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beta-alanine + 4,5-dioxopentanoate
5-aminolevulinate + malonic semialdehyde
D-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
3% of the activity with L-alanine
-
-
ir
delta-amino-n-valerate + 4,5-dioxopentanoate
5-aminolevulinate + 5-oxo-n-pentanoate
DL-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
89% of the activity with L-alanine
-
-
ir
epsilon-amino-n-caproate + 4,5-dioxopentanoate
5-aminolevulinate + 6-oxo-n-hexanoate
gamma-amino-n-butyrate + 4,5-dioxopentanoate
5-aminolevulinate + succinic semialdehyde
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
L-arginine + 4,5-dioxopentanoate
5-aminolevulinate + 5-guanidino-2-oxopentanoate
-
6.8% of the activity with L-alanine
-
-
ir
L-asparagine + 4,5-dioxopentanoate
5-aminolevulinate + 4-amino-2,4-dioxobutanoic acid
-
74% of the activity with L-alanine
-
-
ir
L-aspartate + 4,5-dioxopentanoate
5-aminolevulinate + oxaloacetate
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
L-glutamine + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutaramate
L-histidine + 4,5-dioxopentanoate
5-aminolevulinate + 3-(1H-imidazol-4-yl)-2-oxopropanoate
-
74% of the activity with L-alanine
-
-
ir
L-lysine + 4,5-dioxopentanoate
5-aminolevulinate + 6-amino-2-oxohexanoate
L-ornithine + 4,5-dioxopentanoate
5-aminolevulinate + 5-amino-2-oxopentanoate
L-phenylalanine + 4,5-dioxopentanoate
phenylpyruvate + 5-aminolevulinate
L-serine + 4,5-dioxopentanoate
5-aminolevulinate + 3-hydroxy-2-oxopropanoate
additional information
?
-
beta-alanine + 4,5-dioxopentanoate
5-aminolevulinate + malonic semialdehyde
-
23% of the activity with L-alanine
-
-
ir
beta-alanine + 4,5-dioxopentanoate
5-aminolevulinate + malonic semialdehyde
-
39% of the activity with L-alanine
-
-
ir
beta-alanine + 4,5-dioxopentanoate
5-aminolevulinate + malonic semialdehyde
-
65.6% of the activity with L-alanine
-
-
ir
delta-amino-n-valerate + 4,5-dioxopentanoate
5-aminolevulinate + 5-oxo-n-pentanoate
-
10% of the activity with L-alanine
-
-
ir
delta-amino-n-valerate + 4,5-dioxopentanoate
5-aminolevulinate + 5-oxo-n-pentanoate
-
transaminate at 95% of the rate of alpha-alanine
-
-
ir
epsilon-amino-n-caproate + 4,5-dioxopentanoate
5-aminolevulinate + 6-oxo-n-hexanoate
-
transaminate at 103% of the rate of alpha-alanine
-
-
ir
epsilon-amino-n-caproate + 4,5-dioxopentanoate
5-aminolevulinate + 6-oxo-n-hexanoate
-
34% of the activity with L-alanine
-
-
ir
gamma-amino-n-butyrate + 4,5-dioxopentanoate
5-aminolevulinate + succinic semialdehyde
-
10% of the activity with L-alanine
-
-
ir
gamma-amino-n-butyrate + 4,5-dioxopentanoate
5-aminolevulinate + succinic semialdehyde
-
transaminate at 122% of the rate of alpha-alanine
-
-
ir
gamma-amino-n-butyrate + 4,5-dioxopentanoate
5-aminolevulinate + succinic semialdehyde
-
55% of the activity with L-alanine
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
-
-
-
?
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
9% of the activity with L-alanine
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
-
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
-
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
less than 10% of the activity of alpha-alanine
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
21% of the activity with L-alanine
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
21% of the activity with L-alanine
-
-
ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
-
81.2% of the activity with L-alanine
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
biosynthesis of porphyrin precursors
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
-
?
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
delta-aminolevulinate pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
first committed step in heme synthesis
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
-
?
