2.6.1.86: 2-amino-4-deoxychorismate synthase
This is an abbreviated version!
For detailed information about 2-amino-4-deoxychorismate synthase, go to the full flat file.
Word Map on EC 2.6.1.86
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2.6.1.86
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anthranilate
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ammonia
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phenazine
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synthases
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amidotransferase
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enzyme-bound
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venezuelae
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aminodeoxychorismate
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chorismate-utilizing
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biotechnology
- 2.6.1.86
- anthranilate
- ammonia
- phenazine
- synthases
-
amidotransferase
-
enzyme-bound
- venezuelae
-
aminodeoxychorismate
-
chorismate-utilizing
- biotechnology
Reaction
Synonyms
2-amino-2-deoxyisochorismate (ADIC) synthase, 2-amino-2-deoxyisochorismate synthase, 2-amino-2desoxyisochorismate synthase, ADCS, ADIC synthase, aminodeoxyisochorismate synthase, PabA, PhzE, SgcD
ECTree
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Application
Application on EC 2.6.1.86 - 2-amino-4-deoxychorismate synthase
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biotechnology
conversion of aminodeoxychorismate synthase into anthranilate synthase employing a bioinformatics method for predicting mutations required to functionally interconvert homologous enzymes. Complementation of an anthranilate synthase-deficient strain of Escherichia coli grown on minimal medium leads to several aminodeoxychorismate synthase mutants that allow growth in 6 days compared to 2 days for wild-type anthranilate synthase. The purified mutant enzymes catalyze the conversion of chorismate to anthranilate at rates that are about 50% of the rate of wild-type aminodeoxychorismate synthase-catalyzed conversion of chorismate to aminodeoxychorismate. The residues mutated do not contact the substrate