2.6.1.43: aminolevulinate transaminase
This is an abbreviated version!
For detailed information about aminolevulinate transaminase, go to the full flat file.
Word Map on EC 2.6.1.43
-
2.6.1.43
-
2.6.1.19
-
4-aminobutyrate
-
gaba-t
-
4.1.1.15
-
hyperoxaluria
-
alanine:glyoxylate
-
delta-aminolevulinic
-
l-alanine:4,5-dioxovalerate
-
1.2.1.16
-
4-aminobutyrate:2-oxoglutarate
-
gaba-transaminase
-
medicine
-
gamma-vinyl
-
porphobilinogenase
-
gabaculine
- 2.6.1.43
-
2.6.1.19
- 4-aminobutyrate
- gaba-t
-
4.1.1.15
- hyperoxaluria
-
alanine:glyoxylate
-
delta-aminolevulinic
-
l-alanine:4,5-dioxovalerate
-
1.2.1.16
-
4-aminobutyrate:2-oxoglutarate
- gaba-transaminase
- medicine
-
gamma-vinyl
- porphobilinogenase
- gabaculine
Reaction
Synonyms
4,5-dioxovalerate aminotransferase, 4,5-dioxovaleric acid aminotransferase, 4,5-dioxovaleric acid transaminase, 4,5-dioxovaleric transaminase, 5-aminolevulinic acid transaminase, alanine-dioxovalerate aminotransferase, alanine-gamma,delta-dioxovalerate aminotransferase, alanine:4,5-dioxovalerate aminotransferase, aminolevulinate aminotransferase, aminolevulinic acid transaminase, dioxovalerate transaminase, DOVA transaminase, DOVA-T, EC 2.6.1.19, EC 2.6.1.40, EC 2.6.1.44, gamma,delta-dioxovalerate aminotransferase, gamma,delta-dioxovaleric acid transaminase, L-alanine-4,5-dioxovalerate aminotransferase, L-alanine:4,5-dioxovaleric acid transaminase, L-alanine:dioxovalerate transaminase
ECTree
2.6.1.43 aminolevulinate transaminaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.6.1.43 - aminolevulinate transaminase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
3% of the activity with L-alanine
-
-
ir
DL-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
89% of the activity with L-alanine
-
-
ir
L-arginine + 4,5-dioxopentanoate
5-aminolevulinate + 5-guanidino-2-oxopentanoate
-
6.8% of the activity with L-alanine
-
-
ir
L-asparagine + 4,5-dioxopentanoate
5-aminolevulinate + 4-amino-2,4-dioxobutanoic acid
-
74% of the activity with L-alanine
-
-
ir
L-histidine + 4,5-dioxopentanoate
5-aminolevulinate + 3-(1H-imidazol-4-yl)-2-oxopropanoate
-
74% of the activity with L-alanine
-
-
ir
beta-alanine + 4,5-dioxopentanoate
5-aminolevulinate + malonic semialdehyde
-
23% of the activity with L-alanine
-
-
ir
beta-alanine + 4,5-dioxopentanoate
5-aminolevulinate + malonic semialdehyde
-
39% of the activity with L-alanine
-
-
ir
beta-alanine + 4,5-dioxopentanoate
5-aminolevulinate + malonic semialdehyde
-
65.6% of the activity with L-alanine
-
-
ir
delta-amino-n-valerate + 4,5-dioxopentanoate
5-aminolevulinate + 5-oxo-n-pentanoate
-
10% of the activity with L-alanine
-
-
ir
delta-amino-n-valerate + 4,5-dioxopentanoate
5-aminolevulinate + 5-oxo-n-pentanoate
-
transaminate at 95% of the rate of alpha-alanine
-
-
ir
epsilon-amino-n-caproate + 4,5-dioxopentanoate
5-aminolevulinate + 6-oxo-n-hexanoate
-
transaminate at 103% of the rate of alpha-alanine
-
-
ir
epsilon-amino-n-caproate + 4,5-dioxopentanoate
5-aminolevulinate + 6-oxo-n-hexanoate
-
34% of the activity with L-alanine
-
-
ir
gamma-amino-n-butyrate + 4,5-dioxopentanoate
5-aminolevulinate + succinic semialdehyde
-
10% of the activity with L-alanine
-
-
ir
gamma-amino-n-butyrate + 4,5-dioxopentanoate
5-aminolevulinate + succinic semialdehyde
-
transaminate at 122% of the rate of alpha-alanine
-
-
ir
gamma-amino-n-butyrate + 4,5-dioxopentanoate
5-aminolevulinate + succinic semialdehyde
-
55% of the activity with L-alanine
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
9% of the activity with L-alanine
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
-
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
less than 10% of the activity of alpha-alanine
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
21% of the activity with L-alanine
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
21% of the activity with L-alanine
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
81.2% of the activity with L-alanine
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
biosynthesis of porphyrin precursors
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
delta-aminolevulinate pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
first committed step in heme synthesis
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
alternate route for delta-aminolevulinate formation
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
alternate route for delta-aminolevulinate formation
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-aspartate + 4,5-dioxopentanoate
5-aminolevulinate + oxaloacetate
-
39% of the activity with L-alanine
-
-
ir
L-aspartate + 4,5-dioxopentanoate
5-aminolevulinate + oxaloacetate
-
67% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
39% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
39% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
37% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
37% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
96% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
43.8% of the activity with L-alanine
-
-
ir
L-glutamine + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutaramate
-
74% of the activity with L-alanine
-
-
?
