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Literature summary for 2.4.1.174 extracted from
- Roles of CSGalNAcT1, a key enzyme in regulation of CS synthesis, in neuronal regeneration and plasticity (2018), Neurochem. Int., 119, 77-83 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell membrane | - |
Homo sapiens | - |
- |
| cell membrane | - |
Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan | Homo sapiens | - |
UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan | - |
? |  |
| UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan | Mus musculus | - |
UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8N6G5 | - |
- |
| Homo sapiens | Q8TDX6 | - |
- |
| Mus musculus | Q8BJQ9 | - |
- |
| Mus musculus | Q8C1F4 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Homo sapiens | - |
| astrocyte | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Mus musculus | - |
| central nervous system | - |
Mus musculus | - |
| additional information | isozymes CSGALNACT1 (T1) and CSGALNACT2 (T2) are expressed in different organs | Homo sapiens | - |
| additional information | isozymes CSGALNACT1 (T1) and CSGALNACT2 (T2) are expressed in different organs | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan | - |
Homo sapiens | UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan | - |
? | |
| UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan | - |
Mus musculus | UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CSGalNAcT1 | - |
Homo sapiens |
| CSGalNAcT1 | - |
Mus musculus |
| CSGALNACT2 | - |
Homo sapiens |
| CSGALNACT2 | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | T1 is upregulated in reactive astrocytes after spinal cord injury (SCI) | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | T1KO mice show microscopic abnormalities in the CNS, but are fertile and viable. They have 10% smaller body sizes than wild-type mice due to abnormal skeletal development | Mus musculus |
| metabolism | the first step (GalNAc transfer) of chondroitin sulfate (CS) backbone synthesis is performed by at least two isoforms, CSGALNACT1 (T1) and CSGALNACT2 (T2), which are expressed in different organs, CS metabolism, roles of CS and perineuronal nets (PNNs) in brain function from the perspective of CS synthesis, overview | Homo sapiens |
| metabolism | the first step (GalNAc transfer) of chondroitin sulfate (CS) backbone synthesis is performed by at least two isoforms, CSGALNACT1 (T1) and CSGALNACT2 (T2), which are expressed in different organs, CS metabolism, roles of CS and perineuronal nets (PNNs) in brain function from the perspective of CS synthesis, overview | Mus musculus |
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Release 2023.1 (January 2023)
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