2.3.1.189: mycothiol synthase

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For detailed information about mycothiol synthase, go to the full flat file.

Reaction

Synonyms

MSH acetyltransferase, MSH synthase, MshD, nshD, Rv0819

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.189 mycothiol synthase

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Results	in table
5444	AA Sequence
2	Application
3	Cloned(Commentary)
2	Crystallization (Commentary)
3	General Information
12	Natural Substrates/ Products (Substrates)
28	Organism
1	Pathway
1	Purification (Commentary)
1	Reaction
16	Reference
21	Substrates and Products (Substrate)
26	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.1.189 - mycothiol synthase

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SYSTEMATIC NAME

IUBMB Comments

acetyl-CoA:desacetylmycothiol O-acetyltransferase

This enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium [1]. The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs) [2]. The enzyme has been purified from Mycobacterium tuberculosis H37Rv. Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate [3].