EC Number   |
Expression |
Reference |
|---|
    2.4.1.174 | down |
cajanine is a stilbenic component isolated from Cajanus cajan, it is identified as a potent hepatitis C virus (HCV) inhibitor by phenotypic screening with EC50 of 0.00317 mM. Cajanine inhibits HCV infection by targeting cellular CSGalNAcT-1 protein destabilizing the protein. Cajanine does not inhibit HCV replication at the replicative steps of HCV life cycle. CSGalNAcT-1 is important to support HCV replication at the early stage. Structure-activity relationships and the mechanism of action, and analysis of cajanine derivatives, overview. Cajanine might inhibit HCV replication at early steps of the viral life cycle via downregulating of cellular CSGalNAcT-1 |
759592 |
| 2.4.1.174 | down |
the enzyme is downregulated in Kashin-Beck disease (KBD), an endemic degenerative osteoarthritis, and in primary osteoarthritis, both associated with extracellular matrix degradation |
736281 |
| 2.4.1.174 | more |
induction of gene CSGalNAcT-2 by NTP is much lower compared to CSGalNAcT-1 |
760038 |
| 2.4.1.174 | up |
CSGalNAcT2 gene expression is upregulated during infectious bursal disease virus, IBDV, infection |
737300 |
| 2.4.1.174 | up |
enzyme expression is induced by Neutropin (NTP). Neurotropin activates the phosphatidylinositol 3-kinase-AKT pathway and AKT stimulation, it stimulate glycosaminoglycan synthesis through upregulation of expression of mRNA for chondroitin sulfate N-acetylgalactosaminyltransferase 1. Gene expression profiling shows over 2fold upregulation of 697 genes in response to Neurotropin treatment. Upregulation of IGF1, ANG1, and CSGALNACT1 expression by NTP. Neurotropin (NTP) is a nonprotein extract from inflamed rabbit skin inoculated with vaccinia virus, it has been widely used in Japan and China as an analgesic drug for treatment of chronic pain, such as LBP, postherpetic neuralgia, neck-shoulder-arm syndrome, hyperesthesia of subacute myelo-optic neuropathy, and fibromyalgia. Addition of NTP to the culture medium of nucleus pulposus cells enhances proteoglycan synthesis to halt progressive intervertebral disc (IVD) degeneration |
760038 |
| 2.4.1.174 | up |
T1 is upregulated in reactive astrocytes after spinal cord injury (SCI) |
759849 |
