
N1,N9-bis-(L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide))-norspermidine
-
non-competitive inhibitor
N1,N9-bis-(L-tryptophanyl)-norspermidine
-
competitive inhibitor
N1,N9-bis-(L-tryptophanyl-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide))-norspermidine
-
non-competitive inhibitor
N1,N9-bis-(L-tryptophanyl-L-arginyl)-norspermidine
-
non-competitive inhibitor
N1-((1-(3-(2-(2-oxoimidazolidin-1-yl)ethoxy)-4-(4-phenethylthiazol-2-yl)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
-
-
N1-((1-(4-(4-(2-(naphthalen-2-yl)ethyl)thiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)-methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
-
-
N1-((1-(4-(4-(2-([1,1'-biphenyl]-4-yl)ethyl)thiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
-
-
N1-((1-(4-(4-benzylthiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
-
-
N1-((1-(4-(4-isobutylthiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
-
-
N1-((1-(4-(4-neopentylthiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
-
-
N1-(3-aminopropyl)-N1-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-yl)butane-1,4-diamine
-
-
N1-(3-aminopropyl)-N1-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-yl)propane-1,3-diamine
-
-
N1-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-N9-acetyl-norspermidine
-
-
N1-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-N9-hexanoyl-norspermidine
-
-
N1-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-N9-L-arginyl-norspermidine
-
non-competitive inhibitor
N1-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-norspermidine
-
-
N1-L-arginyl-N9-acetyl-norspermidine
-
-
N1-L-arginyl-N9-hexanoyl-norspermidine
-
-
N1-L-arginyl-norspermidine
-
-
N1-L-tryptophanyl-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-N9-acetyl-norspermidine
-
-
N1-L-tryptophanyl-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-N9-hexanoyl-norspermidine
-
-
N1-L-tryptophanyl-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-norspermidine
-
-
N1-L-tryptophanyl-L-arginyl-N9-acetyl-norspermidine
-
-
N1-L-tryptophanyl-L-arginyl-N9-hexanoyl-norspermidine
-
-
N1-L-tryptophanyl-L-arginyl-N9-L-tryptophanyl-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-norspermidine
-
non-competitive inhibitor
N1-L-tryptophanyl-L-arginyl-norspermidine
-
-
N1-L-tryptophanyl-N9-acetyl-norspermidine
-
-
N1-L-tryptophanyl-N9-hexanoyl-norspermidine
-
-
N1-L-tryptophanyl-norspermidine
-
-
N1N8-bis(dihydrocaffeoyl)spermidine
-
-
N4-(3-chloroacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine
-
N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine
N4-allyl benzofuroxan-5-carboxaldehyde thiosemicarbazone
-
9% of inhibition at a inhibitor dose of 0.1 mM, 13% of inhibition at a inhibitor dose of 0.04 mM
N5-(3-chloroacridin-9-yl)-N1,N1-diethylhexane-1,5-diamine
-
NaCl
-
below 5% remaining activity at 1 M
NADPH
-
NADPH inhibits the enzyme at higher concentration and during longer incubation times, enzyme can be protected by NADP+
naphtho[1,2-b]furan-4,5-dione
-
naphtho[2,3-b]furan-4,9-dione
-
nifuraxide
-
increases oxidation of the enzyme
nifuroxime
-
increases oxidation of the enzyme
nifurprazine
-
increases oxidation of the enzyme
numismine
Lunaria biennis
-
0.1 mM
oxidized 3-acetylpyridine adenine nucleotide
-
wild-type and mutant E201D and E201Q
-
panepoxydone
-
95% inhibition of trypanothione reductase
Pentamidine
-
growth inhibition
pentostam
-
growth inhibition
phenyl(1-(piperidin-1-yl)cyclohexyl)methanone
-
-
phenylarsenoxide
-
+ NADPH
potassium antimony tartrate
-
assay containing 10% vol. methanol
quebrachamine
-
compound is an alkaloid scaffold lead in the search for inhibitors
quinacrine mustard
-
enzyme and inhibitor first forms a reversible complex, then irreversible inactivation of NADPH-reduced and oxidized enzyme occurs, enzyme contains 2 interacting binding sites in the active site for the inhibitors, 2 inhibitor molecules per enzyme monomer are bound, addition of 2-mercaptoethanol prevents inactivation up to 25 mM, clomipramine strongly protects th enzyme from inactivation
spermidine derivatives
-
derivatives of 2-amino-diphenylsulfide + phenothiazine
-
spermine derivatives
-
derivatives of 2-amino-diphenylsulfide + phenothiazine
-
tert-butyl 4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidine-1'-carboxylate
-
-
tert-butyl 4'-cyano-1,4'-bipiperidine-1'-carboxylate
-
-
tert-butyl-L-Leu-L-Arg-L-Arg-7-amido-4-methylcoumarin
reversible and competitive inhibition
tert-butyl-L-Leu-L-Lys-L-Arg-7-amido-4-methylcoumarin
reversible and competitive inhibition
tetrahydrolunarine
Lunaria biennis
-
0.1 mM
tetrahydrolunarinol
Lunaria biennis
-
0.1 mM
thio-NADP+
-
wild-type and mutant E201D and E201Q
trans-4-[3-(3,4-dichlorophenyl)indan-1-yl]morpholine
-
-
trans-benzyl-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]amine
-
-
trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]-4-methylbenzenesulfonamide
-
-
trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]acetamide
-
-
trans-[3-(3,4-dibromophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
-
-
trans-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
-
-
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3,4-dichlorobenzyl)amine
-
-
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3-methylbutyl)amine
-
-
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-aminobenzyl)amine
-
-
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-chlorobenzyl)amine
-
-
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-dimethylaminobenzyl)amine
-
-
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methoxybenzyl)amine
-
-
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methylbenzyl)amine
-
-
trans-[3-(3,4-dichlorophenyl)indan-1-yl]octylamine
-
-
trans-[3-(4-chlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine
-
-
trans-[3-(4-methoxyphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
-
-
trans-[3-(4-methylphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine
-
-
triostam
-
assay containing 10% vol. methanol
Urea
-
1 mM urea has no significant effect on activity whereas 50% enzyme inhibition is observed at 750 mM, enzyme after treatment with urea below 500 mM regains about 95% activity
[(2,2'-bipyridine)Au(OH)2][PF6]
-
-
-
[6-benzyloxycarbonylamino-1,6-bis-(dimethylcarbamoylmethyl-carbamoyl)-hex-3-enyl]-carbamic acid benzyl ester
-
-
[6-benzyloxycarbonylamino-1,6-bis-(dimethylcarbamoylmethyl-carbamoyl)-hexyl]-carbamic acid benzyl ester
-
-
[Au((S)-4-Bn-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6]
-
-
-
[Au((S)-4-iPr-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6]
-
-
-
[Au2(bipy)2(m-O)2](PF6)2
-
-
-
[Cl2AuIII(2-(2'-pyridyl)benzimidazole)AuI(PPh3)](PF6)
-
-
-
[[(7-nitro-2,1,3-benzoxadiazol-4-yl)methyl]sulfanyl]methyl phenylcarbamate
-
reversible. Compound inhibits parasite proliferation with EC50 values between 50 and 5 microM
(3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium
ZINC01063940
(3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium
ZINC01063940
1,3-bis[3-(dimethylamino)propyl]-1,5-dihydro-2H-pyrimido[4,5-beta][1,4]benzothiazine-2,4(3H)-dione
-
11% growth inhibition, no inhibition of glutathione reductase
1,3-bis[3-(dimethylamino)propyl]-1,5-dihydro-2H-pyrimido[4,5-beta][1,4]benzothiazine-2,4(3H)-dione
-
no inhibition of glutathione reductase
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
-
-
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
-
-
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
-
-
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
36% inhibition at 0.1 mM
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
-
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
-
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
-
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
-
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
-
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
-
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine
-
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine
-
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine
-
-
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine
-
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
-
-
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
-
-
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
-
-
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
86% inhibition at 0.04 mM
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
-
-
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
-
-
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
-
-
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
52% inhibition at 0.04 mM
1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium
ZINC05829158
1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium
ZINC05829158
1-(3,4-dichlorobenzyl)-4-(2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-2-oxoethyl)-1-methylpiperazin-1-ium formate
-
-
1-(3,4-dichlorobenzyl)-4-(2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-2-oxoethyl)-1-methylpiperazin-1-ium formate
-
-
1-(3,4-dichlorobenzyl)-4-(2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-2-oxoethyl)-1-methylpiperazin-1-ium formate
-
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
-
-
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
-
-
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
-
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
-
-
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
-
-
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
-
1-(3,4-dichlorophenyl)-2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
-
IC50: 0.004 mM
1-(3,4-dichlorophenyl)-2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
-
-
1-(3,4-dichlorophenyl)-2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
-
IC50: 0.01 mM, 92% inhibition at 0.025 mM
1-(3,4-dichlorophenyl)-2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
-
-
1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane
ZINC00346140
1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane
ZINC00346140
1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide
ZINC1064012
1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide
ZINC1064012
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium
ZINC00702046
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium
ZINC00702046
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
-
-
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
-
-
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
-
-
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
