satellite glial cells in dorsal root ganglia. HMGCS1 but not HMGCS2 immunoreactivity in satellite glial cells is reduced in the fifth lumbar (L5) dorsal root ganglion that contain axotomized neurons following L5 spinal nerve ligation in rats. HMGCS1 protein level in axotomized L5 dorsal root ganglia is reduced after spinal nerve ligation to 66% at 3 days and 58% at 28 days of its level in control samples, whereas HMGCS2 protein is comparable between injured and control dorsal root ganglia
although HMGCS1 expression does not correlate with BRAFV600E mutation in human melanoma cells, HMGCS1 is selectively important for proliferation of BRAFV600E-positive melanoma and colon cancer cells but not control cells harboring activeN/KRAS mutants, and stable knockdown of HMGCS1 only attenuated colony formation and tumor growth potential of BRAFV600E melanoma cells
GhHMGS1A is moderately expressed at 10 and 40 days post anthesis. GhHMGS1D is moderately expressed at 40 days post anthesis. GhHMGS3A is relatively highly expressed at 20 days post anthesis
GhHMGS1A is moderately expressed at 10 and 40 days post anthesis. GhHMGS1D is moderately expressed at 40 days post anthesis. Although the GhHMGS2D expression level is generally low in the examined tissues, GhHMGS2D expression is relatively high in the ovules at 10 and 20 days post anthesis. GhHMGS3A is relatively highly expressed at 20 days post anthesis. GhHMGS3D is significantly expressed at 0 and 30 days post anthesis
hepatic mRNA expression of 3-hydroxyl-3-methyl-glutaryl-CoA synthase is significantly decreased (27%) in the liver of gallstone patients compared with gallstone-free patients
GhHMGS1A and GhHMGS1D were most highly expressed in the roots. The six 3-hydroxy-3-methylglutaryl coenzyme A synthase genes are expressed in all tested tissues, with most genes considerably expressed in the roots. GhHMGS3A and GhHMGS3D expression patterns are similar. Both genes are highly expressed in the roots and ovules at 40 days post anthesis
mRNA levels in newborn rats is low, when suckling begins, there is a net increase in gene expression up to day 12, levels then plateau until day 15, and then decreases progressively throughout the suckling period, becoming zero after weaning (day 21) and remains so in the adult rat
GhHMGS1A is moderately expressed at 10 and 40 days post anthesis. GhHMGS1D is moderately expressed at 40 days post anthesis. Although the GhHMGS2A level is generally low in the examined tissues, GhHMGS2A expression is relatively high in the stems. GhHMGS3A is relatively highly expressed at 20 days post anthesis. GhHMGS3D is significantly expressed at 0 and 30 days post anthesis