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2.3.3.18: 2-phosphinomethylmalate synthase

This is an abbreviated version!
For detailed information about 2-phosphinomethylmalate synthase, go to the full flat file.

Reaction

acetyl-CoA
+
H2O
 +
3-(hydroxyphosphinoyl)pyruvate
=
phosphinomethylmalate
 +
CoA

Synonyms

2-phosphinomethylmalic acid synthase, pmmS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.18 2-phosphinomethylmalate synthase

Inhibitors

Inhibitors on EC 2.3.3.18 - 2-phosphinomethylmalate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxoglutarate
1 mM, 18% inhibition
4-chloromercuribenzoate
ATP
1 mM, 35% inhibition
Ca2+
1 mM, 54% residual activity
Fe2+
1 mM, 50% residual activity
iodoacetamide
1 mM, 82% inhibition
iodoacetic acid
1 mM, 18% residual activity
Mg2+
1 mM, 44% residual activity
phosphate buffer
not inhibitory at 10 mM, 50% loss of activity in 100 mM phosphate buffer
-
Zn2+
1 mM, 24% residual activity