16% inhibition at 0.1 mM
1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium
ZINC05119716
1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium
ZINC05119716
1-ethyl-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 14% inhibition
-
1-ethyl-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 27% inhibition
-
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
-
-
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
-
-
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
-
-
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
28% inhibition at 0.1 mM
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
-
-
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
-
-
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
-
-
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
28% inhibition at 0.1 mM
1-[1-(4,5-diphenylthiophen-2-yl)cyclohexyl]pyrrolidine
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 11% inhibition
-
1-[1-(4,5-diphenylthiophen-2-yl)cyclohexyl]pyrrolidine
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 15% inhibition
-
1-[1-[4,5-bis(2H-1,3-benzodioxol-5-yl)thiophen-2-yl]cyclohexyl]pyrrolidine
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 11% inhibition
-
1-[1-[4,5-bis(2H-1,3-benzodioxol-5-yl)thiophen-2-yl]cyclohexyl]pyrrolidine
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 23% inhibition
-
1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium
ZINC04866531
1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium
ZINC04866531
1-[2-(4-methylpiperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase,60 % inhibition
-
1-[2-(4-methylpiperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 78% inhibition
-
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)-ferrocenylmethyl]-3-p-chloro-phenyl-urea
-
ferrocenic 4-aminoquinoline urea compound 9, growth inhibition
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)-ferrocenylmethyl]-3-p-chloro-phenyl-urea
-
ferrocenic 4-aminoquinoline urea compound 9, growth inhibition
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)-ferrocenylmethyl]-3-p-chloro-phenyl-urea
-
ferrocenic 4-aminoquinoline urea compound 9, enzyme and growth inhibition
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-methoxyphenyl-urea
-
ferrocenic 4-aminoquinoline urea compound 6, growth inhibition
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-methoxyphenyl-urea
-
ferrocenic 4-aminoquinoline urea compound 6, growth inhibition
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-methoxyphenyl-urea
-
ferrocenic 4-aminoquinoline urea compound 6, enzyme and growth inhibition
1-[2-(morpholin-4-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 34% inhibition
-
1-[2-(morpholin-4-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 38% inhibition
-
1-[2-(piperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 80% inhibition
-
1-[2-(piperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 88% inhibition
-
1-[2-(piperidin-4-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 68% inhibition
-
1-[2-(piperidin-4-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 84% inhibition
-
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
-
-
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
-
-
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
-
-
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
25% inhibition at 0.1 mM
12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium
ZINC00347698
12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium
ZINC00347698
2-(1-cyclopentylcyclohexyl)-1-benzothiophene
-
-
2-(1-cyclopentylcyclohexyl)-1-benzothiophene
-
-
2-(1-cyclopentylcyclohexyl)-1-benzothiophene
-
-
2-(1-cyclopentylcyclohexyl)-1-benzothiophene
61% inhibition at 0.04 mM
2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
ZINC03307332
2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
ZINC03307332
2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
ZINC2628155
2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
ZINC2628155
2-(dimethylamino)-N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]acetamide
-
-
2-(dimethylamino)-N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]acetamide
-
-
2-(dimethylamino)-N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]acetamide
-
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
-
-
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
-
-
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
-
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
-
-
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
-
-
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
-
2-[(4-bromophenyl)sulfanyl]-5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]aniline
-
39% inhibition at 0.1 mM
2-[(4-bromophenyl)sulfanyl]-5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]aniline
-
-
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride
-
non-competitive inhibition, 76% inhibition at 0.001 mM
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride
-
non-competitive inhibition, 69.5% inhibition at 0.001 mM
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride
-
non-competitive inhibition, 70% inhibition at 0.001 mM
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride
-
non-competitive inhibition, 83% inhibition at 0.001 mM
2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium
ZINC04427277
2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium
ZINC04427277
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
-
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
-
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
-
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
58% inhibition at 0.1 mM
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
-
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
-
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
-
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
42% inhibition at 0.1 mM
2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-N-(pentafluorobenzyl)-2-oxoethanaminium formate
-
-
2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-N-(pentafluorobenzyl)-2-oxoethanaminium formate
-
-
2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-N-(pentafluorobenzyl)-2-oxoethanaminium formate
-
2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-N-[(5-nitro-2-furyl)methyl]-2-oxoethanaminium formate
-
-
2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-N-[(5-nitro-2-furyl)methyl]-2-oxoethanaminium formate
-
-
2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-N-[(5-nitro-2-furyl)methyl]-2-oxoethanaminium formate
-
3,3'-[5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophene-2,3-diyl]dipyridine
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 10% inhibition
-
3,3'-[5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophene-2,3-diyl]dipyridine
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 10% inhibition
-
3-((10H-phenothiazin-10-yl)methyl)-1-azoniabicyclo[2.2.2]octane
-
3-((10H-phenothiazin-10-yl)methyl)-1-azoniabicyclo[2.2.2]octane
-
3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium
ZINC00347760
3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium
ZINC00347760
3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium
ZINC04128838
3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium
ZINC04128838
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
cationic diaryl sulphide-based inhibitor, 99% growth inhibition
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
-
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
cationic diaryl sulphide-based inhibitor
3-([5-chloro-2-[(4'-methylbiphenyl-4-yl)thio]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
-
-
3-([5-chloro-2-[(4'-methylbiphenyl-4-yl)thio]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
-
-
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
cationic diaryl sulphide-based inhibitor, 99% growth inhibition
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
-
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
cationic diaryl sulphide-based inhibitor
3-([5-chloro-2-[1-naphthylthio]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethyl-propan-1-ammonium chloride
-
-
3-([5-chloro-2-[1-naphthylthio]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethyl-propan-1-ammonium chloride
-
-
3-([5-chloro-2-[2-naphthylthio]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethyl-propan-1-ammonium chloride
-
-
3-([5-chloro-2-[2-naphthylthio]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethyl-propan-1-ammonium chloride
-
-
3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
-
growth inhibition
3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
-
growth inhibition
3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
-
enzyme and growth inhibition
3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
-
-
3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
-
IC50: 0.0065 mM
3-[(5-chloro-2-[[2-(trifluoromethyl)phenyl]thio]phenyl)amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
-
-
3-[(5-chloro-2-[[2-(trifluoromethyl)phenyl]thio]phenyl)amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
-
-
3-[(5-chloro-2-[[3-(trifluoromethyl)phenyl]thio]phenyl)amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
-
-
3-[(5-chloro-2-[[3-(trifluoromethyl)phenyl]thio]phenyl)amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
-
-
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
cationic diaryl sulphide-based inhibitor, 99% growth inhibition
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
-
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
cationic diaryl sulphide-based inhibitor, 38% growth inhibition
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
cationic diaryl sulphide-based inhibitor, 99% growth inhibition
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
-
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
cationic diaryl sulphide-based inhibitor, 0% growth inhibition
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
-
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
-
about 60% inhibition at 0.04 mM
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride
-
-
4,15-iso-atriplicolide isobutyrate
-
0.1 mM, 15 min, 62% inhibition. The enzyme is inhibited by 4,15-iso-atriplicolide esters in its reduced dithiol state
-
4,15-iso-atriplicolide isobutyrate
0.1 mM, 15 min, 80% inhibition
-
4,15-iso-atriplicolide methacrylate
-
0.1 mM, 15 min, 68% inhibition. The enzyme is inhibited by 4,15-iso-atriplicolide esters in its reduced dithiol state
-
4,15-iso-atriplicolide methacrylate