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
alternate route for delta-aminolevulinate formation
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
alternate route for delta-aminolevulinate formation
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
-
ir
L-aspartate + 4,5-dioxopentanoate
5-aminolevulinate + oxaloacetate
-
39% of the activity with L-alanine
-
-
ir
L-aspartate + 4,5-dioxopentanoate
5-aminolevulinate + oxaloacetate
-
67% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
39% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
39% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
37% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
37% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
96% of the activity with L-alanine
-
-
ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
-
43.8% of the activity with L-alanine
-
-
ir
L-glutamine + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutaramate
-
74% of the activity with L-alanine
-
-
?
L-glutamine + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutaramate
-
16% of the activity with L-alanine
-
-
?
L-lysine + 4,5-dioxopentanoate
5-aminolevulinate + 6-amino-2-oxohexanoate
-
9% of the activity with L-alanine
-
-
ir
L-lysine + 4,5-dioxopentanoate
5-aminolevulinate + 6-amino-2-oxohexanoate
-
15% of the activity with L-alanine
-
-
ir
L-ornithine + 4,5-dioxopentanoate
5-aminolevulinate + 5-amino-2-oxopentanoate
-
6% of the activity with L-alanine
-
-
ir
L-ornithine + 4,5-dioxopentanoate
5-aminolevulinate + 5-amino-2-oxopentanoate
-
less than 10% of the activity of alpha-alanine
-
-
ir
L-ornithine + 4,5-dioxopentanoate
5-aminolevulinate + 5-amino-2-oxopentanoate
-
14% of the activity with L-alanine
-
-
ir
L-phenylalanine + 4,5-dioxopentanoate
phenylpyruvate + 5-aminolevulinate
-
71% of the activity with L-alanine
-
-
ir
L-phenylalanine + 4,5-dioxopentanoate
phenylpyruvate + 5-aminolevulinate
-
90.6% of the activity with L-alanine
-
-
ir
L-serine + 4,5-dioxopentanoate
5-aminolevulinate + 3-hydroxy-2-oxopropanoate
-
33% of the activity with L-alanine
-
-
ir
L-serine + 4,5-dioxopentanoate
5-aminolevulinate + 3-hydroxy-2-oxopropanoate
-
33% of the activity with L-alanine
-
-
ir
additional information
?
-
-
glutamate is no substrate, transamination of methylglyoxal yields aminoacetone, less than 1% efficient as amino acceptor as 4,5-dioxopentanoate
-
-
?
additional information
?
-
-
cannot utilize 2-oxoglutarate nor pyruvate as amino acceptors
-
-
?
additional information
?
-
-
cannot utilize 2-oxoglutarate nor pyruvate as amino acceptors
-
-
?
additional information
?
-
-
ability of beta-alanine to replace alpha-alanine as amino group donor is lost during purification, alpha-amino-n-butyrate, alpha-aminoisobutyrate, beta-amino-n-butyrate and beta-aminoisobutyrate are inactive, serine, taurine, glutamine, asparagine, glutamic and aspartic acids, lysine and cysteine all have negligible activity
-
-
?
additional information
?
-
-
does not use 2-oxoglutarate as amino acceptor
-
-
?
additional information
?
-
-
does not use 2-oxoglutarate as amino acceptor
-
-
?
additional information
?
-
-
L-lysine, L-arginine, L-glutamate, L-methionine, L-histidine, glycine, L-phenylalanine, L-threonine, L-asparagine, L-serine, L-proline, L-valine, L-isoleucine, L-leucine, L-tyrosine, L-cysteine and L-tryptophan are all inert as amino donors, methylglyoxal is a poor substrate for the enzyme
-
-
?
additional information
?
-
-
cysteine is no substrate
-
-
?
additional information
?
-
-
DL-alanine, D-alanine, ammonium sulfate, L-glutamate, glycine and phenylalanine cannot replace L-alanine
-
-
?
additional information
?
-
-
DL-alanine, D-alanine, ammonium sulfate, L-glutamate, glycine and phenylalanine cannot replace L-alanine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
biosynthesis of porphyrin precursors
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
delta-aminolevulinate pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
first committed step in heme synthesis
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
alternate route for delta-aminolevulinate formation
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
alternate route for delta-aminolevulinate formation
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
-
ir
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Neuberger, A.; Turner, J.M.
gamma, delta-Dioxovalerate aminotransferase activity in Rhodopseudomonas spheroides
Biochim. Biophys. Acta
67
342-345
1963
Cereibacter sphaeroides
brenda
Varticovski, L.; Kushner, J.P.; Burnham, B.F.