L-glutamine + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutaramate
-
16% of the activity with L-alanine
-
-
?
L-lysine + 4,5-dioxopentanoate
5-aminolevulinate + 6-amino-2-oxohexanoate
-
9% of the activity with L-alanine
-
-
ir
L-lysine + 4,5-dioxopentanoate
5-aminolevulinate + 6-amino-2-oxohexanoate
-
15% of the activity with L-alanine
-
-
ir
L-ornithine + 4,5-dioxopentanoate
5-aminolevulinate + 5-amino-2-oxopentanoate
-
6% of the activity with L-alanine
-
-
ir
L-ornithine + 4,5-dioxopentanoate
5-aminolevulinate + 5-amino-2-oxopentanoate
-
less than 10% of the activity of alpha-alanine
-
-
ir
L-ornithine + 4,5-dioxopentanoate
5-aminolevulinate + 5-amino-2-oxopentanoate
-
14% of the activity with L-alanine
-
-
ir
L-phenylalanine + 4,5-dioxopentanoate
phenylpyruvate + 5-aminolevulinate
-
71% of the activity with L-alanine
-
-
ir
L-phenylalanine + 4,5-dioxopentanoate
phenylpyruvate + 5-aminolevulinate
-
90.6% of the activity with L-alanine
-
-
ir
L-serine + 4,5-dioxopentanoate
5-aminolevulinate + 3-hydroxy-2-oxopropanoate
-
33% of the activity with L-alanine
-
-
ir
L-serine + 4,5-dioxopentanoate
5-aminolevulinate + 3-hydroxy-2-oxopropanoate
-
33% of the activity with L-alanine
-
-
ir
additional information
?
-
-
glutamate is no substrate, transamination of methylglyoxal yields aminoacetone, less than 1% efficient as amino acceptor as 4,5-dioxopentanoate
-
-
?
additional information
?
-
-
cannot utilize 2-oxoglutarate nor pyruvate as amino acceptors
-
-
?
additional information
?
-
-
cannot utilize 2-oxoglutarate nor pyruvate as amino acceptors
-
-
?
additional information
?
-
-
ability of beta-alanine to replace alpha-alanine as amino group donor is lost during purification, alpha-amino-n-butyrate, alpha-aminoisobutyrate, beta-amino-n-butyrate and beta-aminoisobutyrate are inactive, serine, taurine, glutamine, asparagine, glutamic and aspartic acids, lysine and cysteine all have negligible activity
-
-
?
additional information
?
-
-
does not use 2-oxoglutarate as amino acceptor
-
-
?
additional information
?
-
-
does not use 2-oxoglutarate as amino acceptor
-
-
?
additional information
?
-
-
L-lysine, L-arginine, L-glutamate, L-methionine, L-histidine, glycine, L-phenylalanine, L-threonine, L-asparagine, L-serine, L-proline, L-valine, L-isoleucine, L-leucine, L-tyrosine, L-cysteine and L-tryptophan are all inert as amino donors, methylglyoxal is a poor substrate for the enzyme
-
-
?
additional information
?
-
-
DL-alanine, D-alanine, ammonium sulfate, L-glutamate, glycine and phenylalanine cannot replace L-alanine
-
-
?
additional information
?
-
-
DL-alanine, D-alanine, ammonium sulfate, L-glutamate, glycine and phenylalanine cannot replace L-alanine
-
-
?