0.1 mM, 15 min, 41% inhibition
-
4,15-iso-atriplicolide tiglate
-
0.1 mM, 15 min, 87% inhibition. The enzyme is inhibited by 4,15-iso-atriplicolide esters in its reduced dithiol state
-
4,15-iso-atriplicolide tiglate
0.1 mM, 15 min, 89% inhibition
-
4-(2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-2-oxoethyl)-1-methyl-1-(pentafluorobenzyl)piperazin-1-ium formate
-
-
4-(2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-2-oxoethyl)-1-methyl-1-(pentafluorobenzyl)piperazin-1-ium formate
-
-
4-(2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-2-oxoethyl)-1-methyl-1-(pentafluorobenzyl)piperazin-1-ium formate
-
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
-
-
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
-
-
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
-
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
-
-
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
-
-
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
-
4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium
ZINC02240886
4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium
ZINC02240886
5-chloro-2-[(4-chlorophenyl)sulfanyl]-N-[3-(4-methylpiperazin-1-yl)propyl]aniline
-
-
5-chloro-2-[(4-chlorophenyl)sulfanyl]-N-[3-(4-methylpiperazin-1-yl)propyl]aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-(phenylsulfanyl)aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-(phenylsulfanyl)aniline
-
33% inhibition at 0.1 mM
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-(phenylsulfanyl)aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-(phenylsulfanyl)aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-(phenylsulfanyl)aniline
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-naphthalen-1-ylphenyl)sulfanyl]aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-naphthalen-1-ylphenyl)sulfanyl]aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-naphthalen-2-ylphenyl)sulfanyl]aniline
-
less than 5% inhibition at 0.04 mM
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-naphthalen-2-ylphenyl)sulfanyl]aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[2-(trifluoromethyl)phenyl]sulfanyl]aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[2-(trifluoromethyl)phenyl]sulfanyl]aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[3-(trifluoromethyl)phenyl]sulfanyl]aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[3-(trifluoromethyl)phenyl]sulfanyl]aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[4-(trifluoromethyl)phenyl]sulfanyl]aniline
-
-
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[4-(trifluoromethyl)phenyl]sulfanyl]aniline
-
-
5-[2-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 14% inhibition
-
5-[2-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 41% inhibition
-
5-[2-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 29% inhibition
-
5-[2-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 38% inhibition
-
5-[3-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 23% inhibition
-
5-[3-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 43% inhibition
-
5-[3-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 14% inhibition
-
5-[3-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 41% inhibition
-
5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 19% inhibition
-
5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
0.012 mM inhibitor in presence of 0.04 mM trypanothione reductase, 51% inhibition
-
6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium
ZINC01736882
6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium
ZINC01736882
7-methoxy-N-[2-([[2-(4-methylpiperazin-1-yl)ethyl]amino]methyl)-3-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl]-4a,9a-dihydroacridin-2-amine
-
-
7-methoxy-N-[2-([[2-(4-methylpiperazin-1-yl)ethyl]amino]methyl)-3-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl]-4a,9a-dihydroacridin-2-amine
-
-
7-methoxy-N-[2-([[2-(4-methylpiperazin-1-yl)ethyl]amino]methyl)-3-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl]-4a,9a-dihydroacridin-2-amine
31% inhibition at 0.02 mM
ajoene
-
i.e. (E,Z)-4,5,9-trithiadodeca-1,6,11-triene-9-oxide, natural compound from garlic, Allium sativum, covalent inhibition, but also substrate; time- and temperature-dependent inhibition
altenusin
-
no inhibitory activity on viability of amastigotes
altenusin
-
a biphenyl isolated from the endophytic fungus Alternaria sp.
amitryptyline
-
aspidospermine
-
11% growth inhibition, no inhibition of glutathione reductase
aspidospermine
-
no inhibition of glutathione reductase
chinifur
-
inhibits trypanothione reductase and acts as subversive substrate
chinifur
-
increases oxidation of the enzyme
chlorpromazine
-
0.0896 mM, 80% inhibition
clomipramine
-
clomipramine
-
recombinant enzyme
ebselen
-
-
formate
-
-
iodoacetamide
-
inhibition only of the enzyme with reduced cysteine residues in the catalytic center by alkylation
iodoacetamide
-
inhibition only of the enzyme with reduced cysteine residues in the catalytic center by alkylation
juglone
-
-
juglone derivatives
-
-
lunarine
Lunaria biennis
-
IC50: 0.065 mM
lunarine
-
Lunaria derived alkaloid with a unusual 3-oxohexahydrodibenzofuranyl tricyclic scaffold, competitive, reversible formation of a covalent adduct between Cys53 and one of the alpha,beta-unsaturated amide groups of lunarine, mechanism, enzyme needs to be in reduced state
Melarsen oxide
-
inhibition is increased in presence of NADPH, inhibition is abolished by melarsen-trypanothione disulfide adduct
Melarsen oxide
over 95% inhibition at 0.05 mM
melarsen-trypanothione disulfide adduct
-
no inhibition
melarsen-trypanothione disulfide adduct
-
i.e. adduct of p-(4,6-diamino-S-triazinyl-2-yl)aminophenyl arsenoxide with N1,N8-bis-(glutathionyl)spermidine
melarsen-trypanothione disulfide adduct
-
i.e. adduct of p-(4,6-diamino-S-triazinyl-2-yl)aminophenyl arsenoxide with N1,N8-bis-(glutathionyl)spermidine
melarsen-trypanothione disulfide adduct
-
i.e. adduct of p-(4,6-diamino-S-triazinyl-2-yl)aminophenyl arsenoxide with N1,N8-bis-(glutathionyl)spermidine
melarsen-trypanothione disulfide-adduct
-
-
melarsen-trypanothione disulfide-adduct
-
-
melarsen-trypanothione disulfide-adduct
-
-
menadione
-
-
menadione derivatives
-
-
-
menadione derivatives
-
-
-
menadione derivatives
-
-
-
menadione derivatives
-
-
Mepacrine
-
Mepacrine
-
0.0672 mM, 70% inhibition
Mepacrine
-
i.e. quinacrine, competitive inhibition
N'-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N,N-dimethylethane-1,2-diamine
-
-
N'-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N,N-dimethylethane-1,2-diamine
-
-
N'-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N,N-dimethylethane-1,2-diamine
19% inhibition at 0.02 mM
N'-(5-chloro-2-[[2-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
-
-
N'-(5-chloro-2-[[2-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
-
-
N'-(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
-
-
N'-(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
-
-
N'-[2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]-N,N-dimethylpropane-1,3-diamine
-
-
N'-[2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]-N,N-dimethylpropane-1,3-diamine
-
-
N'-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-N,N-dimethyl-1,2-ethanediamine
-
-
N'-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-N,N-dimethyl-1,2-ethanediamine
-
-
N'-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-N,N-dimethyl-1,2-ethanediamine
-
N'-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N,N-dimethylethane-1,2-diamine
-
-
N'-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N,N-dimethylethane-1,2-diamine
-
-
N'-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N,N-dimethylethane-1,2-diamine
28% inhibition at 0.02 mM
N'-[5-chloro-2-(naphthalen-1-ylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
-
-
N'-[5-chloro-2-(naphthalen-1-ylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
-
-
N'-[5-chloro-2-(naphthalen-2-ylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
-
-
N'-[5-chloro-2-(naphthalen-2-ylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
-
-
N'-[5-chloro-2-(phenylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
-
-
N'-[5-chloro-2-(phenylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
-
-
N'-[5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]-N,N-dimethylpropane-1,3-diamine
-
-
N'-[5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]-N,N-dimethylpropane-1,3-diamine
-
-
N,N-dimethyl-N-[3-(7-methoxy-1-methyl-3,4-dihydro-9H-beta-carbolin-9-yl)propyl]amine
-
57% growth inhibition, no inhibition of glutathione reductase, twenty-three heterocyclic compounds are evaluated for their potential as trypanothione reductase inhibitors
N,N-dimethyl-N-[3-(7-methoxy-1-methyl-3,4-dihydro-9H-beta-carbolin-9-yl)propyl]amine
-
no inhibition of glutathione reductase, twenty-three heterocyclic compounds are evaluated for their potential as trypanothione reductase inhibitors
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-2-(4-methylpiperazin-1-yl)acetamide
-
-
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-2-(4-methylpiperazin-1-yl)acetamide
-
-
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-2-(4-methylpiperazin-1-yl)acetamide
20% inhibition at 0.02 mM
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N2,N2-dimethylglycinamide
-
-
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N2,N2-dimethylglycinamide
-
-
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N2,N2-dimethylglycinamide
23% inhibition at 0.02 mM
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
-
-
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
-
-
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
-
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
-
-
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
-
-
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
-
N-(3,4-dichlorobenzyl)-2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-2-oxoethanaminium
-
-
N-(3,4-dichlorobenzyl)-2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-2-oxoethanaminium
-
-
N-(3,4-dichlorobenzyl)-2-[[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]amino]-N,N-dimethyl-2-oxoethanaminium
-
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethylaminomethyl)ferrocenylmethyl]-ethane-1,2-diamine
-
growth inhibition
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethylaminomethyl)ferrocenylmethyl]-ethane-1,2-diamine
-
growth inhibition
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
-
-
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
