2.1.1.257: tRNA (pseudouridine54-N1)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (pseudouridine54-N1)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.257
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2.1.1.257
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methanocaldococcus
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jannaschii
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knot
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haloferax
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spout
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volcanii
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hypermodified
- 2.1.1.257
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methanocaldococcus
- jannaschii
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knot
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haloferax
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spout
- volcanii
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hypermodified
Reaction
Synonyms
COG 1901, COG1901, DUF358, DUF358/Mj1640, Emg1, Hvo_1989, m1-pseudouridine methyltransferase, m1G, m1PSI methyltransferase, M3U, Mja_1640, MjNep1, Nep1, Pfam DUF358, pseudouridine N1-specific methyltransferase, pseudouridine-N1-specific methyltransferase, ribosome assembly factor Nep1, SAM-dependent N1-pseudouridine methyltransferase, TrmY, TrmY protein
ECTree
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General Information
General Information on EC 2.1.1.257 - tRNA (pseudouridine54-N1)-methyltransferase
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evolution
malfunction
metabolism
physiological function
additional information
m1PSI formation in archaeal tRNAs, overview. The enzyme belongs to Cluster of Orthologous Group, COG, 1901
evolution
m1PSI formation in archaeal tRNAs, overview. The enzyme belongs to Cluster of Orthologous Group, COG, 1901
evolution
m1PSI formation in archaeal tRNAs, overview. The enzyme belongs to Cluster of Orthologous Group, COG, 1901
evolution
Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases
evolution
Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases
evolution
the enzyme is a member of the SPOUT-class family of RNA methyltransferases, phylogeny of the methyltransferase family, overview
evolution
the enzyme is a SPOUT-class RNA methyltransferase and belongs to the DUF358 family. The DUF358/Mj1640 protein shows close structural relationship to Nep1, a pseudouridine-N1-specific rRNA methyltransferase
evolution
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Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases
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evolution
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m1PSI formation in archaeal tRNAs, overview. The enzyme belongs to Cluster of Orthologous Group, COG, 1901
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a Hvo_1989 knockout strain lacks N1-methyl pseudouridine modifications at position 54 of its tRNAs, the in-frame deletion of the pseudouridine N1-methyltransferase gene in Haloferax volcanii does not result in a discernable phenotype
malfunction
a mutation in the human Nep1 homolog causes Bowen-Conradi syndrome, a severe developmental disorder
malfunction
deletion of trmY leads to the absence of m1PSI54 in Haloferax volcanii tRNA
Pus10-mediated PSI54 (and PSI55) formation does not require the presence of TrmY activity, overview
metabolism
Pus10-mediated PSI54 (and PSI55) formation does not require the presence of TrmY activity, overview
Nep1 acts as a methyltransferase in ribosome biogenesis
physiological function
Nep1 acts as a methyltransferase in ribosome biogenesis
physiological function
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Nep1 acts as a methyltransferase in ribosome biogenesis
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Methanocaldococcus jannaschii TrmY requires C55 (or possibly U55) in the tRNA to produce m1PSI54
additional information
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Methanocaldococcus jannaschii TrmY requires C55 (or possibly U55) in the tRNA to produce m1PSI54