Literature summary for 2.4.1.174 extracted from

Ji, X.Y.; Chen, J.H.; Zheng, G.H.; Huang, M.H.; Zhang, L.; Yi, H.; Jin, J.; Jiang, J.D.; Peng, Z.G.; Li, Z.R.
Design and synthesis of cajanine analogues against hepatitis C virus through down-regulating host chondroitin sulfate N-acetylgalactosaminyltransferase 1 (2016), J. Med. Chem., 59, 10268-10284 .

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Application

Application	Comment	Organism
drug development	the enzyme is an anti-HCV target to combat drug resistance. Cajanine derivatives are a class of anti-HCV agents downregulating the enzyme	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism
(E)-2-hydroxy-3-isopentyl-4-methoxy-6-styrylbenzoic acid	-	Homo sapiens
(E)-2-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)-6-(2-phenylprop-1-enyl)benzoic acid	-	Homo sapiens
(E)-2-hydroxy-4-methoxy-3-prenyl-6-(2-(thiophen-2-yl)vinyl)-benzoic acid	-	Homo sapiens
(E)-3-(3,7-dimethylocta-2,6-dienyl)-2-hydroxy-4-methoxy-6-phenethylbenzoic acid	-	Homo sapiens
(E)-3-c-6-hydroxy-4-methoxy-5-prenyl-2-styrylbenzoic acid	-	Homo sapiens
(E)-3-methoxy-4-(3-methylbut-2-enyl)-5-styrylphenol	i.e. longistyline C	Homo sapiens
(E)-6-(2-chlorostyryl)-2-hydroxy-4-methoxy-3-prenylbenzoic acid	-	Homo sapiens
(E)-6-(2-methylstyryl)-2-hydroxy-4-methoxy-3-prenylbenzoic acid	-	Homo sapiens
(E)-6-(3-methylstyryl)-2-hydroxy-4-methoxy-3-prenylbenzoic acid	-	Homo sapiens
(E)-6-(4-fluorostyryl)-2-hydroxy-4-methoxy-3-prenylbenzoic acid	-	Homo sapiens
(E)-6-(4-hydroxystyryl)-2-hydroxy-4-methoxy-3-prenylbenzoic acid	-	Homo sapiens
(E)-6-(4-methylstyryl)-2-hydroxy-4-methoxy-3-prenylbenzoic acid	-	Homo sapiens
(E)-6-(but-1-enyl)-2-hydroxy-4-methoxy-3-prenylbenzoic acid	-	Homo sapiens
(E)-ethyl 2-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)-6-styrylbenzoate	-	Homo sapiens
(E)-isopropyl 2-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)-6-styrylbenzoate	-	Homo sapiens
(E)-methyl 2-hydroxy-3-isopentyl-4-methoxy-6-styrylbenzoate	-	Homo sapiens
(E)-methyl 2-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)-6-(2-phenylprop-1-enyl)benzoate	-	Homo sapiens
(E)-methyl 2-hydroxy-4-methoxy-3-prenyl-6-(2-(thiophen-2-yl)-vinyl)benzoate	-	Homo sapiens
(E)-methyl 6-(2-chlorostyryl)-2-hydroxy-4-methoxy-3-prenylbenzoate	-	Homo sapiens
(E)-methyl 6-(2-methylstyryl)-2-hydroxy-4-methoxy-3-prenylbenzoate	-	Homo sapiens
(E)-methyl 6-(3-methylstyryl)-2-hydroxy-4-methoxy-3-prenylbenzoate	-	Homo sapiens
(E)-methyl 6-(4-(tert-butyldimethylsilyloxy)styryl)-2-hydroxy-4-methoxy-3-prenylbenzoate	-	Homo sapiens
(E)-methyl 6-(4-fluorostyryl)-2-hydroxy-4-methoxy-3-prenylbenzoate	-	Homo sapiens
(E)-methyl 6-(4-hydroxystyryl)-2-hydroxy-4-methoxy-3-prenylbenzoate	-	Homo sapiens
(E)-methyl 6-(4-methylstyryl)-2-hydroxy-4-methoxy-3-prenylbenzoate	-	Homo sapiens
(E)-methyl 6-(but-1-enyl)-2-hydroxy-4-methoxy-3-prenylbenzoate	-	Homo sapiens
(E)-methyl 6-styryl-2-hydroxy-4-methoxy-3-prenylbenzoate	-	Homo sapiens
(E)-N-cyclopropyl-2-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)-6-styrylbenzamide	-	Homo sapiens
(E)-tert-butyl 2-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)-6-styrylbenzoate	-	Homo sapiens
2-hydroxy-3-isopentyl-4-methoxy-6-phenethylbenzoic acid	-	Homo sapiens
2-hydroxy-4-methoxy-3-prenyl-6-((1E,3E)-4-phenylbuta-1,3-dienyl)benzoic acid	-	Homo sapiens
2-hydroxy-4-methoxy-3-prenyl-6-phenethylbenzoic acid	-	Homo sapiens
cajanine	cajanine is a stilbenic component isolated from Cajanus cajan, it is identified as a potent hepatitis C virus (HCV) inhibitor by phenotypic screening with EC50 of 0.00317 mM. Cajanine inhibits HCV infection by targeting cellular CSGalNAcT-1 protein destabilizing the protein. Cajanine does not inhibit HCV replication at the replicative steps of HCV life cycle. CSGalNAcT-1 is important to support HCV replication at the early stage. Structure-activity relationships and the mechanism of action, and analysis of cajanine derivatives, EC50 values, overview. Cajanine might inhibit HCV replication at early steps of the viral life cycle via downregulating of cellular CSGalNAcT-1	Homo sapiens
longistyline A	-	Homo sapiens
methyl 2-hydroxy-4-methoxy-3-prenyl-6-((1E,3E)-4-phenylbuta-1,3-dienyl)benzoate	-	Homo sapiens
methyl 2-hydroxy-4-methoxy-3-prenyl-6-phenethylbenzoate	-	Homo sapiens
additional information	2-hydroxy-4-methoxy-6-[(E)-2-phenylethenyl]benzoic acid is not inhibitory	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8TDX6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Huh-7.5 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
chondroitin sulfate N-acetylgalactosaminyltransferase 1	-	Homo sapiens
CSGal-NACT-1	-	Homo sapiens
CSGalNAcT1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	cajanine is a stilbenic component isolated from Cajanus cajan, it is identified as a potent hepatitis C virus (HCV) inhibitor by phenotypic screening with EC50 of 0.00317 mM. Cajanine inhibits HCV infection by targeting cellular CSGalNAcT-1 protein destabilizing the protein. Cajanine does not inhibit HCV replication at the replicative steps of HCV life cycle. CSGalNAcT-1 is important to support HCV replication at the early stage. Structure-activity relationships and the mechanism of action, and analysis of cajanine derivatives, overview. Cajanine might inhibit HCV replication at early steps of the viral life cycle via downregulating of cellular CSGalNAcT-1	down

General Information

General Information	Comment	Organism
malfunction	after silencing of endogenous CSGalNAcT-1 with specific siRNA, the intracellular hepatitis C virus (HCV) RNA load is largely reduced, and the HCV core protein is declined as well	Homo sapiens
physiological function	CSGalNAcT-1 is essential for hepatitis C virus (HCV) replication in human cells	Homo sapiens