-
-
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
-
-
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
46% inhibition at 0.1 mM
N-methyl-N-(2-oxo-2-(2-(phenylthio)phenylamino)ethyl)cyclohexanaminium
-
N-methyl-N-(2-oxo-2-(2-(phenylthio)phenylamino)ethyl)cyclohexanaminium
-
N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide
ZINC00667609
N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide
ZINC00667609
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide
ZINC02647011
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide
ZINC02647011
N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-2-(4-methyl-1-piperazinyl)acetamide
-
-
N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-2-(4-methyl-1-piperazinyl)acetamide
-
-
N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-2-(4-methyl-1-piperazinyl)acetamide
-
N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-2-(4-methyl-1-piperazinyl)ethanimidamide
-
-
N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-2-(4-methyl-1-piperazinyl)ethanimidamide
-
-
N-[2-[(7-methoxy-2-acridinyl)amino]-6-(phenylsulfanyl)benzyl]-2-(4-methyl-1-piperazinyl)ethanimidamide
-
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
-
-
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
-
-
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
19% inhibition at 0.02 mM
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
-
-
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
-
-
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
15% inhibition at 0.02 mM
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
-
-
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
-
-
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
16% inhibition at 0.02 mM
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
-
-
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
-
-
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
12% inhibition at 0.02 mM
N-[5-chloro-2-(phenylthio)phenyl]-3-(4-methylpiperazine-1-yl)-propanamidine
-
-
N-[5-chloro-2-(phenylthio)phenyl]-3-(4-methylpiperazine-1-yl)-propanamidine
-
-
N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine
-
-
N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine
-
-
N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine
-
nifurtimox
-
wild-type and recombinant enzyme overexpressing cells
nifurtimox
-
weak inhibitor of trypanothione reductase
nifurtimox
-
weak inhibitor
nitrofurazone
-
wild-type and recombinant enzyme overexpressing cells
Plumbagin
-
-
plumbagin derivatives
-
-
-
plumbagin derivatives
-
-
-
plumbagin derivatives
-
-
-
plumbagin derivatives
-
-
prochlorperazine
-
-
Quinacrine
-
thioridazine
-
thioridazine
potent irreversible inhibitor. 100% inhibition at 0.010 mM
Trifluoperazine
-
0.0655 mM, 92% inhibition
additional information
-
insights about resveratrol analogs against trypanothione reductase. Molecular modeling, computational docking and in vitro antileishmanial studies
-
additional information
no inhibition by melarsoprol
-
additional information
-
no inhibition by melarsoprol
-
additional information
not inhibited by Ac-KMGISSMVQPKII-NH2 and Ac-KIIPKVQGMSIMS-NH2
-
additional information
-
not inhibited by Ac-KMGISSMVQPKII-NH2 and Ac-KIIPKVQGMSIMS-NH2
-
additional information
Lunaria biennis
-
no inhibition by 0.1 mM cis-3-(1,3-dioxolan-2-yl)-8,9b-bis-(trans-ethyl-acrylyl)-1,2,3,4,4a,9b-hexahydrodibenzofuran
-
additional information
-
increasing ionic strength leads to inhibition, e.g. with NaCl, KCl, (NH4)SO4, HEPES
-
additional information
-
antiparasitic drugs designed using three-dimensional structure
-
additional information
-
neopanepoxydol has no inhibitory activity
-
additional information
a virtual screening of a library of thiadiazine derivatives against trypanothione reductase using molecular docking is performed. Thiadiazine-based compounds are identified as plausible candidates to selectively inhibit the parasitic enzyme
-
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0.0085
(1,3,5-triaza-7-phosphaadamantane)Au(saccharine)
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0065
(1E,2E)-3-(5-nitrofuran-2-yl)prop-2-enal N-hexylsemicarbazone
Trypanosoma cruzi
-
-
0.0829
(2-chloroethoxy)diphenylmethane
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0021
(2E)-3-(5-nitrofuran-2-yl)-N-tricyclo[3.3.1.13,7]dec-1-ylprop-2-enamide
Trypanosoma cruzi
-
-
0.0023
(2E)-N-hexyl-3-(5-nitrofuran-2-yl)prop-2-enamide
Trypanosoma cruzi
-
-
0.023
(2Z)-2-[(2E)-2-(3H-indol-3-ylidene)ethylidene]-1-methyl-1,2-dihydroquinoline
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
(3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium
0.013
(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)(phenyl)-methanone
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0013
1,1'-[ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis(3-benzyl-1,3-dihydro-2H-benzimidazol-2-imine)
Trypanosoma brucei rhodesiense
-
-
0.1
1,1'-[methanediylbis(oxyethane-2,1-diyl)]bis(3-methyl-1,3-dihydro-2H-benzimidazol-2-imine)
Trypanosoma brucei
-
IC50: 0.1 mM
0.004
1,1'-[methanediylbis(oxyethane-2,1-diyl)]bis(3-phenyl-1,3-dihydro-2H-benzimidazol-2-imine)
Trypanosoma brucei
-
IC50: 0.004 mM
0.0086
1,6-dimethyl-3-(4-methylphenyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0044
1-((1-benzo[b]furan-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-((1-benzo[b]thiazol-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.01
1-((1-benzo[b]thiophen-2-yl)cyclohexyl)-4-methylpiperazine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.005
1-((1-benzo[b]thiophen-2-yl)cyclohexyl)diethylamine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00091
1-((1-benzo[b]thiophen-2-yl)cyclohexyl)pyrrolidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.011
1-((1-benzo[b]thiophen-2-yl)cyclopentyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.06
1-((1-benzo[b]thiophen-3-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-((1-biphenyl-4-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-((1-naphthalen-1-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.028
1-((1-naphthalen-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-((1-thiophen-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.115
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.0487
1-((2-benzhydryloxy)ethyl)piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.015
1-((2-benzo[b]thiophen-2-yl)propan-2-yl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.016
1-(1-(3-bromo-benzo[b]thiophen-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-(1-(5-bromo-benzo[b]thiophen-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0011 - 0.05212
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
0.00233
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.00369
1-(1-benzo[b]thiophen-2-yl-cyclohexyl)-piperidine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0033
1-(1-benzo[b]thiophen-2-yl-cyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.002
1-(1-benzylpiperidin-4-yl)-3-phenylthiourea
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
1-(1-benzylpiperidin-4-yl)-3-pyridin-3-ylthiourea
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
1-(1-methylpiperidin-3-yl)-3-(2-phenoxyethyl)-1,3-dihydro-2H-benzimidazol-2-imine
Trypanosoma brucei
-
IC50: 0.1 mM
0.057
1-(1-phenylcyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-(1-phenylpiperidin-4-yl)-3-propylthiourea
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.005
1-(2,4-dichlorophenoxy)-3-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]propan-2-ol
Trypanosoma brucei
-
IC50: 0.005 mM
0.00012 - 0.00633
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
0.00013 - 0.0024
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
0.0109
1-(2-(benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.1
1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium
0.004
1-(2-phenoxyethyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-imine
Trypanosoma brucei
-
IC50: 0.004 mM
0.009
1-(2-phenoxyethyl)-3-[2-(piperidin-1-yl)ethyl]-1,3-dihydro-2H-benzimidazol-2-imine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.00255 - 0.0695
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
0.00236 - 0.0512
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
0.0002 - 0.004
1-(3,4-dichlorophenyl)-2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
0.009
1-(3,4-dichlorophenyl)-2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
Trypanosoma brucei
-
IC50: 0.009 mM
0.01
1-(3,4-dichlorophenyl)-2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanone
Trypanosoma brucei
-
IC50: 0.01 mM
0.0006 - 0.01
1-(3,4-dichlorophenyl)-2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
0.107
1-(3,4-dichlorophenyl)-3-[(4-ethylphenyl)amino]propan-1-one
Trypanosoma brucei
-
-
0.1
1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane
0.0017
1-(3-nitrophenyl)-3-(phenylamino)propan-1-one
Trypanosoma brucei
-
-
0.007
1-(3-phenoxypropyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-imine
Trypanosoma brucei
-
IC50: 0.007 mM
0.0345
1-(3-phenylpropyl)piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0026
1-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)-2-(dimethyl-amino)ethanone
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.012
1-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)-2-phenyl-ethanone
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0066
1-(4'-benzo[b]thiophen-2-yl)-1,4'-(bipiperidine-1'-yl)ethanone
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-(4,6,8-trimethylquinazolin-2-yl)guanidine
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.0399
1-(4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-(2-(naphthalen-2-yl)ethyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamido)butyl)guanidinium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.1
1-(4-bromophenyl)-2-(3-butyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)ethanol
Trypanosoma brucei
-
IC50: 0.1 mM, 42% inhibition at 0.025 mM
0.148
1-(4-chlorophenyl)-3-morpholin-4-ylpropan-1-one
Trypanosoma brucei
-
-
0.1
1-(4-ethoxyphenyl)-2-(2-imino-3-prop-2-en-1-yl-2,3-dihydro-1H-benzimidazol-1-yl)ethanol
Trypanosoma brucei
-
IC50: 0.1 mM, 6% inhibition at 0.025 mM
0.1
1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide
0.1
1-(4-methylquinazolin-2-yl)guanidine
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.008
1-(5-phenoxypentyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-imine
Trypanosoma brucei
-
IC50: 0.008 mM
0.0291 - 0.036
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium
