2.4.1.152: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, go to the full flat file.

Reaction

Synonyms

11639FucT, alpha (1,3) fucosyltransferase, alpha (1,3)-fucosyltransferase, alpha 1,3 fucosyltransferase, alpha 1,3/4 fucosyltransferase Lewis 2, alpha 3-fucosyltransferase IX, alpha(1,3)-fucosyltransferase VII, alpha(1,3)fucosyltransferase IV, alpha(1,3)fucosyltransferase VII, alpha(1-3)fucosyltransferase, alpha-(1,3)-fucosyltransferase, alpha-(1,3)-fucosyltransferase 11, alpha-(1,3)-fucosyltransferase IXa, alpha-(1,3/1,4)-fucosyltransferase, alpha-(1,3/1,4)-FucT, alpha-1,3 FucT-VII, alpha-1,3-fucosyltransferase, alpha-1,3-fucosyltransferase 3, alpha-1,3-fucosyltransferase 9D, alpha-1,3-fucosyltransferase VI, alpha-1,3-FucT3, alpha-13-fucosyltransferase VII, alpha-3-fucosyltransferase, alpha-3-L-fucosyltransferase, alpha1,3 fucosyltransferase, alpha1,3 fucosyltransferase VII, alpha1,3 FucT-VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase 4, alpha1,3-fucosyltransferase 9, alpha1,3-fucosyltransferase C, alpha1,3-fucosyltransferase IX, alpha1,3-fucosyltransferase V, alpha1,3-fucosyltransferase VI, alpha1,3-fucosyltransferase-F, alpha1,3-FucT, alpha1,3-FucTIX, alpha1,3/4-fucosyltransferase, alpha1,3/4-fucosyltransferase VI, alpha1,3FT, alpha1,3fucosyltransferase-VII, alpha1-3 fucosyltransferase, alpha1-3 fucosyltransferase-VII, alpha1-3 FucT, alpha1->3fucosyltransferase, alpha3-fucosyltransferase, alpha3-fucosyltransferase IX, alpha3-fucosyltransferase VII, alpha3-fucosyltransferase-V, alpha3-fucosyltransferase-VI, alpha3/4FucT, CEFT-3, CEFT-4, FT-IV, FT-VII, Fuc-Tb, Fuc-TV, Fuc-TXI, fucosyltransferase, fucosyltransferase 11, fucosyltransferase 4, fucosyltransferase 7, fucosyltransferase IV, fucosyltransferase IX, fucosyltransferase V, fucosyltransferase VI, fucosyltransferase VII, fucosyltransferase, guanosine diphosphofucose-glucoside alpha1-->3-, fucosyltransferase-7, fucosyltransferase-VII, fucosyltransferaseIX, FucT, FucT 9, FucT IX, FucT V, FucT-IX, FucT-VI, FucT-VII, FucT-XI, FucT7, FucT9, FucTC, FucTD, FucTe, FucTVII, FUT VI, FuT-F, FUT-VI, FUT10, FUT11, FUT3, FUT4, FUT5, FUT6, FUT7, Fut9, FUT9a, FutA, FutB, galactoside 3-fucosyltransferase, galactoside 3-L-fucosyltransferase 11, GDL-L-fucose:N-acetyl-beta-D-glucosaminyl alpha-3-L-fucosyltransferase, GDP-Fuc:Galbeta1-4GlcNAc (Fuc to GlcNAc) alpha1-3 fucosyltransferase, GDP-fucose:beta-D-N-acetylglucosaminide 3-alpha-fucosyltransferase, GDP-fucose:Galbeta(1-4)GlcNAc-R alpha(1-3)fucosyltransferase, GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-galactosaminyl-R 3-L-fucosyltransferase, guanosine diphosphofucose glucoside alpha1->3fucosyltransferase, HP_0379, HP_0651, Lewis type alpha1,3-FucT, lewis-negative alpha-3-fucosyltransferase, LEwis-type alpha1,3-fucosyltransferase, Lj4g3v0598850, More, plasma alpha-3-fucosyltransferase, PylT, rat fucosyltransferase VII, rFuc-TVII, rFUT7, sFUT9, UA948FucT, WP-000487420, WP-000487428, WP-000487430, XM_016585847, zebrafisha1-3fucosyltrasferase 1, zFT1

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
3	Activating Compound
574	AA Sequence
20	Application
2	CAS Registry Number
41	Cloned(Commentary)
104	Disease/ Diagnostics
10	Expression
15	General Information
2	General Stability
11	IC50 Value
56	Inhibitors
16	kcat/KM [mM/s]
16	Ki Value [mM]
104	KM Value [mM]
19	Localization
31	Metals/Ions
24	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
124	Organism
7	Pathway
11	PDB ID
19	pH Optimum
3	pH Range
8	Posttranslational Modification
51	Protein Variants
14	Purification (Commentary)
1	Reaction
2	Reaction Type
106	Reference
96	Source Tissue
12	Specific Activity [micromol/min/mg]
2	Storage Stability
206	Substrates and Products (Substrate)
30	Subunits
199	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Range [°C]
24	Turnover Number [1/s]

