Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | insights about resveratrol analogs against trypanothione reductase. Molecular modeling, computational docking and in vitro antileishmanial studies | Leishmania braziliensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | Leishmania braziliensis | - |
trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania braziliensis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | - |
Leishmania braziliensis | trypanothione + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Leishmania braziliensis |
Synonyms | Comment | Organism |
---|---|---|
LbTryR | - |
Leishmania braziliensis |
trypanothione reductase | - |
Leishmania braziliensis |
General Information | Comment | Organism |
---|---|---|
drug target | a promising target for the development of new chemotherapeutics to treat leishmaniasis and Chagas disease. The enzyme is a specific protein in Trypanosomatidae family and is used by the parasite as a strategy for drug resistance. The enzyme is absent in human | Leishmania braziliensis |
physiological function | the enzyme is an essential component of the antioxidant defenses in trypanosomatid parasites | Leishmania braziliensis |