0.1
1-(methylsulfanyl)-4-[3-(methylsulfanyl)-1,2,4-triazin-5-yl]-5,6,7,8-tetrahydroisoquinoline
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.00323 - 0.194
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
0.0452 - 0.1
1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium
0.025
1-biphenyl-4-yl-2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanone
Trypanosoma brucei
-
IC50: 0.025 mM
0.1
1-ethyl-6-methyl-3-(pyridin-3-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0128
1-ethyl-6-methyl-3-(thiophen-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0113
1-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0026
1-ethyl-6-methyl-3-[(Z)-2-phenylethenyl]pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0152
1-ethyl-6-methyl-3-[4-(trifluoromethyl)phenyl]pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.036
1-methyl-(2-(1-piperidin-1-yl)cyclohexyl)-1H-indole
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.033
1-phenyl-3-(1-phenylpiperidin-4-yl)thiourea
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
1-phenyl-3-[1-(pyridin-3-yl)piperidin-4-yl]urea
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
1-propylbenzene
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.00039 - 0.025
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
0.00023 - 0.00424
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
0.00194
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-4-(3-phenyl-propyl)piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0269
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-4-(E)-(3-phenyl-allyl)piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0515
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0787 - 0.1
1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium
0.0032 - 0.0065
1-[2-(4-methylpiperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
0.0025
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)-ferrocenylmethyl]-3-p-chloro-phenyl-urea
Trypanosoma cruzi
-
-
0.002
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-3-[2,6-bis-(trifluoromethyl)-phenyl]-urea
Trypanosoma cruzi
-
-
0.0023
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-methoxyphenyl-urea
Trypanosoma cruzi
-
-
0.0105
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-[2,4-bis-(trifluoromethyl)-phenyl]-urea
Trypanosoma cruzi
-
-
0.0021 - 0.0038
1-[2-(piperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
0.0029
1-[2-(piperidin-4-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
Trypanosoma cruzi
-
pH and temperature not specified in the publication
-
0.1
1-[2-imino-3-(2-morpholin-4-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-phenoxypropan-2-ol
Trypanosoma brucei
-
IC50: 0.1 mM
0.1
1-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3,3-dimethylbutan-2-ol
Trypanosoma brucei
-
IC50: 0.1 mM, 66% inhibition at 0.025 mM
0.016
1-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-(4-methoxyphenoxy)propan-2-ol
Trypanosoma brucei
-
IC50: 0.016 mM
0.005
1-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-phenoxypropan-2-ol
Trypanosoma brucei
-
IC50: 0.005 mM
0.1
1-[2-imino-3-(morpholin-4-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-(4-methylphenoxy)propan-2-ol
Trypanosoma brucei
-
IC50: 0.1 mM
0.009
1-[2-imino-3-(piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-(4-methylphenoxy)propan-2-ol
Trypanosoma brucei
-
IC50: 0.009 mM
0.00009 - 0.0337
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
0.0078
1-[4-(methylsulfonyl)phenyl]-3-piperidin-1-ylpropan-1-one
Trypanosoma brucei
-
-
0.0587 - 0.0753
12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium
0.059
2,2'-(2-imino-1H-benzimidazole-1,3(2H)-diyl)bis(N,N-diethylethanamine)
Trypanosoma brucei
-
IC50: 0.059 mM
0.1
2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
0.1
2-(3-benzyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)-1-(4-chlorophenyl)ethanol
Trypanosoma brucei
-
IC50: 0.1 mM, 32% inhibition at 0.025 mM
0.1
2-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)-N,N-dimethylethanamine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
2-(5-methylfuran-2-yl)-N-(2-morpholinoethyl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0844 - 0.1
2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
0.00531 - 0.0783
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
0.00093 - 0.0309
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
0.00075
2-chloro-10-(3-(4-(3-phenylpropyl)piperazin-1-yl)propyl)-10H-phenothiazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.00132
2-[(4-bromophenyl)sulfanyl]-5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.024
2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methoxyphenyl)ethanol
Trypanosoma brucei
-
IC50: 0.024 mM, 85% inhibition at 0.025 mM
0.0319 - 0.0354
2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium
0.007
2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methoxyphenyl)ethanone
Trypanosoma brucei
-
IC50: 0.007 mM, 91% inhibition at 0.025 mM
0.019
2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methylphenyl)ethanol
Trypanosoma brucei
-
IC50: 0.019 mM
0.029
2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methylphenyl)ethanol
Trypanosoma brucei
-
IC50: 0.029 mM
0.035
2-[3-[2-(dimethylamino)propyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methylphenyl)ethanol
Trypanosoma brucei
-
IC50: 0.035 mM
0.00082 - 0.112
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.00088 - 0.18
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.0003
3,3'-[butane-1,4-diylbis[(3-aminopropyl)imino]]bis(N-[5-chloro-2-[(4-methoxyphenyl)sulfanyl]phenyl]propanamide)
Trypanosoma cruzi
-
IC50: 0.0003 mM
0.0367 - 0.0373
3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium
0.0115 - 0.0146
3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium
0.0033
3-(3,4-dichlorophenyl)-N,N-dimethyl-3-oxopropan-1-aminium chloride
Trypanosoma brucei
-
-
0.1
3-(5-bromo-2-fluorophenyl)-1-butyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
3-(5-bromo-2-fluorophenyl)-1-cyclopentyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0102
3-(5-bromo-2-fluorophenyl)-1-ethyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
3-(5-bromo-2-fluorophenyl)-1-[2-(dimethylamino)ethyl]-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.05
3-(5-bromo-2-fluorophenyl)-6-methyl-1-(propan-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
IC50 above 0.05 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
3-(5-bromo-2-fluorophenyl)-6-methylpyrimido[5,4-e,1,2,4]triazine-5,7(1H,6H)dione
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.092
3-(5-bromo-2-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.013
3-(5-bromothiophen-2-yl)-1-ethyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
3-(methylsulfanyl)-5-phenyl-1,2,4-triazine
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.000068 - 0.00068
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
0.000077 - 0.00077
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
0.015
3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
Trypanosoma cruzi
-
-
0.0032
3-Benzyl-1-[3-(7-chloro-quinolin-4-ylamino)-propyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
Trypanosoma cruzi
-
-
0.0033
3-Benzyl-1-[4-(7-chloro-quinolin-4-ylamino)-butyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
Trypanosoma cruzi
-
-
0.0024
3-Benzyl-1-[6-(7-chloro-quinolin-4-ylamino)-hexyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
Trypanosoma cruzi
-
-
0.0065
3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
Trypanosoma cruzi
-
IC50: 0.0065 mM
0.052
3-cyano-1-azabicyclo[2.2.2]oct-3-yl acetate
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.027
3-methoxy-3'-(methylsulfanyl)-5,5'-bi-1,2,4-triazine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
3-Phenylpropylamine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0015
3-[(2,3-dimethylphenyl)amino]-1-(3-nitrophenyl)propan-1-one
Trypanosoma brucei
-
-
0.0033
3-[(3-fluorophenyl)amino]-1-(3-nitrophenyl)propan-1-one
Trypanosoma brucei
-
-
0.000102 - 0.00102
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
0.000059 - 0.00059
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
0.019
4'-(benzo[b]thiophen-2-yl)-1'-benzyl-1,4'-bipiperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00093
4'-(benzo[b]thiophen-2-yl)-1'-methyl-1,4'bipiperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0051
4'-(benzo[b]thiophen-2-yl)-[1,4']bipiperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.017
4,6,8-trimethyl-N-(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)quinazolin-2-amine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.0517
4-(2-(([1,1'-biphenyl]-4-ylmethyl)amino)-N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-7Hpyrrolo[2,3-d]pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0044
4-(2-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidin-1'-yl)ethyl)morpholine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0388
4-(azepan-1-ylmethyl)-2,6-di-tert-butylphenol
Trypanosoma brucei
-
-
0.0522
4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-((2-(naphthalen-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0946
4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-((3-phenylpropyl)amino)-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.1002
4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-(phenethylamino)-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.000251
4-chloromercuribenzoic acid
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.00058
4-[(7-chloro-4-nitro-2,1,3-benzothiadiazol-5-yl)sulfanyl]quinazoline
Trypanosoma brucei brucei
-
pH 7.5, 22°C
0.0118
4-[(dimethylamino)methyl]-2,6-bis(1-methylethyl)phenol
Trypanosoma brucei
-
-
0.011
4-[1-(1-benzothiophen-2-yl)cyclohexyl]morpholine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00121 - 0.0268
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
0.001 - 0.0246
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
0.1
4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium
0.1
5,6-dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4-ol
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.00061
5,7-dichloro-4-nitro-2,1,3-benzothiadiazole
Trypanosoma brucei brucei
-
pH 7.5, 22°C
0.0297
5-(2-chloroethoxy)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.00097
5-chloro-2-[(4-chlorophenyl)sulfanyl]-N-[3-(4-methylpiperazin-1-yl)propyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.0007
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-naphthalen-1-ylphenyl)sulfanyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.0007
