EC Number   |
General Information |
Reference |
|---|
    1.8.1.12 | drug target |
a promising target for the development of new chemotherapeutics to treat leishmaniasis and Chagas disease. The enzyme is a specific protein in Trypanosomatidae family and is used by the parasite as a strategy for drug resistance. The enzyme is absent in human |
765100 |
| 1.8.1.12 | drug target |
the enzyme fulfills most of the more relevant requirements to be an interesting drug target because it is essential for parasite survival, druggable, and absent in the host, where it is replaced by glutathione reductase |
763905 |
| 1.8.1.12 | drug target |
the enzyme is a promising targets for the development of drugs selective against parasites of the family of trypanosomatids |
-, 764502 |
| 1.8.1.12 | drug target |
the potent biomolecules 3-methoxycarpachromene and masticadienonic acid could be an effective strategy to solve antimony-resistant strains and represent drug candidates as anti-Trypanosomatidae species drugs |
765431 |
| 1.8.1.12 | drug target |
trypanothione (N1,N8-bis(glutathyonil)spermidine) and trypanothione reductase, which are rather unique to trypanosomes and completely absent in mammalian cells |
765386 |
| 1.8.1.12 | physiological function |
glucose-6-phosphate dehydrogenase and trypanothione reductase interaction protects Leishmania donovani from metalloid mediated oxidative stress |
764697 |
| 1.8.1.12 | physiological function |
the enzyme is an essential component of the antioxidant defenses in trypanosomatid parasites |
765100 |
| 1.8.1.12 | physiological function |
the enzyme is essential for parasite survival |
-, 725848 |
| 1.8.1.12 | physiological function |
the enzyme plays a central role in the metabolic pathway of the parasite |
765838 |
| 1.8.1.12 | physiological function |
trypanosomatids possess a unique redox metabolism based on the dithiol trypanothione and the enzyme trypanothione reductase (TR) that differs distinctively from the glutathione and glutathione reductase-based metabolism in mammals |
-, 764502 |
