2.6.1.57: aromatic-amino-acid transaminase This is an abbreviated version! For detailed information about aromatic-amino-acid transaminase, go to the full flat file .
Reaction
an aromatic amino acid +
2-oxoglutarate =
an aromatic oxo acid +
L-glutamate
Synonyms AAT, AAT I-III, AAT1, aminotransferase, aromatic amino acid, ArAT, ArAT-I, ArAT-ITL, ArATPf, ArATPh, Aro8, ARO9, AroAT, AroAT II, AroATEs, AroH, arom. amino acid transferase, arom.-amino-acid transaminase, aromatic amino acid aminotransferase, aromatic amino acid transaminase, aromatic amino transferase I, aromatic aminotransferase, aromatic aminotransferase AT-1, aromatic aminotransferase AT-2, aromatic aminotransferase II, aromatic L-amino acid transaminase, aromatic-amino-acid aminotransferase, aromatic-amino-acid:2-oxoglutarate transaminase, AT-1, AT-2, AT-IA, At1g80360, bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase, CaAro8p, CaAro9p, CaYer152Cp, eAroATEs, F5I6.11, hisC1, indole severe sensitive 1, ISS1, More, pdArAT, pdAroAT, PH1371, phhC, PjAT, SmAroAT, TyrB, TyrB-2, VAT1, Yer152, Yer152C
ECTree
Inhibitors
Inhibitors on EC 2.6.1.57 - aromatic-amino-acid transaminase
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(aminooxy)acetate
AOA, is a broad-spectrum inhibitor of pyridoxal phosphate-dependent enzymatic reactions, such as transaminations. AOA strongly inhibits the growth of Candida albicans in minimal medium with selected amino acids as the sole nitrogen source in an amino acid concentration-dependent manner; AOA, is a broad-spectrum inhibitor of pyridoxal phosphate-dependent enzymatic reactions, such as transaminations. AOA strongly inhibits the growth of Candida albicans in minimal medium with selected amino acids as the sole nitrogen source in an amino acid concentration-dependent manner; AOA, is a broad-spectrum inhibitor of pyridoxal phosphate-dependent enzymatic reactions, such as transaminations. AOA strongly inhibits the growth of Candida albicans in minimal medium with selected amino acids as the sole nitrogen source in an amino acid concentration-dependent manner
2,4,6-trichlorophenoxyacetic acid
-
3-(2-hydroxyphenyl)propionic acid
-
3-(2-methoxyphenyl)propionic acid
-
3-(3,4,5-trimethoxyphenyl)propionic acid
-
3-(3,4-dimethoxyphenyl)propionic acid
-
3-(3-methoxyphenyl)propionic acid
-
3-(4-hydroxyphenyl)propionic acid
-
3-(4-methoxyphenyl)propionic acid
-
3-(p-tolyl)propionic acid
-
3-cyclohexylpropionic acid
-
3-cyclopentylpropionic acid
-
4-(2-thienyl)butyric acid
-
4-(4-nitrophenyl)butyric acid
-
4-aminohydrocinnamic acid
-
4-cyclohexylbutyric acid
-
4-hydroxyphenylpyruvate
-
substrate inhibition
carbidopa
inhibitor of pyridoxal phosphate-dependent enzymes. almost complete inhibition at 0.5 mM
cycloserine
-
0.15 mM, 89% inhibition of aromatic aminotransferase from strain CB 6
Indole pyruvate
-
substrate inhibition
indole-3-pyruvic acid
-
competitive inhibition
Isonicotinohydrazide
-
36% inhibition of aromatic aminotransferase from strain CB 60, enzyme from strain CB 6 is not inhibited
methionine
-
10 mM, inhibits activity of isoenzyme ArAT-I with 1 mM tyrosine by 23%, isoenzyme ArAT-II is not affected
phenylpyruvate
-
substrate inhibition
prephenate
-
substrate inhibition
phenylhydrazine
-
-
phenylhydrazine
-
0.15 mM, 78% inhibition of aromatic aminotransferase from strain CB 60, 56% inhibition of enzyme from strain CB 6
additional information
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enzyme from strain CB 60 is not inhibited by cycloserine
-
additional information
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not inhibited by idoleacetic acid
-