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-naphthalen-2-ylphenyl)sulfanyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.0009
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[2-(trifluoromethyl)phenyl]sulfanyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.00106
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[3-(trifluoromethyl)phenyl]sulfanyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.00203
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[4-(trifluoromethyl)phenyl]sulfanyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.0085
5-nitrofuran-2-carbaldehyde N-butylsemicarbazone
Trypanosoma cruzi
-
-
0.0063 - 0.035
5-[2-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
-
0.0043 - 0.01
5-[2-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
-
0.0048 - 0.02
5-[3-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
0.0056 - 0.025
5-[3-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
0.004 - 0.012
5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
0.1
6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium
0.0042
6-bromo-2-(5-methylfuran-2-yl)-N-(2-morpholinoethyl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0084
6-bromo-2-(5-methylfuran-2-yl)-N-(4-sulfamoylbenzyl)quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-2-(5-methylfuran-2-yl)-N-(morpholin-4-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0047
6-bromo-2-(5-methylfuran-2-yl)-N-(pyridin-2-ylmethyl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0072
6-bromo-2-(5-methylfuran-2-yl)-N-(pyridin-3-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-2-(5-methylfuran-2-yl)-N-phenethylquinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0012
6-bromo-N,N,N-trimethyl-2-(2-(5-methylfuran-2-yl)quinoline-4-carboxamido)ethanaminium iodide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0017
6-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylthiophen-2-yl)-quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0324
6-bromo-N-(2-(dimethylamino)ethyl)-2-(furan-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0011
6-bromo-N-(2-(methylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-N-(furan-2-ylmethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0963
6-bromo-N-[2-(dimethylamino)ethyl]-2-(pyridin-4-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-N-[2-(dimethylamino)ethyl]-2-phenylquinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0051 - 0.1
6-bromo-N-[3-(1H-imidazol-1-ylamino)propyl]-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
0.0116
6-chloro-2-(5-methylfuran-2-yl)-N-[3-(morpholin-4-yl)propyl]quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0265
6-chloro-N-[2-(dimethylamino)ethyl]-3-methyl-2-(4-methylphenyl)quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.028
7-ethoxy-4-methyl-N-(4,4,6-trimethyl-4,5-dihydropyrimidin-2-yl)quinazolin-2-amine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.032
7-ethyl-4-methyl-N-(4,4,6-trimethyl-4,5-dihydropyrimidin-2-yl)quinazolin-2-amine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.00039 - 0.019
7-methoxy-N-[2-([[2-(4-methylpiperazin-1-yl)ethyl]amino]methyl)-3-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl]-4a,9a-dihydroacridin-2-amine
0.0051
8-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0408
Ac-PEIIQSVGISMKM-NH2
Leishmania infantum
pH and temperature not specified in the publication
0.0336
Ac-PEIIQSVGISNLKNL-NH2
Leishmania infantum
pH and temperature not specified in the publication
0.0179
Ac-PKIIQSVGISMKM-NH2
Leishmania infantum
pH and temperature not specified in the publication
0.0157
Ac-PKIIQSVGISNLKNL-NH2
Leishmania infantum
pH and temperature not specified in the publication
0.0043
altenusin
Trypanosoma cruzi
-
-
0.0904
aspidospermine
Leishmania amazonensis
-
-
0.0066
Au(2-(2'-pyridyl)benzimidazole)Cl2
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0061
Au-(N-(1-hydroxy-3-methylbutan-2-yl)pyridine-2-carboxamide)Cl
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0101
AuCl3
Leishmania infantum
-
at pH 7.5 and 25°C
0.0005
auranofin
Leishmania infantum
-
at pH 7.5 and 25°C
0.00494
Bay 11-7085
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.1
benzo[b]thiophen-2-yl(1-(piperidin-1-yl)cyclohexyl)methanone
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0021
bromoacetyl alprenolol menthane
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0024
butyl 4-[[3-(3-nitrophenyl)-3-oxopropyl]amino]benzoate
Trypanosoma brucei
-
-
0.0063
chlorpromazine
Trypanosoma cruzi
pH and temperature not specified in the publication
0.00632
chlorpromazoine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.029
cis-3-oxo-8,9b-bis-(trans-N-(acrylamidospermidyl))-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
IC50: 0.029 mM
0.056
cis-3-oxo-8-trans-(N-acrylamidospermidyl)-9b-trans-ethylacrylyl-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
IC50: 0.056 mM
0.0823
citalopram
Trypanosoma brucei
in 40 mM HEPES, pH 7.4, 1 mM EDTA
0.0038 - 0.0111
clomipramine
0.1
diphenyl(1-(piperidin-1-yl)cyclohexyl)methanol
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00018 - 0.00136
ebselen
0.004
heptyl (2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinecarboxylate
Trypanosoma cruzi
-
-
0.0036
hexyl (2E)-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarboxylate
Trypanosoma cruzi
-
-
0.0008 - 0.0025
hypnophilin
0.00726 - 0.00884
indatraline
0.0527
K[Au(saccharine)2]
Leishmania infantum
-
at pH 7.5 and 25°C
0.0149
K[Au(saccharine)4]
Leishmania infantum
-
at pH 7.5 and 25°C
0.065
lunarine
Lunaria biennis
-
IC50: 0.065 mM
0.0129 - 0.01699
Mepacrine
0.00061 - 0.0243
N'-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N,N-dimethylethane-1,2-diamine
0.00206
N'-(5-chloro-2-[[2-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.00116
N'-(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.00233
N'-[2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.001 - 0.0342
N'-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N,N-dimethylethane-1,2-diamine
0.00189
N'-[5-chloro-2-(naphthalen-1-ylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.00162
N'-[5-chloro-2-(naphthalen-2-ylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.001144
N'-[5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.0183
N,N'-(4,4'-diselanediylbis[4,1-phenylene])bisadamantamide
Leishmania infantum
pH 8.0, 26°C
-
0.014
N,N'-(4,4'-diselanediylbis[4,1-phenylene])bisfuran-2-carboxamide
Leishmania infantum
pH 8.0, 26°C
-
0.00553
N,N'-(4,4'-diselanediylbis[4,1-phenylene])bisnaphthamide
Leishmania infantum
pH 8.0, 26°C
-
0.0485
N,N'-(furan-2,5-diyldibenzene-4,1-diyl)diacetamide
Trypanosoma cruzi
-
IC50: 0.0485 mM, 54% inhibition at 0.02 mg/ml
0.1
N,N-diethyl-2-(2-imino-3-prop-2-en-1-yl-2,3-dihydro-1H-benzimidazol-1-yl)ethanamine
Trypanosoma brucei
-
IC50: 0.1 mM, 31% inhibition at 0.025 mM
0.008
N,N-diethyl-2-[2-imino-3-(2-phenoxyethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanamine
Trypanosoma brucei
-
IC50: 0.008 mM
0.00034
N,N-dimethyl-3-(3-nitrophenyl)-3-oxopropan-1-aminium chloride
Trypanosoma brucei
-
-
0.0029
N,N-dimethyl-3-[4-(methylsulfonyl)phenyl]-3-oxopropan-1-aminium chloride
Trypanosoma brucei
-
-
0.0144
N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
N-(2-(dimethylamino)ethyl)-6-fluoro-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
N-(2-phenoxyethyl)-N'-(2-piperidin-1-ylethyl)benzene-1,2-diamine
Trypanosoma brucei
-
IC50: 0.1 mM
0.0002 - 0.0093
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-2-(4-methylpiperazin-1-yl)acetamide
0.0016 - 0.104
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N2,N2-dimethylglycinamide
0.006 - 0.0469
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
0.00179 - 0.0566
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
0.0024
N-(3,5-di-tert-butyl-4-hydroxybenzyl)-2-hydroxyethanaminium chloride
Trypanosoma brucei
-
-
0.1
N-(4,6-dimethylpyrimidin-2-yl)-4,5,7-trimethylquinazolin-2-amine
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
N-(4,6-dimethylpyrimidin-2-yl)-4,6-dimethylquinazolin-2-amine
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.0027
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-butane-1,4-diamine
Trypanosoma cruzi
-
-
0.0476
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-ethane-1,2-diamine
Trypanosoma cruzi
-
-
0.0021
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-hexane-1,6-diamine
Trypanosoma cruzi
-
-
0.0068
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-propane-1,3-diamine
Trypanosoma cruzi
-
-
0.00028 - 0.0116
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
0.1
N-benzyl-6-bromo-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
N-[(2E)-1-(2-phenoxyethyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]acetamide
Trypanosoma brucei
-
IC50: 0.1 mM
0.033
N-[(4-chlorophenyl)(phenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octan-3-imine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide
0.1
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide
0.0368
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-phenylacetamide
Trypanosoma cruzi
-
IC50: 0.0368 mM
0.0445
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-4-nitrobenzamide
Trypanosoma cruzi
-
IC50: 0.0445 mM
0.0496
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]benzamide
Trypanosoma cruzi
-
IC50: 0.0496 mM
0.0305
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]butanamide
Trypanosoma cruzi
-
IC50: 0.0305 mM
0.0316
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]propanamide
Trypanosoma cruzi
-
IC50: 0.0316 mM
0.00102 - 0.0093
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
0.00274 - 0.121
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
0.00063 - 0.0158
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
0.00091 - 0.0576
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
0.0224
N1-((1-(3-(2-(2-oxoimidazolidin-1-yl)ethoxy)-4-(4-phenethylthiazol-2-yl)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0051
N1-((1-(4-(4-(2-(naphthalen-2-yl)ethyl)thiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)-methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0086
N1-((1-(4-(4-(2-([1,1'-biphenyl]-4-yl)ethyl)thiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0328
N1-((1-(4-(4-benzylthiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0512
N1-((1-(4-(4-isobutylthiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0513
N1-((1-(4-(4-neopentylthiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0078
nifurtimox
Trypanosoma cruzi
-
-
0.0389
panepoxydone
Trypanosoma cruzi
-
-
