2.1.1.321: type III protein arginine methyltransferase

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For detailed information about type III protein arginine methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.321

2.1.1.321

prmt7

histone

monomethylation

metastasis

monomethylarginine

dimethylarginine

nanog

adomet

medicine

Reaction

Synonyms

EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, PRMT-7, PRMT7, protein arginine methyltransferase 7

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.321 type III protein arginine methyltransferase

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Results	in table
1008	AA Sequence
1	Application
4	Cloned(Commentary)
3	Crystallization (Commentary)
24	Disease/ Diagnostics
1	Expression
21	General Information
2	Inhibitors
1	kcat/KM [mM/s]
1	KM Value [mM]
2	Localization
1	Metals/Ions
3	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
26	Organism
1	PDB ID
8	Protein Variants
3	Purification (Commentary)
1	Reaction
24	Reference
27	Source Tissue
37	Substrates and Products (Substrate)
2	Subunits
27	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Range [°C]
1	Turnover Number [1/s]

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Disease on EC 2.1.1.321 - type III protein arginine methyltransferase

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Breast Neoplasms

Automethylation of protein arginine methyltransferase 7 and its impact on breast cancer progression.

28188177

PRMT7 contributes to the metastasis phenotype in human non-small-cell lung cancer cells possibly through the interaction with HSPA5 and EEF2.

30147338

Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression.

25605249

Carcinoma, Hepatocellular

S-adenosylmethionine:protein methyltransferases in hepatomas.

164278

Neoplasm Metastasis

Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.

24247247

PRMT7 contributes to the metastasis phenotype in human non-small-cell lung cancer cells possibly through the interaction with HSPA5 and EEF2.

30147338

Structural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active site.

25195753

Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop.

25294873