General Information

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

General Information on EC 2.4.1.152 - 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to General Information Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Mus musculus

-

suppression of isoform Fut10 expression induces the differentiation of neural stem cells and embryonic stem cells. In addition, knockdown of Fut10 expression in the cortical ventricular zone of the embryonic brain impairs the radial migration of neural precursor cells

736427

metabolism

Bos taurus

A1XCQ0

the enzyme is specifically responsible for Sialyl-Lewis X synthesis

721939

physiological function

13 entries

physiological function

Tetraodon nigroviridis

Q6EV15

glycoproteins from tobacco line xFxG1, in which expression of a hybrid beta-(1-4)-galactosyltransferase and a hybrid a-(1-3)-fucosyltransferase IXa (FUT9a) is combined, contain an abundance of hybrid N-glycans with Lewis X (LeX) epitopes

703055

physiological function

Homo sapiens

-

largest amount of recombinant FucT-IX is obtained in Sf9-insect cells by use of a baculovirus inducible protein production system

703540

physiological function

Homo sapiens

-

protein kinase R is the primary target for Herpes simplex virus type 1 early RNA during induction of FUT3, FUT5, and FUT6, whereby the subsequent steps in the transcriptional activation of these host genes involve a hitherto unknown IMD-0354, yet IKK-2-independent, pathway

703902

physiological function

Mus musculus

-

synthesis of E- and P-selectin ligands, as mediated by the rate-limiting enzyme FucT-VII, plays an important role in the pathogenesis of atherosclerosis

701615

physiological function

Homo sapiens

-

upregulation of selectin ligands in the endometrium at the time of implantation may be mediated, at least in part, by the regulation of FUT4 expression

706697

physiological function

Homo sapiens

-

overexpression of FUT6 in hepatocellular carcinoma cells enhance S-phase cell population, promoted cell growth and colony formation ability. FUT6 plays an important role in hepatocellular carcinoma cell growth by regulating the phosphatidyl inositol 3-kinase/Akt signaling pathway

721501

physiological function

Homo sapiens

-

the enzyme plays a role in colorectal carcinoma metastases by promoting the carbohydration of glycoprotein CD24

723313

physiological function

Homo sapiens

P22083

fucosyltransferase IV is implicated in the modulation of cell migration, invasion and cancer metastasis. The enzyme has a role in epithelial-mesenchymal transition through activation of the phosphatidylinositol 3-kinase/Akt and nuclear factor-kappaB signaling systems, which induce the key mediators Snail and MMP-9 and facilitate the acquisition of a mesenchymal phenotype

735901

physiological function

Mus musculus

-

overexpression of isoform Fut10 enhances the self-renewal of neural stem cells

736427

physiological function

Homo sapiens

-

following FUT7 siRNA transfection, the expression of FUT7 is markedly downregulated. The synthesis of sialyl-Lewisx epitope is also inhibited, consistent with the downregulated expression of FUT7. MHCC-97 cell proliferation is also significantly inhibited following FUT7 siRNA transfection, which is correlated with suppression of the S-phase in cell cycle progression. The knockdown of FUT7 inhibits the activation of phospholipase Cgamma by inhibiting its translocation and phosphorylation

756981

physiological function

Homo sapiens

-

FUT7 overexpression significantly promotes monocyte-endothelial adhesion, while FUT7 knockdown inhibits IL-1beta-induced monocyte-endothelial adhesion. Fucosylation of selectin ligand endomucin is directly involved in IL-1beta-induced monocyte-endothelial adhesion. p38 and extracellular signal-regulated kinase (ERK) MAPK signaling pathway are activated by IL-1beta, while inhibition of the p38/ERK signaling pathway decreases FUT7 expression level and IL-1beta-induced monocyte-endothelial adhesion

757537

physiological function

Nicotiana tabacum

-

knocking-out of two XylT genes and four FucT genes in BY-2 suspension cells using CRISPR/Cas9. Three lines show a strong reduction of beta(1,2)-xylose and alpha(1,3)-fucose, while two lines are completely devoid of them, indicating complete gene inactivation. The KO lines do not show any particular morphology and grow as the wild-type. A KO line transformed with genes encoding a human IgG2 antibody shows an IgG2 expression level as high as in a control transformant. The IgG glycosylation profile shows no beta(1,2)-xylose or alpha(1,3)-fucose present on the glycosylation moiety. The dominant glycoform is the GnGn structure

756828

physiological function

Lotus japonicus

-

proteins derived from the alpha1,3-fucosyltransferase LORE1 insertion mutant completely lack alpha1,3-core fucosylation. The Lotus japonicus convicilin 2 is one of the main glycoproteins undergoing differential expression/N-glycosylation in the mutant. Reduced growth and seed production phenotypes are observed for the mutant plants, even though the relative protein composition and abundance appear unaffected

758015