2.4.1.224: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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For detailed information about glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

alpha-N-acetylglucosaminyltransferase II, exostosin-1, exostosin-2, Exostosin1, Exostosin2, EXT1, EXT2, extosin, glucuronyl-N-acetylglucosaminoproteoglycan 4-alpha-N-acetylglucosaminyltransferase, heparan sulfate polymerase, heparan sulfate synthesis enzyme, KfiA, More, N-acetyl-D-glucosaminyl-(N-acetyl-D-glucosamine) transferase, sister of tout velu, sister of tout-velu, sotv, tout-velu, ttv, UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.224 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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Results	in table
1	Activating Compound
319	AA Sequence
1	Application
2	CAS Registry Number
16	Cloned(Commentary)
76	Disease/ Diagnostics
3	Expression
32	General Information
1	General Stability
8	KM Value [mM]
23	Localization
2	Metals/Ions
15	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
253	Organism
3	Pathway
10	PDB ID
1	pH Optimum
2	pH Range
3	pI Value
8	Posttranslational Modification
23	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
51	Reference
38	Source Tissue
1	Specific Activity [micromol/min/mg]
78	Substrates and Products (Substrate)
6	Subunits
58	Synonyms
1	Systematic Name

Expression

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Expression on EC 2.4.1.224 - glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

EXT1 is significantly decreased in MCF7 cells compared with the non-tumorigenic MCF10A cells, while no significant difference is observed between the two triple-negative cell lines, MDA-MB-231 and HCC38, and the ER- and PR-positive MCF10A cells

Homo sapiens

Q16394, Q93063

758941

the expression of EXT2 is reduced in all cancer cell lines

Homo sapiens

Q16394, Q93063

758941

the overall transcriptional activity of the main heparan sulfate biosynthesis-involved genes (EXT1, EXT2, NDST1,NDST2, GLCE, HS2ST1, HS3ST1, HS3ST2, HS6ST1, HS6ST2, SULF1, SULF2, HPSE) is decreased by 1.5-2fold in Grade II-III glioma (p < 0.01) and by 3-fold in Grade IV glioma (glioblastoma multiforme, GBM) (p < 0.05), as compared with the para-tumourous tissue

Homo sapiens

Q16394, Q93063

759360