2.4.1.B72: C-mannosyltransferase
This is an abbreviated version!
For detailed information about C-mannosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.B72
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2.4.1.B72
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c-mannosylation
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elegans
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thrombospondin
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neuroblast
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acrosome
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round-headed
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netrin
- 2.4.1.B72
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c-mannosylation
- elegans
- thrombospondin
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neuroblast
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acrosome
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round-headed
- netrin
Reaction
transfers a D-mannosyl residue from dolichyl D-mannosyl phosphate to the tryptophan residue of a protein acceptor forming a C-C bond =
Synonyms
C-mannosyltransferase, DPY-19, Dpy-19-like C-mannosyltransferase, Dpy-19-like protein 3, dpy19, DPY19L1, DPY19L3, DPY19L4, dumpy-19, Dumpy-19 protein homologue, Pf DPY-19, PF3D7_0806200, protein dpy-19 homolog 3, protein dumpy-19
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.4.1.B72 - C-mannosyltransferase
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REACTION DIAGRAM
dolichyl D-mannosyl phosphate + MIG-21 protein
dolichyl phosphate + C-mannosylated MIG-21 protein
C-mannosylation at a tryptophan residue
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dolichyl D-mannosyl phosphate + UNC-5 protein
dolichyl phosphate + C-mannosylated UNC-5 protein
C-mannosylation at a tryptophan residue
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cell surface receptors MIG-21 and UNC-5 are acceptor substrates of enzyme DPY-19
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additional information
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cell surface receptors MIG-21 and UNC-5 are acceptor substrates of enzyme DPY-19
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additional information
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C-mannosylation is initially described as a modification of the first tryptophan in the WxxW consensus sequence, but is also observed on tryptophans that are not part of this motif. In addition to WxxW, WxxC is also considered to be a consensus sequence for C-mannosylation
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additional information
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C-mannosylation is initially described as a modification of the first tryptophan in the WxxW consensus sequence, but is also observed on tryptophans that are not part of this motif. In addition to WxxW, WxxC is also considered to be a consensus sequence for C-mannosylation
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additional information
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the enzyme can transfer mannose to adhesive thrombospondin type 1 repeats (TSRs) and type I cytokine receptors. Enzyme Dpy19 of Caenorhabditis elegans can transfer mannose to a short WXXW peptide
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additional information
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the enzyme can transfer mannose to adhesive thrombospondin type 1 repeats (TSRs) and type I cytokine receptors. Enzyme Dpy19 of Caenorhabditis elegans can transfer mannose to a short WXXW peptide
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additional information
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protein C-mannosylation is the attachment of alpha-mannopyranose to tryptophan via a C-C linkage. This post-translational modification typically occurs within the sequence motif WXXW, which is frequently present in thrombospondin type-1 repeats (TSRs). TSRs are especially numerous in and a defining feature of the ADAMTS superfamily. Predicted C-mannosylation sites in the ADAMTS superfamily, overview
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additional information
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DPY19L3 is the C-mannosyltransferase of Rspo1 at residue W156
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additional information
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DPY19L3 is the C-mannosyltransferase of Rspo1 at residue W156
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additional information
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mammalian C-mannosyltransferases DPY19L1 and DPY19L3 do not have a dual WxxW/C recognition motif, but are active C-mannosyltransferases with distinct substrate specificities
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additional information
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mammalian C-mannosyltransferases DPY19L1 and DPY19L3 do not have a dual WxxW/C recognition motif, but are active C-mannosyltransferases with distinct substrate specificities
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additional information
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mammalian C-mannosyltransferases DPY19L1 and DPY19L3 do not have a dual WxxW/C recognition motif, but are active C-mannosyltransferases with distinct substrate specificities
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additional information
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mammalian C-mannosyltransferases DPY19L1 and DPY19L3 do not have a dual WxxW/C recognition motif, but are active C-mannosyltransferases with distinct substrate specificities
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additional information
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the micronemal adhesin thrombospondin-related anonymous protein (TRAP) is C-hexosylated in Plasmodium falciparum sporozoites. When expressed in a mammalian cell line deficient in C-mannosylation, the Plasmodium falciparum Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide
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additional information
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the micronemal adhesin thrombospondin-related anonymous protein (TRAP) is C-hexosylated in Plasmodium falciparum sporozoites. When expressed in a mammalian cell line deficient in C-mannosylation, the Plasmodium falciparum Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide
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additional information
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the micronemal protein MIC2 secreted by Toxoplasma gondii tachyzoites is C-hexosylated. When expressed in a mammalian cell line deficient in C-mannosylation, the Toxoplasma gondii Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide. MIC2 secreted by Toxoplasma tachyzoites is C-mannosylated
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additional information
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the micronemal protein MIC2 secreted by Toxoplasma gondii tachyzoites is C-hexosylated. When expressed in a mammalian cell line deficient in C-mannosylation, the Toxoplasma gondii Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide. MIC2 secreted by Toxoplasma tachyzoites is C-mannosylated
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additional information
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the micronemal protein MIC2 secreted by Toxoplasma gondii tachyzoites is C-hexosylated. When expressed in a mammalian cell line deficient in C-mannosylation, the Toxoplasma gondii Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide. MIC2 secreted by Toxoplasma tachyzoites is C-mannosylated
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additional information
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the micronemal protein MIC2 secreted by Toxoplasma gondii tachyzoites is C-hexosylated. When expressed in a mammalian cell line deficient in C-mannosylation, the Toxoplasma gondii Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide. MIC2 secreted by Toxoplasma tachyzoites is C-mannosylated
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