Biosynthesis of porphyrin precursors. Purification and characterization of mammalian L-alanine:gamma,delta-dioxovaleric acid aminotransferase
J. Biol. Chem.
255
3742-3747
1980
Bos taurus
brenda
Noguchi, T.; Mori, R.
Biosynthesis of porphyrin precursors in mammals. Identity of alanine: gamma, delta-dioxovalerate aminotransferase with alanine:glyoxylate aminotransferase
J. Biol. Chem.
256
10335-10339
1981
Bos taurus
brenda
Bajkowski, A.S.; Friedmann, H.C.
delta-Aminolevulinic acid formation. Purification and properties of alanine:4,5-dioxovalerate, aminotransferase and isolation of 4,5-dioxovalerate from Clostridium tetanomorphum
J. Biol. Chem.
257
2207-2211
1982
Clostridium tetanomorphum
brenda
Shioi, Y.; Doi, M.; Sasa, T.
Purification and characterization of L-alanine:4,5-dioxovalerate (glyoxylate) aminotransferase from radish (Raphanus sativus L.)
Plant Cell Physiol.
25
1487-1493
1984
Raphanus sativus
-
brenda
Shioi, Y.; Nagamine, M.; Sasa, T.
Purification and properties of L-alanine:4,5-dioxovalerate aminotransferase from Chlorella regularis
Arch. Biochem. Biophys.
234
117-124
1984
Chlorella regularis, Chlorella regularis S-50
brenda
Shanker, J.; Datta, K.
Evidence of hemin as an end product inhibitor of L-alanine: 4,5-dioxovalerate transaminase in rat liver mitochondria
FEBS Lett.
189
129-132
1985
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Singh, N.K.; Datta, K.
Purification and characterization of rat kidney L-alanine: 4,5-dioxovalerate transaminase and inhibition by hemin
Biochim. Biophys. Acta
827
305-309
1985
Rattus norvegicus
brenda
Shanker, J.; Datta, K.
Affinity purification and properties of rat liver mitochondrial L-alanine:4,5-dioxovalerate transaminase and its inhibition by hemin
Arch. Biochem. Biophys.
248
652-657
1986
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Rhee, H.i.; Murata, K.; Kimura, A.
L-alanine: 4,5-dioxovalerate aminotransferase from Pseudomonas riboflavina: purification and inactivation by methylglyoxal
J. Biochem.
103
1045-1049
1988
Devosia riboflavina
brenda
Ades, I.Z.
Synthetic substrates for thrombin
Int. J. Biochem.
21
579-587
1989
Gallus gallus
brenda
Prasad, D.D.K.; Prasad, A.R.K.
Characterization of L-alanine:4,5-dioxovaleric acid transaminasefrom bajra (Pennisetum typhoideum) seedlings
Biochem. Int.
18
149-161
1989
Cenchrus americanus
-
brenda
Hoare, K.; Datta, K.
Characteristics of L-alanine:4,5-dioxovaleric acid transaminase: an alternate pathway of heme biosynthesis in yeast
Arch. Biochem. Biophys.
277
122-129
1990
Candida albicans, Candida albicans 3100, Saccharomyces cerevisiae, Saccharomyces cerevisiae 3059 S288C
brenda
McKinney, C.E.; Ades, I.Z.
Production of delta-aminolevulinate: subcellular localization and purification of murine hepatic L-alanine: 4,5-dioxovaleric acid aminotransferase
Int. J. Biochem.
22
347-357
1990
Mus musculus, Mus musculus C57/BL6J
brenda
McKinney, C.E.; Ades, I.Z.
Production of delta-aminolevulinic acid: characterization of murine liver 4,5-dioxovaleric acid: L-alanine aminotransferase
Int. J. Biochem.
23
803-810
1991
Mus musculus
brenda
Singh, N.K.; Tyagi, R.K.; Datta, K.
Cytosolic L-alanine:4,5-dioxovalerate transaminase differs from the mitochondrial form
Eur. J. Biochem.
198
581-587
1991
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Tyagi, R.K.; Datta, K.
In vitro translocation of L-alanine:4,5-dioxovalerate transaminase into rat kidney mitochondria
J. Biochem.
113
557-562
1993
Rattus norvegicus
brenda
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