0.00488
perphenazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.1
phenyl(1-(piperidin-1-yl)cyclohexyl)methanone
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00689
pindobind
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0012
PKIIQSVGICMKM
Leishmania infantum
pH 6.0, 26°C
-
0.0074 - 0.00746
prochlorperazine
0.0221
Quinacrine
Trypanosoma brucei
in 40 mM HEPES, pH 7.4, 1 mM EDTA
0.1
tert-butyl 4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidine-1'-carboxylate
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00958
thioridazine
Trypanosoma brucei
in 40 mM HEPES, pH 7.4, 1 mM EDTA
0.173
trans-4-[3-(3,4-dichlorophenyl)indan-1-yl]morpholine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00307
trans-benzyl-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.2
trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]-4-methylbenzenesulfonamide
Trypanosoma brucei
-
IC50 above 0.2 mM, in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.2
trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]acetamide
Trypanosoma brucei
-
IC50 above 0.2 mM, in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00315
trans-[3-(3,4-dibromophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00223
trans-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0459
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3,4-dichlorobenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00405
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3-methylbutyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00494
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-aminobenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0176
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-chlorobenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00738
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-dimethylaminobenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00414
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methoxybenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.013
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methylbenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00793
trans-[3-(3,4-dichlorophenyl)indan-1-yl]octylamine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0158
trans-[3-(4-chlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.125
trans-[3-(4-methoxyphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0329
trans-[3-(4-methylphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0405
Trifluoperazine
Trypanosoma brucei
in 40 mM HEPES, pH 7.4, 1 mM EDTA
0.00753
triflupromazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0075
triflupromizine
Trypanosoma cruzi
pH and temperature not specified in the publication
-
0.0088
[(2,2'-bipyridine)Au(OH)2][PF6]
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.00505
[Au((S)-4-Bn-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6]
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0014
[Au((S)-4-iPr-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6]
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0228
[Au2(bipy)2(m-O)2](PF6)2
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0006
[Cl2AuIII(2-(2'-pyridyl)benzimidazole)AuI(PPh3)](PF6)
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.00027
[[(7-nitro-2,1,3-benzoxadiazol-4-yl)methyl]sulfanyl]methyl phenylcarbamate
Trypanosoma brucei brucei
-
pH 7.5, 22°C
0.1
(3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium
Trypanosoma brucei
IC50 above 0.1 mM
0.1
(3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium
Trypanosoma cruzi
IC50 above 0.1 mM
0.0011
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
Leishmania donovani
-
at 25°C, pH not specified in the publication
0.0013
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
Plasmodium falciparum
-
at 25°C, pH not specified in the publication
0.00211
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
Trypanosoma brucei rhodesiense
-
at 25°C, pH not specified in the publication
0.05212
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.00012
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
Plasmodium falciparum
-
at 25°C, pH not specified in the publication
0.00032
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
Trypanosoma brucei rhodesiense
-
at 25°C, pH not specified in the publication
0.00253
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
Leishmania donovani
-
at 25°C, pH not specified in the publication
0.00633
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.00013
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
Plasmodium falciparum
-
at 25°C, pH not specified in the publication
0.00023
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
Trypanosoma brucei rhodesiense
-
at 25°C, pH not specified in the publication
0.00186
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
Leishmania donovani
-
at 25°C, pH not specified in the publication
0.0024
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.1
1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium
Trypanosoma brucei
IC50 above 0.1 mM
0.1
1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium
Trypanosoma cruzi
IC50 above 0.1 mM
0.00255
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
Plasmodium falciparum
-
at 25°C
0.0119
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
Trypanosoma brucei rhodesiense
-
at 25°C
0.0695
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
Trypanosoma cruzi
at 25°C
0.00236
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
Plasmodium falciparum
-
at 25°C
0.0085
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
Trypanosoma brucei rhodesiense
-
at 25°C
0.0512
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
Trypanosoma cruzi
at 25°C
0.0002
1-(3,4-dichlorophenyl)-2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
Trypanosoma brucei rhodesiense
-
-
0.004
1-(3,4-dichlorophenyl)-2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
Trypanosoma brucei
-
IC50: 0.004 mM
0.0006
1-(3,4-dichlorophenyl)-2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
Trypanosoma brucei rhodesiense
-
-
0.01
1-(3,4-dichlorophenyl)-2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
Trypanosoma brucei
-
IC50: 0.01 mM, 92% inhibition at 0.025 mM
0.1
1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane
Trypanosoma brucei
IC50 above 0.1 mM
0.1
1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane
Trypanosoma cruzi
IC50 above 0.1 mM
0.1
1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide
Trypanosoma brucei
IC50 above 0.1 mM
0.1
1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide
Trypanosoma cruzi
IC50 above 0.1 mM
0.0291
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium
Trypanosoma cruzi
-
0.036
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium
Trypanosoma brucei
-
0.00323
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
Plasmodium falciparum
-
at 25°C, pH not specified in the publication
0.00458
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
Trypanosoma brucei rhodesiense
-
at 25°C, pH not specified in the publication
0.0759
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.194
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
Leishmania donovani
-
at 25°C, pH not specified in the publication
0.0452
1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium
Trypanosoma cruzi
-
0.1
1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium
Trypanosoma brucei
IC50 above 0.1 mM
0.00039
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
Plasmodium falciparum
-
at 25°C, pH not specified in the publication
0.0106
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.0239
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
Leishmania donovani
-
at 25°C, pH not specified in the publication
0.025
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
Trypanosoma brucei rhodesiense
-
at 25°C, pH not specified in the publication
0.00023
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
Plasmodium falciparum
-
at 25°C, pH not specified in the publication
0.0016
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
Trypanosoma brucei rhodesiense
-
at 25°C, pH not specified in the publication
0.00401
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
Leishmania donovani
-
at 25°C, pH not specified in the publication
0.00424
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.0787
1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium
Trypanosoma cruzi
-
0.1
1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium
Trypanosoma brucei
IC50 above 0.1 mM
0.0032
1-[2-(4-methylpiperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
Trypanosoma cruzi
-
pH and temperature not specified in the publication
-
0.0065
1-[2-(4-methylpiperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
Trypanosoma brucei brucei
pH and temperature not specified in the publication
-
0.0021
1-[2-(piperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
Trypanosoma cruzi
-
pH and temperature not specified in the publication
-
0.0038
1-[2-(piperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
Trypanosoma brucei brucei
pH and temperature not specified in the publication
-
0.00009
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
Plasmodium falciparum
-
at 25°C, pH not specified in the publication
0.00173
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
Trypanosoma brucei rhodesiense
-
at 25°C, pH not specified in the publication
0.0122
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.0337
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
Leishmania donovani
-
at 25°C, pH not specified in the publication
0.0587
12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium
Trypanosoma brucei
-
0.0753
12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium
Trypanosoma cruzi
-
0.1
2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
Trypanosoma brucei
IC50 above 0.1 mM
0.1
2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
Trypanosoma cruzi
IC50 above 0.1 mM
0.0844
2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
Trypanosoma cruzi
-
0.1
2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
Trypanosoma brucei
IC50 above 0.1 mM
0.00531
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
Plasmodium falciparum
-
at 25°C
0.0268
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
Trypanosoma brucei rhodesiense
-
at 25°C
0.0783
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
Trypanosoma cruzi
at 25°C
0.00093
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
Plasmodium falciparum
-
at 25°C
0.0098
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
Trypanosoma brucei rhodesiense
-
at 25°C
0.0309
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
Trypanosoma cruzi
at 25°C
0.0319
2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium
Trypanosoma brucei
-
0.0354
2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium
Trypanosoma cruzi
-
0.00082
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
Plasmodium falciparum
-
at 25°C, pH not specified in the publication
0.00327
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
Trypanosoma brucei rhodesiense
-
at 25°C, pH not specified in the publication
0.0539
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.112
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
Leishmania donovani
-
at 25°C, pH not specified in the publication
0.00088
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
Trypanosoma brucei rhodesiense
-
at 25°C, pH not specified in the publication
0.00627
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
Plasmodium falciparum
-
at 25°C, pH not specified in the publication
0.162
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.18
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
Leishmania donovani
-
at 25°C, pH not specified in the publication
0.0367
3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium
Trypanosoma cruzi
-
0.0373
3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium
Trypanosoma brucei
-
0.0115
3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium
Trypanosoma cruzi
-
0.0146
3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium
Trypanosoma brucei
-
0.000068
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
Trypanosoma brucei rhodesiense
-
-
0.00068
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
Trypanosoma brucei rhodesiense
-
-
0.000077
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
Trypanosoma brucei rhodesiense
-
-
0.00077
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
Trypanosoma brucei rhodesiense
-
-
0.000102
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
Trypanosoma brucei rhodesiense
-
-
0.00102
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
Trypanosoma brucei rhodesiense
-
-
0.000059
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
Trypanosoma brucei rhodesiense
-
-
0.00059
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
Trypanosoma brucei rhodesiense
-
-
0.00121
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
Plasmodium falciparum
-
at 25°C
0.008
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
Trypanosoma brucei rhodesiense
-
at 25°C
0.0268
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
Trypanosoma cruzi
at 25°C
0.001
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
Plasmodium falciparum
-
at 25°C
0.0081
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
Trypanosoma brucei rhodesiense
-
at 25°C
0.0246
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
Trypanosoma cruzi
at 25°C
0.1
4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium
Trypanosoma brucei
IC50 above 0.1 mM
0.1
4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium
Trypanosoma cruzi
IC50 above 0.1 mM
0.0063
5-[2-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
Trypanosoma cruzi
-
pH and temperature not specified in the publication
-
0.035
5-[2-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
Trypanosoma brucei brucei
pH and temperature not specified in the publication
-
0.0043
5-[2-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
Trypanosoma cruzi
-
pH and temperature not specified in the publication
-
0.01
5-[2-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
Trypanosoma brucei brucei
pH and temperature not specified in the publication
-
0.0048
5-[3-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
Trypanosoma cruzi
-
pH and temperature not specified in the publication
-
0.02
5-[3-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
Trypanosoma brucei brucei
pH and temperature not specified in the publication
-
0.0056
5-[3-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
Trypanosoma cruzi
-
pH and temperature not specified in the publication
-
0.025
5-[3-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
Trypanosoma brucei brucei
pH and temperature not specified in the publication
-
0.004
5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
Trypanosoma cruzi
-
pH and temperature not specified in the publication
-
0.012
5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
Trypanosoma brucei brucei
pH and temperature not specified in the publication
-
0.1
6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium
Trypanosoma brucei
IC50 above 0.1 mM
0.1
6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium
Trypanosoma cruzi
IC50 above 0.1 mM
0.0051
6-bromo-N-[3-(1H-imidazol-1-ylamino)propyl]-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-N-[3-(1H-imidazol-1-ylamino)propyl]-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.00039
7-methoxy-N-[2-([[2-(4-methylpiperazin-1-yl)ethyl]amino]methyl)-3-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl]-4a,9a-dihydroacridin-2-amine
Plasmodium falciparum
-
at 25°C
0.0007
7-methoxy-N-[2-([[2-(4-methylpiperazin-1-yl)ethyl]amino]methyl)-3-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl]-4a,9a-dihydroacridin-2-amine
Trypanosoma brucei rhodesiense
-
at 25°C
0.019
7-methoxy-N-[2-([[2-(4-methylpiperazin-1-yl)ethyl]amino]methyl)-3-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl]-4a,9a-dihydroacridin-2-amine
Trypanosoma cruzi
at 25°C
0.0038
clomipramine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0038
clomipramine
Trypanosoma cruzi
pH and temperature not specified in the publication
0.0111
clomipramine
Trypanosoma brucei
in 40 mM HEPES, pH 7.4, 1 mM EDTA
0.00018
ebselen
Trypanosoma brucei
in 40 mM HEPES, pH 7.4, 1 mM EDTA
0.00136
ebselen
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0008
hypnophilin
Trypanosoma cruzi
-
using recombinant trypanothione reductase from Trypanosoma cruzi
0.0025
hypnophilin
Trypanosoma cruzi
-
assay with Trypanosoma cruzi amastigotes
0.00726
indatraline
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.00884
indatraline
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0129
Mepacrine
Leishmania infantum
pH 6.0, 26°C
0.01699
Mepacrine
Leishmania infantum
pH 8.0, 26°C
0.00061
N'-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N,N-dimethylethane-1,2-diamine
Plasmodium falciparum
-
at 25°C
0.00121
N'-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N,N-dimethylethane-1,2-diamine
Trypanosoma brucei rhodesiense
-
at 25°C
0.0243
N'-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N,N-dimethylethane-1,2-diamine
Trypanosoma cruzi
at 25°C
0.001
N'-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N,N-dimethylethane-1,2-diamine
Plasmodium falciparum
-
at 25°C
0.00475
N'-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N,N-dimethylethane-1,2-diamine
Trypanosoma brucei rhodesiense
-
at 25°C
0.0342
N'-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N,N-dimethylethane-1,2-diamine
Trypanosoma cruzi
at 25°C
0.0002
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-2-(4-methylpiperazin-1-yl)acetamide
Plasmodium falciparum
-
at 25°C
0.0053
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-2-(4-methylpiperazin-1-yl)acetamide
Trypanosoma brucei rhodesiense
-
at 25°C
0.0093
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-2-(4-methylpiperazin-1-yl)acetamide
Trypanosoma cruzi
at 25°C
0.0016
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N2,N2-dimethylglycinamide
Plasmodium falciparum
-
at 25°C
0.0169
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N2,N2-dimethylglycinamide
Trypanosoma brucei rhodesiense
-
at 25°C
0.104
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N2,N2-dimethylglycinamide
Trypanosoma cruzi
at 25°C
0.006
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
Plasmodium falciparum
-
at 25°C
0.0231
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
Trypanosoma brucei rhodesiense
-
at 25°C
0.0469
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
Trypanosoma cruzi
at 25°C
0.00179
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
Plasmodium falciparum
-
at 25°C
0.0096
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
Trypanosoma brucei rhodesiense
-
at 25°C
0.0566
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
Trypanosoma cruzi
at 25°C
0.00028
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
Plasmodium falciparum
-
at 25°C, pH not specified in the publication
0.00088
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
Trypanosoma brucei rhodesiense
-
at 25°C, pH not specified in the publication
0.00656
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
Leishmania donovani
-
at 25°C, pH not specified in the publication
0.0116
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.1
N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide
Trypanosoma brucei
IC50 above 0.1 mM
0.1
N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide
Trypanosoma cruzi
IC50 above 0.1 mM
0.1
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide
Trypanosoma brucei
IC50 above 0.1 mM
0.1
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide
Trypanosoma cruzi
IC50 above 0.1 mM
0.00102
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
Plasmodium falciparum
-
at 25°C
0.0034
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
Trypanosoma brucei rhodesiense
-
at 25°C
0.0093
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
Trypanosoma cruzi
at 25°C
0.00274
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
Plasmodium falciparum
-
at 25°C
0.0302
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
Trypanosoma brucei rhodesiense
-
at 25°C
0.121
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
Trypanosoma cruzi
at 25°C
0.00063
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
Plasmodium falciparum
-
at 25°C
0.0051
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
Trypanosoma brucei rhodesiense
-
at 25°C
0.0158
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
Trypanosoma cruzi
at 25°C
0.00091
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
Plasmodium falciparum
-
at 25°C
0.0192
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
Trypanosoma brucei rhodesiense
-
at 25°C
0.0576
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
Trypanosoma cruzi
at 25°C
0.0074
prochlorperazine
Trypanosoma cruzi
pH and temperature not specified in the publication
0.00746
prochlorperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
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